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Author : John Harold Talbott
Publisher : Thieme Medical Publishers
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.3/5 (91 download)
Download or read book Gout and Uric Acid Metabolism written by John Harold Talbott and published by Thieme Medical Publishers. This book was released on 1976 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Oded Sperling
Publisher : Springer Science & Business Media
ISBN 13 : 1475714335
Total Pages : 453 pages
Book Rating : 4.4/5 (757 download)
Download or read book Purine Metabolism in Man written by Oded Sperling and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gout and urie acid lithiasis are known to have affected mankind for thousands of years. It is only recently, however, that great progress has been made in the understanding of the processes involved in purine metabolism and its disorders in man. The key enzymes active in the various pathways of purine synthesis and degradation have become known and their properties are the subject of intensive study. Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. Mutations of other enzymes involved in purine metabolism are being discovered. A great step forward has been made in the treatment of gout with the introduction of uricosuric drugs and more recently of the hypoxanthine analogue allopurinol, a synthetic xanthine oxidase inhibitor. Furthermore, the complex nature of the renal handling of urie acid excretion, although still posing difficult problems, appears to approach clari fication.
Author : Francis H. McCrudden
Publisher :
ISBN 13 :
Total Pages : 330 pages
Book Rating : 4.A/5 ( download)
Download or read book Uric Acid written by Francis H. McCrudden and published by . This book was released on 1905 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John H. Talbott
Publisher :
ISBN 13 :
Total Pages : 303 pages
Book Rating : 4.:/5 (63 download)
Download or read book Gout written by John H. Talbott and published by . This book was released on 1976 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Oded Sperling
Publisher : Springer
ISBN 13 :
Total Pages : 558 pages
Book Rating : 4.:/5 (89 download)
Download or read book Purine Metabolism in Man written by Oded Sperling and published by Springer. This book was released on 1974-03 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gout and urie acid lithiasis are known to have affected mankind for thousands of years. It is only recently, however, that great progress has been made in the understanding of the processes involved in purine metabolism and its disorders in man. The key enzymes active in the various pathways of purine synthesis and degradation have become known and their properties are the subject of intensive study. Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. Mutations of other enzymes involved in purine metabolism are being discovered. A great step forward has been made in the treatment of gout with the introduction of uricosuric drugs and more recently of the hypoxanthine analogue allopurinol, a synthetic xanthine oxidase inhibitor. Furthermore, the complex nature of the renal handling of urie acid excretion, although still posing difficult problems, appears to approach clari fication.
Author : Mathias M. Muller
Publisher : Springer Science & Business Media
ISBN 13 : 1468432850
Total Pages : 396 pages
Book Rating : 4.4/5 (684 download)
Download or read book Purine Metabolism in Man—II written by Mathias M. Muller and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of gouty arthritis has provided a common meeting ground for the research interests of both the basic scientist and the clinician. The interest of the chemist in gout began 1776 with the isolation of uric acid from a concretion of the urinary tract by the Swedish chemist SCHEELE. The same substance was subsequently extracted from a gouty tophus by the British chemist WOLLASTONE in 1797 and a half century later the cause of the deposits of sodium urate In such tophi was traced to a hyperuricemia in the serum of gouty patients by the British physician Alfred Baring GARROD who had also received training in the chemical laboratory and was therefore a fore-runner of many of today's clinician-investigators. The recent surge of progress in understanding of some of the causes of gout in terms of specific enzyme defects marks the entrance of the biochemist into this field of investigation. The identification of the first primary defect of purine metabolism associated with over-production of uric acid, a severe or partial deficiency of the enzyme hypoxanthine-guanine phospho ribosyl transferase was achieved less than a decade ago. The knowledge of the mechanism of purine over-production that it generated led shortly to the identification of families carrying a dominantly (possibly X-linked) inherited increase in the activity of the enzyme phosphoribosylpyrophosphate synthetase as a cause of purine over-production. Yet this is only a start as these two types of enzyme defects account for less than five per cent of gouty patients.
Author :
Publisher :
ISBN 13 :
Total Pages : 336 pages
Book Rating : 4.3/5 (91 download)
Download or read book Proceedings of Conference on Gout and Purine Metabolism written by and published by . This book was released on 1965 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : W.N. Kelley
Publisher : Springer
ISBN 13 : 9783642668685
Total Pages : 642 pages
Book Rating : 4.6/5 (686 download)
Download or read book Uric Acid written by W.N. Kelley and published by Springer. This book was released on 2012-01-05 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: Uric acid has attracted the attention of scientists from a broad spectrum of disciplines, and in recent years dramatic progress has occurred within many of these disciplines. This volume is designed to fill void in the field. Major works in the past five years have provided comprehensive reviews of disorders of uric acid metabolism for the clinical (1-3) as well as short reports of recent progress for the interested scholar (4, 5). In Uric Acid the reader will find extensive reviews of relevant topics selected largely by virtue of recent progress in the field and written by those who, to a considerable extent, qre responsible for that progress. Seven chapters are dedicated to a description of uric acid synthesis, its control, diseases resulting from aberrations in the pathway, and effects of intermediates and end products of this pathway on other metabolic processes. The next five chapters describe our current understanding of the mechanisms by which uric acid is elimi nated by the organism. Then seven chapters review the factors responsible for the human "disease" produced by uric acid in the joints and kidneys. The final four chapters provide a summary of therapeutic approaches to control gout, the most important disease caused per se by uric acid.
