Heart Proteomics

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Manual of Cardiovascular Proteomics

Author : Giulio Agnetti
Publisher : Springer
ISBN 13 : 3319318284
Total Pages : 442 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Manual of Cardiovascular Proteomics by : Giulio Agnetti

Download or read book Manual of Cardiovascular Proteomics written by Giulio Agnetti and published by Springer. This book was released on 2016-09-15 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book fulfils the need to keep up with the high number of innovations in proteomics, and at the same time to warn the readers about the danger of manufacturers and scientists claims around new technologies. Mass spectrometry stands as the core technology in proteomics. The emerging field of targeted proteomics and its potential applications in the cardiovascular arena are also reviewed and discussed. A concluding section highilghts the promise of proteomics in the light of these recent developments. As this technique and its applications have undergone remarkable advances in the past years, recent updates on proteomic applications are covered. Another key concept revealed by proteomic technologies is that the extent of protein post-translational modifications (PTMs) as well as their impact on the phenotype has been underestimated by pre-proteomics science. As such, part of the manual focuses on the emerging role of PTMs in basic cardiovascular sciences and in the clinics. In fact, there is an emerging consensus that the detailed annotation of protein PTMs could lead to a more in-depth representation of biological systems, translating into more specific targets for therapy as well as biomarkers. Moreover, a recent trend is so-called “targeted proteomics”. The approach was awarded the title of “Method of the Year” by Nature in 2013 (see the editorial by Vivien Marx in 1st issue of Nature in Jan 2013). According to a few proteomic scientists the emphasis should not be placed on generating long lists of proteins but lists of proteins with a true biological meaning.

Cardiovascular Proteomics

Author : Fernando Vivanco
Publisher : Springer Science & Business Media
ISBN 13 : 1597452149
Total Pages : 412 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Cardiovascular Proteomics by : Fernando Vivanco

Download or read book Cardiovascular Proteomics written by Fernando Vivanco and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cutting-edge book presents protocols and strategies for proteomic evaluation of cardiovascular disease written by pioneering researchers in the field. Topics explored in this comprehensive volume include obtaining specific heart proteins, techniques for identifying risk biomarkers of atherome plaque rupture, analyzing the secretome of explanted endarterectomies cultured in vitro, and phage display techniques for deciphering the molecular diversity of blood vessels.

Proteomics in Drug Research

Author : Michael Hamacher
Publisher : John Wiley & Sons
ISBN 13 : 9783527312269
Total Pages : 392 pages
Book Rating : 4.3/5 (122 download)

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Book Synopsis Proteomics in Drug Research by : Michael Hamacher

Download or read book Proteomics in Drug Research written by Michael Hamacher and published by John Wiley & Sons. This book was released on 2006-03-31 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: From skillful handling of the wide range of technologies to successful applications in drug discovery -- this handbook has all the information professional proteomics users need. Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field. Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer's disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics. Invaluable reading for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.

Cardiovascular Biomarkers

Author : David A. Morrow
Publisher : Springer Science & Business Media
ISBN 13 : 1597450510
Total Pages : 612 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Cardiovascular Biomarkers by : David A. Morrow

Download or read book Cardiovascular Biomarkers written by David A. Morrow and published by Springer Science & Business Media. This book was released on 2010-04-28 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the four pages committed to a discussion of myocardial infarction in the first edition of Harrison’s Principles of Internal Medicine, published in 1950, there was no mention of use of the laboratory for management of patients. Thirty years later, when the first edition of Braunwald’s Heart Disease, A Textbook of Cardiovascular Medicine was published, 2 out of the 1943 pages in the text contained a discussion of the laboratory examinations in acute myocardial infarction. Our knowledge base of the multitude of ways that physicians can and should use the clinical chemistry laboratory has expanded dramatically since these classic texts were published. The nomenclature has changed: terms such as “cardiac enzymes” have given way to “cardiac biomarkers. ” The number of assays has multiplied, and the operating characteristics of available assays are impr- ing at a gratifying but dizzying rate. We now use biomarkers to diagnose cardiovascular diseases and also to frame our treatment strategies. Thus, there is a clear need for a scholarly compilation of the state of the art of cardiac biomarkers. Dr. David Morrow has expertly edited an authoritative book that answers this need. The 34 chapters in Cardiovascular Biomarkers: Pathophysiology and Disease Mana- ment were written by a group of individuals who are internationally recognized thought leaders and experts in clinical and laboratory medicine.

