Handbook Of Mitochondrial Dysfunction

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Handbook of Mitochondrial Dysfunction

Author : Shamim I. Ahmad
Publisher : CRC Press
ISBN 13 : 0429811772
Total Pages : 480 pages
Book Rating : 4.4/5 (298 download)

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Book Synopsis Handbook of Mitochondrial Dysfunction by : Shamim I. Ahmad

Download or read book Handbook of Mitochondrial Dysfunction written by Shamim I. Ahmad and published by CRC Press. This book was released on 2019-05-15 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.

Mitochondrial Dysfunction

Author : Lawrence H. Lash
Publisher : Elsevier
ISBN 13 : 1483218619
Total Pages : 527 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Mitochondrial Dysfunction by : Lawrence H. Lash

Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Living Well with Mitochondrial Disease

Author : Cristy Balcells
Publisher :
ISBN 13 : 9781606130148
Total Pages : 0 pages
Book Rating : 4.1/5 (31 download)

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Book Synopsis Living Well with Mitochondrial Disease by : Cristy Balcells

Download or read book Living Well with Mitochondrial Disease written by Cristy Balcells and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Living Well with Mitochondrial Disease helps make sense of mitochondrial disease (Mito), an overwhelming and complex group of diagnoses that has grown exponentially in recent years. The most common metabolic disorder, thought to be more common than cystic fibrosis and broader-reaching than most genetic diseases, Mito can affect babies, children, and teens from birth or at any point during their development. Previously healthy adults, as well as adults with a history of unexplained fatigue, are increasingly receiving a Mito diagnosis. Some children with autism spectrum disorders who have medical issues such as digestive difficulties and fatigue are also being identified as having a mitochondrial disorder. This guide is the first book about Mito written for patients and thier families. It takes readers from understanding how the mitochondria work (they are the powerhouse of the cell, providing energy for the entire body), how people with mitochondrial defects are diagnosed and treated, to how to live well when you, your child, or someone you love is struggling with disabling symptoms. Topics include: the journey to diagnosis; the biochemistry of Mito; practical advice for the specific needs of children and adults; understanding and managing symptoms; where to find specialists and support; treatment approaches; and autism and Mito. Writing from the perspective of both a parent and nurse, the author shows adult patients, parents, family members, and caregivers how to achieve the best quality of life possible. Readers will feel empowered as they come to understand the causes of Mito, learn to manage the symptoms, avoid emergencies and make appropriate lifestyle choices.

Mitochondrial Dysfunction and Nanotherapeutics

Author : Marcos Roberto de Oliveira
Publisher : Academic Press
ISBN 13 : 0323886183
Total Pages : 602 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Mitochondrial Dysfunction and Nanotherapeutics by : Marcos Roberto de Oliveira

Download or read book Mitochondrial Dysfunction and Nanotherapeutics written by Marcos Roberto de Oliveira and published by Academic Press. This book was released on 2021-07-15 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine provides a comprehensive overview of mitochondrial dysfunction and current strategies for targeting the organelle. Based on the most current research, the editor lined up a team of worldwide experts to cover the most exciting research in the area, considering the impact through the human life span. This book is structured in two parts that provide a good balance of foundational and applied content. Part I deals with an overview of mitochondrial dysfunction and its role in the aging process, including metabolic diseases, neuro-affective and neurodegenerative disorders, sepsis, and toxicological aspects. Part II covers therapeutic substance delivery to mitochondria with a focus on cancer, neurodegenerative diseases, and increasing the bioavailability of natural compounds of interest. Several nanoscale strategies are described. Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine is a complete resource for researchers in this exciting field. Its comprehensive coverage makes this book particularly interesting to bioscience researchers looking to understand the foundations of mitochondrial health throughout the human life span. Additionally, clinician researchers, medical doctors, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the organelle-targeted delivery strategies. Contains detailed information on mitochondrial dysfunction Reviews our current understanding of the role of mitochondria in aging Includes coverage of specific conditions, including sports and affective disorders, among others Discusses mitochondria targeted delivery of therapeutic compounds

