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Author : Beulah Banfield
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (897 download)
Download or read book Human Serum Albumin Characterisation and Binding Studies by Spectroscopic Techniques written by Beulah Banfield and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Beulah A. Banfield
Publisher :
ISBN 13 :
Total Pages : 718 pages
Book Rating : 4.:/5 (835 download)
Download or read book Human Serum Albumin Characterisation and Binding Studies by Spectroscopic Techniques written by Beulah A. Banfield and published by . This book was released on 2010 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serum Albumin (HSA) is a plasma protein of great significance with an ability to bind nerous endogenous and exogenous ligands, having a single polypeptide chain of 585 amino constructed in three domains of relatively equal size. Although HSA's existence has been own for many years, its characterisation and ability to bind ligands still remain enigmatic. Only 11992 was the crystal structure of HSA reported (Carter and Ho, 1992). Effective crystallisation I the determination of meaningful crystallographic data and structure had proven difficult. The I report concerned HSA crystals grown using zero gravity conditions. i objective of this project is the characterisation of recombinant and native HSA using Ultra-Diet (UV) & circular dichroism spectroscopy (CD) and involved HSA conformational changes, hich altered the ability to bind or off-load ligands. Changing environment, together with the use F characteristic "marker ligands," influences binding to provide a handle that can be utilised and litored. This enables the assignment of binding sites and the study of perturbating conditions. jing conditions such as pH, temperature, ionic strength and solvents in the presence and of ligands were employed to extract further information on this elusive protein, tients of recombinant HSA were also used (namely domain I and domain I + II) under tical conditions as the whole protein in order to help elucidate and assign binding sites.
Author : Dianne Cohen
Publisher :
ISBN 13 : 9781536147872
Total Pages : 0 pages
Book Rating : 4.1/5 (478 download)
Download or read book Human Serum Albumin written by Dianne Cohen and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human serum albumin is found in the intravascular and extracellular space and is the main protein of human blood plasma. Human serum albumin binds water, cations (such as Ca2+, Na+, K+), fatty acids, hormones, bilirubin, thyroxin (T4) and pharmaceuticals. Structurally, the serum albumins are similar, each domain containing five or six internal disulfide bonds. In the opening chapter of Human Serum Albumin: Structure, Binding and Activity the authors review, the structure, content and binding of HSA.Then, the role of albumin in free radical trapping activities and as an oxyradical scavenger is described. A discussion of recent advances in the use of the antioxidant properties of human serum albumin to make drugs detectable in vivo is also presented.Human serum albumin has one tryptophan residue and shows a characteristic fluorescence of around 350 nm under ultraviolet irradiation. Because tryptophan is easily oxidized by reactive oxygen species and/or photoexcited molecules through electron transfer (leading to fluorescence diminishment) a fluorometry of this tryptophan residue is a useful tool to evaluate oxidation. In light of these characteristics, the authors examine the photosensitizing activity of organic photosensitizers, including porphyrins and phenothiazine dyes.The use of magnetic resonance imaging and spectroscopy for the determination of human serum albumin structure, drug binding and in vivo activity is explored, in addition to drug modifications using human serum albumin.Following this, this compilation studies the major approaches for the characterization of human serum albumin as a fluorinated drug delivery agent and fluorinated albumin influence on drug binding. Synthesis and characterization of fluorinated conjugates of albumin and adsorbed human serum albumin on surfaces containing CF3 are also discussed.The concluding study investigates possible similarities and differences in albumin concentration and the presence of tyrosine in urine from a population of healthy and microalbuminuria dependent women. The assessment of subtle changes in albumin concentration, the primary macromolecular component of urine, is critical for the diagnosis of early stage albuminuria, one of the major complications in nephropathy.
Author : Jerry Workman Jr.
Publisher : Academic Press
ISBN 13 : 0080527493
Total Pages : 557 pages
Book Rating : 4.0/5 (85 download)
Download or read book Applied Spectroscopy written by Jerry Workman Jr. and published by Academic Press. This book was released on 1998-06-08 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book delineates practical, tested, general methods for ultraviolet, visible, and infrared spectrometry in clear language for novice users, and serves as a reference resource for advanced spectroscopists. Applied Spectroscopy includes important information and equations which will be referred to regularly. The book emphasizes reflectance and color measurements due to their common usage in todays spectroscopic laboratories, and contains methods for selectinga measurement technique as well as solar and color measurements. Written by experts in the field, this text covers spectrometry of new materials, ceramics, and textiles, and provides an appendix of practical reference data for spectrometry. Book topics include: Practical aspects of spectrometers and spectrometry; Sample preparation; Chemometrics and calibration practices; Reflectance measurements; Standard materials measurements An emphasis is placed on reflectance and color measurements due to their common usage in today's spectroscopic laboratories Methods for selecting a measurement technique are included as well as solar measurements and reference information on sources, detectors, optical fiber and window materials
Author : Theodore Peters Jr.