Author : Mathias M Muller
Publisher : Springer
ISBN 13 : 9781468432862
Total Pages : 396 pages
Book Rating : 4.4/5 (328 download)
Download or read book Purine Metabolism in Man-II written by Mathias M Muller and published by Springer. This book was released on 2014-01-15 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : A. Rapado
Publisher : Springer Science & Business Media
ISBN 13 : 1461591406
Total Pages : 433 pages
Book Rating : 4.4/5 (615 download)
Download or read book Purine Metabolism in Man-III written by A. Rapado and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mathias M. Muller
Publisher : Springer
ISBN 13 : 9781461342250
Total Pages : 641 pages
Book Rating : 4.3/5 (422 download)
Download or read book Purine Metabolism in Man—II written by Mathias M. Muller and published by Springer. This book was released on 2012-12-27 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of gouty arthritis has provided a common meeting ground for the research interests of both the basic scientist and the clinician. The interest of the chemist in gout began 1776 with the isolation of uric acid from a concretion of the urinary tract by the Swedish chemist SCHEELE. The same substance was subsequently extracted from a gouty tophus by the British chemist WOLLASTONE in 1797 and a half century later the cause of the deposits of sodium urate in such tophi was traced to a hyperuricemia in the serum of gouty patients by the British physician Alfred Baring GARROD who had also received training in the chemical laboratory and was therefore a fore-runner of many of today's clinician-investigators. The recent surge of progress in understanding of some of the causes of gout in terms of specific enzyme defects marks the entrance of the biochemist into this field of investigation. The identification of the first primary defect of purine metabolism associated with over-production of uric acid, a severe or partial deficiency of the enzyme hypoxanthine-guanine phospho ribosyltransferase was achieved less than a decade ago. The knowledge of the mechanism of purine over-production that it generated led shortly to the identification of families carrying a dominantly (possibly X-linked) inherited increase in the activity of the enzyme phosphoribosylpyrophosphate synthetase as a cause of purine over-production. Yet this is only a start as these two types of enzyme defects account for less than five per cent of gouty patients.
Author : Francis H McCrudden
Publisher : Legare Street Press
ISBN 13 : 9781020078620
Total Pages : 0 pages
Book Rating : 4.0/5 (786 download)
Download or read book Uric Acid written by Francis H McCrudden and published by Legare Street Press. This book was released on 2023-07-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive scientific study explores the complex role of uric acid and purin bodies in the human body, with a particular focus on their impact on conditions like gout. Written by Francis H. McCrudden, this book is an essential resource for anyone interested in the biochemistry of human health. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
Author : Oded Sperling
Publisher : Springer
ISBN 13 : 9781468432961
Total Pages : 366 pages
Book Rating : 4.4/5 (329 download)
Download or read book Purine Metabolism in Man written by Oded Sperling and published by Springer. This book was released on 2013-02-25 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gout and uric acid lithiasis are known to have affected mankind for thousands of years. It is only recently, however, that great progress has been made in the understanding of the processes involved in purine metabolism and its disorders in man. The key enzymes active in the various pathways of purine synthesis and degradation have become known and their properties are the subject of intensive study. Major contributions to the knowledge of normal purine metabolism in man have derived from the study of inborn errors in patients with purine disorders, specifically complete and partial hypoxanthine-guanine phosphoribosyltransferase deficiency. Mutations of other enzymes involved in purine metabolism are being discovered. A great step forward has been made in the treatment of gout with the introduction of uricosuric drugs and more recently of the hypoxanthine analogue allopurinol, a synthetic xanthine oxidase inhibitor. Furthermore, the complex nature of the renal handling of uric acid excretion, although still posing difficult problems, appears to approach clari fication.
Author : Mathias M. Muller
Publisher : Springer
ISBN 13 : 9780306390890
Total Pages : 641 pages
Book Rating : 4.3/5 (98 download)
Download or read book Purine Metabolism in Man—II written by Mathias M. Muller and published by Springer. This book was released on 1977-03-01 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of gouty arthritis has provided a common meeting ground for the research interests of both the basic scientist and the clinician. The interest of the chemist in gout began 1776 with the isolation of uric acid from a concretion of the urinary tract by the Swedish chemist SCHEELE. The same substance was subsequently extracted from a gouty tophus by the British chemist WOLLASTONE in 1797 and a half century later the cause of the deposits of sodium urate in such tophi was traced to a hyperuricemia in the serum of gouty patients by the British physician Alfred Baring GARROD who had also received training in the chemical laboratory and was therefore a fore-runner of many of today's clinician-investigators. The recent surge of progress in understanding of some of the causes of gout in terms of specific enzyme defects marks the entrance of the biochemist into this field of investigation. The identification of the first primary defect of purine metabolism associated with over-production of uric acid, a severe or partial deficiency of the enzyme hypoxanthine-guanine phospho ribosyltransferase was achieved less than a decade ago. The knowledge of the mechanism of purine over-production that it generated led shortly to the identification of families carrying a dominantly (possibly X-linked) inherited increase in the activity of the enzyme phosphoribosylpyrophosphate synthetase as a cause of purine over-production. Yet this is only a start as these two types of enzyme defects account for less than five per cent of gouty patients.
Author : James B. Wyngaarden
Publisher :
ISBN 13 :
Total Pages : 538 pages
Book Rating : 4.3/5 (91 download)
Download or read book Gout and Hyperuricemia written by James B. Wyngaarden and published by . This book was released on 1976 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (141 download)
Download or read book Purine Metabolism in Man, Biochemistry and Pharmacology of Uric Acid Metabolism written by and published by . This book was released on 1974 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Oded Sperling
Publisher : Springer
ISBN 13 : 9781468432954
Total Pages : 404 pages
Book Rating : 4.4/5 (329 download)
Download or read book Purine Metabolism in Man written by Oded Sperling and published by Springer. This book was released on 2014-01-15 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:
