Heat Shock Proteins And The Cardiovascular System

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Heat Shock Proteins and the Cardiovascular System

Author : A.A. Knowlton
Publisher : Springer Science & Business Media
ISBN 13 : 1461561779
Total Pages : 341 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Heat Shock Proteins and the Cardiovascular System by : A.A. Knowlton

Download or read book Heat Shock Proteins and the Cardiovascular System written by A.A. Knowlton and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heat shock proteins (HSP) were originally described in heat-shocked drosophila by Ritossa in the early 1960's. In the last 5 years it has become apparent that these heat shock proteins have important functions both in the normal cell and in the stressed cell. These proteins constitute an endogenous protective system; mutations in the heat shock proteins can be lethal, and there are no known organisms without heat shock proteins. The first observations on heat shock proteins and the heart were made in the 1980's and interest in these proteins increased over the decade. In the last few years there has been an exponential growth in number of papers published on heat shock proteins and the heart. Heat shock proteins have been implicated in a number of cardiovascular research areas including ischemia, hypertrophy, aging, and atherosclerosis, and this list is growmg. The purpose of this volume is to give an overview of our current understanding of the heat shock proteins in the cardiovascular system, and to summarize the approaches to the study of heat shock proteins in the heart. This volume assembles results from a number of different cardiovascular fields. and provides a comprehensive review of heat shock proteins in the cardiovascular system.

Heat Shock Proteins in Cardiovascular Diseases

Author : Satoru Takeuchi
Publisher : Nova Biomedical Books
ISBN 13 : 9781613245897
Total Pages : 0 pages
Book Rating : 4.2/5 (458 download)

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Book Synopsis Heat Shock Proteins in Cardiovascular Diseases by : Satoru Takeuchi

Download or read book Heat Shock Proteins in Cardiovascular Diseases written by Satoru Takeuchi and published by Nova Biomedical Books. This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heat shock proteins (HSPs) are of historical importance and interest since their discovery in Drosophila chromosomes during elevated temperatures. HSP expression is transcriptionally regulated and is highly specialised in eukaryotes where their induction is based on heat shock mRNA lacking in introns and is thus instantaneous in response to stress. HSPs are implicated in a variety of physiological imbalances. The precise roles of these chaperones in cardiovascular system are an interesting arena but not yet fully understood. This book is a dedicated effort in a concerted approach to describe the various HSPs that are elicited in cardiovascular diseases and to provide an interface between clinicians and biochemists in a concise platform.

Oxidative Stress in Heart Diseases

Author : Sajal Chakraborti
Publisher : Springer Nature
ISBN 13 : 9811382735
Total Pages : 596 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Oxidative Stress in Heart Diseases by : Sajal Chakraborti

Download or read book Oxidative Stress in Heart Diseases written by Sajal Chakraborti and published by Springer Nature. This book was released on 2019-11-06 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.

Heat Shock Proteins in Myocardial Protection

Author : Rakesh C. Kukreja
Publisher : CRC Press
ISBN 13 : 1498712665
Total Pages : 115 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Heat Shock Proteins in Myocardial Protection by : Rakesh C. Kukreja

Download or read book Heat Shock Proteins in Myocardial Protection written by Rakesh C. Kukreja and published by CRC Press. This book was released on 2000-08-01 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myocardial ischemic syndromes pose a major medical problem and a significant economic health care concern. Reperfusion, although used in the clinical arena as essential to the survival of acutely ischemic heart muscle carries with it the risk of "reperfusion injury". Therefore the salvage of additional myocardium is highly desirable. Over a decade ago, it was shown that whole body heat shock activated a powerful endogenous protective mechanism that significantly improved myocardial salvage following prolonged ischemia and reperfusion injury in the heart. A characteristic feature of this heat shock response was the expression of a family of proteins known as heat shock proteins. Many of these proteins function as molecular chaperones, helping to refold proteins denatured as a consequence of lethal injuries and facilitating the synthesis of new proteins to replace those irreparably damaged. Altered expression of these proteins has been extensively documented in association with a diverse array of diseases such as ischemia and perfusion injury, cardiac hypertrophy, fever, inflammation, metabolic diseases, infection, cell and tissue trauma, aging, and cancer. Interestingly, some studies have now shown a direct correlation of the heat shock proteins produced and the degree of myocardial protection. This book is a thorough description of the current state of knowledge of the mechanisms of heat shock proteins induced cardiac protection at the cellular and molecular level, the controversies in this growing field and the potential of treating ischemic heart disease with overexpression of heat shock proteins in patients. The book will be especially useful for investigators interested in studying tissue injury and its protection with the overexpression of heat shock proteins.

