Hyaluronan In Cancer Biology

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Hyaluronan in Cancer Biology

Author : Robert Stern
Publisher : Academic Press
ISBN 13 : 0080921086
Total Pages : 467 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Hyaluronan in Cancer Biology by : Robert Stern

Download or read book Hyaluronan in Cancer Biology written by Robert Stern and published by Academic Press. This book was released on 2009-03-07 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal. The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book will offer a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer. Offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer Chapters are written by the leading international authorities on this subject, from laboratories that focus on the investigation of hyaluronan in cancer initiation, progression, and dissemination Focuses on understanding the mechanisms that drive tumor cell activation, proliferation, and drug resistance

Hyaluronan Signaling and Turnover

Author : Melanie Simpson
Publisher : Academic Press
ISBN 13 : 0128003936
Total Pages : 418 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Hyaluronan Signaling and Turnover by : Melanie Simpson

Download or read book Hyaluronan Signaling and Turnover written by Melanie Simpson and published by Academic Press. This book was released on 2014-07-26 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. This volume covers hyaluronan signaling and turnover. Provides information on cancer research Outstanding and original reviews Suitable for researchers and students

Chemistry and Biology of Hyaluronan

Author : Hari G. Garg
Publisher : Elsevier
ISBN 13 : 0080472222
Total Pages : 625 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Chemistry and Biology of Hyaluronan by : Hari G. Garg

Download or read book Chemistry and Biology of Hyaluronan written by Hari G. Garg and published by Elsevier. This book was released on 2004-07-14 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt: It was probably the French chemist Portes, who first reported in 1880 that the mucin in the vitreous body, which he named hyalomucine, behaved differently from other mucoids in cornea and cartilage. Fifty four years later Karl Meyer isolated a new polysaccharide from the vitreous, which he named hyaluronic acid. Today its official name is hyaluronan, and modern-day research on this polysaccharide continues to grow. Expertly written by leading scientists in the field, this book provides readers with a broad, yet detailed review of the chemistry of hyaluronan, and the role it plays in human biology and pathology. Twenty-seven chapters present a sequence leading from the chemistry and biochemistry of hyaluronan, followed by its role in various pathological conditions, to modified hylauronans as potential therapeutic agents and finally to the functional, structural and biological properties of hyaluronidases. Chemistry and Biology of Hyaluronan covers the many interesting facets of this fascinating molecule, and all chapters are intended to reach the wider research community. Comprehensive look at the chemistry and biology of hyaluronans Essential to Chemists, Biochemists and Medical researchers Broad yet detailed review of this rapidly growing research area

Hyaluronan

Author : Alberto Passi
Publisher : Springer Nature
ISBN 13 : 3031303008
Total Pages : 220 pages
Book Rating : 4.0/5 (313 download)

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Book Synopsis Hyaluronan by : Alberto Passi

Download or read book Hyaluronan written by Alberto Passi and published by Springer Nature. This book was released on 2023-06-22 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the structural and biological properties of the extracellular matrix component and glycosaminoglycan polymer hyaluronan (or hyaluronic acid, HA). The book discusses various aspects of HA biology, e.g., HA synthesis and degradation, as well as the role of HA in embryogenesis, development, and cell maintenance. The reader will learn about the role of HA in different tissues as well as its biological activities triggered by the interaction with different HA receptors. A closer look is had at the involvement of HA in human pathologies such as cancer, kidney fibrosis and wound healing. Biotechnological and biomedical applications for HA such as scaffold generation and drug delivery, including the novel synthetic sulphated HA are explored. This work will appeal to a wide readership within the extracellular matrix and hyaluronan field. It can serve as an introduction to the field for junior scientists but can also help senior scientists to gain a broader view of the field beyond their area of specialization. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.

Hyaluronic Acid

Author : V. N. Khabarov
Publisher : John Wiley & Sons
ISBN 13 : 1118633792
Total Pages : 228 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Hyaluronic Acid by : V. N. Khabarov