Handbook of Mitochondrial Dysfunction

Author : Shamim I. Ahmad
Publisher : CRC Press
ISBN 13 : 0429811772
Total Pages : 480 pages
Book Rating : 4.4/5 (298 download)

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Book Synopsis Handbook of Mitochondrial Dysfunction by : Shamim I. Ahmad

Mitochondrial Diseases

Author : Eylem Taskin
Publisher : BoD – Books on Demand
ISBN 13 : 1789236746
Total Pages : 498 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Mitochondrial Diseases by : Eylem Taskin

Download or read book Mitochondrial Diseases written by Eylem Taskin and published by BoD – Books on Demand. This book was released on 2018-08-29 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are crucial organelles for any cell type. Mitochondria take responsibility for not only energy production but also regulation of cell death, also called apoptosis; calcium storage; and heat production. Therefore, mitochondrial disease is implicated in the mode of action of many harmful factors for cells such as drugs and environmental contaminants, dysfunction of the oxygen transport system, malnutrition, intense exercise, and genetic variations. This book presents up-to-date knowledge about mitochondrial disease and its complex relation to some diseases such as cardiac failure, cancer, and Alzheimer's and Parkinson's diseases. This book will, therefore, be essential for readers who are interested in life sciences, especially in medicine.

The Patient's Guide to Mitochondrial Dysfunction

Author : Travis Jenkins
Publisher : Independently Published
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.8/5 (723 download)

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Book Synopsis The Patient's Guide to Mitochondrial Dysfunction by : Travis Jenkins

Download or read book The Patient's Guide to Mitochondrial Dysfunction written by Travis Jenkins and published by Independently Published. This book was released on 2023-12-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book "The Patient's Guide to Mitochondrial Dysfunction: Diagnosis, Treatment, and Hope" by Travis Jenkins provides a comprehensive overview of mitochondrial dysfunction, offering insights into its diagnosis, treatment, and the hope it brings to those affected. The book delves into the complexities of mitochondrial disease, exploring the challenges faced by patients and the latest advances in research and therapeutic perspectives. It also emphasizes the importance of a patient-centered approach and the power of a positive mindset in navigating the impact of mitochondrial dysfunction. By drawing on a range of sources, including patient care standards, consensus statements, and the patients' perspective, the book offers a well-rounded understanding of the condition and the support available. Overall, "The Patient's Guide to Mitochondrial Dysfunction" serves as a valuable resource for individuals, families, healthcare providers, and researchers seeking a deeper understanding of this critical health issue.

Mitochondrial Dysfunction in Neurodegenerative Disorders

Author : Amy K. Reeve
Publisher : Springer
ISBN 13 : 3319286374
Total Pages : 379 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Mitochondrial Dysfunction in Neurodegenerative Disorders by : Amy K. Reeve

Download or read book Mitochondrial Dysfunction in Neurodegenerative Disorders written by Amy K. Reeve and published by Springer. This book was released on 2016-06-08 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition brings together up-to-date contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease and multiple sclerosis. The reader is guided through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, and on to the consequences of this dysfunction for neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets. Additional chapters have been added to the book to reflect advances in the field and there are many new contributors and topics, including how mitochondria are degraded and the interaction of the mitochondria with pathologically relevant proteins. Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.

Mitochondria Diet

Author : Jeffrey Winzant
Publisher : Independently Published
ISBN 13 :
Total Pages : 56 pages
Book Rating : 4.5/5 (463 download)

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Book Synopsis Mitochondria Diet by : Jeffrey Winzant

Download or read book Mitochondria Diet written by Jeffrey Winzant and published by Independently Published. This book was released on 2021-07-30 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: Did you know that mitochondrial health is an essential key to longevity and overall well-being? Mitochondria are often overlooked in the body's complex cellular structure. They may not get as much attention as the brain or heart, but they are integral to overall health just like any other organ, and your health can be affected by the inner workings of these tiny organelles. For example, when your cells don't use energy properly from food because they cannot metabolize glucose (a type of sugar), your mitochondria cellular structures stop functioning efficiently, resulting in insulin resistance as well-both upstream triggers for health problems like cardiovascular disease, diabetes, cancer, Alzheimer's Disease, Parkinson's Disease and much more. Fortunately, there are many steps that you can take to manage these mitochondrial dysfunctions through nutrition. That's why we have outlined a 3-weeks meal plan designed with your mitochondria in mind. First things first, it's a good idea to understand what mitochondria are and why they are vital for optimal health. Stay tuned for a deep dive into what they do, why you should care about them, and how you can take better care of them through nutrition. In this guide, you'll discover: What are mitochondria Diet tips to help improve your mitochondria function Symptoms you can tell your cellular structures are not working properly A seven-day weekly plan Sample recipes to follow Imagine what changes you can see in your life if you take action today. Scroll up and click buy now to get started.

Handbook on Understanding and Coping with Mitochondrial Disease

Author : Laura Bainbridge
Publisher :
ISBN 13 :
Total Pages : 124 pages
Book Rating : 4.:/5 (884 download)

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Book Synopsis Handbook on Understanding and Coping with Mitochondrial Disease by : Laura Bainbridge

Download or read book Handbook on Understanding and Coping with Mitochondrial Disease written by Laura Bainbridge and published by . This book was released on 2006 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pharmacology of Mitochondria

Author : Harpreet Singh
Publisher : Springer
ISBN 13 : 3319573136
Total Pages : 491 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Pharmacology of Mitochondria by : Harpreet Singh

Download or read book Pharmacology of Mitochondria written by Harpreet Singh and published by Springer. This book was released on 2017-08-11 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: This special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders. The chapters contributed by leading mitochondrial researchers in the handbook will take us through the novel pharmacological strategies via mitochondria to understand their physiological and pathological role as well as present them as therapeutic targets.

Cellular and Molecular Basis of Mitochondrial Inheritance

Author : Peter Sutovsky
Publisher : Springer
ISBN 13 : 3030045706
Total Pages : 126 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Cellular and Molecular Basis of Mitochondrial Inheritance by : Peter Sutovsky

Download or read book Cellular and Molecular Basis of Mitochondrial Inheritance written by Peter Sutovsky and published by Springer. This book was released on 2019-05-09 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including Drosophila, C. elegans, bivalve molusc Mytilus and livestock mammals. Special consideration is given to cellular mechanisms promoting uniparental inheritance of mitochondria and mitochondrial genes, evolutionary perspectives, and biomedical and epidemiological considerations. Contributed by five distinguished mitochondrial research teams from around the world, this volume will target a wide audience of physiologists, anatomists, cell, and developmental and evolutionary biologists, as well as physicians, veterinarians, livestock specialists and biomedical researchers.

Mitochondrial Intoxication

Author : Marcos Roberto de Oliveira
Publisher : Elsevier
ISBN 13 : 0323884636
Total Pages : 800 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Mitochondrial Intoxication by : Marcos Roberto de Oliveira

Download or read book Mitochondrial Intoxication written by Marcos Roberto de Oliveira and published by Elsevier. This book was released on 2022-11-30 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrial Intoxication explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications and impact these have upon mitochondria and the diseases that can result from dysfunction and impairment in the human body. Furthermore, the book provides an overview of mitochondrial physiology and assesses the advances and challenges in testing mitochondrial toxicity. Case studies exploring mitochondrial intoxication in pregnancy and in the geriatric population are also included. This is a comprehensive reference on the main toxicants impacting mitochondria in the human body, and the consequences this can have for health and disease. Features a wide range of toxicants and their effects on mitochondrial physiology Covers molecular markers of mitochondrial intoxication Includes case studies that illustrate the health impacts of toxicity upon mitochondria Considers future directions regarding the study of mitochondrial intoxication

Mitochondria and Cancer

Author : Keshav Singh
Publisher : Springer Science & Business Media
ISBN 13 : 0387848355
Total Pages : 294 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Mitochondria and Cancer by : Keshav Singh

Download or read book Mitochondria and Cancer written by Keshav Singh and published by Springer Science & Business Media. This book was released on 2009-04-05 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.

