DNA Helicases and DNA Motor Proteins

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Publisher : Springer Science & Business Media
ISBN 13 : 1461450373
Total Pages : 308 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis DNA Helicases and DNA Motor Proteins by : Maria Spies

Download or read book DNA Helicases and DNA Motor Proteins written by Maria Spies and published by Springer Science & Business Media. This book was released on 2012-11-19 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, a number of groundbreaking structural and mechanistic studies deepened our understanding of helicase mechanisms and established new approaches for their analyses. Many fundamental mechanistic questions ranging from the mechanism of force generation, mechanochemical coupling to distinct mechanisms by which the same enzyme translocates on DNA removing obstacles, unwinds DNA and/or remodels nucleoprotein complexes, however, remain to be answered. It is even less understood how the helicase motors are incorporated into a wide range of genome maintenance and repair machines. The field has reached a stage when the studies of molecular mechanisms and basic biology of helicases can and shall be integrated with the studies of development, cancer and longevity. The objective of this book is to provide the first systematic overview of structure, function and regulation of DNA helicases and related molecular motors. By integrating the knowledge obtained through the diverse technical approaches ranging from single-molecule biophysics to cellular and molecular biological studies the editors aim to provide a unified view on how helicases function in the cell, are regulated in response to different cellular stresses and are integrated into large macromolecular assemblies to form a complex and adaptive living system.

Helicases from All Domains of Life

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Publisher : Academic Press
ISBN 13 : 9780128146859
Total Pages : 200 pages
Book Rating : 4.1/5 (468 download)

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Book Synopsis Helicases from All Domains of Life by : Renu Tuteja

Download or read book Helicases from All Domains of Life written by Renu Tuteja and published by Academic Press. This book was released on 2018-10-15 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Helicases are ubiquitous enzymes found throughout evolution. Research in the helicase field has been going on for a long time now but in recent past with the completion of so many genomes, these enzymes have been discovered in a number of organisms. But the available literature is scattered. The huge number of identified DNA and RNA helicases, along with the structural and functional differences among them, make difficult for the interested scholar to grasp a comprehensive view of the field. Helicases from all Domains of Life is the first book to compile information about helicases from many different organisms in one place. Knowledge of the functions and features of helicases across the different kingdoms of life are a valuable source of novel ideas and information The book begins with a chapter on the evolutionary history of helicases followed by three "overview" chapters: one for bacteria/archaea (which are not mentioned), one for plants/algae and one for human helicases The overview chapters are followed by specific chapters on selected helicases of great importance from a biological/applicative point of view

RNA Helicases

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Publisher : Academic Press
ISBN 13 : 0123972299
Total Pages : 589 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis RNA Helicases by :

Download or read book RNA Helicases written by and published by Academic Press. This book was released on 2012-11-13 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases. The contributions in this volume cover the broad scope of methods in the research on these enzymes. Several chapters describe quantitative biophysical and biochemical approaches to study molecular mechanisms and conformational changes of RNA helicases. Further chapters cover structural analysis, examination of co-factor effects on several representative examples, and the analysis of cellular functions of select enzymes. Two chapters outline approaches to the analysis of inhibitors that target RNA helicases. This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases The contributions in this volume cover the broad scope of methods in the research on these enzymes

Helicases from All Domains of Life

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Publisher : Academic Press
ISBN 13 : 0128146869
Total Pages : 298 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Helicases from All Domains of Life by : Renu Tuteja

Download or read book Helicases from All Domains of Life written by Renu Tuteja and published by Academic Press. This book was released on 2018-09-21 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Helicases from All Domains of Life is the first book to compile information about helicases from many different organisms in a single volume. Research in the helicase field has been going on for a long time now, but the completion of so many genomes of these ubiquitous enzymes has made it difficult to keep up with new discoveries. As the huge number of identified DNA and RNA helicases, along with the structural and functional differences among them, make it difficult for the interested scholar to grasp a comprehensive view of the field, this book helps fill in the gaps. Presents updates on the functions and features of helicases across the different kingdoms Begins with a chapter on the evolutionary history of helicases Contains specific chapters on selected helicases of great importance from a biological/applicative point-of-view

DNA helicases: expression, functions and clinical implications

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Publisher : Frontiers Media SA
ISBN 13 : 2889195759
Total Pages : 80 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis DNA helicases: expression, functions and clinical implications by : Fumiaki Uchiumi

