Helical Collagen Fibrils Produced In Vitro

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Helical Collagen Fibrils Produced in Vitro

Author : Richard Kil
Publisher :
ISBN 13 : 9780494400777
Total Pages : 160 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Helical Collagen Fibrils Produced in Vitro by : Richard Kil

Download or read book Helical Collagen Fibrils Produced in Vitro written by Richard Kil and published by . This book was released on 2007 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the most ubiquitous protein in animals, collagen is a key protein of study in a number of fields including materials engineering, biotechnology, and regenerative medicine. A cornerstone of these studies is the self-assembly pathway of fibrils in vivo and in vitro. Although non-helical fibrils have dominated past work, helical fibrils have recently garnered more attention, though only in vivo. Here, it is demonstrated that helical fibrils can be reconstituted in vitro with high initial monomer concentrations above 0.75mg/mL, from acid-solubilized type I collagen extracted from calfskin. Simultaneous and warm starts were used in 0.025M phosphate buffer, at temperatures spanning 24--37°C, with final pH values of & sim;7.2. Characterization for the first time by atomic force microscopy reveals a right-handed helical structure, and that they are indistinguishable from in vivo helical fibrils. The self-assembly pathway is discussed based on the final morphologies revealed.

Collagen

Author : Marcel E. Nimni
Publisher : CRC Press
ISBN 13 : 135108769X
Total Pages : 516 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Collagen by : Marcel E. Nimni

Download or read book Collagen written by Marcel E. Nimni and published by CRC Press. This book was released on 2018-01-18 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This series was conceived with the idea of integrating current aspects of ongoing research in the collagen field. The book consists of a spectrum of papers which discus divers aspects such as X-ray structure, the thermodynamics and mechanism of fibrillogenesis, and the use of collagen as a biomaterial for the manufacturing of many implantable, sometimes lifesaving, devises.

Collagen

Author : Peter Fratzl
Publisher : Springer Science & Business Media
ISBN 13 : 0387739068
Total Pages : 516 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Collagen by : Peter Fratzl

Download or read book Collagen written by Peter Fratzl and published by Springer Science & Business Media. This book was released on 2008-05-10 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not only does this book provide a comprehensive review of current research advances in collagen structure and mechanics, it also explores this biological macromolecule’s many applications in biomaterials and tissue engineering. Readers gain an understanding of the structure and mechanical behavior of type I collagen and collagen-based tissues in vertebrates across all length scales, from the molecular (nano) to the organ (macro) level.

Ultrastructure of the Connective Tissue Matrix

Author : P. Motta
Publisher : Springer Science & Business Media
ISBN 13 : 1461328314
Total Pages : 224 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Ultrastructure of the Connective Tissue Matrix by : P. Motta

Download or read book Ultrastructure of the Connective Tissue Matrix written by P. Motta and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the techniques of electron microscopy have developed so widely and rapidly that they now cover the fields of research once the unique ll:panage of sister research techniques such as biochemistry, physiology, immunology, X-ray diffraction, etc. It is now possible to reach molecular and submolecular levels, making this technique indispensable in every type of research. Electron microscopy alone often provides enough information to solve given problems. In the field of the connective tissue matrix, knowledge of the molecular structure of collagen, pro teoglycans and elastin and their interaction has been to a large extent elucidated by electron microscopy. The field over which electron microscopy ranges in the investigation of the connective tissue matrix is so wide that the aim of this volume is to collect the main ultrastructural acquisitions disseminated in various journals and monographs in one book. The intent ofthis volume is to: (a) integrate different and new microscopic methods and review the results of such an integrative approach; (b) present a comprehensive ultrastructural account of selected aspects of the field; (c) point out gaps or controversial topics in our knowledge; (d) outline pertinent future research and expansion of the subject.

Cell Biology of Extracellular Matrix

Author : E.D. Hay
Publisher : Springer Science & Business Media
ISBN 13 : 1461537703
Total Pages : 478 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Cell Biology of Extracellular Matrix by : E.D. Hay

Download or read book Cell Biology of Extracellular Matrix written by E.D. Hay and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the ten-year interval since the first edition of this volume went to press, our knowledge of extracellular matrix (ECM) function and structure has enor mously increased. Extracellular matrix and cell-matrix interaction are now routine topics in the meetings and annual reviews sponsored by cell biology societies. Research in molecular biology has so advanced the number of known matrix molecules and the topic of gene structure and regulation that we won dered how best to incorporate the new material. For example, we deliberated over the inclusion of chapters on molecular genetics. We decided that with judicious editing we could present the recent findings in molecular biology within the same cell biology framework that was used for the first edition, using three broad headings: what is extracellular matrix, how is it made, and what does it do for cells? Maintaining control over the review of literature on the subject of ECM was not always an easy task, but we felt it was essential to production of a highly readable volume, one compact enough to serve the the student as an introduction and the investigator as a quick update on graduate the important recent discoveries. The first edition of this volume enjoyed con hope the reader finds this edition equally useful. siderable success; we D. Hay Elizabeth vii Contents Introductory Remarks 1 Elizabeth D. Hay PART I. WHAT IS EXTRACELLULAR MATRIX? Chapter 1 Collagen T. F. Linsenmayer 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2. The Collagen Molecule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2. 1. Triple-Helical Domain(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Research Methods in Biomineralization Science

Author :
Publisher : Elsevier
ISBN 13 : 0124166555
Total Pages : 703 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Research Methods in Biomineralization Science by :

Download or read book Research Methods in Biomineralization Science written by and published by Elsevier. This book was released on 2013-10-31 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in biomineralization science, and includes sections on such topics as determining solution chemistry, structure and nucleation; probing structure and dynamics at surfaces; and interfaces mapping biomineral and morphology and ultrastructure. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers research methods in biomineralization science - Contains sections on such topics as and includes sections on such topics as determining solution chemistry, structure and nucleation; probing structure and dynamics at surfaces; and interfaces mapping biomineral and morphology and ultrastructure

Computational Biophysics of the Skin

Author : Bernard Querleux
Publisher : CRC Press
ISBN 13 : 981446385X
Total Pages : 550 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Computational Biophysics of the Skin by : Bernard Querleux

Download or read book Computational Biophysics of the Skin written by Bernard Querleux and published by CRC Press. This book was released on 2016-04-19 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: The accessibility of the skin in vivo has resulted in the development of non-invasive methods in the past 40 years that offer accurate measurements of skin properties and structures from microscopic to macroscopic levels. However, the mechanisms involved in these properties are still only partly understood. Similar to many other domains, including

Methods in Extracellular Matrix Biology

Author :
Publisher : Academic Press
ISBN 13 : 9780128122976
Total Pages : 0 pages
Book Rating : 4.1/5 (229 download)

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Book Synopsis Methods in Extracellular Matrix Biology by :

Download or read book Methods in Extracellular Matrix Biology written by and published by Academic Press. This book was released on 2018-01-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Extra Cellular Matrix, Volume 142, a new volume in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Unique to this updated volume are sections devoted to Elastin, Quantification of collagen and elastin, Fibrillins, Lysyl oxidase, Fibulins, Matrilins, Hyaluronic Acid, Small leucine-rich proteoglycans, Syndecans, Fibronectin, SPARC, Thrombospondins, Tenascins, Collagen IV, Multi-photon analysis of ECM, Cell-derived extracellular matrices, Laminins, Fibrillar Collagens, Imaging ECM in developing embryos, Analysis of Matrix Degradation, Ultrastructural analysis of ECM, Versican and Large proteoglycans, and an ECM crosslink analysis. This series covers a wide array of topics about the extracellular matrix, including an understanding of crucial proteins and glycoproteins components of ECM.

Second Harmonic Generation Imaging

Author : Francesco S. Pavone
Publisher : Taylor & Francis
ISBN 13 : 1439849153
Total Pages : 465 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Second Harmonic Generation Imaging by : Francesco S. Pavone

Download or read book Second Harmonic Generation Imaging written by Francesco S. Pavone and published by Taylor & Francis. This book was released on 2016-04-19 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Second-harmonic generation (SHG) microscopy has shown great promise for imaging live cells and tissues, with applications in basic science, medical research, and tissue engineering. Second Harmonic Generation Imaging offers a complete guide to this optical modality, from basic principles, instrumentation, methods, and image analysis to biomedical a

Biology of Invertebrate and Lower Vertebrate Collagens

Author : A. Bairati
Publisher : Springer Science & Business Media
ISBN 13 : 146847636X
Total Pages : 582 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Biology of Invertebrate and Lower Vertebrate Collagens by : A. Bairati

Download or read book Biology of Invertebrate and Lower Vertebrate Collagens written by A. Bairati and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge in the field of the biology of the extracellular matrix, and in particular of collagen, has made considerable progress over the last ten years, especially in mammals, birds and ln man with respect to very important applied medical aspects. Basic knowledge in the animal kingdom overall has increased more slowly and haphazardly. We, therefore, considered it useful to organize a meeting specifically devoted to the study of the invertebrate and lower vertebrate collagens. The NATO Scientific Division financed an Advanced Research Workshop aimed at bringing together experts qualified in collagen biology (with morphological, biochemical and genetic specialization) with researchers who are currently studying collagenous tissues of invertebrates and lower vertebrates. The Medical-Biology Committee of the CNR-Rome and the University of Milan also supplied interest and support for the organization of this Meeting. The format of the workshop consisted in: 1) main lectures on the most recent aspects of collagen biology; 2) minireviews on the current knowledge of collagenous tissues in the various invertebrate phyla and in fish; 3) contributed papers on particular aspects of research in specific fields; 4) workshops on the methodology of studying collagen. As we had intended, the Workshop gave a comprehensive overview of acquired knowledge and of the present state of research actlvlty. It permitted wide interdisciplinary discussion, enabling collabora tions to be established and new research themes to be chosen. This volume contains the text of all the contributions presented at the Meeting, including posters.

The Extracellular Matrix: an Overview

Author : Robert Mecham
Publisher : Springer Science & Business Media
ISBN 13 : 3642165559
Total Pages : 429 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis The Extracellular Matrix: an Overview by : Robert Mecham

Download or read book The Extracellular Matrix: an Overview written by Robert Mecham and published by Springer Science & Business Media. This book was released on 2011-02-16 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Fibrous Proteins: Structures and Mechanisms

Author : David A.D. Parry
Publisher : Springer
ISBN 13 : 3319496743
Total Pages : 630 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Fibrous Proteins: Structures and Mechanisms by : David A.D. Parry

Download or read book Fibrous Proteins: Structures and Mechanisms written by David A.D. Parry and published by Springer. This book was released on 2017-01-18 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the readers with an up-to-date review of the design, structure and function of a representative selection of fibrous proteins in both health and disease. The importance of the α-helical coiled coil, a conformational motif based on the heptad repeat in the amino acid sequence of all α-fibrous proteins (and parts of some globular proteins) is underlined by three Chapters devoted to its design, structure, function and topology. Specific proteins covered in the text and which depend on the coiled coil for their structure and function, include the intermediate filament proteins, tropomyosin, myosin, paramyosin, fibrin and members of the spectrin superfamily. Also described are fibrous proteins based on the β-pleated sheet and collagen conformations. Recombinant structural proteins, especially of silk and collagen, are discussed in the context of developing new biomaterials with varied applications. Established researchers and postgraduate students in the fields of protein chemistry, biochemistry and structural biophysics will find Fibrous Proteins: Structures and Mechanisms to be an invaluable collection of topical reviews that describe the basic advances made in the field of fibrous proteins over the past decade. This book, written by recognized authorities in the field, provides a clear account of the current status of fibrous protein research and, in addition, establishes the basis for deciding the most appropriate directions for future activity, including the applications of protein engineering and the commercial exploitation of new biomaterials.

