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Homeostasis Nephrotoxicity And Renal Anomalies In The Newborn
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Book Synopsis Homeostasis, Nephrotoxicity, and Renal Anomalies in the Newborn by : J. Strauss
Download or read book Homeostasis, Nephrotoxicity, and Renal Anomalies in the Newborn written by J. Strauss and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the 11th of the Pediatric Nephrology series created to help us be in touch with developments which are relevant to the problems we face daily in clinical practice and the questions we ask and try to answer in clinical and experimental research. Like volume IX, this one focuses on one of the subgroups to which we are committed--the neonates' special fluid and electrolyte requirements. This volume has more on blood pressure and renal function and looks at the hormonal regulators. There is greater depth about intoxications and nephrotic agents, congenital disorders and mineral metabolism. The exchanges were stimulating and the controversies were brought out without need of much of my usual prodding. At Julie Ingelfinger's suggestion, at the end of each panel discussion I have added a comment to highlight the main points as I see them. Otherwise, the format remains as in past editions: the papers given related to the four major topic areas, each followed by panel and registrant discussion. Although the transcription is almost verbatim, you will not find the names of the discussants, purposely omitted to ease my editorial work and to encourage everyone to speak candidly. Some of the questions and answers are those submitted to the panelists after the sessions, incorporated here by request. Also, frequent references are made to others' work but their names have been omitted.
Book Synopsis Homeostasis, Nephrotoxicity, and Renal Anomalies in the Newborn by : J. Strauss
Download or read book Homeostasis, Nephrotoxicity, and Renal Anomalies in the Newborn written by J. Strauss and published by Springer. This book was released on 2011-10-12 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the 11th of the Pediatric Nephrology series created to help us be in touch with developments which are relevant to the problems we face daily in clinical practice and the questions we ask and try to answer in clinical and experimental research. Like volume IX, this one focuses on one of the subgroups to which we are committed--the neonates' special fluid and electrolyte requirements. This volume has more on blood pressure and renal function and looks at the hormonal regulators. There is greater depth about intoxications and nephrotic agents, congenital disorders and mineral metabolism. The exchanges were stimulating and the controversies were brought out without need of much of my usual prodding. At Julie Ingelfinger's suggestion, at the end of each panel discussion I have added a comment to highlight the main points as I see them. Otherwise, the format remains as in past editions: the papers given related to the four major topic areas, each followed by panel and registrant discussion. Although the transcription is almost verbatim, you will not find the names of the discussants, purposely omitted to ease my editorial work and to encourage everyone to speak candidly. Some of the questions and answers are those submitted to the panelists after the sessions, incorporated here by request. Also, frequent references are made to others' work but their names have been omitted.
Book Synopsis Neonatal Nutrition and Metabolism by : Patti J. Thureen
Download or read book Neonatal Nutrition and Metabolism written by Patti J. Thureen and published by Cambridge University Press. This book was released on 2012-12-13 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neonatal nutrition has a pivotal role in normal child development and is of even greater importance in the sick or premature neonate. This 2006 edition includes a comprehensive account of the basic science, metabolism and nutritional requirements of the neonate, and a greatly expanded number of chapters dealing in depth with clinical issues ranging from IUGR, intravenous feeding, nutritional therapies for inborn errors of metabolism, and care of the neonatal surgical patient. Evolving from these scientific and clinical aspects, the volume highlights the important long-term effects of fetal and neonatal growth on health in later life. In addition, there are very practical chapters on methods and techniques for assessing nutritional status, body composition, and evaluating metabolic function.
Download or read book Nephrotoxicity written by Peter Bach and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 737 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a growing awareness that nephrotoxicity represents a key factor in human nephropathies, where, irrespective of the causative agent, only a few clinical end-effects are diagnosed. Thus nephropathies are generally classified as acute or chronic renal failure, malignancies or immunological changes. The weaknesses in diagnosing nephropathies arises because of the effective role the kidney plays in maintaining homeostasis, despite the fact that it has been extensively damaged. The frequencies of some type of chemically-induced acute renal failure is well documented, but the causes of chronic renal failure, malignancy, and other nephropathies are far more difficult to associate with a chemical aetiology. Many of the new therapeutic agents have important beneficial effects, but they are found to have marked nephrotoxic effects. Thus there is a growing urgency to increase the stringency of chemical safety evaluation for their potential nephrotoxic effects. This is strongly countered by the increased financial pressure to identify potentially nephrotoxic chemicals earlier in their development and humanitarian considerations to more closely relate animal test to the clinical situation. Part of the challenge may be achieved by the increasing use of in vitro techniques.
Download or read book The Cystic Kidney written by K.D. Gardner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a book about renal cysts and cystic kidneys. Its contributors have created a resource of current information in a field that once aroused only curiosity, but that now stands at the leading edge of molecular nephrology. Its authorship includes 'oldtimers', who bring the wisdom of experience, and 'newcomers', whose presence attests to the contributions made by the investigative and technological advances of the past decade. Its text is organized to carry the reader from renal cyst to cystic renal disease. Each of its chapters defines or explores a challenge or an advance. Cells that line renal cysts are diverse in structure, type, and perhaps function. The cysts themselves lie within an interstitium that is not normal and may influence cyst development and growth. Experimental analogs of human disease offer increasing opportunities to basic researchers to examine, in sequence and under controlled circumstances, those events that favor nephron dilation, cyst growth and ultimate renal failure.
Book Synopsis New Therapeutic Strategies in Nephrology by : V.E. Andreucci
Download or read book New Therapeutic Strategies in Nephrology written by V.E. Andreucci and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the 3rd International Meeting on Current Therapy in Nephrology (Sorrento, Italy, May 27-30, 1990)
Book Synopsis Persistent Renal-Genitourinary Disorders by : J. Strauss
Download or read book Persistent Renal-Genitourinary Disorders written by J. Strauss and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Pediatric Nephrology series is a focus on salient points which at the time of each annual seminar are of importance to the practicing pediatrician and nephrologist, the clinical researcher, and basic researcher interested in clinical problems. Hence the format of selected papers and panel discussions to capture the tenor of the times. More thorough coverage of many of the subjects can be found in current journals and textbooks listed in the authors' references. Those searching for the conventional should look there rather than here since our aim is not to cover each subject in its entirety but to secure attention to the controversial aspects of the subjects, dispel the notion that there is one answer to a question, and raise the level of inclination toward dynamic problem solving. The basic subject chosen this year reflects dominant concerns this year and the participants chosen--speakers and discussants--represent certain views relevant to the subject at this time. To reflect the tempo and flavor produced by this unique blend, the discussions are included almost verbatim. For some this means readability; for others, excess verbiage. The careful reader will notice that I have been the chairman of all sessions and have moderated all discussions. This is in keeping with our aim to ferret out interrelated basic questions and varying answers to the subjects--seen as related in problems and solutions. In the discussions, all names have been deleted.
Book Synopsis Acute Continuous Renal Replacement Therapy by : Emil P. Paganini
Download or read book Acute Continuous Renal Replacement Therapy written by Emil P. Paganini and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: The initial observations of dialytic support were brought from the laboratory and confined to patients with reversible acute renal failure. The thought at that time was one of short term maintenance. It was theorized that removal of waste products from the blood, albeit incomplete and inefficient, might allow these patients time to regenerate damaged tubules and regain renal function. After a dis appointing earlier experience in survival, greater sophisti cation and broader practice refined the dialysis skills and reduced mortality. It also became apparent that long periods of support were possible and successful attempts were then made in utilizing this technology in patients with chronic renal failure. These early young patients were a very select group who possessed only renal dysfunction and no other systemic involvement. Nonetheless, they demonstrated a one year survival of only 55-64%. There are presently over 80,000 patients on dialytic support in the United States and over 250,000 patients worldwide dependent on artificial replace ment. Mortality statistics vary but despite a 20-30% systemic disease involvement and a fifth decade average age in the North American experience, the one year survival has risen to apparently 90%.
Download or read book Vasopressin written by L. Kovács and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mechanisms by which animals regulate the volume and composition of their body fluids has long had a particular fascination for students of biology. As a consequence, the subject can lay claim to an impressive record of ground breaking scientific achievements as well as a provocative body of philosophical speculation concerning the role of the system in the origin and evolution of life. Indeed, the entire concept of homeostasis on which so much of o~r current biologic thinking is based, derives from Claude Bernard's pioneering exploration of the forces that determine the composition of this 'internal sea'. Other seminal achievements credited to this area of inquiry include the first description of a genetically transmitted human disease (familial neurogenic diabetes insipidus); the first isolation sequencing and synthesis of a peptide hormone (vasopressin and oxytocin); the first demonstration of peptide hormone synthesis by way of a larger protein precursor; the first description of resistance to the biologic actions of a hormone (nephrogenic diabetes insipidus); and the conceptual realization of the unique counter-current mechanism that permits concentration of the urine. This record of far reaching and fundamental advances has been distinguished by many fruitful inter actions between clinical and basic science.
Book Synopsis Continuous Ambulatory Peritoneal Dialysis in the USA by : A.S. Lindblad
Download or read book Continuous Ambulatory Peritoneal Dialysis in the USA written by A.S. Lindblad and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Final Report of the USA CAPO Registry summarizes eight years of observation and analysis that reflects the experiences of 485 clinical centers and over 25,000 CAPO patients. As such, it offers a wealth of information, available here for the first time to interested parties around the world. Because the National Institutes of Health was quick to see the potential of CAPO as a promising therapy for patients with end stage renal disease, the Registry project was begun soon after its introduction into clinical practice in the USA. Accordingly, the Registry offered the nephrology community in the United States a special opportunity to study this emerging new therapy in some detail, an opportunity not previously available for any other form of dialysis. As will be seen in this report, the result of this early and intensive research effort has been the development of a vast amount of clinically important information regarding the utilization, safety, and efficacy of this important dialytic therapy.
Book Synopsis Diuretics: Basic, Pharmacological, and Clinical Aspects by : V.E. Andreucci
Download or read book Diuretics: Basic, Pharmacological, and Clinical Aspects written by V.E. Andreucci and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: The need for adequate means by which to improve urine output is very old. Even in the "Scuola Salernitana", the oldest medieval medical school in Western Europe, about 1000 years ago it was taught how to improve urine output. The list of known "diuretica" included herbs, plants, roots, vegetables, in particular asparagus, fennel and carrot. The first diuretic drugs, however, were mercurial compounds. Thus, calomel, mercurous chloride, was initially used as a diuretic in the sixteenth century by Paracelsus, being one of the ingredients of the so-called "Guy's Hospital pill". But calomel had a cathartic effect so that it was replaced by organic mercurial compounds. These diuretics were clearly toxic. After the discovery of the car bonic anhydrase, in the early 1930s, and the introduction of sulfanilamide as a chemotherapeutic agent, it was observed that this drug was inhibiting carbonic anhydrase in vitro and urinary acidification in vivo thereby causing metabolic acidosis; urine output, however, appeared to increase. Subsequent studies led to the synthesis of more potent analogs, in particular acetazolamide. Studies on car bonic anhydrase inhibitors led to the synthesis of benzothiadiazides which disclosed much less inactivating action on carbonic anhydrase and much more diuretic effect through an inhibition of tubular transport of sodium and chloride. Chlorothiazide was the first member of this class of diuretics. Thiazides are still used in clinical practice.
Book Synopsis Guide to Reprocessing of Hemodialyzers by : Norman Deane
Download or read book Guide to Reprocessing of Hemodialyzers written by Norman Deane and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to provide information for the nephrologist to gain a perspective on the medical, scientific, and technical aspects of reprocess ing of hemodialyzers. The book is also designed to serve the needs of the associated medical, nursing, and technical staffs of dialysis facilities for data on reuse of hemodialyzers. As an information source, the book will prove to be useful for those who may be considering reprocessing of dialyzers, as well as persons who are currently involved in this aspect of the practice of nephrology. We have focused on the clinical and technological aspects of hemodialyzer reprocessing and have not dealt with socioeconomic considerations. We do wish to share with physicians performing hemodialysis several observations we have made as a result of assembling this volume. We believe that hemodialyzer reuse has had a beneficial impact on the quality of care for hemodialysis patients in consideration of the following factors. There is an increased awareness of membrane biocompatibility issues that has been brought to the forefront with the application of reuse. Utilization ofhemodialyzer reprocess ing has enabled nephrologists . to compare the effect of various measures on biocompatibility when the patient is exposed to either a new or a reprocessed device. Previously, few readily available comparisons existed. In the practice of dialysis, water quality has always been of considerable importance. With the advent of widespread hemodialyzer reprocessing, the issues of water bacteriology and water quality have become more prominent.
Book Synopsis Renal Transplantation: Sense and Sensitization by : S.M. Gore
Download or read book Renal Transplantation: Sense and Sensitization written by S.M. Gore and published by Springer Science & Business Media. This book was released on 2007-08-28 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1986, the Committee of Experts on Blood Transfusion and Immunohae- tology of the Council of Europe chose for their Programme of Co-ordinated Research "An investigation of the procurement and sharing of transplantable organs for potential recipients who are highly sensitized to HLA-antigens". This topic was of common concern to all centres practising renal transplan- tion. The terms of reference of the study were: To estimate the number of patients who are virtually "untransplantable" because of high sensitization in each European country. To study the nature of immunization in terms of the type and specificity of antibodies present in the blood and techniques used for their detection. To investigate possible practical solutions - both current and future, invo- ing cross-matching procedures, the circulation of reference material from patients, and the willingness of the national organizations to share resources. 4. To explore other methods of resolving this problem. Although the study did not offer the prospect of a brilliant new insight into the problem of high sensitization, it was unique in several ways: for the first time we saw all European organizations collaborating in a common project to provide information on their activities, their problems and the methods to resolve them; it introduced, for this subject, relatively novel statistical methods to investigate susceptibility to sensitization and factors affecting transplant outcome; it enabled a large database of transplanted highly sensitized patients and matched controls to be assembled, that would have been unavailable as a research resource at any single centre.
Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1000 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Tubulo-Interstitial Nephropathies by : Alberto Amerio
Download or read book Tubulo-Interstitial Nephropathies written by Alberto Amerio and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the 4th Bari Seminar in Nephrology, April 25-28, 1990
Book Synopsis Current Therapy in Nephrology by : Antonia Dal Canton
Download or read book Current Therapy in Nephrology written by Antonia Dal Canton and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the 2nd International Meeting on Current Therapy in Nephrology (Sorrento, Italy, May 22-25, 1988)
Book Synopsis Fetal and Neonatal Physiology E-Book by : Richard A. Polin
Download or read book Fetal and Neonatal Physiology E-Book written by Richard A. Polin and published by Elsevier Health Sciences. This book was released on 2011-08-13 with total page 2202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fetal and Neonatal Physiology, edited by Drs. Polin, Fox, and Abman, focuses on physiologic developments of the fetus and newborn and their impact on the clinical practice of neonatology. A must for practice, this 4th edition brings you the latest information on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Gain a comprehensive, state-of-the-art understanding of normal and abnormal physiology, and its relationship to disease in the fetus and newborn premature infant, from Dr. Richard Polin and other acknowledged worldwide leaders in the field. Understand the implications of fetal and neonatal physiology through chapters devoted to clinical correlation. Apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Effectively manage the consequences of intrauterine infections with three new chapters covering intrauterine infection and preterm birth, intrauterine infection and brain injury, and intrauterine infection and chronic lung disease.
