Hierarchical Modeling Of Gene Environment Interactions In A Case Control Study

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Human Genome Epidemiology, 2nd Edition

Author : Muin J. Khoury
Publisher : Oxford University Press
ISBN 13 : 0195398440
Total Pages : 701 pages
Book Rating : 4.1/5 (953 download)

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Book Synopsis Human Genome Epidemiology, 2nd Edition by : Muin J. Khoury

Download or read book Human Genome Epidemiology, 2nd Edition written by Muin J. Khoury and published by Oxford University Press. This book was released on 2010-01-20 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of Human Genome Epidemiology, published in 2004, discussed how the epidemiologic approach provides an important scientific foundation for studying the continuum from gene discovery to the development, applications and evaluation of human genome information in improving health and preventing disease. Since that time, advances in human genomics have continued to occur at a breathtaking pace.With contributions from leaders in the field from around the world, this new edition is a fully updated look at the ways in which genetic factors in common diseases are studied. Methodologic developments in collection, analysis and synthesis of data, as well as issues surrounding specific applications of human genomic information for medicine and public health are all discussed. In addition, the book focuses on practical applications of human genome variation in clinical practice and disease prevention. Students, clinicians, public health professionals and policy makers will find the book a useful tool for understanding the rapidly evolving methods of the discovery and use of genetic information in medicine and public health in the 21st century.

Phenotypes and Endophenotypes

Author :
Publisher :
ISBN 13 :
Total Pages : 660 pages
Book Rating : 4.:/5 (9 download)

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Book Synopsis Phenotypes and Endophenotypes by :

Download or read book Phenotypes and Endophenotypes written by and published by . This book was released on 2009 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Gene-Environment Interactions

Author : Lucio G. Costa
Publisher : John Wiley & Sons
ISBN 13 : 0471758035
Total Pages : 577 pages
Book Rating : 4.4/5 (717 download)

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Book Synopsis Gene-Environment Interactions by : Lucio G. Costa

Download or read book Gene-Environment Interactions written by Lucio G. Costa and published by John Wiley & Sons. This book was released on 2005-12-16 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the play between heredity and environment, and relating it to disease causation, is the task of ecogenetics. Gene-Environment Interactions: Fundamentals of Ecogenetics presents the first comprehensive survey of this discipline, reflecting its relationship with toxicology, epidemiology, pharmacology, public health, and other medical and biological fields. Divided into four sections, the text elucidates key basic and advanced topics: * Section 1 covers fundamentals, including the history of the discipline, a discussion of the molecular laboratory tools currently available to assess genotypes, using such measurements in molecular epidemiology studies, and the statistical issues involved in their analysis. * Section 2 focuses on a number of key genetic polymorphisms relevant for ecogenetics, including enzymes of phase I and phase II metabolism, enzymes involved in DNA repair, as well as receptors and ion channels. This highlights characteristics of selected, widely studied genotypic/phenotypic differences, and allows discussion of how given genetic variations can influence responses to exogenous chemicals. * Section 3 examines gene-environment interactions through a disease-based approach, addressing how genetic polymorphisms can influence susceptibility to various diseases. Chapters cover important disease conditions such as various types of cancer, neurodegenerative diseases, cardiovascular disease, chronic pulmonary diseases, infectious diseases, diabetes, and obesity. * The final section discusses the ethical, legal, and social issues that arise when investigating and evaluating genetic polymorphisms in human populations, as well as the impact of ecogenetics on risk assessment, regulatory policies, and medicine and public health. Packed with clear examples illustrating concepts, as well as numerous tables and figures, Gene-Environment Interactions: Fundamentals of Ecogenetics is a unique resource for a wide range of physicians, students, and other specialists.

Human Genome Epidemiology, 2nd Edition

Author : Muin Khoury
Publisher : Oxford University Press
ISBN 13 : 0199749345
Total Pages : 701 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis Human Genome Epidemiology, 2nd Edition by : Muin Khoury

Download or read book Human Genome Epidemiology, 2nd Edition written by Muin Khoury and published by Oxford University Press. This book was released on 2010-01-20 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of Human Genome Epidemiology, published in 2004, discussed how the epidemiologic approach provides an important scientific foundation for studying the continuum from gene discovery to the development, applications and evaluation of human genome information in improving health and preventing disease. Since that time, advances in human genomics have continued to occur at a breathtaking pace. With contributions from leaders in the field from around the world, this new edition is a fully updated look at the ways in which genetic factors in common diseases are studied. Methodologic developments in collection, analysis and synthesis of data, as well as issues surrounding specific applications of human genomic information for medicine and public health are all discussed. In addition, the book focuses on practical applications of human genome variation in clinical practice and disease prevention. Students, clinicians, public health professionals and policy makers will find the book a useful tool for understanding the rapidly evolving methods of the discovery and use of genetic information in medicine and public health in the 21st century.

The Work of Raymond J. Carroll

Author : Marie Davidian
Publisher : Springer
ISBN 13 : 3319058010
Total Pages : 599 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis The Work of Raymond J. Carroll by : Marie Davidian

Download or read book The Work of Raymond J. Carroll written by Marie Davidian and published by Springer. This book was released on 2014-06-06 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains Raymond J. Carroll's research and commentary on its impact by leading statisticians. Each of the seven main parts focuses on a key research area: Measurement Error, Transformation and Weighting, Epidemiology, Nonparametric and Semiparametric Regression for Independent Data, Nonparametric and Semiparametric Regression for Dependent Data, Robustness, and other work. The seven subject areas reviewed in this book were chosen by Ray himself, as were the articles representing each area. The commentaries not only review Ray’s work, but are also filled with history and anecdotes. Raymond J. Carroll’s impact on statistics and numerous other fields of science is far-reaching. His vast catalog of work spans from fundamental contributions to statistical theory to innovative methodological development and new insights in disciplinary science. From the outset of his career, rather than taking the “safe” route of pursuing incremental advances, Ray has focused on tackling the most important challenges. In doing so, it is fair to say that he has defined a host of statistics areas, including weighting and transformation in regression, measurement error modeling, quantitative methods for nutritional epidemiology and non- and semiparametric regression.

Journal of the National Cancer Institute

Author :
Publisher :
ISBN 13 :
Total Pages : 1336 pages
Book Rating : 4.:/5 (334 download)

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Book Synopsis Journal of the National Cancer Institute by :

Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 1990 with total page 1336 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Statistical Approaches to Gene X Environment Interactions for Complex Phenotypes

Author : Michael Windle
Publisher : MIT Press
ISBN 13 : 0262034689
Total Pages : 306 pages
Book Rating : 4.2/5 (62 download)

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Book Synopsis Statistical Approaches to Gene X Environment Interactions for Complex Phenotypes by : Michael Windle

Download or read book Statistical Approaches to Gene X Environment Interactions for Complex Phenotypes written by Michael Windle and published by MIT Press. This book was released on 2016-07-08 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Findings from the Human Genome Project and from Genome-Wide Association (GWA) studies indicate that many diseases and traits manifest a more complex genomic pattern than previously assumed. These findings, and advances in high-throughput sequencing, suggest that there are many sources of influence-genetic, epigenetic, and environmental. This volume investigates the role of the interactions of genes and environment (G x E) in diseases and traits (referred to by the contributors as complex phenotypes) including depression, diabetes, obesity, and substance use.

Journal of The National Cancer Institute Monographs, No. 26, 1999

Author :
Publisher :
ISBN 13 :
Total Pages : 120 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Journal of The National Cancer Institute Monographs, No. 26, 1999 by :

Download or read book Journal of The National Cancer Institute Monographs, No. 26, 1999 written by and published by . This book was released on 2000 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of Statistical Methods for Case-Control Studies

Author : Ørnulf Borgan
Publisher : CRC Press
ISBN 13 : 1351650122
Total Pages : 612 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Handbook of Statistical Methods for Case-Control Studies by : Ørnulf Borgan

Download or read book Handbook of Statistical Methods for Case-Control Studies written by Ørnulf Borgan and published by CRC Press. This book was released on 2018-06-27 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Statistical Methods for Case-Control Studies is written by leading researchers in the field. It provides an in-depth treatment of up-to-date and currently developing statistical methods for the design and analysis of case-control studies, as well as a review of classical principles and methods. The handbook is designed to serve as a reference text for biostatisticians and quantitatively-oriented epidemiologists who are working on the design and analysis of case-control studies or on related statistical methods research. Though not specifically intended as a textbook, it may also be used as a backup reference text for graduate level courses. Book Sections Classical designs and causal inference, measurement error, power, and small-sample inference Designs that use full-cohort information Time-to-event data Genetic epidemiology About the Editors Ørnulf Borgan is Professor of Statistics, University of Oslo. His book with Andersen, Gill and Keiding on counting processes in survival analysis is a world classic. Norman E. Breslow was, at the time of his death, Professor Emeritus in Biostatistics, University of Washington. For decades, his book with Nick Day has been the authoritative text on case-control methodology. Nilanjan Chatterjee is Bloomberg Distinguished Professor, Johns Hopkins University. He leads a broad research program in statistical methods for modern large scale biomedical studies. Mitchell H. Gail is a Senior Investigator at the National Cancer Institute. His research includes modeling absolute risk of disease, intervention trials, and statistical methods for epidemiology. Alastair Scott was, at the time of his death, Professor Emeritus of Statistics, University of Auckland. He was a major contributor to using survey sampling methods for analyzing case-control data. Chris J. Wild is Professor of Statistics, University of Auckland. His research includes nonlinear regression and methods for fitting models to response-selective data.

