Hormones Genes And Cancer

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Hormones, Genes, and Cancer

Author : Brian E. Henderson
Publisher : Oxford University Press
ISBN 13 : 0199771588
Total Pages : 467 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis Hormones, Genes, and Cancer by : Brian E. Henderson

Download or read book Hormones, Genes, and Cancer written by Brian E. Henderson and published by Oxford University Press. This book was released on 2003-03-13 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormonal carcinogenesis is an important and controversial area of current research. In addition to accelerating existing cancers, can hormones play the role of primary carcinogens? How do genetic factors influence hormone-related cancer risk? Hormones, Genes, and Cancer addresses these questions. Over the past few decades, cancer research has focused on external environmental causes(e.g., tobacco smoke, viruses, asbestos). With the advent of new genetic sequencing techniques, we are just now beginning to understand how the body's internal environment(i.e., the hormones and growth factors that determine normal development) influences cancer etiology and prevention. From molecular insights to clinical analyses, this volume provides state-of-the-art information on the complex interactions between hormones and genes and cancer. The epidemiology and molecular endocrinology of prostate, breast, uterine, ovarian and testicular cancer are detailed in this timely treatise.

Hormones, Genes, and Cancer

Author : Brian E. Henderson
Publisher :
ISBN 13 : 9780197707128
Total Pages : 0 pages
Book Rating : 4.7/5 (71 download)

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Book Synopsis Hormones, Genes, and Cancer by : Brian E. Henderson

Download or read book Hormones, Genes, and Cancer written by Brian E. Henderson and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormonal carcinogenesis is an important and controversial area of research. In addition to accelerating existing cancers, can hormones play the role of primary carcinogens? And how do genetic factors influence hormone-related cancer risk? This work addresses these questions.

Hormones and Cancer

Author : Wayne V. Vedeckis
Publisher : Springer Science & Business Media
ISBN 13 : 1461242665
Total Pages : 618 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Hormones and Cancer by : Wayne V. Vedeckis

Download or read book Hormones and Cancer written by Wayne V. Vedeckis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series, Hormones in Health and Disease, was launched in 1993 to provide a scientific platform for investigators engaged in research on the biological actions of hormones and to anticipate relevance for their findings in clinical applications. The first volume of the series was dedicated to the discussion and understanding of molecular mechanisms by which steroid hormones influence target cells in normal and pathological conditions. With the diversity of information and the vast amount of literature on steroid hormone physiology, a more thorough treatment of Hormones and Cancer was identified as a timely topic. In this second volume in the series, Dr. Wayne V. Vedeckis has success fully undertaken the monumental task of editing the findings of the leading investigators in hormone and cancer research. Dr. Vedeckis brings to this project two decades of research experience in hormone action; he is actively engaged in elucidating hormone and cancer interrelations. It is a pleasure to welcome him to the series as an editor and congratulate him and all contribu tors in presenting this comprehensive treatise. The 20 chapters include discussions on contemporary topics relating control of cell division and signal transduction to the basic mechanisms of carcinogenesis by cloning patient genes, and recognizing the importance of steroid receptors in treatment protocols of various endocrine abnormalities.

Hormonal Carcinogenesis III

Author : Jonathan J. Li
Publisher : Springer Science & Business Media
ISBN 13 : 1461220920
Total Pages : 610 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Hormonal Carcinogenesis III by : Jonathan J. Li

Download or read book Hormonal Carcinogenesis III written by Jonathan J. Li and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since our previous symposium in 1995, the pace of research in hormones and cancer has accelerated. Progress in our understanding of hormonal carcinogenic processes has been a direct result of the advances made in cell biology, endocrinology, and carcinogenesis at the molecular level. The newer fields of molecular genetics and cytogenetics already have and are expected to continue to playa major role in furthering our understanding of the cellular and molecular events in hormonal carcinogenesis. It has become increasingly clear that the risk of naturally occurring sex hormones in carcinogenic processes, both in human and in animal models, requires only minute quantities of hormones, at both the serum and tissue levels. Moreover, hormone target tissues for neoplastic transformation, perhaps with the exception of the liver, generally have relatively modest ability to metabolize sex hormones, such as the breast and prostate. Table 1 summarizes the serum, and in most cases, the tissue levels of sex hormones, both endogenously and exogenously ingested, which are associated with increased risk for endocrine-associated cancers such as breast, endometrium, and prostate, as well as the hormone levels of four experimental models that have been shown to elicit high tumor incidences. In contrast to the human, in which the hormone levels are cyclic, however, the latter require continuous hormone exposure at these relatively low levels.

Genes, Oncogenes, and Hormones

Author : Robert B. Dickson
Publisher : Springer Science & Business Media
ISBN 13 : 146153500X
Total Pages : 478 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Genes, Oncogenes, and Hormones by : Robert B. Dickson

Download or read book Genes, Oncogenes, and Hormones written by Robert B. Dickson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, and easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc.; and second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current di agnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

Cancer and the Environment

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309169240
Total Pages : 160 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Cancer and the Environment by : Institute of Medicine

Download or read book Cancer and the Environment written by Institute of Medicine and published by National Academies Press. This book was released on 2002-08-01 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Roundtable on Environmental Health Sciences, Research, and Medicine wanted to address the link between environmental factors and the development of cancer in light of recent advances in genomics. They asked what research tools are needed, how new scientific information can be applied in a timely manner to reduce the burden of cancer, and how this can be flexible enough to treat the individual.

Hormonal Carcinogenesis V

Author : Jonathan J. Li
Publisher : Springer Science & Business Media
ISBN 13 : 0387690808
Total Pages : 647 pages
Book Rating : 4.3/5 (876 download)

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Book Synopsis Hormonal Carcinogenesis V by : Jonathan J. Li

Download or read book Hormonal Carcinogenesis V written by Jonathan J. Li and published by Springer Science & Business Media. This book was released on 2008-04-24 with total page 647 pages. Available in PDF, EPUB and Kindle. Book excerpt: Information gathered from cell-free systems, cell cultures, animal models, and human studies, together provide important insights to our understanding of hormonal cancer causation, development, and prevention; the primary objective of these Symposia. A special emphasis is placed on the two major endocrine-related cancers, that is, breast and prostate. The emerging fields of colon, lung, and pancreatic cancers in relation to hormones are examined.

Testis cancer: genes, environment, hormones

Author : Alberto Ferlin
Publisher : Frontiers Media SA
ISBN 13 : 2889196720
Total Pages : 88 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Testis cancer: genes, environment, hormones by : Alberto Ferlin