Publisher : Academic Press
ISBN 13 : 0080527043
Total Pages : 455 pages
Book Rating : 4.0/5 (85 download)
Download or read book All About Albumin written by Theodore Peters Jr. and published by Academic Press. This book was released on 1995-12-21 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, All About Albumin summarizes the chemistry, genetics, metabolism, clinical implications, and commercial aspects of albumin. It provides the most up-to-date sequences, structures, and compositions of many species, and includes more than 2000 references. Includes up-to-date sequences, structures, and compositions of many species Reviews the protein chemistry, genetic control, and metabolism of albumin Covers medical and cell culture applications in vivo and in vitro, with a section on handling albumin in the laboratory Presents the relationship of albumin to its superfamily with an updated scheme for their evolution First complete coverage of all aspects of serum albumin in one volume, with more than 2000 references
Author : Joseph R. Lakowicz
Publisher : Springer Science & Business Media
ISBN 13 : 146157658X
Total Pages : 487 pages
Book Rating : 4.4/5 (615 download)
Download or read book Principles of Fluorescence Spectroscopy written by Joseph R. Lakowicz and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorescence methods are being used increasingly in biochemical, medical, and chemical research. This is because of the inherent sensitivity of this technique. and the favorable time scale of the phenomenon of fluorescence. 8 Fluorescence emission occurs about 10- sec (10 nsec) after light absorp tion. During this period of time a wide range of molecular processes can occur, and these can effect the spectral characteristics of the fluorescent compound. This combination of sensitivity and a favorable time scale allows fluorescence methods to be generally useful for studies of proteins and membranes and their interactions with other macromolecules. This book describes the fundamental aspects of fluorescence. and the biochemical applications of this methodology. Each chapter starts with the -theoreticalbasis of each phenomenon of fluorescence, followed by examples which illustrate the use of the phenomenon in the study of biochemical problems. The book contains numerous figures. It is felt that such graphical presentations contribute to pleasurable reading and increased understand ing. Separate chapters are devoted to fluorescence polarization, lifetimes, quenching, energy transfer, solvent effects, and excited state reactions. To enhance the usefulness of this work as a textbook, problems are included which illustrate the concepts described in each chapter. Furthermore, a separate chapter is devoted to the instrumentation used in fluorescence spectroscopy. This chapter will be especially valuable for those perform ing or contemplating fluorescence measurements. Such measurements are easily compromised by failure to consider a number of simple principles.
Author :
Publisher :
ISBN 13 :
Total Pages : 4 pages
Book Rating : 4.:/5 (254 download)
Download or read book Nachdem Wir, Bürgermeister und Rath der Stadt Lüneburg, mißfällig vernehmen müssen, daß die Französische Kriegs-Gefangene allhier das Brennholtz, welches ihnen zu ihrer Nothdurfft gelieffert wird, und wovon sie bey zweckmässiger Verbrauchung nichts übrig haben können, zum Theil verkauffen, und daß dagegen in den Häusern, welche ihnen zu ihrem Auffenthalt allhier angewiesen sind, sich bald dieses bald jenes an Brettern, Pfählen ... abgerissen finde ... written by and published by . This book was released on 1758 with total page 4 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464930198
Total Pages : 96 pages
Book Rating : 4.4/5 (649 download)
Download or read book Advances in Serum Albumin Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Serum Albumin Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Serum Albumin. The editors have built Advances in Serum Albumin Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Serum Albumin in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Serum Albumin Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Gillian Sudlow
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (216 download)
Download or read book The Use of Spectroscopic Techniques to Study the Binding of Drugs to Human Serum Albumin and to Characterize Interactions Between Drugs at Protein Binding Sites written by Gillian Sudlow and published by . This book was released on 1975 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Irving Wainer
Publisher : CRC Press
ISBN 13 : 9780824788193
Total Pages : 450 pages
Book Rating : 4.7/5 (881 download)
Download or read book Drug Stereochemistry written by Irving Wainer and published by CRC Press. This book was released on 1993-02-24 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maintaining and enhancing its focus on key issues in the development, regulatory approval and use of stereoisomeric compounds, this edition continues to cover in detail all aspects of chiral drugs from the academic, governmental, industrial and clinical points of view.;Completely rewritten and updated throughout, Drug Stereochemistry: illustrates current indirect chromatographic methods for the resolution of drug enantiomers; treats the rapidly growing area of enantioselective gas chromatography; discusses the latest in HPLC resolution of enantiomeric drugs; uses verapamil as a model to show how stereoselective pharmacokinetics affect pharmacodynamics; and supplies an in-depth study on the effect of stereoselective plasma protein binding.;This edition offers entirely new chapters that: discuss the recent decisions and present position of the US Food and Drug Administration on the development of stereoisomeric drugs; explicate enzymatic synthesis of stereochemically pure drugs; review the toxicological, pharmacokinetic and pharmacodynamic differences found among stereoisomers; elucidate the stereoselective transport of drugs across epithelia; and give a physician's perspective on the questions and problems caused by stereoisomeric drugs in practice as well as the pharmaceutical industry's collective viewpoint based on a national survey.