Proteomic and Genomic Analysis of Cardiovascular Disease

Author : Jennifer E. Van Eyk
Publisher : John Wiley & Sons
ISBN 13 : 3527605452
Total Pages : 423 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Proteomic and Genomic Analysis of Cardiovascular Disease by : Jennifer E. Van Eyk

Download or read book Proteomic and Genomic Analysis of Cardiovascular Disease written by Jennifer E. Van Eyk and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the very first book to focus on this new approach that will eventually aid in developing new diagnostic markers and therapies for controlling and treating heart disease - the number-one killer in the industrialized world. Divided into two parts, the book describes not only the potentials, but also the limitations of these technologies. The editors, both well known within the scientific community, provide new insights into the biochemical and cellular mechanisms of cardiovascular disease, as well as covering the transition into clinical applications. In so doing, they highlight the various strategies and technical aspects so as to assist the growing number of researchers intending to utilize these approaches. The result is an excellent way of educating and informing graduate students, post-doctoral fellows as well as researchers in academia and industry about the latest developments in this area.

Platelet Proteomics

Author : Ángel García-Alonso
Publisher : John Wiley & Sons
ISBN 13 : 0470463376
Total Pages : 432 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Platelet Proteomics by : Ángel García-Alonso

Download or read book Platelet Proteomics written by Ángel García-Alonso and published by John Wiley & Sons. This book was released on 2011-05-31 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of the book is to introduce platelets, and their functional role in thrombotic and cardiovascular disease, justifying the relevance of platelet proteomics research. Focus then shifts to the recent developments on mass spectrometry (MS)-based proteomics. This chapter shows potential applications for platelet proteomics not yet carried out. It includes examples of post-translational modifications (PTMs) analysis in platelets. The second part of the book focuses on the main research done so far on platelet proteomics. This includes general proteome mapping by non-gel based separation methods (MudPit), analysis of the general platelet proteome and signaling cascades by gel-based separation methods (2-DE), sub-proteome analyses (secretome/releasate, membrane proteins, organelles). Finally, the last section links the platelet transcriptome and application to disease. This section is highly relevant and includes chapters on proteomics, transcriptomics, functional genomics, systems biology, and their applications to platelet-related diseases.

Proteomics

Author : Tsz Kwong Man
Publisher : BoD – Books on Demand
ISBN 13 : 9533078324
Total Pages : 454 pages
Book Rating : 4.5/5 (33 download)

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Book Synopsis Proteomics by : Tsz Kwong Man

Download or read book Proteomics written by Tsz Kwong Man and published by BoD – Books on Demand. This book was released on 2012-02-10 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical research has entered a new era of characterizing a disease or a protein on a global scale. In the post-genomic era, Proteomics now plays an increasingly important role in dissecting molecular functions of proteins and discovering biomarkers in human diseases. Mass spectrometry, two-dimensional gel electrophoresis, and high-density antibody and protein arrays are some of the most commonly used methods in the Proteomics field. This book covers four important and diverse areas of current proteomic research: Proteomic Discovery of Disease Biomarkers, Proteomic Analysis of Protein Functions, Proteomic Approaches to Dissecting Disease Processes, and Organelles and Secretome Proteomics. We believe that clinicians, students and laboratory researchers who are interested in Proteomics and its applications in the biomedical field will find this book useful and enlightening. The use of proteomic methods in studying proteins in various human diseases has become an essential part of biomedical research.

Biomarkers for Heart Failure, An Issue of Heart Failure Clinics

Author : Toru Suzuki
Publisher : Elsevier Health Sciences
ISBN 13 : 0323566421
Total Pages : 129 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Biomarkers for Heart Failure, An Issue of Heart Failure Clinics by : Toru Suzuki

Download or read book Biomarkers for Heart Failure, An Issue of Heart Failure Clinics written by Toru Suzuki and published by Elsevier Health Sciences. This book was released on 2017-11-27 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Heart Failure Clinics, edited by Dr. Toru Suzuki, will cover Biomarkers for Heart Failure, including but not limited to Proenkephalin, B-type and mid-regional pro atrial natriuretic peptides , N-terminal B-type natriuretic peptide, Soluble T2, Adrenomedullin, Copeptin, Non-Coding RNAs, Troponin, Growth differentiation factor (GDF-15) , Galectin-3, Proteomic biomarkers, and Metabolic biomarkers .

Proteomics: Biomedical and Pharmaceutical Applications

Author : Hubert Hondermarck
Publisher : Springer Science & Business Media
ISBN 13 : 1402023235
Total Pages : 396 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Proteomics: Biomedical and Pharmaceutical Applications by : Hubert Hondermarck

Download or read book Proteomics: Biomedical and Pharmaceutical Applications written by Hubert Hondermarck and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human biology has now entered into a phase of post-genomics and it might not be an exaggeration to say that the major outcome of the human genome sequencing has finally been to open the way to the exploration of the proteome-proteomics. Proteins are the functional output of genes and there are two main expected outcomes from human proteomics. The first is to discover new molecular markers for early diagnosis and profiling of pathologies. The second is to decipher the intracellular signaling pathways leading to the initiation and progression of pathologies, for the identification of new targets and the development of innovative therapeutic strategies. This is clearly a promising challenge that this book explores through a series of ongoing experiences and projects representative of the new era in which biology and medicine have now entered.