Download or read book Testis cancer: genes, environment, hormones written by Alberto Ferlin and published by Frontiers Media SA. This book was released on 2015-10-29 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: Testicular cancer (TC) is the most common cancer in males aged 20-40 years, with a worldwide incidence of 7.5 per 100,000, but the rates vary considerably between countries and ethnic groups and there is evidence also for an increasing incidence in last decades. About 95% of all TCs are represented by testicular germ cell tumors (TGCTs), which include seminoma and non-seminoma histological types. It is generally assumed that the development of TGCT is under endocrine control. In particular, unbalanced androgen/estrogen levels and/or activity are believed to represent the key events for TGCT development and progression. Furthermore, recent evidence has suggested genetic association of TGCT with variations in genes involved in hypothalamic-pituitary-testicular axis and steroidogenic enzymes. This recent evidence expands the current knowledge on the role of genetic contribution in testicular cancer susceptibility, and supports the hypothesis that variations in hormone metabolism genes might change the hormonal environment implicated in testicular carcinogenesis. Therefore, hormonal carcinogenesis is an important and controversial area of current research in TGCT, and further attention is given to genetic factors influencing hormone-related cancer risk. The genetic component to TGCT is in general strong. In fact, although environmental factors clearly contribute to TGCT development (and probably to its increasing incidence in some geographical areas), the proportion of TGCT susceptibility accounted for by the genetic effects is estimated at 25%. TGCT has high familial risks compared with most other cancer types that are generally no more than two-fold: brothers of individuals with TGCT have an 8- to 12-fold increased risk of disease, and sons of affected individuals have a 4- to 6-fold increased risk. Despite this strong familial relative risk, early results from linkage studies identified a limited relationship with genetic factors, suggesting that TGCT is a genetically complex trait. However, more recently, four genome-wide association studies (GWAS) from the UK and USA have reported association of TGCTs with six new loci (KITLG, SPRY4, BAK1, DMRT1, TERT, and ATF7IP). The strongest association for TGCT susceptibility was found for SNPs in KITLG (ligand for the membrane-bound receptor tyrosine kinase KIT) gene with a greater than 2.5-fold increased risk of disease per major allele, which is the highest reported for any cancer to date. These studies are being now replicated by other researches and attention is given to the relationship between these genetic variations, TGCT risk and frequently associated anomalies of the reproductive tract, such as cryptorchidism and infertility. Finally, over the past few decades, TCGT research has focused also on external environmental causes acting mainly as endocrine disrupters of androgen and oestrogen pathways, even during the foetal development of the testis. It is well known that the testicular dysgenesis syndrome (TDS) hypothesis, proposed ten years ago, suggests that disturbed testicular development in fetal life may result in one or more of four disorders postnatally, named cryptorchidism, hypospadias, poor semen quality, and TGCT. These four disorders are therefore considered as one clinical entity and are linked together by epidemiological and pathophysiological relations. The relative contribution of genetics and environment in TGCT development, and the interactions between endocrine disruptors and variations in genes involved in hormonal carcinogenesis is therefore another interesting area of research.

Holland-Frei Cancer Medicine

Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2008 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.

Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Testis Cancer: Genes, Environment, Hormones

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)

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Book Synopsis Testis Cancer: Genes, Environment, Hormones by :

Download or read book Testis Cancer: Genes, Environment, Hormones written by and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Testicular cancer (TC) is the most common cancer in males aged 20-40 years, with a worldwide incidence of 7.5 per 100,000, but the rates vary considerably between countries and ethnic groups and there is evidence also for an increasing incidence in last decades. About 95% of all TCs are represented by testicular germ cell tumors (TGCTs), which include seminoma and non-seminoma histological types. It is generally assumed that the development of TGCT is under endocrine control. In particular, unbalanced androgen/estrogen levels and/or activity are believed to represent the key events for TGCT development and progression. Furthermore, recent evidence has suggested genetic association of TGCT with variations in genes involved in hypothalamic-pituitary-testicular axis and steroidogenic enzymes. This recent evidence expands the current knowledge on the role of genetic contribution in testicular cancer susceptibility, and supports the hypothesis that variations in hormone metabolism genes might change the hormonal environment implicated in testicular carcinogenesis. Therefore, hormonal carcinogenesis is an important and controversial area of current research in TGCT, and further attention is given to genetic factors influencing hormone-related cancer risk. The genetic component to TGCT is in general strong. In fact, although environmental factors clearly contribute to TGCT development (and probably to its increasing incidence in some geographical areas), the proportion of TGCT susceptibility accounted for by the genetic effects is estimated at 25%. TGCT has high familial risks compared with most other cancer types that are generally no more than two-fold: brothers of individuals with TGCT have an 8- to 12-fold increased risk of disease, and sons of affected individuals have a 4- to 6-fold increased risk. Despite this strong familial relative risk, early results from linkage studies identified a limited relationship with genetic factors, suggesting that TGCT is a genetically complex trait. However, more recently, four genome-wide association studies (GWAS) from the UK and USA have reported association of TGCTs with six new loci (KITLG, SPRY4, BAK1, DMRT1, TERT, and ATF7IP). The strongest association for TGCT susceptibility was found for SNPs in KITLG (ligand for the membrane-bound receptor tyrosine kinase KIT) gene with a greater than 2.5-fold increased risk of disease per major allele, which is the highest reported for any cancer to date. These studies are being now replicated by other researches and attention is given to the relationship between these genetic variations, TGCT risk and frequently associated anomalies of the reproductive tract, such as cryptorchidism and infertility. Finally, over the past few decades, TCGT research has focused also on external environmental causes acting mainly as endocrine disrupters of androgen and oestrogen pathways, even during the foetal development of the testis. It is well known that the testicular dysgenesis syndrome (TDS) hypothesis, proposed ten years ago, suggests that disturbed testicular development in fetal life may result in one or more of four disorders postnatally, named cryptorchidism, hypospadias, poor semen quality, and TGCT. These four disorders are therefore considered as one clinical entity and are linked together by epidemiological and pathophysiological relations. The relative contribution of genetics and environment in TGCT development, and the interactions between endocrine disruptors and variations in genes involved in hormonal carcinogenesis is therefore another interesting area of research.

