Handbook Of Carcinogenic Potency And Genotoxicity Databases

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Handbook of Carcinogenic Potency and Genotoxicity Databases

Author : Lois Swirsky Gold
Publisher : CRC Press
ISBN 13 : 9781439810644
Total Pages : 840 pages
Book Rating : 4.8/5 (16 download)

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Book Synopsis Handbook of Carcinogenic Potency and Genotoxicity Databases by : Lois Swirsky Gold

Download or read book Handbook of Carcinogenic Potency and Genotoxicity Databases written by Lois Swirsky Gold and published by CRC Press. This book was released on 1996-11-26 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique new reference contains the Carcinogenic Potency Database (CPDB), which analyzes results of decades of animal cancer tests, including all Technical Reports of the National Toxicology Program (NTP) and the general published literature. A guide to the literature of animal cancer tests, the CPDB includes references to each published experiment and never-before published analyses. For each of 5,000 long-term experiments on 1,300 chemicals, the user-friendly format includes data on the species, strain, and sex of the test animal; features of experimental protocol such as the route of administration, duration of dosing, dose levels, and duration of the experiment; histopathology and tumor incidence; the shape of the dose-response curve; published author's opinion about the carcinogenicity at each site; and reference to the original publication of the test results. In addition, a measure of carcinogenic potency, the TD50, its statistical significance and confidence limits, are given for each tumor site. An overview is provided of earlier publication updates, such as positivity rates, reproducibility, interspecies extrapolation, and ranking possible carcinogenic hazards. The book also includes a summary of the NTP genetic toxicity test results on 1,500 chemicals, which are referenced to the original publications, including the Salmonella (Ames) test, L5178Y mouse lymphoma cell mutation test, chromosome aberration and sister chromatid exchange tests in cultured Chinese hamster ovary cells, and the sex-linked recessive lethal mutation test in Drosophila melanogaster. An index with chemicals listed by CAS number allows cross referencing between the carcinogenicity and genotoxicity databases, making data easy to find.

Handbook of Carcinogenic Potency and Genotoxicity Databases

Author : Lois Swirsky Gold
Publisher : CRC Press
ISBN 13 : 9780849326844
Total Pages : 768 pages
Book Rating : 4.3/5 (268 download)

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Book Synopsis Handbook of Carcinogenic Potency and Genotoxicity Databases by : Lois Swirsky Gold

Download or read book Handbook of Carcinogenic Potency and Genotoxicity Databases written by Lois Swirsky Gold and published by CRC Press. This book was released on 1996-11-26 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique new reference contains the Carcinogenic Potency Database (CPDB), which analyzes results of decades of animal cancer tests, including all Technical Reports of the National Toxicology Program (NTP) and the general published literature. A guide to the literature of animal cancer tests, the CPDB includes references to each published experiment and never-before published analyses. For each of 5,000 long-term experiments on 1,300 chemicals, the user-friendly format includes data on the species, strain, and sex of the test animal; features of experimental protocol such as the route of administration, duration of dosing, dose levels, and duration of the experiment; histopathology and tumor incidence; the shape of the dose-response curve; published author's opinion about the carcinogenicity at each site; and reference to the original publication of the test results. In addition, a measure of carcinogenic potency, the TD50, its statistical significance and confidence limits, are given for each tumor site. An overview is provided of earlier publication updates, such as positivity rates, reproducibility, interspecies extrapolation, and ranking possible carcinogenic hazards. The book also includes a summary of the NTP genetic toxicity test results on 1,500 chemicals, which are referenced to the original publications, including the Salmonella (Ames) test, L5178Y mouse lymphoma cell mutation test, chromosome aberration and sister chromatid exchange tests in cultured Chinese hamster ovary cells, and the sex-linked recessive lethal mutation test in Drosophila melanogaster. An index with chemicals listed by CAS number allows cross referencing between the carcinogenicity and genotoxicity databases, making data easy to find.