Collagen

Author : Irit Sagi
Publisher : Humana Press
ISBN 13 : 9781493990948
Total Pages : 254 pages
Book Rating : 4.9/5 (99 download)

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Book Synopsis Collagen by : Irit Sagi

Download or read book Collagen written by Irit Sagi and published by Humana Press. This book was released on 2019-04-06 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume compiles state-of-the-art protocols that will serve as recipes for scientists researching collagen, an abundant protein with great importance to health and disease, as well as in applications like food, cosmetics, pharmaceuticals, cosmetic surgery, artificial skin, and glue. Beginning with a section on in vitro models for the characterization of collagen formation, the book continues by highlighting large-scale analysis of collagen with mass spectrometry in order to elucidate the proteomics, degradomics, interactomes, and cross-linking of collagen, high resolution imaging approaches for collagen by the use of scanning electron microscopy and multiphoton imaging, as well as the role of collagen during physiological and pathological conditions. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Collagen: Methods and Protocols is an ideal guide to high quality and repeatable protocols in this vital field of study.

Biochemistry of Collagens, Laminins and Elastin

Author : Morten Karsdal
Publisher : Academic Press
ISBN 13 : 0128098996
Total Pages : 274 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Biochemistry of Collagens, Laminins and Elastin by : Morten Karsdal

Download or read book Biochemistry of Collagens, Laminins and Elastin written by Morten Karsdal and published by Academic Press. This book was released on 2016-07-29 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease. - Provides a comprehensive introduction to collagen and structural proteins - Provides insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation - Includes a chapter dedicated to the biomarkers of structural proteins - Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states

Biochemistry of Collagen

Author : Gopalasamudram Ramachandran
Publisher : Springer Science & Business Media
ISBN 13 : 1475746024
Total Pages : 546 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Biochemistry of Collagen by : Gopalasamudram Ramachandran

Download or read book Biochemistry of Collagen written by Gopalasamudram Ramachandran and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Collagen is a fascinating protein not only because of its ubiquitous occurrence in multicellular animals, but also because of its unique chemi cal structure. As the predominant constituent in bone, cartilage, skin, tendon, and tooth, it is not surprising that collagen is of interest to anatomists, biochemists, biomedical engineers, cell biologists, dermatolo gists, dental surgeons, leather chemists, orthopedic surgeons, physiologists, physicians, zoologists, and a host of others. This book was planned to provide an up-to-date comprehensive survey of all aspects of biochemistry of collagen. The recent discovery of genetically distinct collagens with tissue specificity has opened a new era in collagen biochemistry, and Karl Piez discusses this in the opening chapter on primary structure. In the next chapter, Ramachandran and Rama krishnan deal with the molecular structure of collagen, placing special emphasis on the conformational aspects of its polypeptide chains. Follow ing the consideration of primary and secondary structure of collagen, the three-dimensional arrangement of collagen molecules in the fibrils is covered by Miller in Chapter 3. Collagen is generally in the insoluble state in the living organism due to the cross-linking of individual molecules, and Tanzer describes the various aspects of this cross-linkage in Chapter 4. The biosynthesis of collagen is discussed in depth by Prockop and his colleagues.

Biomarkers in Liver Disease

Author : Victor R. Preedy
Publisher : Springer
ISBN 13 : 9789400776746
Total Pages : 0 pages
Book Rating : 4.7/5 (767 download)

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Book Synopsis Biomarkers in Liver Disease by : Victor R. Preedy

Download or read book Biomarkers in Liver Disease written by Victor R. Preedy and published by Springer. This book was released on 2017-07-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists.