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Guidelines For Preclinical And Clinical Evaluation Of Agents Used In The Prevention Or Treatment Of Postmenopausal Osteoporosis
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Author :United States. Food and Drug Administration. Division of Metabolism and Endocrine Drug Products Publisher : ISBN 13 : Total Pages :20 pages Book Rating :4.:/5 (352 download)
Book Synopsis Guidelines for Preclinical and Clinical Evaluation of Agents Used in the Prevention Or Treatment of Postmenopausal Osteoporosis by : United States. Food and Drug Administration. Division of Metabolism and Endocrine Drug Products
Download or read book Guidelines for Preclinical and Clinical Evaluation of Agents Used in the Prevention Or Treatment of Postmenopausal Osteoporosis written by United States. Food and Drug Administration. Division of Metabolism and Endocrine Drug Products and published by . This book was released on 1994 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :United States. Food and Drug Administration. Division of Metabolism and Endocrine Drug Products Publisher : ISBN 13 : Total Pages :16 pages Book Rating :4.:/5 (319 download)
Book Synopsis Guidelines for the Clinical Evaluation of Drugs Used in the Treatment of Osteoporosis by : United States. Food and Drug Administration. Division of Metabolism and Endocrine Drug Products
Download or read book Guidelines for the Clinical Evaluation of Drugs Used in the Treatment of Osteoporosis written by United States. Food and Drug Administration. Division of Metabolism and Endocrine Drug Products and published by . This book was released on 1979 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Guidelines for Preclinical Evaluation and Clinical Trials in Osteoporosis by : World Health Organization
Download or read book Guidelines for Preclinical Evaluation and Clinical Trials in Osteoporosis written by World Health Organization and published by . This book was released on 1998-01-01 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive guidelines for the design, implementation, and interpretation of preclinical studies and clinical trials of agents undergoing investigation for the management of osteoporosis. Noting the magnitude of the public health problem caused by osteoporosis and related fractures, the book responds to the urgent need for a cohesive and rational approach to the search for new therapeutic or preventive agents. Recommended principles and methods reflect the consensus reached by a large number of international experts, representatives of the pharmaceutical industry, and drug regulatory authorities. The book opens with a brief discussion of the current and future public health problem caused by osteoporotic fractures, followed by conceptual and operational definitions of osteoporosis and a recommended classification of four intervention categories that facilitate the definition of treatment objectives and the design of targetted studies. Against this background, the next chapter offers a detailed guide to the aims, design, conduct and interpretation of preclinical studies. Specific recommendations are given for the selection of in vitro and animal models, the design of the study, including dose ranges and duration of treatment, and the most appropriate end-points for assessing efficacy. The most extensive chapter provides a comprehensive description of basic principles and methods to follow during clinical trials. Information ranges from a discussion of problems with the use of bone mineral density to predict fracture risk, through advice on the choice of tests and techniques for measuring the effects of interventions, to a discussion of general principles of trial design, including selection of study population, treatment regimen, duration of studies, sample size, and frequency of measurement. Drawing on these detailed principles and methods, subsequent chapters offer concise guidance specific to phase I and phase II studies, phase III studies in severe osteoporosis, phase III studies in osteoporosis without fragility fractures, and phase III studies in osteopenia. The book concludes with chapters outlining principles and methods for phase III clinical trials in subjects with normal bone mass, and for phase IV studies.
Book Synopsis Guidelines for Clinical Evaluation of Agents Used in the Treatment Or Prevention of Osteoporosis by : United States. Food and Drug Administration
Download or read book Guidelines for Clinical Evaluation of Agents Used in the Treatment Or Prevention of Osteoporosis written by United States. Food and Drug Administration and published by . This book was released on 1985 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Clinical Trials in Osteoporosis by : Derek Pearson
Download or read book Clinical Trials in Osteoporosis written by Derek Pearson and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Trials in Osteoporosis is a practical handbook on clinical trials in the growing field of osteoporosis. Topics covered include study design, technical issues, data collection, quality assurance, data analysis and presentation. It aims to take the user through the process step-by-step from start to finish, also providing a background on regulatory guidelines, ethical implications, endpoints, current therapies and the ideal drug to use. There are no other books at present that specifically address the issue of clinical trials in osteoporosis. A number of issues dealt with in this book have been brought together in one publication for the first time. Clinical Trials in Osteoporosis is intended to serve as a practical manual for clinicians and scientists coming to the subject new and to provide a standard for existing centers to measure themselves against.
