Handbook Of Anticancer Pharmacokinetics And Pharmacodynamics

Download Handbook Of Anticancer Pharmacokinetics And Pharmacodynamics full books in PDF, epub, and Kindle. Read online Handbook Of Anticancer Pharmacokinetics And Pharmacodynamics ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics

Author : Michelle A. Rudek
Publisher : Springer Science & Business Media
ISBN 13 : 1461491355
Total Pages : 828 pages
Book Rating : 4.4/5 (614 download)

DOWNLOAD NOW!

Book Synopsis Handbook of Anticancer Pharmacokinetics and Pharmacodynamics by : Michelle A. Rudek

Download or read book Handbook of Anticancer Pharmacokinetics and Pharmacodynamics written by Michelle A. Rudek and published by Springer Science & Business Media. This book was released on 2014-01-10 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics

Author : William Figg
Publisher : Humana Press
ISBN 13 : 9781588291776
Total Pages : 623 pages
Book Rating : 4.2/5 (917 download)

DOWNLOAD NOW!

Book Synopsis Handbook of Anticancer Pharmacokinetics and Pharmacodynamics by : William Figg

Download or read book Handbook of Anticancer Pharmacokinetics and Pharmacodynamics written by William Figg and published by Humana Press. This book was released on 2004-03-26 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading investigators synthesize the entire laboratory and clinical process of developing anticancer drugs to create a single indispensable reference that covers all the steps from the identification of cancer-specific targets to phase III clinical trials. These expert authors provide their best guidance on a wide variety of issues, including clinical trial design, preclinical screening, and the development and validation of bioanalytic methods. The chapters on identifying agents to test in phase III trials and on trial design for the approval of new anticancer agents offer a unique roadmap for moving an agent to NDA submission.

Principles of Anticancer Drug Development

Author : Elizabeth Garrett-Mayer
Publisher : Springer Science & Business Media
ISBN 13 : 1441973583
Total Pages : 673 pages
Book Rating : 4.4/5 (419 download)

DOWNLOAD NOW!

Book Synopsis Principles of Anticancer Drug Development by : Elizabeth Garrett-Mayer

Download or read book Principles of Anticancer Drug Development written by Elizabeth Garrett-Mayer and published by Springer Science & Business Media. This book was released on 2010-12-29 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs.

Cancer Pharmacology

Author : Ashkan Emadi, MD, PhD
Publisher : Springer Publishing Company
ISBN 13 : 0826149332
Total Pages : 471 pages
Book Rating : 4.8/5 (261 download)

DOWNLOAD NOW!

Book Synopsis Cancer Pharmacology by : Ashkan Emadi, MD, PhD

Download or read book Cancer Pharmacology written by Ashkan Emadi, MD, PhD and published by Springer Publishing Company. This book was released on 2023-10-06 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Pharmacology: An Illustrated Manual of Anticancer Drugs, Second Edition is a visually engaging reference detailing the essential basic and clinical science of all approved, effective, and life-prolonging drug therapies in oncology. Now with a greater emphasis on clinical context, application, and management in each chapter, this significantly revised edition provides both early-career and seasoned clinicians with a practical, bench-to-bedside approach and patient-oriented guide. The book provides detailed coverage of the major advances in cancer pharmacology at the forefront of our standards of care for solid tumors and hematologic malignancies, in addition to the basic science that is directly necessary and applicable when at the patient’s bedside. Everything from traditional cytotoxic agents to targeted genomic, epigenomic, hormonal, and immunotherapeutic agents is explored, in addition to a new chapter covering pharmacogenomics. Accompanied by elegant illustrations, each chapter details the tumor microenvironment, chemical structures of agents, pharmacodynamics, pharmacokinetics, pharmacogenomic and molecular properties of the various agents, and their mechanisms of action. The book covers alkylating agents, antimetabolites, antimitotics, epigenetic modulators, hormonal agents, targeted therapies, monoclonal antibodies, immunotherapeutic agents, and much more. Thoroughly updated to include new FDA-approved treatments and applications, and written by leading experts in cancer pharmacology, this second edition continues to be a “must have” for anyone involved in the basic, translational, or clinical aspects of oncology and hematology, including clinicians, pharmacists, nurses, and trainees. Key Features: Over 150 beautiful illustrations depict structures, pharmacokinetics, pharmacodynamics, and pharmacogenomics associated with each class of agents Contains more than 160 high-yield hematology and oncology board-style chapter review questions (more than double the previous edition) with descriptive rationales Describes how chemotherapy, targeted therapy, immunotherapy, and hormonal therapy work, and why they are expected to work adjuvantly, neoadjuvantly, and in combination with other treatment modalities Thoroughly updated and revised chapters cover new FDA drug approvals, disease-site indications, clinical applications and management of drug-to-drug interactions, and toxicities Discusses challenges related to drug development, drug approval, and regulatory issues in relation to anticancer treatments Provides important pharmacotherapy context with clinical pearls in each chapter that help support a patient-oriented, bedside approach