Author : Anita Kober
Publisher :
ISBN 13 :
Total Pages : 48 pages
Book Rating : 4.:/5 (33 download)
Download or read book Binding of Drugs to Human Serum Albumin written by Anita Kober and published by . This book was released on 1980 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Stephen E. Harding
Publisher : Oxford University Press, USA
ISBN 13 : 9780199637478
Total Pages : 474 pages
Book Rating : 4.6/5 (374 download)
Download or read book Protein-ligand Interactions, Structure and Spectroscopy written by Stephen E. Harding and published by Oxford University Press, USA. This book was released on 2001 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text on protein-ligand interactions offers a selection of the most useful and easily applied methods and acts as a guide to the principal techniques used.
Author : Gordon Lee Nordby
Publisher :
ISBN 13 :
Total Pages : 94 pages
Book Rating : 4.:/5 (654 download)
Download or read book The Hydrogen Ion Binding Characteristics of Human Serum Albumin as Influenced by the Perfluoro-oxtanoate Ion written by Gordon Lee Nordby and published by . This book was released on 1954 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Isabel Moraes
Publisher : Springer
ISBN 13 : 3319350722
Total Pages : 188 pages
Book Rating : 4.3/5 (193 download)
Download or read book The Next Generation in Membrane Protein Structure Determination written by Isabel Moraes and published by Springer. This book was released on 2016-08-23 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews current techniques used in membrane protein structural biology, with a strong focus on practical issues. The study of membrane protein structures not only provides a basic understanding of life at the molecular level but also helps in the rational and targeted design of new drugs with reduced side effects. Today, about 60% of the commercially available drugs target membrane proteins and it is estimated that nearly 30% of proteins encoded in the human genome are membrane proteins. In recent years much effort has been put towards innovative developments to overcome the numerous obstacles associated with the structure determination of membrane proteins. This book reviews a variety of recent techniques that are essential to any modern researcher in the field of membrane protein structural biology. The topics that are discussed are not commonly found in textbooks. The scope of this book includes: Expression screening using fluorescent proteins The use of detergents in membrane protein research The use of NMR Synchrotron developments in membrane protein structural biology Visualisation and X-ray data collection of microcrystals X-ray diffraction data analysis from multiple crystals Serial millisecond crystallography Serial femtosecond crystallography Membrane protein structures in drug discovery The information provided in this book should be of interest to anyone working in the area of structural biology. Students will find carefully prepared overviews of basic ideas and advanced protein scientists will find the level of detail required to apply the material directly to their day to day work. Chapters 4, 5, 6, 8 and 9 of this book are published open access under a CC BY 4.0 license at link.springer.com.
Author : Jennifer J. McManus
Publisher : Humana
ISBN 13 : 9781493996803
Total Pages : 266 pages
Book Rating : 4.9/5 (968 download)
Download or read book Protein Self-Assembly written by Jennifer J. McManus and published by Humana. This book was released on 2020-08-08 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores experimental and computational approaches to measuring the most widely studied protein assemblies, including condensed liquid phases, aggregates, and crystals. The chapters in this book are organized into three parts: Part One looks at the techniques used to measure protein-protein interactions and equilibrium protein phases in dilute and concentrated protein solutions; Part Two describes methods to measure kinetics of aggregation and to characterize the assembled state; and Part Three details several different computational approaches that are currently used to help researchers understand protein self-assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Protein Self-Assembly: Methods and Protocols is a valuable resource for researchers who are interested in learning more about this developing field.
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481672339
Total Pages : 198 pages
Book Rating : 4.4/5 (816 download)
Download or read book Albumins—Advances in Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Albumins—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about C-Reactive Protein. The editors have built Albumins—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about C-Reactive Protein in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Albumins—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Paul M. Dewick
Publisher : John Wiley & Sons
ISBN 13 : 1118681967
Total Pages : 711 pages
Book Rating : 4.1/5 (186 download)
Download or read book Essentials of Organic Chemistry written by Paul M. Dewick and published by John Wiley & Sons. This book was released on 2013-03-20 with total page 711 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essentials of Organic Chemistry is an accessible introduction to the subject for students of Pharmacy, Medicinal Chemistry and Biological Chemistry. Designed to provide a thorough grounding in fundamental chemical principles, the book focuses on key elements of organic chemistry and carefully chosen material is illustrated with the extensive use of pharmaceutical and biochemical examples. In order to establish links and similarities the book places prominence on principles and deductive reasoning with cross-referencing. This informal text also places the main emphasis on understanding and predicting reactivity rather than synthetic methodology as well as utilising a mechanism based layout and featuring annotated schemes to reduce the need for textual explanations. * tailored specifically to the needs of students of Pharmacy Medical Chemistry and Biological Chemistry * numerous pharmaceutical and biochemical examples * mechanism based layout * focus on principles and deductive reasoning This will be an invaluable reference for students of Pharmacy Medicinal and Biological Chemistry.