Inflammation in Heart Failure

Author : Matthijs Blankesteijn
Publisher : Academic Press
ISBN 13 : 0128004851
Total Pages : 221 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Inflammation in Heart Failure by : Matthijs Blankesteijn

Download or read book Inflammation in Heart Failure written by Matthijs Blankesteijn and published by Academic Press. This book was released on 2014-12-05 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation in Heart Failure, edited by W. Matthijs Blankesteijn and Raffaele Altara, is the first book in a decade to provide an in-depth assessment on the causes, symptoms, progression and treatments of cardiac inflammation and related conditions. This reference uses two decades of research to introduce new methods for identifying inflammatory benchmarks from early onset to chronic heart failure and specifically emphasizes the importance of classifying at-risk subgroups within large populations while determining the patterns of cytokines in such classifications. Further, the book details clinical applications of the pathophysiological mechanisms of heart failure, diagnosis and therapeutic strategies. Inflammation in Heart Failure's breadth of subject matter, easy-to-follow structure, portability, and high-quality illustrations create an accessible benefit for researchers, clinicians and students. - Presents updated information and research on the relevant inflammatory mediators of heart failure to aid in targeting future translational research as well as the improvement of early diagnosis and treatment - Provides research into better understanding the different inflammatory mediators that signal the underlying diseases that potentially lead to heart failure - Contains 20 years of research, offering a brief overview of the topic leading to current opinions on, and treatment of, heart failure - Provides a structured, systematic and balanced overview of the role of inflammation in heart failure making it a useful resource for researchers and clinicians, as well as those studying cardiovascular diseases

Protein Biochemistry and Proteomics

Author : Hubert Rehm
Publisher : Elsevier
ISBN 13 : 0080458432
Total Pages : 252 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Protein Biochemistry and Proteomics by : Hubert Rehm

Download or read book Protein Biochemistry and Proteomics written by Hubert Rehm and published by Elsevier. This book was released on 2006-03-24 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hubert Rehm's Protein Biochemistry and Proteomics is more than a laboratory manual; it is a strategic guide that provides the reader with tips and tricks for more successful lab experiments. Using a conversational yet professional tone, Rehm provides an overview of a variety of methods in protein biochemistry/proteomics. He provides short and precise summaries of routine procedures as well as listings of the advantages and disadvantages of alternative methods. Readers will immediately sense that the author if very familiar with the challenges, and frustration of the daily lab routine. Never before has such an honest, tactical guide been available for those conducting lab experiments within the field of biochemistry. - Shows how to avoid experimental dead ends and helps users develop an instinct for the right experiment at the right time - Contains short and precise summaries of routine procedures (e.g. column chromatography, gel electrophoresis), and lists the advantages and disadvantages of alternative methods - Includes over 100 detailed figures and tables - Contains a chapter on proteomics

Precision Medicine for Investigators, Practitioners and Providers

Author : Joel Faintuch
Publisher : Academic Press
ISBN 13 : 0128191791
Total Pages : 646 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Precision Medicine for Investigators, Practitioners and Providers by : Joel Faintuch

Download or read book Precision Medicine for Investigators, Practitioners and Providers written by Joel Faintuch and published by Academic Press. This book was released on 2019-11-16 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Precision Medicine for Investigators, Practitioners and Providers addresses the needs of investigators by covering the topic as an umbrella concept, from new drug trials to wearable diagnostic devices, and from pediatrics to psychiatry in a manner that is up-to-date and authoritative. Sections include broad coverage of concerning disease groups and ancillary information about techniques, resources and consequences. Moreover, each chapter follows a structured blueprint, so that multiple, essential items are not overlooked. Instead of simply concentrating on a limited number of extensive and pedantic coverages, scholarly diagrams are also included. - Provides a three-pronged approach to precision medicine that is focused on investigators, practitioners and healthcare providers - Covers disease groups and ancillary information about techniques, resources and consequences - Follows a structured blueprint, ensuring essential chapters items are not overlooked

Digital Health, An Issue of Heart Failure Clinics, E-Book

Author : Ragavendra R. Baliga
Publisher : Elsevier Health Sciences
ISBN 13 : 0323920209
Total Pages : 153 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Digital Health, An Issue of Heart Failure Clinics, E-Book by : Ragavendra R. Baliga

