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Author : Hemanth J. Varghese
Publisher :
ISBN 13 :
Total Pages : 340 pages
Book Rating : 4.:/5 (16 download)
Download or read book Growth, Microcirculation and Survival in Cancer Metastasis written by Hemanth J. Varghese and published by . This book was released on 2004 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : F. William Orr
Publisher : CRC Press
ISBN 13 : 9780849361548
Total Pages : 326 pages
Book Rating : 4.3/5 (615 download)
Download or read book Microcirculation in Cancer Metastasis written by F. William Orr and published by CRC Press. This book was released on 1991-07-25 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although mechanisms involved in the spread of cancer have been the subject of a major research endeavor over the past decade, metastatic tumors still account for significant clinical morbidity and the failure of cancer treatment. Not only are the vascular pathways the most common route for the dissemination of cancer cells, but interactions between the cells and the circulation act as important rate-regulators for the metastatic process. This authoritative, multi-authored volume addresses the importance of microcirculation in cancer metastasis. The book begins with up-to-date reviews on the biology of endothelial cells and the structure and physiology of the normal and tumor microcirculations, and then emphasizes interactions between components of the microcirculation and cancer cells. Metastasis is discussed through chapters exploring the entry of cancer cells into the circulation, the biophysics and morphology of cancer cell traffic and arrest, interactions with host cells and the basement membranes, and angiogenesis. This fascinating book will interest oncologists, pathologists, and students of metastasis or the microcirculation.
Author : Kenneth V. Honn
Publisher : Springer Science & Business Media
ISBN 13 : 146133831X
Total Pages : 637 pages
Book Rating : 4.4/5 (613 download)
Download or read book Hemostatic Mechanisms and Metastasis written by Kenneth V. Honn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Domenico Ribatti
Publisher : Springer Science & Business Media
ISBN 13 : 940074935X
Total Pages : 122 pages
Book Rating : 4.4/5 (7 download)
Download or read book Morphofunctional Aspects of Tumor Microcirculation written by Domenico Ribatti and published by Springer Science & Business Media. This book was released on 2012-09-29 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes abnormalities in the blood vessels of tumors, identifying a number of specific tumor endothelial markers, as well as chromosomal abnormalities. Shows how these markers may be used to deliver drugs selectively to the tumor microvasculature.
Author : Caterina A. M. La Porta
Publisher : Cambridge University Press
ISBN 13 : 1108150330
Total Pages : 187 pages
Book Rating : 4.1/5 (81 download)
Download or read book The Physics of Cancer written by Caterina A. M. La Porta and published by Cambridge University Press. This book was released on 2017-04-20 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have witnessed an increasing number of theoretical and experimental contributions to cancer research from different fields of physics, from biomechanics and soft-condensed matter physics to the statistical mechanics of complex systems. Reviewing these contributions and providing a sophisticated overview of the topic, this is the first book devoted to the emerging interdisciplinary field of cancer physics. Systematically integrating approaches from physics and biology, it includes topics such as cancer initiation and progression, metastasis, angiogenesis, cancer stem cells, tumor immunology, cancer cell mechanics and migration. Biological hallmarks of cancer are presented in an intuitive yet comprehensive way, providing graduate-level students and researchers in physics with a thorough introduction to this important subject. The impact of the physical mechanisms of cancer are explained through analytical and computational models, making this an essential reference for cancer biologists interested in cutting-edge quantitative tools and approaches coming from physics.
Author : David Lyden
Publisher : Cambridge University Press
ISBN 13 : 1139498754
Total Pages : 661 pages
Book Rating : 4.1/5 (394 download)
Download or read book Cancer Metastasis written by David Lyden and published by Cambridge University Press. This book was released on 2011-04-25 with total page 661 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metastasis is responsible for a large burden of morbidity and mortality among cancer patients, and currently few therapies specifically target metastatic disease. Further scientific dissection of the underlying pathways is required to pave the way for new therapeutic targets. This groundbreaking new text comprehensively covers the processes underlying cancer metastasis and the clinical treatment of metastatic disease. Whereas previous volumes have been compendia of laboratory research articles, the internationally renowned authors of this volume have summarized the state-of-the-art research in the metastasis field. A major section covers the cellular and molecular pathways of metastasis and experimental techniques and the systems and models applied in this field. Subsequently, the clinical aspects of the major cancer types are considered, focusing on disease-specific research and therapeutic approaches to metastatic disease. The focus is on novel pathophysiological insights and emerging therapies; future directions for research and unmet clinical needs are also discussed.