A Clinician's Guide to Chemotherapy Pharmacokinetics and Pharmacodynamics

Author : Louise B. Grochow
Publisher : Lippincott Williams & Wilkins
ISBN 13 :
Total Pages : 612 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis A Clinician's Guide to Chemotherapy Pharmacokinetics and Pharmacodynamics by : Louise B. Grochow

Download or read book A Clinician's Guide to Chemotherapy Pharmacokinetics and Pharmacodynamics written by Louise B. Grochow and published by Lippincott Williams & Wilkins. This book was released on 1998 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Drug Metabolism and Pharmacokinetics Quick Guide

Author : Siamak Cyrus Khojasteh
Publisher : Springer Science & Business Media
ISBN 13 : 1441956298
Total Pages : 222 pages
Book Rating : 4.4/5 (419 download)

DOWNLOAD NOW!

Book Synopsis Drug Metabolism and Pharmacokinetics Quick Guide by : Siamak Cyrus Khojasteh

Download or read book Drug Metabolism and Pharmacokinetics Quick Guide written by Siamak Cyrus Khojasteh and published by Springer Science & Business Media. This book was released on 2011-04-07 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.

Pharmacokinetics and Toxicokinetics

Author : Mehdi Boroujerdi
Publisher : CRC Press
ISBN 13 : 1482221357
Total Pages : 538 pages
Book Rating : 4.4/5 (822 download)

DOWNLOAD NOW!

Book Synopsis Pharmacokinetics and Toxicokinetics by : Mehdi Boroujerdi

Download or read book Pharmacokinetics and Toxicokinetics written by Mehdi Boroujerdi and published by CRC Press. This book was released on 2015-02-24 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacokinetics and Toxicokinetics provides an overview of pharmacokinetics and toxicokinetics in a comprehensible, interrelated, and applied manner. It integrates the principles held in common by both fields through a logical and systematic approach. The book presents mathematical descriptions of physiological processes employed in different appr

Anticancer Drug Development

Author : Bruce C. Baguley
Publisher : Elsevier
ISBN 13 : 0080490441
Total Pages : 397 pages
Book Rating : 4.0/5 (84 download)

DOWNLOAD NOW!

Book Synopsis Anticancer Drug Development by : Bruce C. Baguley

Download or read book Anticancer Drug Development written by Bruce C. Baguley and published by Elsevier. This book was released on 2001-11-17 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. One work that can be consulted for all aspects of anticancer drug development Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques Hundreds of references that allow the reader to access relevant scientific and medical literature Clear illustrations, some in color, that provide both understanding of the field and material for teaching

Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents

Author : Michael W. Jann
Publisher : Springer
ISBN 13 : 3319278835
Total Pages : 601 pages
Book Rating : 4.3/5 (192 download)

DOWNLOAD NOW!