Download or read book DNA helicases: expression, functions and clinical implications written by Fumiaki Uchiumi and published by Frontiers Media SA. This book was released on 2015-06-26 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: Helicases are the proteins that bind to double- or single-stranded DNA and/or RNA chains to unwind higher order structures, usually consuming energy from the hydrolysis of ATP molecules. The biological roles of helicases are associated with a variety of DNA and/or RNA metabolisms, including DNA-replication, -repair, -recombination, RNA processing, and transcription. Dysfunctions of helicases cause various diseases, such as xeroderma pigmentosum (XP), premature aging syndrome, cancer and immunodeficiency, in humans. Moreover, recent genetic analyses revealed that mutations in helicase-encoding genes are frequently found in patients of specific diseases. Some helicases regulate cellular senescence by controlling integrity of genomes, and others play a role in neuromuscular functions presumably by modulating processing of mRNAs. However, the molecular mechanisms of how helicases are regulated in order to maintain our health are not yet fully understood. In this research topic, we will focus on the expression and functions of helicases and their encoding genes, reviewing recent research progresses that provide new insights into development of clinical and pharmaceutical treatments targeting helicases.

Biochemistry and Genetics of Recq-Helicases

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Publisher : Springer Science & Business Media
ISBN 13 : 1461514053
Total Pages : 101 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Biochemistry and Genetics of Recq-Helicases by : David B. Lombard

Download or read book Biochemistry and Genetics of Recq-Helicases written by David B. Lombard and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemistry And Genetics of RecQ-Helicases provides a background into the role of helicases in general and RecQ helicases specifically in DNA repair. Helicases- enzymes which break down hydrogen bonds between nucleic acid strands in a nucleoside triphosphate-dependent manner-are ubiquitous in biology, participating in processes as diverse as replication, repair, recombination, transcription, and translation. The RecQ-family helicases are a group of helicases which have important roles in the maintenance of genomic stability in many organisms. In humans, mutations in three RecQ-family helicases lead to disease. This book thoroughly examines these helicases. Mutations in the BLM gene lead to Bloom syndrome, a disorder characterized by a susceptibility to many types of cancer. Mutations in the WRN gene cause Werner syndrome, a disease which in some respects resembles premature aging. Finally, mutations in a newly characterized RecQ-family member, RECQ4, may lead to the very rare recessive disorder Rothmund-Thomson syndrome, a condition characterized by developmental abnormalities and some aging-like manifestations. This book is intended for any researchers invested in these particular disorders, or with a general interest in DNA.

Genome Stability

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Publisher : Academic Press
ISBN 13 : 0323856802
Total Pages : 762 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Genome Stability by : Igor Kovalchuk

Download or read book Genome Stability written by Igor Kovalchuk and published by Academic Press. This book was released on 2021-07-17 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability research and outcomes for human disease Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair

Multiplication of RNA Plant Viruses

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Publisher : Springer Science & Business Media
ISBN 13 : 1402047258
Total Pages : 353 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Multiplication of RNA Plant Viruses by : Chundi L. Mandahar

Download or read book Multiplication of RNA Plant Viruses written by Chundi L. Mandahar and published by Springer Science & Business Media. This book was released on 2006-09-05 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemical studies on plant virus RNA replication have advanced considerably since 2000, primarily because of new genetic, molecular, biochemical, and enzymatic studies. This book generates understanding of multiplication of plus-sense RNA plant viruses, especially at molecular level. Certain virus-encoded essential proteins, nucleotide sequence motifs, and RNA secondary structures are central to virus RNA replication, which has a number of stages. Each is a complex phenomenon requiring specific factors and conditions.

DNA Repair Protocols

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Publisher : Springer Science & Business Media
ISBN 13 : 1592599737
Total Pages : 498 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis DNA Repair Protocols by : Daryl S. Henderson

Download or read book DNA Repair Protocols written by Daryl S. Henderson and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of this book, published in 1999 and called DNA Repair Protocols: Eukaryotic Systems, brought together laboratory-based methods for studying DNA damage and repair in diverse eukaryotes: namely, two kinds of yeast, a nematode, a fruit fly, a toad, three different plants, and human and murine cells. This second edition of DNA Repair Protocols covers mammalian cells only and hence its new subtitle, Mammalian Systems. There are two reasons for this fresh emphasis, both of them pragmatic: to cater to the interests of what is now a largely mammalocentric DNA repair field, and to expedite editing and prod- tion of this volume. Although DNA Repair Protocols: Mammalian Systems is a smaller book than its predecessor, it actually contains a greater variety of methods. Fourteen of the book’s thirty-two chapters are entirely new and areas of redundancy present in the first edition have been eliminated here (for example, now just two chapters describe assays for nucleotide excision repair [NER], rather than seven). All eighteen returning chapters have been revised, many of them ext- sively. In order to maintain a coherent arrangement of topics, the four-part p- titioning seen in the first edition was dispensed with and chapters concerned with ionizing radiation damage and DNA strand breakage and repair were re- cated to near the front of the book. Finally, an abstract now heads each chapter.

Biochemistry (2 Volume Set)

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Publisher : Academic Press
ISBN 13 : 012492543X
Total Pages : 1059 pages
Book Rating : 4.1/5 (249 download)

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Book Synopsis Biochemistry (2 Volume Set) by : David E. Metzler

Download or read book Biochemistry (2 Volume Set) written by David E. Metzler and published by Academic Press. This book was released on 2003-04-04 with total page 1059 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemistry: The Chemical Reactions of Living Cells is a well-integrated, up-to-date reference for basic biochemistry, associated chemistry, and underlying biological phenomena. Biochemistry is a comprehensive account of the chemical basis of life, describing the amazingly complex structures of the compounds that make up cells, the forces that hold them together, and the chemical reactions that allow for recognition, signaling, and movement. This book contains information on the human body, its genome, and the action of muscles, eyes, and the brain. * Thousands of literature references provide introduction to current research as well as historical background * Contains twice the number of chapters of the first edition * Each chapter contains boxes of information on topics of general interest

Biochemical, Physiological and Molecular Avenues for Combating Abiotic Stress in Plants

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Publisher : Academic Press
ISBN 13 : 0128130679
Total Pages : 324 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Biochemical, Physiological and Molecular Avenues for Combating Abiotic Stress in Plants by : Shabir Hussain Wani

Download or read book Biochemical, Physiological and Molecular Avenues for Combating Abiotic Stress in Plants written by Shabir Hussain Wani and published by Academic Press. This book was released on 2018-06-12 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemical, Physiological and Molecular Avenues for Combating Abiotic Stress in Plants is a must-have reference for researchers and professionals in agronomy, plant science and horticulture. As abiotic stress tolerance is a constant challenge for researchers and professionals working on improving crop production, this book combines recent advances with foundational content, thus offering in-depth coverage on a variety of abiotic stress tolerance mechanisms that help us better understand and improve plant response and growth under stress conditions. The mechanisms explored in this book include stress perception, signal transduction and synthesis of stress-related proteins and other molecules. In addition, the book provides a critical understanding of the networks of genes responsible for abiotic stress tolerance and their utilization in the development of stress tolerance in plants. Practical breeding techniques and modern genetic analyses are also discussed. Unlocks the physiological, biochemical and molecular basis of abiotic stress response and tolerance in crop plants Presents comprehensive information on abiotic stress tolerance, from gene to whole plant level Includes content on antioxidant metabolism, marker-assisted selection, microarrays, next-generation sequencing and genome editing techniques

Molecular Motors

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Publisher : John Wiley & Sons
ISBN 13 : 3527605657
Total Pages : 604 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Molecular Motors by : Manfred Schliwa

Download or read book Molecular Motors written by Manfred Schliwa and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: The latest knowledge on molecular motors is vital for the understanding of a wide range of biological and medical topics: cell motility, organelle movement, virus transport, developmental asymmetry, myopathies, and sensory defects are all related to the function or malfunction of these minute molecular machines. Since there is a vast amount of information on motor mechanisms and potential biomedical and nanobiotechnological applications, this handbook fulfills the need for a collection of current research results on the functionality, regulation, and interactions of cytoskeletal, DNA, and rotary motors. Here, leading experts present a concise insight, ranging from atomic structure, biochemistry, and biophysics to cell biology, developmental biology and pathology. Basic principles and applications make this book a valuable reference tool for researchers, professionals, and clinicians alike - all set to become a "classic" in the years to come.

Brenner's Encyclopedia of Genetics

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Publisher : Academic Press
ISBN 13 : 0080961568
Total Pages : 4360 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Brenner's Encyclopedia of Genetics by : Stanley Maloy

Download or read book Brenner's Encyclopedia of Genetics written by Stanley Maloy and published by Academic Press. This book was released on 2013-03-03 with total page 4360 pages. Available in PDF, EPUB and Kindle. Book excerpt: The explosion of the field of genetics over the last decade, with the new technologies that have stimulated research, suggests that a new sort of reference work is needed to keep pace with such a fast-moving and interdisciplinary field. Brenner's Encyclopedia of Genetics, Second Edition, Seven Volume Set, builds on the foundation of the first edition by addressing many of the key subfields of genetics that were just in their infancy when the first edition was published. The currency and accessibility of this foundational content will be unrivalled, making this work useful for scientists and non-scientists alike. Featuring relatively short entries on genetics topics written by experts in that topic, Brenner's Encyclopedia of Genetics, Second Edition, Seven Volume Set provides an effective way to quickly learn about any aspect of genetics, from Abortive Transduction to Zygotes. Adding to its utility, the work provides short entries that briefly define key terms, and a guide to additional reading and relevant websites for further study. Many of the entries include figures to explain difficult concepts. Key terms in related areas such as biochemistry, cell, and molecular biology are also included, and there are entries that describe historical figures in genetics, providing insights into their careers and discoveries. This 7-volume set represents a 25% expansion from the first edition, with over 1600 articles encompassing this burgeoning field Thoroughly up-to-date, with many new topics and subfields covered that were in their infancy or not inexistence at the time of the first edition. Timely coverage of emergent areas such as epigenetics, personalized genomic medicine, pharmacogenetics, and genetic enhancement technologies Interdisciplinary and global in its outlook, as befits the field of genetics Brief articles, written by experts in the field, which not only discuss, define, and explain key elements of the field, but also provide definition of key terms, suggestions for further reading, and biographical sketches of the key people in the history of genetics

The DNA Replication Machinery as Therapeutic Targets

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Publisher : Frontiers Media SA
ISBN 13 : 2889459276
Total Pages : 144 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis The DNA Replication Machinery as Therapeutic Targets by : Andrew F. Gardner

Download or read book The DNA Replication Machinery as Therapeutic Targets written by Andrew F. Gardner and published by Frontiers Media SA. This book was released on 2019-09-19 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: In all organisms, the DNA replication machinery is responsible for accurate and efficient duplication of the chromosome. Inhibitors of replication proteins are commonly used in anti-cancer and anti-viral therapies. This eBook on “The DNA Replication Machinery as Therapeutic Targets” examines the normal functions of replication proteins as well as strategies to target each step during the replication process including DNA unwinding, DNA synthesis, and DNA damage bypass and repair. Articles discuss current strategies to develop drugs targeting DNA replication proteins as well as future outlooks and needs.

Mechanism of DNA Unwinding by Hexameric Helicases

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Publisher :
ISBN 13 :
Total Pages : 556 pages
Book Rating : 4.:/5 (34 download)

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Book Synopsis Mechanism of DNA Unwinding by Hexameric Helicases by : Alexander Ivanov Alexandrov

Download or read book Mechanism of DNA Unwinding by Hexameric Helicases written by Alexander Ivanov Alexandrov and published by . This book was released on 2001 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Algorithms on Strings, Trees, and Sequences

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Publisher : Cambridge University Press
ISBN 13 : 0521585198
Total Pages : 556 pages
Book Rating : 4.5/5 (215 download)

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Book Synopsis Algorithms on Strings, Trees, and Sequences by : Dan Gusfield

Download or read book Algorithms on Strings, Trees, and Sequences written by Dan Gusfield and published by Cambridge University Press. This book was released on 1997-05-28 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes a range of string problems in computer science and molecular biology and the algorithms developed to solve them.

Progress in Nucleic Acid Research and Molecular Biology

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Publisher : Academic Press
ISBN 13 : 0080863280
Total Pages : 346 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis Progress in Nucleic Acid Research and Molecular Biology by :

Download or read book Progress in Nucleic Acid Research and Molecular Biology written by and published by Academic Press. This book was released on 1991-05-02 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Nucleic Acid Research and Molecular Biology