Author :
Publisher : Elsevier
ISBN 13 : 9780080490229
Total Pages : 285 pages
Book Rating : 4.4/5 (92 download)
Download or read book Advances in Cancer Research written by and published by Elsevier. This book was released on 2000-04-19 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here once again, outstanding and original reviews are presented. New Paradigms for the Treatment of Cancer: The Role of Anti-aiogenesis Agents The Hepatocyte Growth Factor/Met Pathway in Development, Tumorigenesis, and B-Cell Differentiation Clinical Targets for Anti-metastasis Therapy Animal Models of Melanoma: Recent Advances and Future Prospects The Indispensable Role of Microenvironment in the Natural History of Low-Grade B-Cell Neoplasms Epstein-Barr Virus Latency: LMP2, a Regulator or Means for Epstein-Barr Birus Biochemistry and Pathological Importance of Mucin-Associated Antigens in Gastrointenstinal Neoplasia Studies on Polyomavirus Persistence and Polyomavirus-Induced Tumor Development in Relation to the Immune System
Author : R. John Bicknell
Publisher :
ISBN 13 :
Total Pages : 416 pages
Book Rating : 4.3/5 (91 download)
Download or read book Tumour Angiogenesis written by R. John Bicknell and published by . This book was released on 1997 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumour Angiogenesis is the first comprehensive book to cover all areas of this rapidly expanding research area. Each chapter is written by world experts in the field and topics covered include in vivo models, mechanisms, inhibition, and the role of macrophages, cytokines, proteases,extracellular matrix components, nitric oxide, prostanoids and oncogenes/tumour suppressor genes in angiogenesis. Other chapters examine the role of specific growth factors in angiogenesis - these include vascular endothelial growth factor, the basic fibroblast growth factor family, transforminggrowth factor-beta, tumour necrosis factor-alpha, platelet-derived endothelial cell growth factor/thymidine phosphorylase and pleiotrophin and related molecules. Clinical issues are addressed in chapters that deal with the prognostic and predictive value of tumour microvessel density and thetherapeutic significance of microregional blood flow. The two final chapters examine the feasibility of targeting tumour vasculature using either antibodies or gene therapy.
Author :
Publisher :
ISBN 13 :
Total Pages : 884 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2005 with total page 884 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Domenico Ribatti
Publisher : Springer
ISBN 13 : 3319684485
Total Pages : 111 pages
Book Rating : 4.3/5 (196 download)
Download or read book Inflammation and Angiogenesis written by Domenico Ribatti and published by Springer. This book was released on 2017-11-08 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is focused on the analysis of the role played by immune cell components in the angiogenic process associated with inflammation and tumor growth. Both innate and adaptive immune cells are involved in the mechanisms of endothelial cell proliferation, migration and activation, through the production and release of a large spectrum of pro-angiogenic mediators. These may create the specific microenvironment that favors an increased rate of tissue vascularization. The link between chronic inflammation and tumorigenesis was first proposed by Rudolf Virchow in 1863 after the observation that infiltrating leukocytes are a hallmark of tumors and first established a causative connection between the lymph reticular infiltrate at sites of chronic inflammation and the development of cancer. Tumors were described as wounds that never heal and surgeons have long described the tendency of tumors to recur in healing resection margin and it has been reported that wound healing environment provides an opportunistic matrix for tumor growth. As angiogenesis is the result of a net balance between the activities exerted by positive and negative regulators, this book will also provide information on some anti-angiogenic properties of immune cells that may be utilized for a potential pharmacological use as anti-angiogenic agents in inflammation as well as in cancer. The work is written for researchers in the field and also for graduate students which approach this matter.
Author : Stanley P. Leong
Publisher : Springer Nature
ISBN 13 : 303093084X
Total Pages : 785 pages
Book Rating : 4.0/5 (39 download)
Download or read book Cancer Metastasis Through the Lymphovascular System written by Stanley P. Leong and published by Springer Nature. This book was released on 2022-06-24 with total page 785 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook describes in detail the process of cancer metastasis from a single cell in the primary site through its arduous journey to the sentinel lymph node as the main gateway and beyond to distant sites. The most up-to-date knowledge on key topics in the molecular biology, diagnosis, and treatment of metastatic cancer is highlighted by a large panel of experts. The book begins with a comprehensive overview of the genetic and molecular mechanisms that promote or inhibit cancer metastasis through lymphatic pathways to lymph nodes or through vascular pathways to distant sites, providing the reader with an essential basic knowledge. This is followed by further details on the role of the immune system within the primary tumor and the lymph node and the importance of the microenvironment at the metastatic site. The role of the sentinel lymph node in cancer metastasis is emphasized. Special attention is also given to state-of-the-art imaging techniques for the detection of early-stage cancer and cancer metastases, as well as the use of liquid biopsies in sarcoma, prostate, gastrointestinal, and lung cancer. Clinical patterns of malignant tumors arising in different organ systems are compared, described, and discussed with the goal of determining what similarities and/or differences exist. The book concludes with a detailed discussion of surgical intervention, radiation, and systemic therapy of primary and metastatic cancer, and briefly previews several emerging topics, such as the latest findings on personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis and the application of artificial intelligence in cancer metastasis research. By providing fundamental knowledge of the biological and clinical aspects of cancer metastasis, this book will be an important reference for cancer researchers, clinical oncologists, teachers, and students. Written by experts in the field, each chapter includes a summary of the chapter's key points and open-ended questions that address pressing issues in the field and encourage the reader to consider future directions.
Author : D.R. Welch
Publisher : Springer Science & Business Media
ISBN 13 : 0306478218
Total Pages : 275 pages
Book Rating : 4.3/5 (64 download)
Download or read book Cancer Metastasis — Related Genes written by D.R. Welch and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Being diagnosed with cancer is devastating. But when the cancer cells have to spread to form secondary colonies, the prognosis for the patient is worse. If meaningful improvements in survival are to occur, then control of metastasis will be a foundation. Relatively little is known about the control of the metastatic process at the molecular level. This volume begins to explore our current knowledge regarding the underlying molecular and biochemical mechanisms controlling the metastatic phenotype. While all of the authors attempted to put their findings into a context for translation to the clinical situation, the state-of-the-art does not fully allow this. Nonetheless, we write these summaries of our work as an early effort toward that end. I am grateful to all of the authors who have contributed generously of their time and energies to make this volume a reality. To metastasize, neoplastic cells dissociate from the primary tumor, enter a circulatory compartment (typically lymphatics or blood vasculature), survive transport, arrest, exit the circulation and finally proliferate at a discontinuous site in response to local growth factors. Unless cells accomplish every step of the metastatic cascade, metastases cannot develop. The process is highly inefficient, i. e. ,
Author : Hans E. Kaiser
Publisher : Springer Science & Business Media
ISBN 13 : 1402067291
Total Pages : 251 pages
Book Rating : 4.4/5 (2 download)
Download or read book Selected Aspects of Cancer Progression: Metastasis, Apoptosis and Immune Response written by Hans E. Kaiser and published by Springer Science & Business Media. This book was released on 2008-05-20 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: The processes of tumor metastasis, apoptosis and anti-tumor immune response are among the most complex yet rapidly advancing fields in the area of cancer research. This monograph, with its leading authorship, presents a comprehensive coverage of the recent advances in the various key concepts in these fundamental aspects of human cancer. It contains state-of-the-science reviews on invasion, metastasis, angiogenesis, apoptosis and immunologic aspects related to cancer.
Author :
Publisher :
ISBN 13 :
Total Pages : 660 pages
Book Rating : 4.E/5 ( download)
Download or read book Cancer Research written by and published by . This book was released on 2009-11 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Domenico Ribatti
Publisher : Academic Press
ISBN 13 : 0128194944
Total Pages : 198 pages
Book Rating : 4.1/5 (281 download)
Download or read book Tumor Vascularization written by Domenico Ribatti and published by Academic Press. This book was released on 2020-01-21 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels. Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment
Author : H.M. Pinedo
Publisher : Springer Science & Business Media
ISBN 13 : 1461317576
Total Pages : 143 pages
Book Rating : 4.4/5 (613 download)
Download or read book Treatment of Soft Tissue Sarcomas written by H.M. Pinedo and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the major advances of the last decade concerning the treatment of patients with soft tissue sarcomas is that an increased number of patients are being discussed in multidisciplinary teams prior to the initial treatment. The present volume on soft tissue sarcomas in the series Cancer Treatment and Research reflects the multidisciplinary approach with a focus on recent developments. The availability of new histopathologic techniques has reduced the number of unclassified sarcomas and has furhter increased the importance of the histo pathologist in providing estimates of the prognosis of the patient as well as data for the planning of treatment strategy. Further data for this strategy will be provided by diagnostic imaging. In this field, the role of magnetic reson ance imaging has been further defined. Of utmost importance is the recent trend toward consensus in staging. The modification of the staging system of the American Joint Commission for Cancer Staging and End Results Report ing brings the possibility of a single staging system within reach in the next decade. As surgery still provides the only chance for cure, the importance of being the most sparing as possible is obvious. For this reason, radiotherapy has been applied with success. The introduction of relatively new radiation tech niques is therefore being observed with interest.
Author : John H. Barker
Publisher : Routledge
ISBN 13 : 0429536909
Total Pages : 485 pages
Book Rating : 4.4/5 (295 download)
Download or read book Clinically Applied Microcirculation Research written by John H. Barker and published by Routledge. This book was released on 2019-06-04 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1995: Clinically Applied Microcirculation Research combines state-of-the-art microcirculation technology with present and potential applications in clinical medicine. This comprehensive guide unites the expertise of clinicians and basic researchers from around the world. Many of the chapters are authored by scientist/physician teams. The book provides a broad overview of how microcirculation is involved in clinical research. This is also a valuable reference source for both the history of and latest developments in microcirculation research.