Book Synopsis Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents by : Michael W. Jann

Download or read book Applied Clinical Pharmacokinetics and Pharmacodynamics of Psychopharmacological Agents written by Michael W. Jann and published by Springer. This book was released on 2016-03-02 with total page 601 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive resource on psychotropic medications, detailing the latest methods for defining their characteristics, their use in different patient populations, and drug-drug interactions; an important collection of information forclinicians, students, researchers, and members of the pharmaceutical industry alike. The first section provides the foundational principles of these drugs. Mathematical modeling of parameters that affect their entryto,and exit from, the central nervous system (CNS) compartment are presented on an individual basis and then applied to target populations with specific disease states. Methods and characteristics that inform the transfer of these drugs from the laboratory bench to use in patient care are discussed, including imaging techniques, genetics and physiological barriers, such as the blood-brain barrier. The second section describes the characteristics of specific agents,nominally arranged intodifferent therapeutic categories and with reference crossover use in different disease states. The pharmacologic characteristics of different drug formulations are explored in the context of their ability to improve patient adherence. The third section focuses on drug-drug interactions.Psychotropic medications from different categories are frequently prescribed together,or alongside medications used to treat comorbid conditions, and the information provided is directly relevant to the clinic, as a result. The clinical application of pharmacokinetics and pharmacodynamics of CNS agents has made significant progress over the past 50 years and new information is reported by numerous publications in psychiatry, neurology, and pharmacology.Our understanding of the interrelationship between these medications, receptors, drug transporters, as well as techniques for measurement and monitoring their interactions,isfrequently updated. However, with information presented on a host of different platforms, and in different formats, obtaining the full picture can be difficult. This title aims to collate this information into a single source that can be easily interpreted and applied towards patient care by the clinical practitioner, and act as a reference for all others who have an interest in psychopharmacological agents.

Development of Therapeutic Agents Handbook

Author : Shayne Cox Gad
Publisher : John Wiley & Sons
ISBN 13 : 1118077113
Total Pages : 1943 pages
Book Rating : 4.1/5 (18 download)

DOWNLOAD NOW!

Book Synopsis Development of Therapeutic Agents Handbook by : Shayne Cox Gad

Download or read book Development of Therapeutic Agents Handbook written by Shayne Cox Gad and published by John Wiley & Sons. This book was released on 2011-10-24 with total page 1943 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive look at current drug discovery and development methods—and the roadmap for the future Providing both understanding and guidance in characterizing potential drugs and their production and synthesis, Development of Therapeutic Agents Handbook gives professionals a basic tool to facilitate research and development within this challenging process. This comprehensive text brings together, in one resource, a compendium of concepts, approaches, methodologies, and limitations that need to be considered in the formulation of therapeutic agents across a range of therapeutic fields. Both a reference and a call to action for the pharmaceutical industry, Development of Therapeutic Agents Handbook examines recent innovations taking shape in the various medical disciplines involved in drug discovery, and shows why these advances need to be embraced universally among researchers to improve their solution strategies. Additional subject matter includes: Extensive coverage and in-depth look into novel treatments and therapeutics Discussion of hot topics like new drugs and nutraceuticals, the discovery and development of vaccines, cancer therapeutics, and market overviews Coverage of therapeutic drug development for specific disease areas, such as cardiology, oncology, breast cancer, and kidney diseases As research in biology, chemistry, medicine, and technology rapidly progresses, it is becoming increasingly important for medical researchers to maintain an up-to-date knowledge base of emerging trends directing promising new therapies. Development of Therapeutic Agents Handbook serves this purpose, acting as both a one-stop reference rich in valid science, and a tool to carve out new pathways in the pursuit of bringing safer and more effective drugs to the marketplace.