Endocrine Tumor Syndromes and Their Genetics

Author : Constantine A. Stratakis
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318023302
Total Pages : 202 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Endocrine Tumor Syndromes and Their Genetics by : Constantine A. Stratakis

Download or read book Endocrine Tumor Syndromes and Their Genetics written by Constantine A. Stratakis and published by Karger Medical and Scientific Publishers. This book was released on 2013 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: From classic MEN syndromes to various germline and somatic mutations in sporadic tumors In these times, a book should aspire to present the most significant advances in the field, reflect the themes of the moment, and provide a useful compendium for future reference. This book accomplishes all three objectives by discussing the changing world of modern genetics in endocrine tumors and its impact on clinical practice. Clinicians have to incorporate modern genetics and systems biology in their daily practice. Educators and researchers have to introduce molecular pathways and their genetic variability in their teaching, as well as understanding of classic physiology and pathophysiology. Taking these aspects into account, the chapters in this book cover both the classic multiple endocrine neoplasia (MEN) syndromes, as well as newly described ones, such as Carney triad and Carney- Stratakis syndrome. Furthermore, the genetics of paragangliomas as well as thyroid, parathyroid, and pituitary tumors are examined. Outlining the latest research and its obvious implications for our understanding the genetics of endocrine tumor formation and molecular biology of cancer and their potential therapeutic implications, this book is not only useful for researchers but even more so for practicing clinicians, in particular internists, endocrinologists, oncologists, pediatricians, surgeons, pathologists, geneticists, and genetic counselors.

Regulation of Gene Expression by Hormones

Author : Kenneth McKerns
Publisher : Springer Science & Business Media
ISBN 13 : 1468444182
Total Pages : 350 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Regulation of Gene Expression by Hormones by : Kenneth McKerns

Download or read book Regulation of Gene Expression by Hormones written by Kenneth McKerns and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Foundation for Biochemical Endocrinology is incorporated as a nonprofit research and educational organization. It is dedicated to the dissemination of knowledge, cooperative research programs, and cultural interaction on an international basis. The Foundation is concerned with both basic research and practical applications of biological knowledge to the betterment of humanity. Among our interests are global resource management, human reproduction, hormonal regulation of normal and cancer cells, study of aging and degenerative diseases, brain peptides, peptide neurotransmitter compounds, mechanism of action of hormones, peptide hormone synthesis, and recombinant DNA techniques. This monograph is the ninth sponsored by the Foundation in the Biochemical Endocrinology series. The previous four have been: Hormonally Active Brain Peptides: Structure and Function (1982), K. W. McKerns and V. Pantie, eds.; Reproductive Processes and Contraception (1981), K. W. McKerns, ed.; Synthesis and Release of Adenohypophyseal Hormones (1980), M. Jutisz and K. W. McKerns, eds.; and Structure and Function of the Gonadotropins (1978), K. W. McKerns, ed. These have all been published by Plenum Press.

Introduction to the Cellular and Molecular Biology of Cancer

Author : Margaret Knowles
Publisher : OUP Oxford
ISBN 13 : 9780191513817
Total Pages : 564 pages
Book Rating : 4.5/5 (138 download)

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Book Synopsis Introduction to the Cellular and Molecular Biology of Cancer by : Margaret Knowles

Download or read book Introduction to the Cellular and Molecular Biology of Cancer written by Margaret Knowles and published by OUP Oxford. This book was released on 2005-07-28 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: . What is cancer?, L.M. Franks and Margaret A. Knowles. 2. The causes of cancer, Naomi Allen, Robert Newton, Amy Berrington de Gonzalez, Jane Green, Emily Banks, and Timothy J. Key. 3. Inherited Susceptibility to Cancer, D. Timothy Bishop. 4. DNA Repair and Cancer, Beate Koberle, John P. Wittschieben, and Richard D. Wood. 5. Epigenetic Events in Cancer, Jonathan C. Cheng and Peter A. Jones. 6. Molecular Cytogenetics of Cancer, Denise. Sheer and Janet Shipley. 7. Oncogenes, Margaret A. Knowles. 8. Tumour suppressor genes, Sonia Lain and David P. Lane. 9. The cancer cell cycle, Chris J. Norbury. 10. Cellular immortalization and telomerase activation in cancer, Robert F. Newbold. 11. Growth factors and their signalling pathways in cancer, Sally A. Prigent. 12. Apoptosis: molecular physiology and significance for cancer therapeutics, Dean A. Fennell. 13. Mechanisms of Viral Carcinogenesis, Paul Farrell. 14. Cytokines and Cancer, Peter W. Szlosarek and Frances R. Balkwill. 15. Hormones and cancer, Charlotte L. Bevan. 16. The spread of tumours, Ian Hart. 17. Angiogenesis, K.Tahtis and R.Bicknell. 18. Stem cells, heamopoiesis, and leukaemia, Mel Greaves. 19. Animal models of cancer, Jos Jonkers and Anton Berns. 20. The immunology of cancer, Peter C. L. Beverley. 21. The molecular pathology of cancer, Tatjana Crnogorac-Jurcevic, Richard Poulsom, and Nicholas R. Lemoine. 22. From transcriptome to proteome, Silvana Debernardi, Rachel Craven, Bryan D. Young, and Rosamonde E. Banks. 23. Local treatment of cancer, Ian S. Fentiman. 24. Chemotherapy, D.R. Camidge and D.I. Jodrell. 25. Radiotherapy and molecular radiotherapy, Anne Kiltie. 26. Monoclonal antibodies and therapy, T. Geldart, M.J. Glennie, and P.W.M. Johnson. 27. Immunotherapy of cancer, Andrew M. Jackson and Joanne Porte. 28. Cancer gene therapy, John David Chester. 29. Screening, Peter Sasieni and Jack Cuzick. 30. Conclusions and prospects, Peter Selby and Margaret A Knowles.

Hormones and Breast Cancer

Author :
Publisher : Elsevier
ISBN 13 : 0124166768
Total Pages : 421 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Hormones and Breast Cancer by :

Download or read book Hormones and Breast Cancer written by and published by Elsevier. This book was released on 2013-06-25 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume focuses on hormones and breast cancer. Contributions from leading authorities Informs and updates on all the latest developments in the field

Steroid Hormones and Cell Cycle Regulation

Author : Kerry L. Burnstein
Publisher : Springer Science & Business Media
ISBN 13 : 1461509653
Total Pages : 264 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Steroid Hormones and Cell Cycle Regulation by : Kerry L. Burnstein

Download or read book Steroid Hormones and Cell Cycle Regulation written by Kerry L. Burnstein and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the tissue culture dish to genetically modified mice, this volume explores the long recognized role of steroid hormones in regulating cell proliferation and differentiation. Many striking effects of steroid hormones are apparent during development and neoplasia and these topics are covered extensively. Several chapters address the pharmacological uses of steroid and related hormones, their analogs and antagonists in controlling growth of endocrine cancers. This book also highlights the complex role of cross talk between steroid hormones and signals initiated at the cell surface in the regulation of cell cycle in hormone responsive tissues.