Download or read book Hyaluronic Acid written by V. N. Khabarov and published by John Wiley & Sons. This book was released on 2015-03-16 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hyaluronic acid is an essential part of connective, epithelial and neural tissues, and contributes to cell proliferation and migration. It is used as a stimulating agent for collagen synthesis and is a common ingredient in skin-care products, a multi-billion dollar industry, as it is believed to be a key factor in fighting the aging process. Hyaluronic Acid: Production, Properties, Application in Biology and Medicine consists of six chapters discussing the various issues of hyaluronic acid research. In Chapter 1, a historical analysis recounts the discovery and milestones of the research leading to the practical applications of hyaluronan. Chapter 2 is dedicated to biological role of the hyaluronic acid in nature, in particular in the human body. The chapter starts from the phylogenesis of hyaluronic acid, then describes hyaluronan functions in human ontogenesis and especially the role which hyaluronan plays in extracellular matrix of the different tissues. Chapter 3 describes the methods to manufacture and purify hyaluronic acid, including the analytical means for assessing quality of the finished product. Chapter 4 discusses the structure and rheological properties of hyaluronic acid considering effects on conformation and biological properties related to molecular weight. In Chapter 5, the physical and chemical methods for modifying the structure of hyaluronan are discussed including cross-linking using bi-functional reagents, solid-phase modification and effects of the combined action of high pressures and shift deformation. The final chapter focuses on the products derived from hyaluronic acid, including therapeutics composed of modified hyaluronan conjugated to vitamins, amino acids and oligo-peptides. The biological roles and medical applications of this polysaccharide have been extensively studied and this book provides a wealth of scientific data demonstrating the critical role of hyaluronic acid and its promise as a multifaceted bio-macromolecule. Approaching hyaluronic acid from multiple angles, this book links relationships between its biological functions, structure and physical–chemical properties. It will be an invaluable resource to researchers, both industrial and academic, involved in all aspects of hyaluronan-based technologies.

The Chemistry, Biology and Medical Applications of Hyaluronan and Its Derivatives

Author : T. C. Laurent
Publisher : Portland Press, London
ISBN 13 :
Total Pages : 368 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis The Chemistry, Biology and Medical Applications of Hyaluronan and Its Derivatives by : T. C. Laurent

Download or read book The Chemistry, Biology and Medical Applications of Hyaluronan and Its Derivatives written by T. C. Laurent and published by Portland Press, London. This book was released on 1998 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to collect within one volume information on hyaluronan. This polysaccharide has received rapid attention for two reasons: it has important regulative functions within cell biology; and it has become a commercially important product because of its use in ophthalmic surgery and treatment of joint diease. A number of other practical applications are also discussed. The book covers various aspects of hyaluronan from the structure and chemistry of the polymer to its metabolism, cell biological interactions, behaviour in pathological processes, and potentially new medical applications.

Extracellular Matrix in Tumor Biology

Author : Rolf A. Brekken
Publisher : Springer
ISBN 13 : 3319609076
Total Pages : 115 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Extracellular Matrix in Tumor Biology by : Rolf A. Brekken

Download or read book Extracellular Matrix in Tumor Biology written by Rolf A. Brekken and published by Springer. This book was released on 2017-08-04 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an overview on the influence of Extracellular Matrix (ECM) on tumor progression. It covers topics such as signaling induced by structural ECM proteins including collagen and fibronectin, the control of ECM deposition and the turnover in tumors. Also discussed are the migration of cells through basement membranes and the function of proteoglycans including lumican and veriscan in tumor progression. Biomaterial-based in-vitro models as well as C. elegans models of the tumor microenvironment are used to show how these models can lead to a greater understanding of the disease mechanisms that promote cancer progression. The book addresses researchers working on cancer biology or ECM, and oncologists alike.

Tumor Microenvironment

Author : Alexander Birbrair
Publisher : Springer Nature
ISBN 13 : 3030401464
Total Pages : 189 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Tumor Microenvironment by : Alexander Birbrair

Download or read book Tumor Microenvironment written by Alexander Birbrair and published by Springer Nature. This book was released on 2020-04-07 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor during cancer development. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include heparan sulphate, hyaluronan, fibronectin, perlecan, glypican, matrix metalloproteinases, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components – Part A updates us on what we know about the different aspects of the tumor microenvironment, as well as apprises us on the future advances in the field. For the newest generation of researchers, this volume serves as a useful introduction to the history of scientists’ focus on the tumor microenvironment, and explores how this knowledge is currently applied in cancer treatments. The book is an essential text for advanced cell biology and cancer biology students, as well as for scientists seeking an update on the developments in tumor microenvironment research. All of the chapter authors are renowned international experts in the field of cancer biology, and in the specific subfields that are the focus of their chapters.

The Biology of Hyaluronan

Author : David Evered
Publisher : John Wiley & Sons
ISBN 13 : 0470513780
Total Pages : 308 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis The Biology of Hyaluronan by : David Evered

Download or read book The Biology of Hyaluronan written by David Evered and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents state-of-the-art applications in hyaluronan research, from hyaluronan's physicochemical properties to its clinical role as a connective tissue marker and its surgical implications, particularly in ear, eye and orthopaedic surgery. Covers hyaluronan's synthesis and catabolism, its role in cells, its interactions with specific binding proteins, and its role in the embryonic nervous system.