Pharmacokinetic-Pharmacodynamic Modeling and Simulation

Author : Peter L. Bonate
Publisher : Springer Science & Business Media
ISBN 13 : 1441994858
Total Pages : 634 pages
Book Rating : 4.4/5 (419 download)

DOWNLOAD NOW!

Book Synopsis Pharmacokinetic-Pharmacodynamic Modeling and Simulation by : Peter L. Bonate

Download or read book Pharmacokinetic-Pharmacodynamic Modeling and Simulation written by Peter L. Bonate and published by Springer Science & Business Media. This book was released on 2011-07-01 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a second edition to the original published by Springer in 2006. The comprehensive volume takes a textbook approach systematically developing the field by starting from linear models and then moving up to generalized linear and non-linear mixed effects models. Since the first edition was published the field has grown considerably in terms of maturity and technicality. The second edition of the book therefore considerably expands with the addition of three new chapters relating to Bayesian models, Generalized linear and nonlinear mixed effects models, and Principles of simulation. In addition, many of the other chapters have been expanded and updated.

Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics

Author : Alexander A. Vinks
Publisher : Springer Science & Business Media
ISBN 13 : 0387756132
Total Pages : 467 pages
Book Rating : 4.3/5 (877 download)

DOWNLOAD NOW!

Book Synopsis Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics by : Alexander A. Vinks

Download or read book Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics written by Alexander A. Vinks and published by Springer Science & Business Media. This book was released on 2013-11-23 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development. The book will be designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader will be introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, and the translation of in vitro and animal model data to basic research and clinical situations in humans.

Polypharmacology in Drug Discovery

Author : Jens-Uwe Peters
Publisher : John Wiley & Sons
ISBN 13 : 0470590904
Total Pages : 542 pages
Book Rating : 4.4/5 (75 download)

DOWNLOAD NOW!

Book Synopsis Polypharmacology in Drug Discovery by : Jens-Uwe Peters

Download or read book Polypharmacology in Drug Discovery written by Jens-Uwe Peters and published by John Wiley & Sons. This book was released on 2012-03-13 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential outline of the main facets of polypharmacology in drug discovery research Extending drug discovery opportunities beyond the "one drug, one target" philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for treating bacterial infections, epilepsy, cancer, psychiatric disorders, and more. Filled with a collection of instructive case studies that reinforce the material and illuminate the subject, this practical guide: Covers the two-sided nature of polypharmacology—its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal articles Overviews state-of-the-art approaches and developments to help readers understand concepts and issues related to polypharmacology Fosters interdisciplinary drug discovery research by embracing computational, synthetic, in vitro and in vivo pharmacological and clinical aspects of polypharmacology A clear road map for helping readers successfully navigate around the problems involved with promiscuous ligands and targets, Polypharmacology in Drug Discovery provides real examples, in-depth explanations and discussions, and detailed reviews and opinions to spark inspiration for new drug discovery projects.

Pharmacokinetics and Toxicokinetic Considerations - Vol II

Author : Rakesh Kumar Tekade
Publisher : Academic Press
ISBN 13 : 0323913164
Total Pages : 816 pages
Book Rating : 4.3/5 (239 download)

DOWNLOAD NOW!

Book Synopsis Pharmacokinetics and Toxicokinetic Considerations - Vol II by : Rakesh Kumar Tekade

Download or read book Pharmacokinetics and Toxicokinetic Considerations - Vol II written by Rakesh Kumar Tekade and published by Academic Press. This book was released on 2022-02-05 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacokinetics and Toxicokinetic Considerations explains the central principles, cutting-edge methodologies, and incipient thought processes applied to toxicology research. As part of the Advances in Pharmaceutical Product Development and Research series, the book provides expert literature on dose, dosage regimen and dose adjustment, medication errors, and approaches for its prevention, the concept of pharmacotherapy, and managed care in clinical interventions. It expounds on strategies to revamp the pharmacokinetics of the drug and the factors affecting the stability of drugs and their metabolites in biological matrices. Finally, the book offers focused elaborations on various bioanalytical methods for bioavailability and bioequivalence assessment and integrates the wide-ranging principles and concepts shared by toxicokinetics and pharmacodynamics as mutual crosstalk rather than isolated observations. It will be helpful to researchers and advanced students working in the pharmaceutical, cosmetics, biotechnology, food, and related industries including toxicologists, pharmacists, and pharmacologists. Allows readers to systematically integrate up-to-date research findings into their laboratory work Presents focused explorations of bioanalytical methods for bioavailability and bioequivalence assessment Provides clinical applications of concepts

Anticancer Agents from Natural Products, Second Edition

Author : Gordon M. Cragg
Publisher : CRC Press
ISBN 13 : 1439813825
Total Pages : 786 pages
Book Rating : 4.4/5 (398 download)

DOWNLOAD NOW!

Book Synopsis Anticancer Agents from Natural Products, Second Edition by : Gordon M. Cragg

Download or read book Anticancer Agents from Natural Products, Second Edition written by Gordon M. Cragg and published by CRC Press. This book was released on 2011-10-10 with total page 786 pages. Available in PDF, EPUB and Kindle. Book excerpt: The approach to drug discovery from natural sources has yielded many important new pharmaceuticals inaccessible by other routes. In many cases the isolated natural product may not be an effective drug for any of several reasons, but it nevertheless may become a drug through chemical modification or have a novel pharmacophore for future drug design. In summarizing the status of natural products as cancer chemotherapeutics, Anticancer Agents from Natural Products, Second Edition covers the: History of each covered drug—a discussion of its mechanism on action, medicinal chemistry, synthesis, and clinical applications Potential for novel drug discovery through the use of genome mining as well as future developments in anticancer drug discovery Important biosynthetic approaches to "unnatural" natural products Anticancer Agents from Natural Products, Second Edition discusses how complex target-oriented synthesis—enabled by historic advances in methodology—has enormously expanded the scope of the possible. This book covers the current clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. It also reviews drug candidates currently in clinical development since many of these will be clinically used drugs in the future. Examples include the drugs etoposide and teniposide derived from the lead compound podophyllotoxin; numerous analogs derived from taxol; topotecan, derived from camptothecin; and the synthetic clinical candidates, E7389 and HTI-286, developed from the marine leads, halichondrin B and hemiasterlin.

Handbook of Anticancer Drug Development

Author : Daniel Budman
Publisher : Lippincott Raven
ISBN 13 : 9780781740104
Total Pages : 502 pages
Book Rating : 4.7/5 (41 download)

DOWNLOAD NOW!

Book Synopsis Handbook of Anticancer Drug Development by : Daniel Budman

Download or read book Handbook of Anticancer Drug Development written by Daniel Budman and published by Lippincott Raven. This book was released on 2003 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Perhaps no area of pharmacology has progressed further or faster than that of anticancer drugs. With this concise and informative resource, you'll explore the full spectrum of anticancer drug evolution -- from research and development, through clinical trials, to licensure and utilization.

Drug and Biological Development

Author : Ronald P. Evens
Publisher : Springer Science & Business Media
ISBN 13 : 0387329781
Total Pages : 394 pages
Book Rating : 4.3/5 (873 download)

DOWNLOAD NOW!

Book Synopsis Drug and Biological Development by : Ronald P. Evens

Download or read book Drug and Biological Development written by Ronald P. Evens and published by Springer Science & Business Media. This book was released on 2007-08-14 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a complete discussion of product development in the pharmaceutical and biotechnology industries from discovery, to product launch, through life cycle management. The book is organized for optimal usefulness in the education and training of health care professionals (MD, PharmD, PhD), at universities. The format is a set of figures, tables and lists, along with detailed narrative descriptions, including real-life examples, illustrations, controversies in industry, and references. The editors and authors of the book are industry and research experts in a variety of disciplines.