Stress Proteins

Author : David S. Latchman
Publisher : Springer Science & Business Media
ISBN 13 : 3642582591
Total Pages : 436 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Stress Proteins by : David S. Latchman

Download or read book Stress Proteins written by David S. Latchman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work is concerned with a group of proteins which were originally consid ered to be an esoteric phenomenon but which have now been shown to play critical roles both in normal and stressed cells as well as being involved in a variety of human diseases. It is the purpose of this work to give a comprehen sive view of these proteins and their various aspects. After an introductory chapter providing an overview of these proteins, the work is divided into four main sections each of which deals with one important aspect of these proteins. Thus, the first section contains a series of chapters which describe individual stress proteins and their roles in particular biological phenomena. Evidently, the induction of these proteins by elevated tempera ture or other stresses is their defining feature and the second section of this book therefore considers the regulation of stress protein gene expression both by stressful stimuli such as elevated temperature or ischaemia and by non stressful stimuli such as cytokines.

Heat Shock Proteins in Cancer

Author : Stuart K. Calderwood
Publisher : Springer Science & Business Media
ISBN 13 : 1402064012
Total Pages : 399 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Heat Shock Proteins in Cancer by : Stuart K. Calderwood

Download or read book Heat Shock Proteins in Cancer written by Stuart K. Calderwood and published by Springer Science & Business Media. This book was released on 2007-09-09 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.

Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks

Author : Peter Csermely
Publisher : Springer Science & Business Media
ISBN 13 : 0387399755
Total Pages : 218 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks by : Peter Csermely

Download or read book Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks written by Peter Csermely and published by Springer Science & Business Media. This book was released on 2007-08-09 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book makes a novel synthesis of the molecular aspects of the stress response and long term adaptation processes with the system biology approach of biological networks. Authored by an exciting mixture of top experts and young rising stars, it provides a comprehensive summary of the field and identifies future trends.

Immunity and Atherosclerosis

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (141 download)

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Book Synopsis Immunity and Atherosclerosis by :

Download or read book Immunity and Atherosclerosis written by and published by . This book was released on 1980 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Big Book on Small Heat Shock Proteins

Author : Robert M. Tanguay
Publisher : Springer
ISBN 13 : 331916077X
Total Pages : 603 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis The Big Book on Small Heat Shock Proteins by : Robert M. Tanguay

Download or read book The Big Book on Small Heat Shock Proteins written by Robert M. Tanguay and published by Springer. This book was released on 2015-06-15 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based upon a workshop entitled “The Small HSP World” held in Québec 2-5 October 2014. Twenty-five scientists provided chapters for the book. The chapters are from the best scientists currently working in this field. These colleagues include Arrigo, Benesch, Benjamin, Buchner-Haslbeck-Weinkauf, Benndorf, Boelens, Carra, Chang, Currie, Ecroyd, Emanuelsson, Fu, Garrido, Golenhofen, Gusev, Hightower, Kampinga, Lavoie, MacRae, Quinlan, Tanguay, Vierling, Vigh, Weeks and Wu. Briefly, the book starts with the structure of small heat shock proteins, moving to their functions and finishing with their involvement in diseases. Although this is quite broad, the structural aspect will be the unifying theme of the book.

Heat Shock Proteins and Whole Body Physiology

Author : Alexzander A. A. Asea
Publisher : Springer Science & Business Media
ISBN 13 : 9048133815
Total Pages : 431 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Heat Shock Proteins and Whole Body Physiology by : Alexzander A. A. Asea

Download or read book Heat Shock Proteins and Whole Body Physiology written by Alexzander A. A. Asea and published by Springer Science & Business Media. This book was released on 2009-12-10 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heat Shock Proteins and Whole Body Physiology is an exciting new book in the Heat Shock Proteins series which provides the most up-to-date review on novel mechanisms insights into the important role played by heat shock proteins in human physiology. Written by leaders in the field of heat shock protein exercise physiology, neuroscience and aging, the chapters systematically and in a step wise fashion takes the reader through the fascinating mechanisms by which heat shock proteins modulate human disease and pathophysiology and provides answers as to its biological significance to the host. Section I, introduces the readers to the role played by heat shock proteins in various diseases and disorders (Heat Shock Proteins and Disease). Section II, addresses the role heat shock proteins play in psychological disorders including post traumatic stress disorders and learning (Heat Shock Proteins and Psychological Stress). Section III, present a detailed review of the role played by heat shock proteins in exercise physiology (Heat Shock Proteins and Exercise Physiology). This book is a must read for heat shock protein researchers, graduate and postgraduate fellows in the field of Medicine in general and specialities in Excersie Physiology, Neuroscience, Immunology, Aging and Pathology.