Essentials of Glycobiology

Author : Ajit Varki
Publisher : CSHL Press
ISBN 13 : 9780879696818
Total Pages : 694 pages
Book Rating : 4.6/5 (968 download)

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Book Synopsis Essentials of Glycobiology by : Ajit Varki

Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Molecular Regulation of Endocytosis

Author : Brian Ceresa
Publisher : BoD – Books on Demand
ISBN 13 : 9535106627
Total Pages : 470 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Molecular Regulation of Endocytosis by : Brian Ceresa

Download or read book Molecular Regulation of Endocytosis written by Brian Ceresa and published by BoD – Books on Demand. This book was released on 2012-07-06 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Regulation of Endocytosis is a compilation of scientific "short stories" about the entry of external substances into cells. As one can see from the chapters, endocytosis regulates diverse processes such as homeostasis of the cell, signal transduction, entry of pathogens and viruses. In addition to the experimental techniques embedded in each chapter, entire chapters are dedicated to experimental approaches that will be useful to all scientists and their model systems. For those more clinically oriented, the final chapters look to the future and ways of utilizing endocytic pathways for therapeutic purposes.

The Extracellular Matrix and the Tumor Microenvironment

Author : Ilona Kovalszky
Publisher : Springer Nature
ISBN 13 : 3030997081
Total Pages : 493 pages
Book Rating : 4.0/5 (39 download)

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Book Synopsis The Extracellular Matrix and the Tumor Microenvironment by : Ilona Kovalszky

Download or read book The Extracellular Matrix and the Tumor Microenvironment written by Ilona Kovalszky and published by Springer Nature. This book was released on 2022-07-06 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression. Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression. Two chapters focus specifically on the critical role of the ECM in tumor angiogenesis, linking this process to cellular infiltration and metastatic behavior of tumors. The final part describes how the ECM influences the success of immuno- and chemotherapy in cancer patients, its potential as biomarkers for diagnosis, prognosis, and therapeutic target, as well as the mechanism of resistance-associated changes in the ECM. This book is an interesting read for anyone who want to know more about ECM and cancer biology. Early career scientists can use it as an introduction to the field, offering an excellent tool for studying ECM. Advanced researchers and clinicians can gain a broader overview of the subject, considering the role of ECM for influencing every cancer hallmark as well as in the response of cancer treatments. The work serves to inspire future research and shows that the ECM should be considered as an important factor in the development of cancer therapeutics. The series "Biology of Extracellular Matrix" is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.

Cancer

Author : Gary S. Stein
Publisher : John Wiley & Sons
ISBN 13 : 1118962885
Total Pages : 708 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Cancer by : Gary S. Stein

Download or read book Cancer written by Gary S. Stein and published by John Wiley & Sons. This book was released on 2019-09-18 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to recent insights into the genetic and epigenetic parameters of cancer biology and pathology and emerging clinical applications The thoroughly updated second edition of The Biology and Treatment of Cancer, now titled Cancer: Prevention, Early Detection, Treatment and Recovery, goes beyond reviewing the fundamental properties of cancer biology and the relevant issues associated with treatment of the disease. The new edition contains coverage of additional "patient centric" topics and presents cancer biology with selection of topics, facts, and perspectives written in easy-to-understand terms. With contributions from noted experts, the book explores recent advances in the understanding of cancer including breakthroughs in the molecular and cellular basis of cancer and provides strategies for approaching cancer prevention, early detection, and treatment. The authors incorporate recent information on the genetic and epigenetic parameters of cancer biology and pathology with indications of emerging clinical applications. The text offers a unique guide to cancer prevention, early detection, treatment, and recovery for students, caregivers, and most importantly cancer patients. This significant book: Incorporates current insight into the genetic and epigenetic parameters of cancer biology and pathology and information on emerging clinical applications Contains contributions from leaders in cancer research, care, and clinical trials Offers an accessible guide to an accurate and balanced understanding of cancer and the cancer patient Focuses on the importance of cancer prevention, early detection, treatment, and survivorship Written for medical students, students of cancer biology, and caregivers and cancer patients, Cancer: Prevention, Early Detection, Treatment and Recovery offers an authoritative overview of the challenges and opportunities associated with cancer biology, cancer research, and the spectrum of clinical considerations.

Targeting of Prostate Cancer with Hyaluronan-Binding Proteins

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (946 download)

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Book Synopsis Targeting of Prostate Cancer with Hyaluronan-Binding Proteins by :

Download or read book Targeting of Prostate Cancer with Hyaluronan-Binding Proteins written by and published by . This book was released on 2001 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study is to test if hyaluronan (HA) binding proteins (HABP), an abundant protein in cartilage, is a new category of anti-tumor substance. This hypothesis is based on the facts that: (1) the shake cartilage powder or its extracts have been widely used by patients with different tumors in USA, Europe and Asia for a decade, in believing that avascular cartilage might contain some natural anti-tumor/angiogenesis substance; (2) certain angiogenic inhibitor, such as endostatin, has HA binding domain; and (3) some hyaluronan binding proteins, such as soluble CD44 and proteins from scapular chondrocytes or have anti-tumor/angiogenesis effect. In the past year, we have purified a large quantity of hyaluronan binding proteins from bovine cartilage and test its anti-tumor and anti-angiogenesis effects. The result are promising, indicating that (1) HABP can inhibit the anchorage- dependent and independent growth of tumor cells; (2) HABP can inhibit proliferation and migration of endothelial cells in vitro and angiogenesis in vivo; (3) HABP can reduce the growth of TSU prostate cancer and other tumor in vivo; (4) HABP can inhibit the experimental lung metastasis. It seems that HABP is a good candidate for development into a new anti- tumor agent. Next year, we will focus on test HABP from human source using molecular biology approaches. The human HABP will be cloned, inserted into expression vector and transfected into prostate cancer cells or infected in established prostate tumor to see the effect of human HABP on tumor growth. The underlying molecular mechanism of HABP by which it exerts anti-tumor/angiogenesis effect will also be explored.

Hyaluronic Acid

Author : Riia Rautiola
Publisher :
ISBN 13 : 9781536170597
Total Pages : 128 pages
Book Rating : 4.1/5 (75 download)

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Book Synopsis Hyaluronic Acid by : Riia Rautiola

Download or read book Hyaluronic Acid written by Riia Rautiola and published by . This book was released on 2020-03 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hyaluronic acid, or hyaluronan, is a water soluble, anionic extracellular matrix glycosaminoglycan polymer with variable molecular weight that determines its physiological role, rheological properties and applications. Since its discovery in the early 1930s, there has been an increased awareness concerning the biology of hyaluronic acid, its signaling pathways and its role in the biomedical and cosmeceutical industry. Being an endogenous molecule, hyaluronic acid is biocompatible, biodegradable, and has strong mucoadhesive, viscoelastic properties. The authors provide chemical modification approaches to hyaluronic acid, as well as address the magnitude of applications of hyaluronic acid-based targeted drug vectors and patents. The closing study discusses glycosaminoglycans, a specialized group of unbranched, anionic disaccharide polymers attached by a covalent linkage to the membrane proteins via sulphate groups in their sugar moieties.

Nanomaterials for Cancer Therapy

Author : Challa S. S. R. Kumar
Publisher : Wiley-VCH
ISBN 13 :
Total Pages : 448 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Nanomaterials for Cancer Therapy by : Challa S. S. R. Kumar

Download or read book Nanomaterials for Cancer Therapy written by Challa S. S. R. Kumar and published by Wiley-VCH. This book was released on 2006-07-24 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first comprehensive overview on nanotechnological approaches to cancer therapy brings together therapeutic oncology and nanotechnology, showing the various strategic approaches to selectively eliminating cancerous cells without damaging the surrounding healthy tissue. The strategies covered include magnetic, optical, microwave and neutron absorption techniques, nanocapsules for active agents, nanoparticles as active agents, and active and passive targeting, while also dealing with fundamental aspects of how nanoparticles cross biological barriers. A valuable single source gathering the many articles published in specialized journals often difficult to locate for members of the other disciplines involved.

Functional Analysis of the Lymphatic Vessel Hyaluronan Receptor-1 (LYVE-1) in Tumor Growth and Progression

Author : Christa Hahmann
Publisher : Cuvillier Verlag
ISBN 13 : 3736923678
Total Pages : 108 pages
Book Rating : 4.7/5 (369 download)

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Book Synopsis Functional Analysis of the Lymphatic Vessel Hyaluronan Receptor-1 (LYVE-1) in Tumor Growth and Progression by : Christa Hahmann

Download or read book Functional Analysis of the Lymphatic Vessel Hyaluronan Receptor-1 (LYVE-1) in Tumor Growth and Progression written by Christa Hahmann and published by Cuvillier Verlag. This book was released on 2007-09-13 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: