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Heterogeneity Of Alzheimers Disease
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Book Synopsis Heterogeneity of Alzheimer’s Disease by : Francois Boller
Download or read book Heterogeneity of Alzheimer’s Disease written by Francois Boller and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: The term "Alzheimer's disease" is currently used to refer to senile and also presenile dementia, but the heterogeneity of this disorder is demonstrated in many of its aspects. This is of great theoretical interest, and with the appearance of new therapeutic interventions, it may well also start to have very significant practical importance. To shed some light on the debate, the Fondation Ipsen organized an international symposium which took place on April 6, 1992. This volume contains the proceedings of this meeting, which was attended by researchers in epidemiology, clinical neurology and geriatrics, neuropsychology, neuropathology, molecular biology, and genetics.
Book Synopsis Heterogeneity of Alzheimer's disease by : François Boller
Download or read book Heterogeneity of Alzheimer's disease written by François Boller and published by Springer Verlag. This book was released on 1992 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Heterogeneity of Alzheimer's Disease by : Kaj Blennow
Download or read book Heterogeneity of Alzheimer's Disease written by Kaj Blennow and published by . This book was released on 1990 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Understanding Heterogeneity in Alzheimer's Disease by :
Download or read book Understanding Heterogeneity in Alzheimer's Disease written by and published by . This book was released on 2019 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Understanding Heterogeneity in Alzheimer's Disease: a Neurophysiological Perspective by :
Download or read book Understanding Heterogeneity in Alzheimer's Disease: a Neurophysiological Perspective written by and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neuroimaging in Dementia by : Frederik Barkhof
Download or read book Neuroimaging in Dementia written by Frederik Barkhof and published by Springer Science & Business Media. This book was released on 2011-02-11 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: This up-to-date, superbly illustrated book is a practical guide to the effective use of neuroimaging in the patient with cognitive decline. It sets out the key clinical and imaging features of the various causes of dementia and directs the reader from clinical presentation to neuroimaging and on to an accurate diagnosis whenever possible. After an introductory chapter on the clinical background, the available "toolbox" of structural and functional neuroimaging techniques is reviewed in detail, including CT, MRI and advanced MR techniques, SPECT and PET, and image analysis methods. The imaging findings in normal ageing are then discussed, followed by a series of chapters that carefully present and analyze the key findings in patients with dementias. Throughout, a practical approach is adopted, geared specifically to the needs of clinicians (neurologists, radiologists, psychiatrists, geriatricians) working in the field of dementia, for whom this book will prove an invaluable resource.
Book Synopsis Modelling Progression and Heterogeneity in Alzheimer's Disease by : Alexandra Young
Download or read book Modelling Progression and Heterogeneity in Alzheimer's Disease written by Alexandra Young and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Heterogeneity in Alzheimer's Disease by :
Download or read book Heterogeneity in Alzheimer's Disease written by and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Key findings: I. Does clinical heterogeneity among individuals with AD and FTD relate to differences in the underlying neurobiological manifestation of the disease? We observed dissociable atrophy patterns among individuals with an atypical AD variant (i.e., PCA), and these are associated with distinct visual processing deficits, e.g., ventral atrophy is associated to object perception. Cognitively-defined subgroups of individuals within the spectrum of typical late-onset AD dementia exhibit differential patterns of regional atrophy, e.g., left-lateralized temporal atrophy in the language subgroup. Cognitively-defined subgroups of individuals with AD dementia display distinct hypometabolic patterns and longitudinal trajectories of brain metabolism, e.g., faster parietal decline in metabolism for the visuospatial subgroup. Individuals with FTD and prominent right-sided anterior temporal atrophy (i.e., rtvFTD) display a clinical phenotype that is most notably characterized by prosopagnosia, and which is distinct from AD and other FTD variants. II. What are the associations between genetics and the clinical/neuroanatomical manifestation of AD? Cognitive subgroup-specific atrophy patterns are related to distinct regional gene expression profiles. By examining biological functions related to these gene expression profiles, we found that some biological pathways are related to atrophy in multiple subgroups (e.g., mitochondrial dysfunction), while other pathways were subgroup-specific (e.g., cell-cycle in the memory subgroup). APOEe2 carriership among individuals with AD dementia is related to a clinical phenotype with more non-amnestic (i.e., language, attention and executive) impairments, and a radiological phenotype with greater vascular involvement (i.e., more microbleeds and white matter hyperintensities) compared to APOEe3 homozygotes and APOEe4 carriers.
Book Synopsis Neuropsychological Heterogeneity in Alzheimer's Disease by : Jason A. King
Download or read book Neuropsychological Heterogeneity in Alzheimer's Disease written by Jason A. King and published by . This book was released on 2004 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modelling Progression and Heterogeneity in Alzheimer's Disease by : A. L. Young
Download or read book Modelling Progression and Heterogeneity in Alzheimer's Disease written by A. L. Young and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Alzheimer Disease written by and published by . This book was released on 1988 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Spectrum of Hope by : Gayatri Devi
Download or read book The Spectrum of Hope written by Gayatri Devi and published by Workman Publishing Company. This book was released on 2017-10-31 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imagine finding a glimmer of good news in a diagnosis of Alzheimer’s. And imagine how that would change the outlook of the 5 million Americans who suffer from Alzheimer’s disease and other dementias, not to mention their families, loved ones, and caretakers. A neurologist who’s been specializing in dementia and memory loss for more than 20 years, Dr. Gayatri Devi rewrites the story of Alzheimer’s by defining it as a spectrum disorder—like autism, Alzheimer’s is a disease that affects different people differently. She encourages people who are worried about memory impairment to seek a diagnosis, because early treatment will enable doctors and caregivers to manage the disease more effectively through drugs and other therapies. Told through the stories of Dr. Devi’s patients, The Spectrum of Hope humanizes the science, and offers equal parts practical advice and wisdom with skillful ease, along with real hope. Here are chapters on how to maintain independence and dignity; how to fight depression, anxiety, and apathy; how to communicate effectively with a person suffering from dementia. Plus chapters on sexuality, genetics, going public with the diagnosis, even putting together a bucket list—because through her practice, Dr. Devi knows that the majority of Alzheimer’s patients continue to live and work in their communities. They babysit their grandkids, drive to the store (or own the store), serve their clients, or otherwise live fulfilling lives. That’s news that 5 million people are waiting to hear.
Book Synopsis Phenotypic Heterogeneity and Preclinical Change in Familial Alzheimer's Disease by : Natalie Sarah Ryan
Download or read book Phenotypic Heterogeneity and Preclinical Change in Familial Alzheimer's Disease written by Natalie Sarah Ryan and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Alzheimer's Disease by : George Perry
Download or read book Alzheimer's Disease written by George Perry and published by IOS Press. This book was released on 2006 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This is the book edition of the Journal of Alzheimer's Disease, Volume 9, No.3 Supplement (2006)"--T.p. verso.
Book Synopsis Deciphering Neuropathological Heterogeneity in Alzheimer's Disease by :
Download or read book Deciphering Neuropathological Heterogeneity in Alzheimer's Disease written by and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Alzheimer’s Disease Pathophysiology by :
Download or read book Alzheimer’s Disease Pathophysiology written by and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently, approximately 50 million individuals have dementia, and this number is expected to rise due to increased life expectancy. Responsible for approximately 70% of dementia cases, Alzheimer’s disease (AD) is the leading cause of dementia. AD is caused by accumulation of amyloid plaques and tau tangles in the brain, resulting in neuronal death and cognitive impairment. AD has several stages: first, there is a long preclinical period, followed by a prodromal or mild cognitive impairment (MCI) stage, which finally results in an AD-type clinical dementia stage wherein the affected individual ultimately can no longer live independently. Until recently, a diagnosis of AD relied on clinical criteria. However, pathological studies showed that clinical symptoms do not always accurately reflect the underlying pathology. The current research framework definition of AD now requires biomarkers that reflect amyloid and tau pathology, regardless of cognitive state. Such biomarkers include cerebrospinal fluid (CSF) levels of amyloid-beta 1-42 (amyloid), phosphorylated tau (p-tau) and total tau (t-tau). While amyloid and tau are important in diagnosing AD, an unresolved issue is that despite many clinical trials targeting amyloid and tau proteins, no disease-modifying treatments are available. The limited success of clinical trials targeting amyloid and tau may reflect that AD pathophysiology is heterogeneous, with patients differing in the precise underlying causes. The first studies that analysed biological heterogeneity focussed on the core AD biomarkers, and showed subgroups of individuals with AD dementia with different tau levels. It remains largely unknown if tau subgroups also exist in earlier clinical stages of AD, and if they differ in other biological processes. Another approach to study biological heterogeneity in AD is with new CSF proteomic technologies, which can analyse large numbers of proteins simultaneously.
Book Synopsis Deciphering Pathological Heterogeneity in Familial Alzheimer's Disease by : Nanet Willumsen
Download or read book Deciphering Pathological Heterogeneity in Familial Alzheimer's Disease written by Nanet Willumsen and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