Mitochondria and the Future of Medicine

Author : Lee Know
Publisher : Chelsea Green Publishing
ISBN 13 : 1603587683
Total Pages : 274 pages
Book Rating : 4.6/5 (35 download)

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Book Synopsis Mitochondria and the Future of Medicine by : Lee Know

Download or read book Mitochondria and the Future of Medicine written by Lee Know and published by Chelsea Green Publishing. This book was released on 2018-02-19 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: "From infertility to aging to cancer and neurological disease, Dr. Lee Know will teach you that mitochondria play a central role in much that we care about in health and disease."—Stephanie Seneff, senior research scientist, MIT and author of Toxic Legacy With information for patients and practitioners on optimizing mitochondrial function for greater health and longevity Why do we age? Why does cancer develop? What's the connection between heart failure and Alzheimer's disease, or infertility and hearing loss? Can we extend lifespan, and if so, how? What is the Exercise Paradox? Why do antioxidant supplements sometimes do more harm than good? Many will be amazed to learn that all these questions, and many more, can be answered by a single point of discussion: mitochondria and bioenergetics. In Mitochondria and the Future of Medicine, Naturopathic Doctor Lee Know tells the epic story of mitochondria, the widely misunderstood and often-overlooked powerhouses of our cells. The legendary saga began over two billion years ago, when one bacterium entered another without being digested, which would evolve to create the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that have been responsible for this life-giving energy. By understanding how our mitochondria work, in fact, it is possible to add years to our lives, and life to our years. Current research, however, has revealed a dark side: many seemingly disconnected degenerative diseases have tangled roots in dysfunctional mitochondria. However, modern research has also endowed us with the knowledge on how to optimize its function, which is of critical importance to our health and longevity. Dr. Know offers cutting-edge information on supplementation and lifestyle changes for mitochondrial optimization and how to implement their use successfully, including: CoQ10 D-Ribose Cannabinoids Ketogenic dietary therapy and more! Mitochondria and the Future of Medicine is an invaluable resource for practitioners interested in mitochondrial medicine and the true roots of chronic illness and disease, as well as anyone interested in optimizing their health. "Dr. Lee Know does a brilliant job shedding light on this once ignored organelle and shows us how to care for our most important metabolic system."—Dr. Nasha Winters, co-author of The Metabolic Approach to Cancer

Diagnosis and Management of Mitochondrial Disorders

Author : Michelangelo Mancuso
Publisher : Springer
ISBN 13 : 3030055175
Total Pages : 382 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Diagnosis and Management of Mitochondrial Disorders by : Michelangelo Mancuso

Download or read book Diagnosis and Management of Mitochondrial Disorders written by Michelangelo Mancuso and published by Springer. This book was released on 2019-05-03 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will help readers navigate the complexity of mitochondrial disorders, by addressing the role of mitochondrial dysfunction and the complex pathophysiological mechanisms associated with a growing number of illnesses, not only of neurological interest. Further, it provides updated concepts on genotype-phenotype correlations, clinical syndromes, diagnostic algorithms and therapies. Written by the world’s foremost mitochondrial researchers, the book comprehensively presents the state-of-the-art in mitochondrial medicine, making it of interest to a wide variety of specialists, including neurologists, geneticists, internists and biologists.

Mitochondrial Medicine

Author : Volkmar Weissig
Publisher : Springer Nature
ISBN 13 : 1071612662
Total Pages : 456 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Mitochondrial Medicine by : Volkmar Weissig

Download or read book Mitochondrial Medicine written by Volkmar Weissig and published by Springer Nature. This book was released on 2021-05-31 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume II guides readers through chapters on mitochondrial dysfunction, functional’ mitochondria, mitochondrial retrograde, mitochondrial dNTP pool quantification, mitochondrial ADP-ribosylation, blue-native gel approach, 3D optical cryo-imaging method, mitochondrial ATP and ROS production, protocol for untargeted metabolomic analysis, and methods for analysis of nitrotyrosine-containing proteins. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Mitochondrial Medicine, Second Edition, Volume 2: Assessing Mitochondria aims to be a comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.