Book Synopsis Guidelines for the Clinical Evaluation of Drugs Used in the Treatment of Osteoporosis by :
Download or read book Guidelines for the Clinical Evaluation of Drugs Used in the Treatment of Osteoporosis written by and published by . This book was released on 1979 with total page 5 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Prevention and Treatment of Osteoporosis in the High-Risk Patient by : Cyrus Cooper
Download or read book Prevention and Treatment of Osteoporosis in the High-Risk Patient written by Cyrus Cooper and published by CRC Press. This book was released on 2005-01-25 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: The outcome of recent clinical trials in osteoporosis was the impetus for this volume. In these studies of two bisphosphonates, an interaction between bone mineral density (BMD) and the treatment effect was seen, such that these agents appeared to lose their effect as BMD increased. To practitioners this is counter-intuitive. Why should treatment w
Book Synopsis Treatment of the Postmenopausal Woman by : Rogerio A. Lobo
Download or read book Treatment of the Postmenopausal Woman written by Rogerio A. Lobo and published by Elsevier. This book was released on 2007-06-05 with total page 902 pages. Available in PDF, EPUB and Kindle. Book excerpt: For anyone who treats postmenopausal women, this latest edition of Rogerio Lobo's classic work combines the best from two well-known references: Menopause, and the second edition of Treatment of the Postmenopausal Woman. By adding significant discussions of the basic science behind menopause, it is possible to objectively assess the clinical value and limitations of current approaches to treatment and provide a basis and rationale for strategies that will result in better individualized and specialized care. Not only does the third edition discuss diagnosis and treatment of menopause but it covers biological, anatomical, physiological, pathobiological, and pharmacological aspects as well bringing together, in one source, all of the information needed to understand and treat postmenopausal conditions. Over 50% new material representing the vast amount of information available since the Women's Health Initiative (WHI) clinical trials were completed making this the most up-to-date reference on postmenopausal women Includes several new sections on comparisons between clinical trials and observational data, urology, and pelvic support Each section is preceded by a preface to put the area into context with many chapters having suggested treatment regimens
Book Synopsis The IACUC Handbook, Second Edition by : Jerald Silverman
Download or read book The IACUC Handbook, Second Edition written by Jerald Silverman and published by CRC Press. This book was released on 2006-10-04 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its establishment by USDA regulation in the mid-1980s, the Institutional Animal Care and Use Committee (IACUC) has evolved as the premier instrument of animal welfare oversight within research institutions in the United States. By addressing questions and problems that often confront institutions, The IACUC Handbook, Second Edition provides accurate, succinct answers. It features comprehensive updates for all pertinent federal laws, regulations, and policies. It also contains an expanded survey of IACUC practices from institutions around the nation. With accessible information, this new editionprovides a foundation for those attempting to understand and implement the many and varied responsibilities of these committees.
Book Synopsis Osteoporosis, Two-Volume Set by : Robert Marcus
Download or read book Osteoporosis, Two-Volume Set written by Robert Marcus and published by Academic Press. This book was released on 2001-09-20 with total page 861 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteoporosis is the most comprehensive, authoritative reference on this disease. Some of the topics covered include basic biology, anatomy, physiology, pathophysiology, preclinical issues, experimental medicine, management, and therapeutics. Written by renowned experts in this field, this book is a must-have for the researcher, the academic clinician, or anyone in the field of bone biology. Key Features* The source on osteoporosis* Written by expert investigators in their respective fields* Each chapter provides timely, comprehensive, and scholarly discussion* Fully illustrated in color and black & white* Covers everything from basic anatomy and physiology to diagnosis, management and treatment
Author :Andrea Giustina Publisher :Karger Medical and Scientific Publishers ISBN 13 :3805572964 Total Pages :213 pages Book Rating :4.8/5 (55 download)
Book Synopsis Glucocorticoid-induced Osteoporosis by : Andrea Giustina
Download or read book Glucocorticoid-induced Osteoporosis written by Andrea Giustina and published by Karger Medical and Scientific Publishers. This book was released on 2002 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteoporosis is one of the most clinically relevant disabling chronic disease encountered in clinical practice. A common cause of osteoporosis is glucocorticoid excess, as glucocorticoids may increase bone resorption, inhibit bone formation, have indirect actions on bone by decreasing intestinal calcium absorption and induce hypercalciuria. This book presents a comprehensive overview of the effects of glucocorticoids on bone metabolism and structure and on the diagnosis and treatment of glucocorticoid-induced osteoporosis. It aims at providing updated information on the pathogenesis, diagnosis and treatment of this often dramatic complication of glucocorticoid excess. Being one of the few publications completely devoted to glucocorticoid-induced osteoporosis it will heighten the awareness of specialists who prescribe glucocorticoids of the clinical relevance of this treatment complication. 'Glucocorticoid-Induced Osteoporosis' is addressed to clinical experts as well as to general practitioners who will both benefit from the comprehensive and integrative view of the management of patients exposed to glucocorticoids.
Download or read book Federal Register written by and published by . This book was released on 2004 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Royal College of Physicians of London Publisher :Royal College of Physicians ISBN 13 :9781860160790 Total Pages :126 pages Book Rating :4.1/5 (67 download)
Book Synopsis Osteoporosis by : Royal College of Physicians of London
Download or read book Osteoporosis written by Royal College of Physicians of London and published by Royal College of Physicians. This book was released on 1999 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Federal Register Index written by and published by . This book was released on 2002 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Osteoporosis Research by : Gustavo Duque
Download or read book Osteoporosis Research written by Gustavo Duque and published by Springer Science & Business Media. This book was released on 2011-05-23 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteoporosis Research - Animal Models, presents in a very illustrative and practical manner, general methodologies of bone studies in animals, as well as the particular features of the most commonly used animal models in the field. Research in the field of osteoporosis has grown in recent years. This has resulted in significant advances in determining the causes of osteoporosis, assessing risk factors, and creating new treatment methods. The use of animal models provides important knowledge about pathological conditions that can eventually lead to the development of more effective clinical treatment of diseases in both humans and animals. Osteoporosis Research - Animal Models, is an essential tool for researchers in the bone field. This book aids researchers in selecting their appropriate model and highlights the experiments that can be strategically designed to optimize the potential of an animal to develop the cardinal features of osteoporosis in humans. This book addresses the importance of recent findings from animal models and their significance on the pathogenesis of osteoporosis in relation to human disease.
Book Synopsis Animal Models in Orthopaedic Research by : Yuehuei H. An
Download or read book Animal Models in Orthopaedic Research written by Yuehuei H. An and published by CRC Press. This book was released on 2020-04-30 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal Models in Orthopaedic Research is a reference book of the major animal models used in the study of orthopaedic conditions and in the in vivo study of biomaterials. Use of animal models provides important knowledge about pathological conditions that can eventually lead to the development of more effective clinical treatment of diseases in bot
Book Synopsis Principles of Osteoimmunology by : Peter Pietschmann
Download or read book Principles of Osteoimmunology written by Peter Pietschmann and published by Springer Science & Business Media. This book was released on 2011-11-29 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteoimmunology is a new and rapidly developing field of great importance. It deals with mechanisms and possible treatments of bone-related diseases, such as osteoporosis, rheumatoid arthritis and periodontitis, that are caused by or associated with a malfunctioning immune system. This book describes the basics of bone biology and of the immune system and provides insight into the molecular mechanisms of bone diseases. In addition, clinical data is presented and put into context with the newest research findings. It was intended for all scientists and physicians working in immunology, pathophysiology and osteology.
