Hormone/Behavior Relations of Clinical Importance

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Author :
Publisher : Academic Press
ISBN 13 : 9780080958002
Total Pages : 1182 pages
Book Rating : 4.9/5 (58 download)

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Book Synopsis Hormone/Behavior Relations of Clinical Importance by : Robert H. Rubin

Download or read book Hormone/Behavior Relations of Clinical Importance written by Robert H. Rubin and published by Academic Press. This book was released on 2010-03-16 with total page 1182 pages. Available in PDF, EPUB and Kindle. Book excerpt: A single volume of 41 articles, Hormone/Behavior Relations of Clinical Importance is an authoritative selection of relevant chapters from the Hormones Brain and Behavior 2e MRW, the most comprehensive source of neuroendocrinological information assembled to date (AP July 2009). The study of hormones as they impact the brain and, subsequently, behavior is a central topic in neuroscience, endocrinology and psychiatry. This volume offers an overview of neuroendocrinological topics, approaching the subject from the perspective of hormone-brain function, hormone-behavior relations, sex differences, and the impact on various diseases/pathologies. Many basic human behavioral functions are subject to the influence of hormones - sexual orientation, the experience of pain, fertility, immunity - as are clinical conditions such as diabetes, substance abuse disorder, eating disorders, PTSD, TBI, pain, Alzheimer's, stress/anxiety, affective disorders, and more. There is considerable commercial clinical potential in the study of hormones - drug companies are currently developing a Cholecystokinin (hormonal peptide) booster to reduce appetite in those who suffer from sever obesity, and catamenial epilepsy (features seizure exacerbation in relation to the menstrual cycle) is resistant to treatment by standard antiepileptic medications, but may be hormonally controlled. These issues and more are covered, and there is simply no other current single-volume reference with such comprehensive coverage and depth. Authors selected are the internationally renowned experts for the particular topics on which they write, and the volume is richly illustrated with over 150 figures (50 in color). A collection of articles reviewing our fundamental knowledge of neuroendocrinology, the book provides an essential, affordable reference for researchers, clinicians and graduate students in the area. - Offering outstanding scholarship, each chapter is written by an expert in the topic area and approximately 25% of chapters are written by international contributors (7 countries represented) - Provides more fully vetted expert knowledge than any existing work with broad appeal for the US, UK and Europe, accurately crediting the contributions to research in those regions - Heavily illustrated with 150 figures, approximately 50 in color, presenting the material in the most visually useful form for the reader - Fully explores various clinical conditions associated with the hormones and the brain (PTSD, TBI, Stress & Anxiety, eating disorders, diabetes, addictive disorders, Alzheimer's, affective disorders) - Broad coverage of disorders makes the volume relevant to clinicians as well as researchers and basic scientists

Principles of Hormone/Behavior Relations

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Author :
Publisher : Academic Press
ISBN 13 : 0128026677
Total Pages : 572 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Principles of Hormone/Behavior Relations by : Donald W Pfaff

Download or read book Principles of Hormone/Behavior Relations written by Donald W Pfaff and published by Academic Press. This book was released on 2018-01-10 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Hormone/Behavior Relations, Second Edition, provides an introduction to the underlying principles of endocrine regulation of behavior, a newly emerging area of research within neurobiology and endocrinology. It addresses the properties of hormone/behavior relations, including the influence of family background, timing issues, neuroanatomical features, cellular mechanisms, and the importance of environmental context and evolution. This new edition incorporates critical advances in the field, also including increased coverage of hormonal influences on food intake, and on the cardiovascular system. The addition of entirely new principles provides further coverage of epigenetics and appetite. Thoroughly revised and updated, this book is an ideal resource for neuroscientists and researchers engaging in this rapidly expanding field of study. Provides a unique structure where each chapter addresses a key principle that is illustrated by numerous basic experimental and clinical examples Includes user-friendly features, such as boxed figures with extended captions and references, numerous clinical notes, and a comprehensive list of abbreviations Contains numerous illustrations that highlight both the clinical and basic science information

Hormones, Brain, and Behavior

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Author :
Publisher :
ISBN 13 :
Total Pages : 932 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Hormones, Brain, and Behavior by : Donald W. Pfaff

Download or read book Hormones, Brain, and Behavior written by Donald W. Pfaff and published by . This book was released on 2002 with total page 932 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breadth (from molecules to ecophysiology), ranging from basic science to clinical research, making this reference of interest to a broad range of scientists in a variety of fields. Key Features * Contributors from 16 different countries and more than 70 institutions * Unlike any other hormone reference on the market Hormones, Brain and Behavior addresses hormone effects in all major vertebrate and non-vertebrate models * A timely, current reference on an emerging field with each chapter providing an in-depth exploration of the topic * Discusses molecular aspects of hormone function, systems, development, and hormone-related diseases * Addresses hormone effects in both the developing and adult nervous system Topics include: * Mammalian and Non-mammalian Hormone-behavior Systems * Cellular and Molecular Mechanisms of Hormone Actions on Behavior * Development of Hormone-dependent Neuronal Systems * Hormone/Behavior Relations of Clinical Importance.

Molecular Mechanisms of Hormone Actions on Behavior

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Author :
Publisher : Academic Press
ISBN 13 : 9780080958583
Total Pages : 1100 pages
Book Rating : 4.9/5 (585 download)

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Book Synopsis Molecular Mechanisms of Hormone Actions on Behavior by : Anne M. Etgen

Download or read book Molecular Mechanisms of Hormone Actions on Behavior written by Anne M. Etgen and published by Academic Press. This book was released on 2010-03-16 with total page 1100 pages. Available in PDF, EPUB and Kindle. Book excerpt: A single volume of 31 articles, Mechanisms of Hormone Actions on Behavior is an authoritative selection of relevant chapters from the Hormones Brain and Behavior 2e MRW, the most comprehensive source of neuroendocrinological information assembled to date (AP June 2009). The study of hormones as they impact the brain and, subsequently, behavior is a central topic in neuroscience, endocrinology and psychiatry. This volume offers an overview of neuroendocrinological topics, approaching the subject from the perspective of the mechanisms which control hormone actions on behavior. Female, male and stress hormones are discussed at the cellular, behavioral and developmental level, and sexual differentiation of the development of hormone-dependent neuronal systems, neuropeptides/neuromodulators, and steroid-inducedneuroplasticity are addressed. There is simply no other current single-volume reference with such comprehensive coverage and depth. Authors selected are the internationally renowned experts for the particular topics on which they write, and the volume is richly illustrated with over 175 figures (over 50 in color). A collection of articles reviewing our fundamental knowledge of the mechanisms of neuroendocrinology, the book provides an essential, affordable reference for researchers, clinicians and graduate students in the area. - The most comprehensive single-volume source of up-to-date data on the mechanisms behind neuroendocrinology, with review articles covering x,y z - Chapters synthesize information otherwise dispersed across a number of journal articles and book chapters, thus saving researchers the time consuming process of finding and integrating this information themselves - Offering outstanding scholarship, each chapter is written by an expert in the topic area and approximately 35% of chapters are written by international contributors - Provides more fully vetted expert knowledge than any existing work with broad appeal for the US, UK and Europe, accurately crediting the contributions to research in those regions - Heavily illustrated with 175 figures, approximately 54 in color - Presents material in most visually useful form for the reader

New Aspects of Human Ethology

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Author :
Publisher : Springer
ISBN 13 : 9781475785791
Total Pages : 239 pages
Book Rating : 4.7/5 (857 download)

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Book Synopsis New Aspects of Human Ethology by : Klaus Atzwanger

Download or read book New Aspects of Human Ethology written by Klaus Atzwanger and published by Springer. This book was released on 2013-10-03 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rough-and-tumble play provided one of the paradigmatic examples of the appli- tion of ethological methods, back in the 1970's. Since then, a modest number of - searchers have developed our knowledge of this kind of activity, using a variety of methods, and addressing some quite fundamental questions about age changes, sex diff- ences, nature and function of behaviour. In this chapter I will review work on this topic, mentioning particularly the interest in comparing results from different informants and different methods of investigation. Briefly, rough-and-tumble play (or R&T for short) refers to a cluster of behaviours whose core is rough but playful wrestling and tumbling on the ground; and whose general characteristic is that the behaviours seem to be agonistic but in a non-serious, playful c- text. The varieties of R&T, and the detailed differences between rough-and-tumble play and real fighting, will be discussed later. 2. A BRIEF HISTORY OF RESEARCH ON R&T In his pioneering work on human play, Groos (1901) described many kinds of rough-and-tumble play. However, R&T was virtually an ignored topic from then until the late 1960's. There was, of course, a flowering of observational research on children in the 1920s and 1930s, especially in North America; but this research had a strong practical o- entation, and lacked the cross-species perspective and evolutionary orientation present in Groos' work.

