I. An Asymmetric Variant of the 1-azadiene Diels-Alder Reaction. II. Total Synthesis, Stereochemical Reassignment and Absolute Configuration of Chlorofusin

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ISBN 13 :
Total Pages : 560 pages
Book Rating : 4.:/5 (763 download)

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Book Synopsis I. An Asymmetric Variant of the 1-azadiene Diels-Alder Reaction. II. Total Synthesis, Stereochemical Reassignment and Absolute Configuration of Chlorofusin by : Ryan C. Clark

Download or read book I. An Asymmetric Variant of the 1-azadiene Diels-Alder Reaction. II. Total Synthesis, Stereochemical Reassignment and Absolute Configuration of Chlorofusin written by Ryan C. Clark and published by . This book was released on 2008 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the inverse electron demand Diels-Alder reaction of N-sulfonyl-1-aza-1,3-butadienes with electron-rich dienophiles has been extensively examined in our laboratory, we sought to control the absolute configuration of the tetrahydropyridine products and thereby extend the utility of the methodology. The first detailed study of a room temperature asymmetric Diels-Alder reaction of N-sulfonyl-1-aza-1,3-butadienes enlisting a series of nineteen enol ethers bearing chiral auxilaries is described herein. Many of these auxilaries provided highly diastereoselective reactions (in both the endo and facial sense) largely the result of a highly organized [4+2] cycloaddition transition state. Three readily accessible and previously unexplored butyrolactone and pyrrolidinone auxilaries rationally emerged from the studies and provide exceptional selectivities (up to 49:1 endo:exo and 48:1 facial).

Activity-Based Protein Profiling

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Publisher : Springer
ISBN 13 : 3030111431
Total Pages : 420 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Activity-Based Protein Profiling by : Benjamin F. Cravatt

Download or read book Activity-Based Protein Profiling written by Benjamin F. Cravatt and published by Springer. This book was released on 2019-01-25 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions.

Chembiomolecular Science

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Publisher : Springer Science & Business Media
ISBN 13 : 4431540385
Total Pages : 320 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Chembiomolecular Science by : Masakatsu Shibasaki

Download or read book Chembiomolecular Science written by Masakatsu Shibasaki and published by Springer Science & Business Media. This book was released on 2012-10-02 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the forefront of life sciences today is the emerging discipline of chembiomolecular science. This new term describes the integration of the frontier fields of chemical biology, chemistry, and pharmacology. Chembiomolecular science aims to elucidate new biological mechanisms as potential drug targets and enhance the creation of new drug therapies. This book comprises the proceedings of the Uehara Memorial Foundation Symposium 2011, which focused on the most recent advances in chembiomolecular science made by leading experts in the field. The book is divided into three main topics. The first is the chemical approach to understanding complex biological systems on a molecular level using chemical compounds as a probe. The second describes the biological approach used to develop new lead drug compounds. The third focuses on the biological system that serves as the potential drug target, the beginning step in the process of developing new drugs. Replete with the latest research, the book will draw the attention of all scientists interested in the synergies between chemistry and biology to elucidate life on a molecular level and to promote drug discovery. Ultimately, the book helps promote the understanding of biological functions at the molecular level and create new pharmaceuticals that can contribute to improving human health.

Heterocycles in Bio-organic Chemistry

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ISBN 13 :
Total Pages : 256 pages
Book Rating : 4.4/5 (91 download)

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Book Synopsis Heterocycles in Bio-organic Chemistry by : J. Bergman

Download or read book Heterocycles in Bio-organic Chemistry written by J. Bergman and published by . This book was released on 1991 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will contribute to a better understanding of the mechanism of action of bioheterocycles in bioprocesses.