Stress Proteins

Author : Milton J. Schlesinger
Publisher : Springer Science & Business Media
ISBN 13 : 3642758150
Total Pages : 125 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Stress Proteins by : Milton J. Schlesinger

Download or read book Stress Proteins written by Milton J. Schlesinger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: All living organisms are exposed to rapidly changing environmental conditions which may lead to external stress. How organisms cope with stress - especially on the molecular level - is explained in Stress Proteins. Cells react to external stress - where the temperature-induced reaction known as "heat shock response" is the best studied example of stress - by activating special genes and subsequently synthesizing stress proteins. Surprisingly, this stress response is not only similar for all types of stress but even the involved stress proteins are virtually identical in all organisms from prokaryotic to eukaryotic cells, from bacteria to humans. This universality shows that stress proteins are vital for surviving and indicates that these proteins play an essential role in normal cell functions, in cell growth and metabolism. This explains the great interest in stress response research.

Heat Shock Proteins in Inflammatory Diseases

Author : Alexzander A. A. Asea
Publisher : Springer
ISBN 13 : 9783030851705
Total Pages : 0 pages
Book Rating : 4.8/5 (517 download)

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Book Synopsis Heat Shock Proteins in Inflammatory Diseases by : Alexzander A. A. Asea

Download or read book Heat Shock Proteins in Inflammatory Diseases written by Alexzander A. A. Asea and published by Springer. This book was released on 2022-10-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Heat Shock Proteins in Inflammatory Diseases provides the most comprehensive highlight and insight of the expression, function and therapeutic activity of Heat Shock Proteins in inflammatory diseases including sepsis, psoriasis, neurodegenerative diseases, cancers, viral infection and autoimmune rheumatic diseases. Using an integrative approach, the contributors provide a synopsis of the most current updates on the state of HSP in inflammatory diseases. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Immune Surveillance

Author : Richard T. Smith
Publisher : Elsevier
ISBN 13 : 0323146260
Total Pages : 553 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Immune Surveillance by : Richard T. Smith

Download or read book Immune Surveillance written by Richard T. Smith and published by Elsevier. This book was released on 2012-12-02 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immune Surveillance deals with the issues regarding tumor immunology and surveillance, in which the central theme is all about the life span of the mammalian host that is depleted by the environment with mutagenic agents and solutions. The book is divided into six chapters. It includes discussions on the organization and modulation of cell membrane receptors, as well as the origin and expression of membrane antigens. It also covers the topics on the triggering mechanisms for and effector mechanisms activated by the cellular recognition. These topics analyze and evaluate alternatives for the recognition and destruction mechanisms in the knowledge of cell cooperation and requirements for immune recognition. A chapter provides discourse on a solution for the paradox of thriving tumors based on the demonstrable in vitro host immunity. Another discusses the generation of antibody diversity and the theory of self-tolerance. The last chapter explains the evaluation of the evidence for immune surveillance. This reference will be invaluable to those who specialize in immunology.

The Hsp60 Chaperonin

Author : Peter Bross
Publisher : Springer
ISBN 13 : 331926088X
Total Pages : 92 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis The Hsp60 Chaperonin by : Peter Bross

Download or read book The Hsp60 Chaperonin written by Peter Bross and published by Springer. This book was released on 2015-12-08 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this unique overview of the Hsp60 chaperonin, Peter Bross addresses molecular biologists, medical research scientists and individuals interested in molecular or general biology. First, Bross discusses the basics of the Hsp60 chaperonin in terms of its structure and the molecular mechanisms determining its function. Second, the author highlights the multiple roles of Hsp60 for cellular systems and regulatory pathways, especially in connection with neurodegenerative diseases caused by Hsp60 deficiency. Finally, the author highlights controversial observations suggesting additional, non-standard functions of Hsp60 in and outside mitochondria as well as possible gaps in our understanding of the chaperonin. This volume serves as a snapshot suitable for experienced researcher working in fields related to molecular chaperones yet still accessible to researchers entering the field.

Heat Stress in Sport and Exercise

Author : Julien D. Périard
Publisher : Springer
ISBN 13 : 3319935151
Total Pages : 296 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Heat Stress in Sport and Exercise by : Julien D. Périard

Download or read book Heat Stress in Sport and Exercise written by Julien D. Périard and published by Springer. This book was released on 2019-03-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is designed to provide a flowing description of the physiology of heat stress, the illnesses associated with heat exposure, recommendations on optimising health and performance, and an examination of Olympic sports played in potentially hot environmental conditions. In the first section the book examines how heat stress effects performance by outlining the basics of thermoregulation and how these responses impact on cardiovascular, central nervous system, and skeletal muscle function. It also outlines the pathophysiology and treatment of exertional heat illness, as well as the role of hydration status during exercise in the heat. Thereafter, countermeasures (e.g. cooling and heat acclimation) are covered and an explanation as to how they may aid in decreasing the incidence of heat illness and minimise the impairment in performance is provided. A novel and particular feature of the book is its inclusion of sport-specific chapters in which the influence of heat stress on performance and health is described, as well as strategies and policies adopted by the governing bodies in trying to offset the deleterious role of thermal strain. Given the breadth and scope of the sections, the book will be a reference guide for clinicians, practitioners, coaches, athletes, researchers, and students.

Regulation of Heat Shock Protein Responses

Author : Alexzander A A Asea
Publisher : Springer
ISBN 13 : 3319747150
Total Pages : 472 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Regulation of Heat Shock Protein Responses by : Alexzander A A Asea

Download or read book Regulation of Heat Shock Protein Responses written by Alexzander A A Asea and published by Springer. This book was released on 2018-05-01 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This books provides the most up-to-date reviews on current advances in our understanding of the regulation of heat shock protein responses. Key basic scientists and clinical research laboratories from major universities, academic medical centers and pharmaceutical companies around the world have contributed chapters that review present research activity and importantly project this field into the future. For easy readability, the book is sub divided into four sections, including, Section I - HSP and Stress Responses; Section II - Chaperone Functions of HSP; Section III - HSP in Human Diseases; Section IV - Prognosis & Diagnosis of HSP. The book is a must read for researchers involved in biomedical research, drug discovery and design to improve human health.

Caffeine in Food and Dietary Supplements

Author : Leslie A. Pray
Publisher :
ISBN 13 : 9780309297493
Total Pages : 0 pages
Book Rating : 4.2/5 (974 download)

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Book Synopsis Caffeine in Food and Dietary Supplements by : Leslie A. Pray

Download or read book Caffeine in Food and Dietary Supplements written by Leslie A. Pray and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Caffeine in Food and Dietary Supplements is the summary of a workshop convened by the Institute of Medicine in August 2013 to review the available science on safe levels of caffeine consumption in foods, beverages, and dietary supplements and to identify data gaps. Scientists with expertise in food safety, nutrition, pharmacology, psychology, toxicology, and related disciplines; medical professionals with pediatric and adult patient experience in cardiology, neurology, and psychiatry; public health professionals; food industry representatives; regulatory experts; and consumer advocates discussed the safety of caffeine in food and dietary supplements, including, but not limited to, caffeinated beverage products, and identified data gaps. Caffeine, a central nervous stimulant, is arguably the most frequently ingested pharmacologically active substance in the world. Occurring naturally in more than 60 plants, including coffee beans, tea leaves, cola nuts and cocoa pods, caffeine has been part of innumerable cultures for centuries. But the caffeine-in-food landscape is changing. There are an array of new caffeine-containing energy products, from waffles to sunflower seeds, jelly beans to syrup, even bottled water, entering the marketplace. Years of scientific research have shown that moderate consumption by healthy adults of products containing naturally-occurring caffeine is not associated with adverse health effects. The changing caffeine landscape raises concerns about safety and whether any of these new products might be targeting populations not normally associated with caffeine consumption, namely children and adolescents, and whether caffeine poses a greater health risk to those populations than it does for healthy adults. This report delineates vulnerable populations who may be at risk from caffeine exposure; describes caffeine exposure and risk of cardiovascular and other health effects on vulnerable populations, including additive effects with other ingredients and effects related to pre-existing conditions; explores safe caffeine exposure levels for general and vulnerable populations; and identifies data gaps on caffeine stimulant effects.