Hormones and Growth Factors in Development and Neoplasia

Author : Robert B. Dickson
Publisher : Wiley-Liss
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Hormones and Growth Factors in Development and Neoplasia by : Robert B. Dickson

Download or read book Hormones and Growth Factors in Development and Neoplasia written by Robert B. Dickson and published by Wiley-Liss. This book was released on 1998-05-06 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormones and Growth Factors in Development and Neoplasia Edited by Robert B. Dickson, Lombardi Cancer Research Center, Georgetown University David S. Salomon, Laboratory of Tumor Immunology and Biology, National Cancer Institute, NIH The study of hormones is critical to our understanding of developmental aberrations leading to cancer, and the discovery of polypeptide growth factors has led to profound insights into the duality of control of development and cancer by hormones at the tissue and cellular levels. In this book, leading researchers in the field present a cohesive overview of several important growth factor systems and how they interact with endocrine hormones in the context of tissue-tissue interactions; control of cellular growth, differentiation, and death; and reciprocal control of receptors and ligands at the molecular level. In its first two sections, Hormones and Growth Factors in Development and Neoplasia introduces important growth factors and hormonal systems in invertebrate and amphibian model systems, highlights early evolutionary and developmental functions for the classes of molecules later shown to be important in human cancer, establishes the roles of growth factors and hormones in mammalian development, and focuses on early embryonic events and later events leading to sexual dimorphism. The book's third section discusses in detail the control of postnatal developmental processes in male and female reproductive tracts, focusing on the prostate and mammary glands as well as the female reproductive tract, all of which are of special importance in hormonally driven cancers. Finally, the book takes a direct look at cancers and the molecular mechanisms of hormone-growth factor interactions. Among the many topics covered in this timely volume are: * Ecdysone in development of Drosophila * The progesterone receptor in mammalian development * Regulation of cell survival and apoptosis in the reproductive tracts and the breast * Hormones, growth factors, oncogenes, and prostate cancer With its novel approach, authoritative coverage, and broad scope, Hormones and Growth Factors in Development and Neoplasia is informative and relevant for researchers across a spectrum of disciplines, including cancer research, endocrinology, developmental biology, and cell biology.

Hormonal Carcinogenesis IV

Author : Jonathan J. Li
Publisher : Springer Science & Business Media
ISBN 13 : 0387237615
Total Pages : 562 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Hormonal Carcinogenesis IV by : Jonathan J. Li

Download or read book Hormonal Carcinogenesis IV written by Jonathan J. Li and published by Springer Science & Business Media. This book was released on 2006-08-10 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been over a decade since the First International Symposium on Hormonal Carcinogenesis convened in 199 1. Since then, the field has rapidly expanded with considerable progress in both breast and prostate cancers; while ovarian and endometrial cancer have been hampered, in part, due to the absence of suitable hormone-mediated animal models. While knock-out, transgenic, and cell-culture systems have been extremely useful in identifying specific genelprotein alterations and the ensuing pathways affected, the precise molecular mechanisms whereby sex hormones elicit their oncogenic effects still remain elusive. Moreover, despite the considerable progress made in breast cancer research, the exact role of progestins in the presence or absence of estrogen in breast growth, differentiation, and malignant transformation is lacking. Elucidating the incipient molecular alterations in earlylpre-invasive lesions elicited by these hormones is a growing important focus of this field. The main purpose of these Symposia has been to address vital questions that impact our understanding of the causation, dependency, progression, resistance, and prevention of hormonally-associated cancers. We are indebted to the Scientific Advisory Board members who worked with us reviewing and offering suggestions to finalize the scientific program. We offer special thanks for the guidance and support of Dr. Gerald Mueller. His wisdom played an indispensable role in maintaining the excellence of these Symposia. We also acknowledge the numerous external reviewers that worked diligently to revise and improve the quality of the manuscripts. We are very grateful to Ms. Tandria Price.