Carcinogenic Potency Database ; Avoidable Cancer Causes

Author :
Publisher :
ISBN 13 :
Total Pages : 326 pages
Book Rating : 4.:/5 (341 download)

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Book Synopsis Carcinogenic Potency Database ; Avoidable Cancer Causes by :

Download or read book Carcinogenic Potency Database ; Avoidable Cancer Causes written by and published by . This book was released on 1995 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Carcinogenic Potency Database; Endocrine Disruptors

Author : L. S. Gold
Publisher : DIANE Publishing
ISBN 13 : 0788185365
Total Pages : 130 pages
Book Rating : 4.7/5 (881 download)

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Book Synopsis Carcinogenic Potency Database; Endocrine Disruptors by : L. S. Gold

Download or read book Carcinogenic Potency Database; Endocrine Disruptors written by L. S. Gold and published by DIANE Publishing. This book was released on 2000-03 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Papers include: supp. to the carcinogenic potency database (CPD): results of animal bioassays published in 1993 to 1994; supplemental plot of the CPD; workshop on characterizing the effects of endocrine disruptors on human health at environmental exposure levels; an approach to the development of quantitative models to assess the effects of exposure to environmentally relevant levels of endocrine disruptors on homeostasis in adults; evaluating the effects of endocrine disruptors on endocrine function during development; and species, interindividual, and tissue specificity in endocrine signaling. Illustrated.

Genetic Toxicology and Cancer Risk Assessment

Author : Wai Nang Choy
Publisher : CRC Press
ISBN 13 : 0824745221
Total Pages : 405 pages
Book Rating : 4.8/5 (247 download)

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Book Synopsis Genetic Toxicology and Cancer Risk Assessment by : Wai Nang Choy

Download or read book Genetic Toxicology and Cancer Risk Assessment written by Wai Nang Choy and published by CRC Press. This book was released on 2001-08-31 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation! This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization. Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines! Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models discusses the threshold concept of carcinogenesis demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens considers structural activity relationship (SAR) analysis of chemical carcinogenicity describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays illustrates the use of genetic biomarkers for dosimetry analysis and more! Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.

Environmental Health Perspectives

Author :
Publisher :
ISBN 13 :
Total Pages : 1162 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Environmental Health Perspectives by :

Download or read book Environmental Health Perspectives written by and published by . This book was released on 2002 with total page 1162 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Human and Ecological Risk Assessment

Author : Dennis J. Paustenbach
Publisher : John Wiley & Sons
ISBN 13 : 111974296X
Total Pages : 1319 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis Human and Ecological Risk Assessment by : Dennis J. Paustenbach

Download or read book Human and Ecological Risk Assessment written by Dennis J. Paustenbach and published by John Wiley & Sons. This book was released on 2024-04-15 with total page 1319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understand the fundamentals of human risk assessment with this introduction and reference Human risk assessments are a precondition for virtually all industrial action or environmental regulation, all the more essential in a world where chemical and environmental hazards are becoming more abundant. These documents catalog potential environmental, toxicological, ecological, or other harms resulting from a particular hazard, from chemical spills to construction projects to dangerous workplaces. They turn on a number of variables, of which the most significant is the degree of human exposure to the hazardous agent or process. Human and Ecological Risk Assessment combines the virtues of a textbook and reference work to introduce and analyze these vital documents. Beginning with the foundational theory of human health risk assessment, it then supplies case studies and detailed analysis illustrating the practice of producing risk assessment documents. Fully updated and authored by leading authorities in the field, the result is an indispensable work. Readers of the second edition of Human and Ecological Risk Assessment will also find: Over 40 entirely new case studies reflecting the latest in risk assessment practice Detailed discussion of hazards including air emissions, contaminated food and soil, hazardous waste sites, and many more Case studies from multiple countries to reflect diverse international standards Human and Ecological Risk Assessment is ideal for professionals and advanced graduate students in toxicology, industrial hygiene, occupational medicine, environmental science, and all related subjects.

The Science of Risk Assessment

Author : United States. Congress. House. Committee on Science. Subcommittee on Energy and Environment
Publisher :
ISBN 13 :
Total Pages : 648 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis The Science of Risk Assessment by : United States. Congress. House. Committee on Science. Subcommittee on Energy and Environment

Download or read book The Science of Risk Assessment written by United States. Congress. House. Committee on Science. Subcommittee on Energy and Environment and published by . This book was released on 1998 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Synthesis Green Metrics

Author : John Andraos
Publisher : CRC Press
ISBN 13 : 0429683421
Total Pages : 486 pages
Book Rating : 4.4/5 (296 download)

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Book Synopsis Synthesis Green Metrics by : John Andraos

Download or read book Synthesis Green Metrics written by John Andraos and published by CRC Press. This book was released on 2018-12-07 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Green chemistry promotes improved syntheses as an intellectual endeavour that can have a great impact both on preserving and utilizing our planet’s finite resources and the quality of human life. This masterful accomplishment provides an evaluation of environmental impact metrics according to life cycle assessment analysis based on the Mackay compartment environmental model and Guinée environmental impact potentials formalism. Assumptions, limitations, and dealing with missing data are addressed. Best literature resources for finding key toxicological parameters are provided and applied to individual reactions as well as entire synthesis plans, in order to target molecules of interest. Key Features: Provides an evaluation of environmental impact metrics according to life cycle assessment analysis Summarises safety-hazard metrics according to the same model as life cycle assessment including occupational exposure limits, risk phrases, flammability, and other physical parameters The book will be useful in a range of chemistry courses, from undergraduate to advanced graduate courses, whether based in lectures, tutorials or laboratory experiments

Insight on Genotoxicity

Author : Shiv Shankar Shukla
Publisher : CRC Press
ISBN 13 : 100019731X
Total Pages : 164 pages
Book Rating : 4.0/5 (1 download)

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Book Synopsis Insight on Genotoxicity by : Shiv Shankar Shukla

Download or read book Insight on Genotoxicity written by Shiv Shankar Shukla and published by CRC Press. This book was released on 2020-10-14 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic toxicology is considered to be an important assessment tool as there is genetic impact of artificial chemicals. Insight on Genotoxicity discusses testing, mechanism, prediction, and bioindicator of genotoxicity taking into consideration recent advances in nano-engineered particles. Corollary of DNA dent is also discussed in detail taking into consideration the impact of ICH guidelines on genotoxicity testing, which is important for drug discovery innovation and development. Perspective review of genotoxicity evaluation in phytopharmaceuticals has been mentioned along with the prevention of genotoxicity in brief viewpoint. Salient Features Presents methods, standard protocols, and guidelines for genotoxicity testing Examines the impact of ICH Guidelines on genetic toxicity testing which is a regulatory requirement for drug discovery and development Defines appropriate strategies about advances in in vivo genotoxicity testing which have been listed along with progress and prospects Discusses advancement in the high-throughput approaches for genotoxicity testing Details computational prediction of genotoxicity with consideration of mutagenicity, chromosomal damage caused and strategies for computational prediction in drug development

Occupational Cancers

Author : Sisko Anttila
Publisher : Springer Nature
ISBN 13 : 3030307662
Total Pages : 641 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Occupational Cancers by : Sisko Anttila

Download or read book Occupational Cancers written by Sisko Anttila and published by Springer Nature. This book was released on 2020-02-10 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised and updated new edition of a successful book is a multidisciplinary, comprehensive guide to occupational factors of malignant diseases. Building on the first edition, new research discoveries and their consequences in our understanding on carcinogenic mechanisms, diagnosis and attribution of occupational cancers are discussed. Examples of such discoveries are germline and acquired mutations of BAP1 in malignant mesothelioma, which have led to changes in diagnostic criteria, and carcinogen-specific genetic and epigenetic alterations in lung cancer. There are several new chapters, including gastrointestinal cancers, epidemiology of lung cancer, cancer of thyroid, and the role of primary health care in occupational cancer control. Occupational Cancers is aimed at experienced and trainee oncologists, pathologists, clinicians in occupational health, and pulmonologists, as well as epidemiologists, clinical researchers, lawyers and public health officials.

Quantitative Structure-Activity Relationship (QSAR) Models of Mutagens and Carcinogens

Author : Romualdo Benigni
Publisher : CRC Press
ISBN 13 : 1135505691
Total Pages : 441 pages
Book Rating : 4.1/5 (355 download)

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Book Synopsis Quantitative Structure-Activity Relationship (QSAR) Models of Mutagens and Carcinogens by : Romualdo Benigni

Download or read book Quantitative Structure-Activity Relationship (QSAR) Models of Mutagens and Carcinogens written by Romualdo Benigni and published by CRC Press. This book was released on 2003-02-26 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applied with success in a number of areas, QSAR studies have become particularly popular in the rational design of drugs and pesticides. Much has been published on the principles of QSAR in this area, but not on their application s to toxic chemicals. This book provides the first comprehensive, interdisciplinary presentation of QSAR studies on

Information Resources in Toxicology

Author : P.J. Bert Hakkinen
Publisher : Academic Press
ISBN 13 : 9780080920030
Total Pages : 1552 pages
Book Rating : 4.9/5 (2 download)

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Book Synopsis Information Resources in Toxicology by : P.J. Bert Hakkinen