Combinatorial Chemistry

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Publisher : Oxford University Press, USA
ISBN 13 : 9780199637546
Total Pages : 476 pages
Book Rating : 4.6/5 (375 download)

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Book Synopsis Combinatorial Chemistry by : Hicham Fenniri

Download or read book Combinatorial Chemistry written by Hicham Fenniri and published by Oxford University Press, USA. This book was released on 2000 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combinatorial Chemistry is a genuine practical guide covering all the major areas of combinatorial chemistry from an experimental and conceptual point of view. Being one of the most powerful of modern technologies, combinatorial chemistry has had implications to many areas of chemistry and biology and the current approaches to drug, catalyst, receptor, and materials development and discovery are all included in this volume. It also contains protocols on solid, liquid, and solution phase synthesis and expedient methods of library screening and evaluation. The use of automation and robotics is also explained. It is written at a level easily accessible to novices and will enable readers to use combinatorial techniques to the best advantage.

Comprehensive Supramolecular Chemistry

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Publisher : Pergamon
ISBN 13 : 9780080406107
Total Pages : 0 pages
Book Rating : 4.4/5 (61 download)

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Book Synopsis Comprehensive Supramolecular Chemistry by : Jerry L. Atwood

Download or read book Comprehensive Supramolecular Chemistry written by Jerry L. Atwood and published by Pergamon. This book was released on 1996-07-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Supramolecular Chemistry covers for the first time in eleven detailed volumes the exciting inter- and multidisciplinary area of modern supramolecular chemistry. This subject, which has now reached an astonishing diversity and complexity, has developed at a remarkably rapid pace following the initial discoveries of crown ethers and cryptands in the late sixties. The numerous references, including many recent citations, constitute an unrivalled in-depth source for direct entry to the widespread primary literature on any aspect of this most highly topical area. The many carefully selected illustrations and instructive schematic representations make the chapters easily readable.

Synthesis of Peptides and Peptidomimetics

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ISBN 13 : 9783131255143
Total Pages : 847 pages
Book Rating : 4.2/5 (551 download)

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Book Synopsis Synthesis of Peptides and Peptidomimetics by : Murray Goodman

Download or read book Synthesis of Peptides and Peptidomimetics written by Murray Goodman and published by . This book was released on 2002 with total page 847 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Recent Advances in Medicinal Chemistry, Volume 1

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Publisher : Elsevier
ISBN 13 : 0128039620
Total Pages : 487 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Recent Advances in Medicinal Chemistry, Volume 1 by : Atta-ur Rahman

Download or read book Recent Advances in Medicinal Chemistry, Volume 1 written by Atta-ur Rahman and published by Elsevier. This book was released on 2015-06-16 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally published by Bentham and now distributed by Elsevier, Recent Advances in Medicinal Chemistry, Volume 1 covers leading-edge research and recent developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The fourteen updated reviews include unique experimental data and references, and each article highlights an important topic in current medicinal chemistry research. Topics covered include: aureolic acid group of anti-cancer antibiotics and non-steroidal anti-inflammatory drugs; aromatase inhibitors in adjuvant endocrine treatment of early-stage breast cancer in postmenopausal women; Rho GTPases and statins in targeting and developing therapies for tumors; and more. - Edited and written by leading experts in medicinal chemistry research - Reviews recent advances in the field, including the characterization of inorganic nanomaterials as therapeutic vehicles - Covers a variety of topical areas, such as HPLC and in the analysis of tricyclic antidepressants in biological samples, and tannins and their influence on health

Strategies and Tactics in Organic Synthesis

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Publisher : Academic Press
ISBN 13 : 9780124502840
Total Pages : 522 pages
Book Rating : 4.5/5 (28 download)

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Book Synopsis Strategies and Tactics in Organic Synthesis by : Michael Harmata

Download or read book Strategies and Tactics in Organic Synthesis written by Michael Harmata and published by Academic Press. This book was released on 2004-11-03 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title provides a forum for investigators to discuss their approach to the science and art of organic synthesis in a unique way. There are stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners.

Strategies and Tactics in Organic Synthesis

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Publisher : Academic Press
ISBN 13 : 9780124502819
Total Pages : 469 pages
Book Rating : 4.5/5 (28 download)

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Book Synopsis Strategies and Tactics in Organic Synthesis by : Thomas Lindberg

Download or read book Strategies and Tactics in Organic Synthesis written by Thomas Lindberg and published by Academic Press. This book was released on 1989-01-11 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a unique account of the synthesis of organic molecules. All of the contributors are acknowledged experts in organic synthesis.