Hormones and Behaviour

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Author :
Publisher : Cambridge University Press
ISBN 13 : 1139468162
Total Pages : 11 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Hormones and Behaviour by : Nick Neave

Download or read book Hormones and Behaviour written by Nick Neave and published by Cambridge University Press. This book was released on 2007-12-20 with total page 11 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in non-invasive sampling techniques have led to an increase in the study of hormones and behaviour. Behaviour is complex but can be explained to a large degree by interactions between various psychological and physiological components, such as the interplay between hormonal and psychological systems. This new textbook from Nick Neave offers a detailed introduction to the fascinating science of behavioural endocrinology from a psychological perspective, examining the relationships between hormones and behaviour in both humans and animals. Neave explains the endocrine system and the ways in which hormones can influence brain structure and function, and presents a series of examples to demonstrate how hormones can influence specific behaviours, including sexual determination and differentiation, neurological differentiation, parental behaviours, aggressive behaviours and cognition. This introductory textbook will appeal to second and third year social science undergraduate students in psychology and biomedicine.

Offspring

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Publisher : National Academies Press
ISBN 13 : 030908718X
Total Pages : 399 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Offspring by : National Research Council

Download or read book Offspring written by National Research Council and published by National Academies Press. This book was released on 2003-05-04 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite recent advances in our understanding of the genetic basis of human behavior, little of this work has penetrated into formal demography. Very few demographers worry about how biological processes might affect voluntary behavior choices that have demographic consequences even though behavioral geneticists have documented genetics effects on variables such as parenting and divorce. Offspring: Human Fertility Behavior in Demographic Perspective brings together leading researchers from a wide variety of disciplines to review the state of research in this emerging field and to identify promising research directions for the future.

Hormones, Brain and Behavior

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Author :
Publisher : Elsevier
ISBN 13 : 0080534155
Total Pages : 957 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Hormones, Brain and Behavior by :

Download or read book Hormones, Brain and Behavior written by and published by Elsevier. This book was released on 2002-06-18 with total page 957 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormones, Brain and Behavior, Third Edition offers a state-of-the-art overview of hormonally-mediated behaviors, including an extensive discussion of the effects of hormones on insects, fish, amphibians, birds, rodents, and humans. Entries have been carefully designed to provide a valuable source of information for students and researchers in neuroendocrinology and those working in related areas, such as biology, psychology, psychiatry, and neurology. This third edition has been substantially restructured to include both foundational information and recent developments in the field. Continuing the emphasis on interdisciplinary research and practical applications, the book includes articles aligned in five main subject sections, with new chapters included on genetic and genomic techniques and clinical investigations. This reference provides unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics. The topics cover an unusual breadth (from molecules to ecophysiology), ranging from basic science to clinical research, making this reference of interest to a broad range of scientists in a variety of fields. Contributors from 16 different countries and more than 70 institutions Unlike any other hormone reference on the market Hormones, Brain and Behavior addresses hormone effects in all major vertebrate and non-vertebrate models A timely, current reference on an emerging field with each chapter providing an in-depth exploration of the topic Discusses molecular aspects of hormone function, systems, development, and hormone-related diseases Addresses hormone effects in both the developing and adult nervous system Topics include: Mammalian and Non-mammalian Hormone-behavior Systems Cellular and Molecular Mechanisms of Hormone Actions on Behavior Development of Hormone-dependent Neuronal Systems Hormone/Behavior Relations of Clinical Importance

Hormones, Brain and Behavior

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Author :
Publisher : Academic Press
ISBN 13 : 012532104X
Total Pages : 957 pages
Book Rating : 4.1/5 (253 download)

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Book Synopsis Hormones, Brain and Behavior by : Donald W. Pfaff

Download or read book Hormones, Brain and Behavior written by Donald W. Pfaff and published by Academic Press. This book was released on with total page 957 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Exploring the Biological Contributions to Human Health

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Author :
Publisher : National Academies Press
ISBN 13 : 9780309132978
Total Pages : 288 pages
Book Rating : 4.1/5 (329 download)

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Book Synopsis Exploring the Biological Contributions to Human Health by : Institute of Medicine

Download or read book Exploring the Biological Contributions to Human Health written by Institute of Medicine and published by National Academies Press. This book was released on 2001-07-02 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.

Social Hormones and Human Behavior: What Do We Know and Where Do We Go from Here

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889194078
Total Pages : 96 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Social Hormones and Human Behavior: What Do We Know and Where Do We Go from Here by : Idan Shalev

Download or read book Social Hormones and Human Behavior: What Do We Know and Where Do We Go from Here written by Idan Shalev and published by Frontiers Media SA. This book was released on 2015-02-11 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxytocin (OT) and arginine vasopressin (AVP) are the paramount social hormones in mammals and accumulating evidence also strengthens the unique role of these neuropeptides also in human social behavior. Indeed from voles to humans, OT and AVP modulate an intriguing number of social behaviors resonating across species such as the quality of pair bonding, parenting, modulations of social stress, in-group & out-group relationships and social communications. Recent molecular genetic studies of the oxytocin (OXTR), arginine vasopressin 1a (AVPR1a) and arginine vasopressin 1b (AVPR1b) receptors have strengthened the role of these two neuropeptides in a range of normal and pathological human behaviors. Importantly, dysfunctions in the OT and AVP neural pathways are likely contributing to deficits in social skills and communication in disorders such as autism. This Research Topic covers the state of the science and provides a deep view of social hormone research in humans to illustrates how pharmacological, genetic and neuroimaging strategies can be successfully combined toward unraveling the mystery of how human social behavior is regulated. Understanding human social behavior at the molecular level, i.e. social neuroscience, is not only crucial for treatment and diagnosis of disorders characterized by deficits in social cognition but also has important implications in establishing the congruence of findings from different approaches in the Social Sciences and Biology. We bring together in this issue a broad spectrum of investigators from the neurosciences, genetics, psychology, economics and political science towards a deeper understanding of the biological roots of human social behavior. We hope that this transdisciplinary Research Topic will bring new insights and ideas to the field, give future perspectives while also addressing open questions and limitation in order to develop intervention and prevention strategies, and to translate the basic social hormone research into clinical applications. This Research Topic covers the state of the science and provides a deep view of social hormone research in humans to illustrates how pharmacological, genetic and neuroimaging strategies can be successfully combined toward unraveling the mystery of how human social behavior is regulated. Understanding human social behavior at the molecular level, aka social neuroscience, is not only crucial for treatment and diagnosis of disorders characterized by deficits in social cognition but such an understanding has important implications for consilience of the Social Sciences and Biology. We bring together in this issue a broad spectrum of investigators from the neurosciences, genetics, psychology, economics and political science towards a deeper understanding of the biological roots of human social behavior. We hope that this transdisciplinary Research Topic will bring new insights and ideas to the field, give future perspectives while also addressing open questions and limitation in order to develop intervention and prevention strategies, and to translate the basic social hormone research into clinical applications.

The Hormone Factor in Mental Health

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Author :
Publisher : Jessica Kingsley Publishers
ISBN 13 : 0857007297
Total Pages : 416 pages
Book Rating : 4.8/5 (57 download)

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Book Synopsis The Hormone Factor in Mental Health by : Linda M. Rio

Download or read book The Hormone Factor in Mental Health written by Linda M. Rio and published by Jessica Kingsley Publishers. This book was released on 2013-09-21 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine imbalances can cause a whole host of physical and mental health problems. Yet, there is currently no definitive source of information that shows how hormones can bridge the gap between mental health and medical health modalities. This book is a bold crossover between the disciplines of medical and mental health, exploring the understanding that some of the major mental diagnoses belong not only to the field of mental health but also to that of medicine. Clients with depression, anxiety, sexual dysfunction, infertility, suicidality, anger and rage, fatigue, apathy, cognitive impairments, confusion, eating disorders, and poor body image may actually be presenting symptoms of hormonal disorders. Beginning with patient stories that display the devastating effects of misdiagnosis and the struggle to obtain the correct treatment, it provides members of the mental health profession with an authentic understanding of the impact of endocrine imbalances and disorders. With contributions from some of the world's most respected physicians, psychiatrists and psychotherapists, it provides accurate medical and psychological information about hormone imbalances and disorders, how to recognise the signs in patients, and how to treat them effectively. A comprehensive resource that provides all the information needed to identify endocrine disorders in patients successfully; this book will be of immeasurable value to clinical psychologists, marriage and family therapists, social workers, doctors, nurses and mental health clinicians.

Stress: Neuroendocrinology and Neurobiology

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Author :
Publisher : Academic Press
ISBN 13 : 0128024232
Total Pages : 460 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Stress: Neuroendocrinology and Neurobiology by : George Fink

Download or read book Stress: Neuroendocrinology and Neurobiology written by George Fink and published by Academic Press. This book was released on 2016-12-15 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stress: Neuroendocrinology and Neurobiology: Handbook of Stress Series, Volume 2, focuses on neuroendocrinology, the discipline that deals with the way that the brain controls hormonal secretion, and in turn, the way that hormones control the brain. There have been significant advances in our understanding of neuroendocrine molecular and epigenetic mechanisms, especially in the way in which stress-induced hormonal and neurochemical changes affect brain plasticity, neuronal connectivity, and synaptic function. The book features the topic of epigenetics, and how it enables stress and other external factors to affect genetic transmission and expression without changes in DNA sequence. Integrated closely with new behavioral findings and relevance to human disorders, the concepts and data in this volume offer the reader cutting-edge information on the neuroendocrinology of stress. Volume 2 is of prime interest to neuroscientists, clinicians, researchers, academics, and graduate students in neuroendocrinology, neuroscience, biomedicine, endocrinology, psychology, psychiatry, and in some areas of the social sciences, including stress and its management in the workplace. Includes chapters that offer impressive scope with topics addressing the neuroendocrinology and endocrinology of stress Presents articles carefully selected by eminent stress researchers and prepared by contributors that represent outstanding scholarship in the field Richly illustrated, with explanatory figures and tables

The Oxytocin Factor

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Author :
Publisher : Da Capo Press
ISBN 13 : 0786752599
Total Pages : 226 pages
Book Rating : 4.7/5 (867 download)

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Book Synopsis The Oxytocin Factor by : Kerstin Uvnas Moberg

Download or read book The Oxytocin Factor written by Kerstin Uvnas Moberg and published by Da Capo Press. This book was released on 2003-09-18 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years there have been exciting scientific discoveries about a powerful hormone whose role in the human body has long been neglected. Oxytocin is the hormone involved in bonding, sex, childbirth, and breast-feeding, as well as in relaxation and feelings of calm. It is the mirror image of the stress hormone (adrenaline), which triggers the "fight or flight" systems in the body. Much has been written about the latter but the many-sided importance of oxytocin is currently known only to specialists in obstetrics, physiology, and psychiatry. The Oxytocin Factor, by Dr. Kerstin Uvnäs-Moberg, is the first book on the subject for a general audience. The new research findings, as well as the potentially beneficial applications of this hormone in reducing anxiety states, stress, addictions, and problems of childbirth, are not only fascinating but of great significance to all our lives.

Drive

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Author :
Publisher : MIT Press
ISBN 13 : 9780262661478
Total Pages : 346 pages
Book Rating : 4.6/5 (614 download)

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Book Synopsis Drive by : Donald W. Pfaff

Download or read book Drive written by Donald W. Pfaff and published by MIT Press. This book was released on 1999 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: What arouses an animal or human from an inactive, nonresponsive state to a condition of activity and responsiveness? What are the biological mechanisms for this change? In this book Donald W. Pfaff focuses on a reproductive behavior typical of many female animals. Sensory stimuli from the male trigger responses in a well-defined circuit of nerve cells. At the top of the circuit, certain nerve cells receive and retain sex hormones such as estrogens and progesterone. As a result, specific genes in these nerve cells are turned on at specific times, affecting in turn the rest of the neural circuit and causing a state of sexual responsiveness. According to Pfaff, the biological bases for the most primitive human drives are largely explained by mechanisms uncovered in animal brains that have not changed in their fundamental properties over millions of years of evolution. Focusing on a single instinctive behavior, in this case the sex drive, is an important step toward understanding the biological reasons for the change from unmotivated to motivated animal behavior.

Basic Neurochemistry

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Author :
Publisher : Lippincott Raven
ISBN 13 :
Total Pages : 1216 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Basic Neurochemistry by : George J. Siegel

Download or read book Basic Neurochemistry written by George J. Siegel and published by Lippincott Raven. This book was released on 1999 with total page 1216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Illustrations by Lorie M. Gavulic, MFA Sponsored by the American Society for Neurochemistry.

Microbial Endocrinology

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1441955763
Total Pages : 325 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Microbial Endocrinology by : Mark Lyte

Download or read book Microbial Endocrinology written by Mark Lyte and published by Springer Science & Business Media. This book was released on 2010-04-06 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial endocrinology represents a newly emerging interdisciplinary field that is formed by the intersection of the fields of neurobiology and microbiology. This book will introduce a new perspective to the current understanding not only of the factors that mediate the ability of microbes to cause disease, but also to the mechanisms that maintain normal homeostasis. The discovery that microbes can directly respond to neuroendocrine hormones, as evidenced by increased growth and production of virulence-associated factors, provides for a new framework with which to investigate how microorganisms interface not only with vertebrates, but also with invertebrates and even plants. The reader will learn that the neuroendocrine hormones that one most commonly associates with mammals are actually found throughout the plant, insect and microbial communities to an extent that will undoubtedly surprise many, and most importantly, how interactions between microbes and neuroendocrine hormones can influence the pathophysiology of infectious disease.