Download or read book Information Resources in Toxicology written by P.J. Bert Hakkinen and published by Academic Press. This book was released on 2009-08-19 with total page 1552 pages. Available in PDF, EPUB and Kindle. Book excerpt: This latest version of Information Resources in Toxicology (IRT) continues a tradition established in 1982 with the publication of the first edition in presenting an extensive itemization, review, and commentary on the information infrastructure of the field. This book is a unique wide-ranging, international, annotated bibliography and compendium of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. Thoroughly updated, the current edition analyzes technological changes and is rife with online tools and links to Web sites. IRT-IV is highly structured, providing easy access to its information. Among the “hot topics covered are Disaster Preparedness and Management, Nanotechnology, Omics, the Precautionary Principle, Risk Assessment, and Biological, Chemical and Radioactive Terrorism and Warfare are among the designated. • International in scope, with contributions from over 30 countries • Numerous key references and relevant Web links • Concise narratives about toxicologic sub-disciplines • Valuable appendices such as the IUPAC Glossary of Terms in Toxicology • Authored by experts in their respective sub-disciplines within toxicology

Cancer Risk Assessment

Author : Ching-Hung Hsu
Publisher : John Wiley & Sons
ISBN 13 : 1118035127
Total Pages : 727 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Cancer Risk Assessment by : Ching-Hung Hsu

Download or read book Cancer Risk Assessment written by Ching-Hung Hsu and published by John Wiley & Sons. This book was released on 2010-12-08 with total page 727 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous.

Information Resources in Toxicology

Author : Philip Wexler
Publisher : Academic Press
ISBN 13 : 0127447709
Total Pages : 953 pages
Book Rating : 4.1/5 (274 download)

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Book Synopsis Information Resources in Toxicology by : Philip Wexler

Download or read book Information Resources in Toxicology written by Philip Wexler and published by Academic Press. This book was released on 2000 with total page 953 pages. Available in PDF, EPUB and Kindle. Book excerpt: History: -- K.D. Watson, P. Wexler, and J. Everitt. -- Highlights in the History of Toxicology. -- Selected References in the History of Toxicology. -- A Historical Perspective of Toxicology Information Systems. -- Books and Special Documents: -- G.L. Kennedy, Jr., P. Wexler, N.S. Selzer, and L.A. Malley. -- General Texts. -- Analytical Toxicology. -- Animals in Research. -- Biomonitoring/Biomarkers. -- Biotechnology. -- Biotoxins. -- Cancer. -- Chemical Compendia. -- Chemical--Cosmetics and Other Consumer. -- Products. -- Chemical--Drugs. -- Chemical--Dust and Fibers. -- Chemical--Metals. -- Chemicals--Pesticides -- Chemicals--Solvents. -- Chemical--Selected Chemicals. -- Clinical Toxicology. -- Developmental and Reproductive Toxicology. -- Environmental Toxicology--General. -- Environmental Toxicology-- Aquatic. -- Environmental Toxicology--Atmospheric. -- Environmental Toxicology--Hazardous Waste. -- Environmental Toxicology--Terrestrial. -- Environmental Toxicology--Wildlife. -- Ep ...

Politicizing Science

Author : Michael Gough
Publisher : Hoover Institution Press
ISBN 13 : 0817939334
Total Pages : 321 pages
Book Rating : 4.8/5 (179 download)

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Book Synopsis Politicizing Science by : Michael Gough

Download or read book Politicizing Science written by Michael Gough and published by Hoover Institution Press. This book was released on 2013-09-01 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book leading scientists share their experiences and observations of developing and testing hypotheses, offering insights on the dangers of manipulating science for political gain. It describes how politicization--whether by misapplication, overextension, or outright manipulation of the scientific record to advance particular policy agendas--imposes expenditures of money, missed opportunities, and burdens on the economy.

Predictive Toxicology in Drug Safety

Author : Jinghai J. Xu
Publisher : Cambridge University Press
ISBN 13 : 1139493094
Total Pages : pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Predictive Toxicology in Drug Safety by : Jinghai J. Xu

Download or read book Predictive Toxicology in Drug Safety written by Jinghai J. Xu and published by Cambridge University Press. This book was released on 2010-09-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: According to the Institute of Medicine (IOM) and U.S. Food and Drug Administration (FDA), 'developing new scientific approaches to detecting, understanding, predicting and preventing adverse events' was a critical path to the future of drug safety. This book brings together a collection of state-of-the-art chapters, written by experts in the drug safety field. It provides information on the present knowledge of drug side effects and their mitigation strategy during drug discovery, gives guidance for risk assessment and promotes evidence-based toxicology. Each specific area of toxicology relevant for drug discovery is discussed in detail, including theory, experimental approaches and data interpretation supported by comprehensive up-to-date references. Many chapters provide fascinating case studies, which are of general interest for those who have basic science training and are interested in how chemicals interact with the human body.