Respiratory Genetics

Author : Edwin Silverman
Publisher : CRC Press
ISBN 13 : 0340814322
Total Pages : 555 pages
Book Rating : 4.3/5 (48 download)

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Book Synopsis Respiratory Genetics by : Edwin Silverman

Download or read book Respiratory Genetics written by Edwin Silverman and published by CRC Press. This book was released on 2005-09-30 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a recent explosion of knowledge in the field of respiratory genetics. This authoritative text brings together current knowledge in respiratory genetics in a single volume. The book includes a comprehensive introductory section to provide guidance and aid understanding of key basic concepts in respiratory genetics, including statistical methods, sample collection, bioinformatics, and functional genomics. This is followed by a series of disease-specific chapters that review epidemiology, natural history, monogenic determinants, complex disease components, disease management, and likely future developments. Respiratory Genetics is an essential reference for pulmonologists, translational researchers, and clinical geneticists, and the text will also be a useful library reference.

Encyclopedia of Environmetrics

Author : Abdel H. El-Shaarawi
Publisher : John Wiley & Sons
ISBN 13 : 9780471899976
Total Pages : 660 pages
Book Rating : 4.8/5 (999 download)

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Book Synopsis Encyclopedia of Environmetrics by : Abdel H. El-Shaarawi

Download or read book Encyclopedia of Environmetrics written by Abdel H. El-Shaarawi and published by John Wiley & Sons. This book was released on 2002 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of environmetric research and its applications... Environmetrics covers the development and application of quantitative methods in the environmental sciences. It provides essential tools for understanding, predicting, and controlling the impacts of agents, both man-made and natural, which affect the environment. Basic and applied research in this area covers a broad range of topics. Primary among these are the quantitative sciences, such as statistics, probability and applied mathematics, chemometrics, and econometrics. Applications are also important, for example in, ecology and environmental biology, public health, atmospheric science, geology, engineering, risk management, and regulatory/governmental policy amongst others. * Divided into 12 sections, the Encyclopedia brings together over 600 detailed articles which have been carefully selected and reviewed through the collaborative efforts of the Editors-in-Chief and the appropriate Section Editor * Presented in alphabetical order all the articles will include an explanatory introduction, extensive cross-referencing and an up-to-date bibliography providing literature references for further reading. Presenting state of the art information in a readable, highly accessible style, the scope and coverage provided by the Encyclopedia of Environmetrics will ensure its place as the landmark reference for the many scientists, educators, and decision-makers working across this multidisciplinary field. An essential reference tool for university libraries, research laboratories, government institutions and consultancies concerned with the environmental sciences, the Encyclopedia of Environmetrics brings together for the first time, comprehensive coverage of the full range of topics, techniques and applications covered by this multidisciplinary field. There is currently no central reference source which addresses the needs of this multidisciplinary community. This new Encyclopedia will fill this gap by providing a comprehensive source of relevant fundamental concepts in environmetric research, development and applications for statisticians, mathematicians, economists, environmentalists, ecologist, government officials and policy makers.

Statistical Methods in Genetic Epidemiology

Author : Duncan C. Thomas
Publisher : Oxford University Press
ISBN 13 : 019515939X
Total Pages : 458 pages
Book Rating : 4.1/5 (951 download)

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Book Synopsis Statistical Methods in Genetic Epidemiology by : Duncan C. Thomas

Download or read book Statistical Methods in Genetic Epidemiology written by Duncan C. Thomas and published by Oxford University Press. This book was released on 2004-01-29 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: This balanced and well-integrated text gives a lucid overview of the entire process of genetic epidemiology, from familial aggregation through segregation, likage, and association studies. It is illustrated throughout with examples from the literature on cancer genetics. Statistical concepts are developed in depth, but with a focus on applications. Introductory chapters on molecular biology, Mendelian genetics, epidemiology, statistics, and population genetics are included. Oriented to graduate students in biostatistics, epidemiology, and human genetics, the book will also be a useful reference for researchers. It gives equal emphasis to study designs and data analysis.

Computational Methods for Genetics of Complex Traits

Author :
Publisher : Academic Press
ISBN 13 : 0123808634
Total Pages : 211 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Computational Methods for Genetics of Complex Traits by :

Download or read book Computational Methods for Genetics of Complex Traits written by and published by Academic Press. This book was released on 2010-11-10 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in knowledge gained from genetics reasearch. This thematic volume of Advances in Genetics looks at Computational Methods for Genetics of Complex traits. - Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models - Includes methods for testing with ethical, legal, and social implications - Critically analyzes future prospects

Design, Analysis, and Interpretation of Genome-Wide Association Scans

Author : Daniel O. Stram
Publisher : Springer Science & Business Media
ISBN 13 : 1461494435
Total Pages : 344 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Design, Analysis, and Interpretation of Genome-Wide Association Scans by : Daniel O. Stram

Download or read book Design, Analysis, and Interpretation of Genome-Wide Association Scans written by Daniel O. Stram and published by Springer Science & Business Media. This book was released on 2013-11-23 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the statistical aspects of designing, analyzing and interpreting the results of genome-wide association scans (GWAS studies) for genetic causes of disease using unrelated subjects. Particular detail is given to the practical aspects of employing the bioinformatics and data handling methods necessary to prepare data for statistical analysis. The goal in writing this book is to give statisticians, epidemiologists, and students in these fields the tools to design a powerful genome-wide study based on current technology. The other part of this is showing readers how to conduct analysis of the created study. Design and Analysis of Genome-Wide Association Studies provides a compendium of well-established statistical methods based upon single SNP associations. It also provides an introduction to more advanced statistical methods and issues. Knowing that technology, for instance large scale SNP arrays, is quickly changing, this text has significant lessons for future use with sequencing data. Emphasis on statistical concepts that apply to the problem of finding disease associations irrespective of the technology ensures its future applications. The author includes current bioinformatics tools while outlining the tools that will be required for use with extensive databases from future large scale sequencing projects. The author includes current bioinformatics tools while outlining additional issues and needs arising from the extensive databases from future large scale sequencing projects.

Epigenetics and Pathology

Author : Kasirajan Ayyanathan
Publisher : CRC Press
ISBN 13 : 1926895789
Total Pages : 426 pages
Book Rating : 4.9/5 (268 download)

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Book Synopsis Epigenetics and Pathology by : Kasirajan Ayyanathan

Download or read book Epigenetics and Pathology written by Kasirajan Ayyanathan and published by CRC Press. This book was released on 2013-11-25 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important book explores recent research by experts in the field pertaining to the role played by genetic factors in human pathology. A range of perspectives creates a well-rounded picture, including: host-pathogen interactions causal relationships between genes and the environment the effects of environmental chemicals on gene expression DNA methylation The book also covers the analysis and provides models for understanding the epigenetics-pathology connection. This book is designed for use by senior undergraduate and graduate students from several disciplines such as general, molecular, cellular biology, genetics, genomics, proteomics, and bioinformatics. It will also serve as a reference book for existing researchers and new investigators entering this rather unexplored field.

Public Health

Author : Jay Maddock
Publisher : BoD – Books on Demand
ISBN 13 : 9535106414
Total Pages : 448 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Public Health by : Jay Maddock

Download or read book Public Health written by Jay Maddock and published by BoD – Books on Demand. This book was released on 2012-05-30 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Public health can be thought of as a series of complex systems. Many things that individual living in high income countries take for granted like the control of infectious disease, clean, potable water, low infant mortality rates require a high functioning systems comprised of numerous actors, locations and interactions to work. Many people only notice public health when that system fails. This book explores several systems in public health including aspects of the food system, health care system and emerging issues including waste minimization in nanosilver. Several chapters address global health concerns including non-communicable disease prevention, poverty and health-longevity medicine. The book also presents several novel methodologies for better modeling and assessment of essential public health issues.

Environmental Epigenetics

Author : L. Joseph Su
Publisher : Springer
ISBN 13 : 1447166787
Total Pages : 327 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Environmental Epigenetics by : L. Joseph Su

Download or read book Environmental Epigenetics written by L. Joseph Su and published by Springer. This book was released on 2015-05-18 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.