Download or read book Digital Health, An Issue of Heart Failure Clinics, E-Book written by Ragavendra R. Baliga and published by Elsevier Health Sciences. This book was released on 2022-04-05 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Heart Failure Clinics, guest editors Drs. Ragavendra R. Baliga and Dipti Itchhaporia bring their considerable expertise to the topic of Digital Health, sometimes referred to as eHealth. Top experts in the field cover key topics in the field such as using AI to better predict/develop biomarkers; telehealth in heart failure; EHR in heart failure; artificial intelligence and mechanical circulatory support; and more. - Contains 11 relevant, practice-oriented topics including devices to improve symptoms and reduce morbidity and mortality in heart failure; utilizing artificial intelligence to enhance equity in minority populations; 3-D printing in heart failure; machine learning in cardiac imaging; and more. - Provides in-depth clinical reviews on digital health, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Introduction to Proteomics

Author : Nawin C. Mishra
Publisher : John Wiley & Sons
ISBN 13 : 047092084X
Total Pages : 202 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Introduction to Proteomics by : Nawin C. Mishra

Download or read book Introduction to Proteomics written by Nawin C. Mishra and published by John Wiley & Sons. This book was released on 2011-09-19 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteomics provides an introductory insight on proteomics, discussing the basic principles of the field, how to apply specific technologies and instrumentation, and example applications in human health and diseases. With helpful study questions, this textbook presents an easy to grasp and solid overview and understanding of the principles, guidelines, and especially the complex instrumentation operations in proteomics for new students and research scientists. Written by a leader in proteomics studies, Proteomics offers an expert perspective on the field and the future of proteomics.

Diabetes and Heart Failure: Basic, Translational, and Clinical Research

Author : Claudio de Lucia
Publisher : Frontiers Media SA
ISBN 13 : 283252527X
Total Pages : 110 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Diabetes and Heart Failure: Basic, Translational, and Clinical Research by : Claudio de Lucia

Download or read book Diabetes and Heart Failure: Basic, Translational, and Clinical Research written by Claudio de Lucia and published by Frontiers Media SA. This book was released on 2023-06-05 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Post-Genomic Cardiology

Author : José Marín-García
Publisher : Academic Press
ISBN 13 : 0124046428
Total Pages : 935 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Post-Genomic Cardiology by : José Marín-García

Download or read book Post-Genomic Cardiology written by José Marín-García and published by Academic Press. This book was released on 2014-05-09 with total page 935 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the "epigenome, comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. - Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches - Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome - Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs

Braunwald's Heart Disease - E-Book

Author : Peter Libby
Publisher : Elsevier Health Sciences
ISBN 13 : 0323824714
Total Pages : 2473 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Braunwald's Heart Disease - E-Book by : Peter Libby

Download or read book Braunwald's Heart Disease - E-Book written by Peter Libby and published by Elsevier Health Sciences. This book was released on 2021-10-15 with total page 2473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current, comprehensive, and evidence-based Braunwald's Heart Disease remains the most trusted reference in the field and the leading source of reliable cardiology information for practitioners and trainees worldwide. The fully updated 12th Edition continues the tradition of excellence with dependable, state-of-the-art coverage of new drugs, new guidelines, more powerful imaging modalities, and recent developments in precision medicine that continue to change and advance the practice of cardiovascular medicine. Written and edited by global experts in the field, this award-winning text is an unparalleled multimedia reference for every aspect of this complex and fast-changing area. - Offers balanced, dependable content on rapidly changing clinical science, clinical and translational research, and evidence-based medicine. - Includes 76 new contributing authors and 14 new chapters that cover Artificial intelligence in Cardiovascular Medicine; Wearables; Influenza, Pandemics, COVID-19, and Cardiovascular Disease; Tobacco and Nicotine Products in Cardiovascular Disease; Cardiac Amyloidosis; Impact of the Environment on Cardiovascular Health, and more. - Features a new introductory chapter Cardiovascular Disease: Past, Present, and Future by Eugene Braunwald, MD, offering his unique, visionary approach to the field of cardiology. Dr. Braunwald also curates the extensive, bimonthly online updates that include "Hot Off the Press" (with links to Practice Update) and "Late-Breaking Clinical Trials". - Provides cutting-edge coverage of key topics such as proteomics and metabolomics, TAVR, diabetocardiology, and cardio-oncology. - Contains 1,850 high-quality illustrations, radiographic images, algorithms, and charts, and provides access to 215 videos called out with icons in the print version. - Highlights the latest AHA, ACC, and ESC guidelines to clearly summarize diagnostic criteria and clinical implications. - Provides tightly edited, focused content for quick, dependable reference. Flexible format options include either one or two volumes in print, as well as a searchable eBook with ongoing updates. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.