Good News - Bad News: The Two Faces of Immune Privilege

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889193314
Total Pages : 110 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Good News - Bad News: The Two Faces of Immune Privilege by : Rachel R. Caspi

Download or read book Good News - Bad News: The Two Faces of Immune Privilege written by Rachel R. Caspi and published by Frontiers Media SA. This book was released on 2014-11-19 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immune privilege was once thought to be the property of a few select sites that include the eye, brain, testis, pregnant uterus and (of all things) the hamster cheek pouch, and was believed to be mainly based on sequestration behind blood-tissue barriers. This view has changed. Immune privilege is now considered to constitute a more general phenomenon through which tissues are able to actively direct and control immune responses taking place in their “territory” to preserve their structural and functional integrity in the face of inflammatory processes. These positive aspects of immune privilege can be hijacked by tumors to their survival advantage and to the detriment of the host. This Research Topic dissects the beneficial and deleterious consequences of immune privilege in terms of the cellular and molecular mechanisms that various tissues and tumors use, each in its own fashion, to regulate immune processes that affect them, at the local and the systemic level.

Between the World and Me

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Publisher : One World
ISBN 13 : 0679645985
Total Pages : 163 pages
Book Rating : 4.6/5 (796 download)

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Book Synopsis Between the World and Me by : Ta-Nehisi Coates

Download or read book Between the World and Me written by Ta-Nehisi Coates and published by One World. This book was released on 2015-07-14 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: #1 NEW YORK TIMES BESTSELLER • NATIONAL BOOK AWARD WINNER • NAMED ONE OF TIME’S TEN BEST NONFICTION BOOKS OF THE DECADE • PULITZER PRIZE FINALIST • NATIONAL BOOK CRITICS CIRCLE AWARD FINALIST • ONE OF OPRAH’S “BOOKS THAT HELP ME THROUGH” • NOW AN HBO ORIGINAL SPECIAL EVENT Hailed by Toni Morrison as “required reading,” a bold and personal literary exploration of America’s racial history by “the most important essayist in a generation and a writer who changed the national political conversation about race” (Rolling Stone) NAMED ONE OF THE MOST INFLUENTIAL BOOKS OF THE DECADE BY CNN • NAMED ONE OF PASTE’S BEST MEMOIRS OF THE DECADE • NAMED ONE OF THE TEN BEST BOOKS OF THE YEAR BY The New York Times Book Review • O: The Oprah Magazine • The Washington Post • People • Entertainment Weekly • Vogue • Los Angeles Times • San Francisco Chronicle • Chicago Tribune • New York • Newsday • Library Journal • Publishers Weekly In a profound work that pivots from the biggest questions about American history and ideals to the most intimate concerns of a father for his son, Ta-Nehisi Coates offers a powerful new framework for understanding our nation’s history and current crisis. Americans have built an empire on the idea of “race,” a falsehood that damages us all but falls most heavily on the bodies of black women and men—bodies exploited through slavery and segregation, and, today, threatened, locked up, and murdered out of all proportion. What is it like to inhabit a black body and find a way to live within it? And how can we all honestly reckon with this fraught history and free ourselves from its burden? Between the World and Me is Ta-Nehisi Coates’s attempt to answer these questions in a letter to his adolescent son. Coates shares with his son—and readers—the story of his awakening to the truth about his place in the world through a series of revelatory experiences, from Howard University to Civil War battlefields, from the South Side of Chicago to Paris, from his childhood home to the living rooms of mothers whose children’s lives were taken as American plunder. Beautifully woven from personal narrative, reimagined history, and fresh, emotionally charged reportage, Between the World and Me clearly illuminates the past, bracingly confronts our present, and offers a transcendent vision for a way forward.

Communities in Action

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Publisher : National Academies Press
ISBN 13 : 0309452961
Total Pages : 583 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Communities in Action by : National Academies of Sciences, Engineering, and Medicine

Download or read book Communities in Action written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-04-27 with total page 583 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the United States, some populations suffer from far greater disparities in health than others. Those disparities are caused not only by fundamental differences in health status across segments of the population, but also because of inequities in factors that impact health status, so-called determinants of health. Only part of an individual's health status depends on his or her behavior and choice; community-wide problems like poverty, unemployment, poor education, inadequate housing, poor public transportation, interpersonal violence, and decaying neighborhoods also contribute to health inequities, as well as the historic and ongoing interplay of structures, policies, and norms that shape lives. When these factors are not optimal in a community, it does not mean they are intractable: such inequities can be mitigated by social policies that can shape health in powerful ways. Communities in Action: Pathways to Health Equity seeks to delineate the causes of and the solutions to health inequities in the United States. This report focuses on what communities can do to promote health equity, what actions are needed by the many and varied stakeholders that are part of communities or support them, as well as the root causes and structural barriers that need to be overcome.

The Two Kinds of Decay

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Publisher : Macmillan + ORM
ISBN 13 : 1429940980
Total Pages : 194 pages
Book Rating : 4.4/5 (299 download)

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Book Synopsis The Two Kinds of Decay by : Sarah Manguso

Download or read book The Two Kinds of Decay written by Sarah Manguso and published by Macmillan + ORM. This book was released on 2009-05-26 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: A poet and author recounts her nine-year struggle with a rare autoimmune disease in this spare and unsparing memoir of illness and recovery. At twenty-one, just as she was starting to comprehend the puzzles of adulthood, Sarah Manguso was faced with another: a wildly unpredictable disease that appeared suddenly and tore through her twenties, paralyzing her for weeks at a time, programming her first to expect nothing from life and then, furiously, to expect everything. In this captivating story, Manguso recalls her struggle: arduous blood cleansings, collapsed veins, multiple chest catheters, the deaths of friends and strangers, addiction, depression, and, worst of all for a writer, the trite metaphors that accompany prolonged illness. A book of tremendous grace and self-awareness, The Two Kinds of Decay transcends the very notion of what an illness story can and should be. Praise for The Two Kinds of Decay A New York Times Book Review Editors’ Choice Best Book of the Year, San Francisco Chronicle and Time Out Chicago “Moving . . . a fiercely truthful memoir.” —The Boston Globe “Hers is not a day-by-day description of this grueling time, but an impressionistic text filled with bright, poetic flashes. . . . Many sick people learn to live in the moment, but the power of Manguso’s writing makes that truism revelatory.” —The Washington Post Book World “Sarah Manguso has miraculously elevated the act of memory. She has found honesty, fear, longing and beauty in every moment of her young life, giving this book an intensity found nowhere else. You put it down panting with wonder and grief, but never with pity. A breakthrough in the memoir, and in writing.” —Andrew Sean Greer

Rage

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Publisher : Simon and Schuster
ISBN 13 : 1982131764
Total Pages : 480 pages
Book Rating : 4.9/5 (821 download)

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Book Synopsis Rage by : Bob Woodward

Download or read book Rage written by Bob Woodward and published by Simon and Schuster. This book was released on 2020-09-15 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rage is an unprecedented and intimate tour de force of new reporting on the Trump presidency facing a global pandemic, economic disaster and racial unrest. Woodward, the #1 international bestselling author of Fear: Trump in the White House, has uncovered the precise moment the president was warned that the Covid-19 epidemic would be the biggest national security threat to his presidency. In dramatic detail, Woodward takes readers into the Oval Office as Trump’s head pops up when he is told in January 2020 that the pandemic could reach the scale of the 1918 Spanish Flu that killed 675,000 Americans. In 17 on-the-record interviews with Woodward over seven volatile months—an utterly vivid window into Trump’s mind—the president provides a self-portrait that is part denial and part combative interchange mixed with surprising moments of doubt as he glimpses the perils in the presidency and what he calls the “dynamite behind every door.” At key decision points, Rage shows how Trump’s responses to the crises of 2020 were rooted in the instincts, habits and style he developed during his first three years as president. Revisiting the earliest days of the Trump presidency, Rage reveals how Secretary of Defense James Mattis, Secretary of State Rex Tillerson and Director of National Intelligence Dan Coats struggled to keep the country safe as the president dismantled any semblance of collegial national security decision making. Rage draws from hundreds of hours of interviews with firsthand witnesses as well as participants’ notes, emails, diaries, calendars and confidential documents. Woodward obtained 25 never-seen personal letters exchanged between Trump and North Korean leader Kim Jong Un, who describes the bond between the two leaders as out of a “fantasy film.” Trump insists to Woodward he will triumph over Covid-19 and the economic calamity. “Don’t worry about it, Bob. Okay?” Trump told the author in July. “Don’t worry about it. We’ll get to do another book. You’ll find I was right.”

Global Trends 2040

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Author :
Publisher : Cosimo Reports
ISBN 13 : 9781646794973
Total Pages : 158 pages
Book Rating : 4.7/5 (949 download)

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Book Synopsis Global Trends 2040 by : National Intelligence Council

Download or read book Global Trends 2040 written by National Intelligence Council and published by Cosimo Reports. This book was released on 2021-03 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The ongoing COVID-19 pandemic marks the most significant, singular global disruption since World War II, with health, economic, political, and security implications that will ripple for years to come." -Global Trends 2040 (2021) Global Trends 2040-A More Contested World (2021), released by the US National Intelligence Council, is the latest report in its series of reports starting in 1997 about megatrends and the world's future. This report, strongly influenced by the COVID-19 pandemic, paints a bleak picture of the future and describes a contested, fragmented and turbulent world. It specifically discusses the four main trends that will shape tomorrow's world: - Demographics-by 2040, 1.4 billion people will be added mostly in Africa and South Asia. - Economics-increased government debt and concentrated economic power will escalate problems for the poor and middleclass. - Climate-a hotter world will increase water, food, and health insecurity. - Technology-the emergence of new technologies could both solve and cause problems for human life. Students of trends, policymakers, entrepreneurs, academics, journalists and anyone eager for a glimpse into the next decades, will find this report, with colored graphs, essential reading.

A Promise for the Baby

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Publisher : Harlequin
ISBN 13 : 1460324544
Total Pages : 195 pages
Book Rating : 4.4/5 (63 download)

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Book Synopsis A Promise for the Baby by : Jennifer Lohmann

Download or read book A Promise for the Baby written by Jennifer Lohmann and published by Harlequin. This book was released on 2014-01-01 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: He always does the right thing There's one exception to Karl Milek's rule—the Vegas weekend that leaves him with a night to remember, and a beautiful new wife he'd rather forget. Those divorce papers are put on hold, however, when Vivian shows up on his doorstep pregnant. Karl offers her shelter and everything else she needs until their baby is born. Yet soon he realizes that he could definitely get used to seeing Vivian in the mornings, sharing dinner with her at night…and inhaling her jasmine scent. But he doesn't think he can risk giving his wife the one thing she wants most—his love.

The Plague Year

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Publisher : Vintage
ISBN 13 : 0593320735
Total Pages : 417 pages
Book Rating : 4.5/5 (933 download)

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Book Synopsis The Plague Year by : Lawrence Wright

Download or read book The Plague Year written by Lawrence Wright and published by Vintage. This book was released on 2021-06-08 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the Pulitzer Prize–winning author of The Looming Tower, and the pandemic novel The End of October: an unprecedented, momentous account of Covid-19—its origins, its wide-ranging repercussions, and the ongoing global fight to contain it "A book of panoramic breadth ... managing to surprise us about even those episodes we … thought we knew well … [With] lively exchanges about spike proteins and nonpharmaceutical interventions and disease waves, Wright’s storytelling dexterity makes all this come alive.” —The New York Times Book Review From the fateful first moments of the outbreak in China to the storming of the U.S. Capitol to the extraordinary vaccine rollout, Lawrence Wright’s The Plague Year tells the story of Covid-19 in authoritative, galvanizing detail and with the full drama of events on both a global and intimate scale, illuminating the medical, economic, political, and social ramifications of the pandemic. Wright takes us inside the CDC, where a first round of faulty test kits lost America precious time . . . inside the halls of the White House, where Deputy National Security Adviser Matthew Pottinger’s early alarm about the virus was met with confounding and drastically costly skepticism . . . into a Covid ward in a Charlottesville hospital, with an idealistic young woman doctor from the town of Little Africa, South Carolina . . . into the precincts of prediction specialists at Goldman Sachs . . . into Broadway’s darkened theaters and Austin’s struggling music venues . . . inside the human body, diving deep into the science of how the virus and vaccines function—with an eye-opening detour into the history of vaccination and of the modern anti-vaccination movement. And in this full accounting, Wright makes clear that the medical professionals around the country who’ve risked their lives to fight the virus reveal and embody an America in all its vulnerability, courage, and potential. In turns steely-eyed, sympathetic, infuriated, unexpectedly comical, and always precise, Lawrence Wright is a formidable guide, slicing through the dense fog of misinformation to give us a 360-degree portrait of the catastrophe we thought we knew.

United States Attorneys' Manual

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Publisher :
ISBN 13 :
Total Pages : 720 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis United States Attorneys' Manual by : United States. Department of Justice

Download or read book United States Attorneys' Manual written by United States. Department of Justice and published by . This book was released on 1985 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Parenting Matters

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Publisher : National Academies Press
ISBN 13 : 0309388570
Total Pages : 525 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Parenting Matters by : National Academies of Sciences, Engineering, and Medicine

Download or read book Parenting Matters written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-11-21 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: Decades of research have demonstrated that the parent-child dyad and the environment of the familyâ€"which includes all primary caregiversâ€"are at the foundation of children's well- being and healthy development. From birth, children are learning and rely on parents and the other caregivers in their lives to protect and care for them. The impact of parents may never be greater than during the earliest years of life, when a child's brain is rapidly developing and when nearly all of her or his experiences are created and shaped by parents and the family environment. Parents help children build and refine their knowledge and skills, charting a trajectory for their health and well-being during childhood and beyond. The experience of parenting also impacts parents themselves. For instance, parenting can enrich and give focus to parents' lives; generate stress or calm; and create any number of emotions, including feelings of happiness, sadness, fulfillment, and anger. Parenting of young children today takes place in the context of significant ongoing developments. These include: a rapidly growing body of science on early childhood, increases in funding for programs and services for families, changing demographics of the U.S. population, and greater diversity of family structure. Additionally, parenting is increasingly being shaped by technology and increased access to information about parenting. Parenting Matters identifies parenting knowledge, attitudes, and practices associated with positive developmental outcomes in children ages 0-8; universal/preventive and targeted strategies used in a variety of settings that have been effective with parents of young children and that support the identified knowledge, attitudes, and practices; and barriers to and facilitators for parents' use of practices that lead to healthy child outcomes as well as their participation in effective programs and services. This report makes recommendations directed at an array of stakeholders, for promoting the wide-scale adoption of effective programs and services for parents and on areas that warrant further research to inform policy and practice. It is meant to serve as a roadmap for the future of parenting policy, research, and practice in the United States.

Immunological Mechanisms and Therapies in Brain Injuries and Stroke

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1461489156
Total Pages : 390 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Immunological Mechanisms and Therapies in Brain Injuries and Stroke by : Jun Chen

Download or read book Immunological Mechanisms and Therapies in Brain Injuries and Stroke written by Jun Chen and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent research has revealed the importance of immunological mechanisms and inflammation in delaying damage and/or promoting repair after an acute injury to the central nervous system. This book provides a comprehensive and up-to-date overview of the role of immunological mechanisms and therapies for treating acute neurological injuries such as cerebral ischemia, hemorrhage, and brain and spinal cord trauma. In several sections, the contributing authors provide a review of immunological mechanisms involved in neurological injury and of various translational and clinical research aimed at harnessing those mechanisms for better patient outcomes.​

Lost in the Meritocracy

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Publisher : Anchor
ISBN 13 : 0307279456
Total Pages : 226 pages
Book Rating : 4.3/5 (72 download)

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Book Synopsis Lost in the Meritocracy by : Walter Kirn

Download or read book Lost in the Meritocracy written by Walter Kirn and published by Anchor. This book was released on 2010-06-01 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: A New York Times Notable Book A Daily Beast Best Book of the Year A Huffington Post Best Book of the Year From elementary school on, Walter Kirn knew how to stay at the top of his class: He clapped erasers, memorized answer keys, and parroted his teachers’ pet theories. But when he launched himself eastward to an Ivy League university, Kirn discovered that the temple of higher learning he had expected was instead just another arena for more gamesmanship, snobbery, and social climbing. In this whip-smart memoir of kissing-up, cramming, and competition, Lost in the Meritocracy reckons the costs of an educational system where the point is simply to keep accumulating points and never to look back—or within.

A History of Transplantation Immunology

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Publisher : Academic Press
ISBN 13 : 008053399X
Total Pages : 506 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis A History of Transplantation Immunology by : Leslie Brent

Download or read book A History of Transplantation Immunology written by Leslie Brent and published by Academic Press. This book was released on 1996-11-18 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Those entering the field of transplantation are frequently unaware of the topics historical roots and even of the background on which modern discoveries in tolerance, histocompabatibility antigens, and xenotransplantation are based. A History of Transplantation Immunology is an account, written by one of the founding fathers of the field, of how tissue and organ transplantation has become one of the most successful branches of late 20th century medicine. The book helps place the work of contemporary scientists into its proper context and makes fascinating reading for immunologists in all stages of their career. - Describes landmarks in immunology and places them in historical context - Beautifully written by one of the founding fathers of the field - Portrays the surprising history of events in a colorful and readable manner - Contains biographical sketches of some of the pioneers - Illustrates the development of key ideas in immunology--tolerance, graft rejection, and transplantation - Foreword by Ray Owen

The Good, The Bad and The Ugly - 175+ Western Novels & Short Stories in One Edition

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Author :
Publisher : Good Press
ISBN 13 :
Total Pages : 15304 pages
Book Rating : 4.8/5 (596 download)

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Book Synopsis The Good, The Bad and The Ugly - 175+ Western Novels & Short Stories in One Edition by : Mark Twain

Download or read book The Good, The Bad and The Ugly - 175+ Western Novels & Short Stories in One Edition written by Mark Twain and published by Good Press. This book was released on 2023-11-27 with total page 15304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The anthology 'The Good, The Bad and The Ugly - 175+ Western Novels & Short Stories in One Edition' presents an unparalleled compilation, showcasing the vast landscapes of the American West through the prism of over forty authors eyes. This diverse collection spans the spectrum from the gritty realism of pioneer life to the mythic valorization of the cowboy ethos, exploring themes of adventure, lawlessness, and the human struggle against natural elements. The variegated literary styles, including the refined prose of Twain, the rugged simplicity of London, and the narrative ingenuity of Harte, underscore the multifaceted nature of Western storytelling. These stories capture the spirit of an era, offering readers a mosaic of courageous heroes, nefarious outlaws, and spirited pioneers navigating the rugged terrains of life in Western America. The backgrounds of the contributing authors encompass a broad spectrum of American literature, from the well-known figures such as Mark Twain and Jack London to less visible but equally significant writers like William Patterson White and Marah Ellis Ryan. Collectively, they represent a formidable assembly weaving together the historical, cultural, and literary movements of their time. Each contributes a unique voice to the exploration of the Western frontier, reflecting their personal experiences, imaginations, and the zeitgeist of the late 19th to early 20th centuries. This confluence of diverse perspectives provides a rich, nuanced understanding of the Western genre, inviting readers to ponder the complexities of frontier life and the enduring appeal of Western narratives. 'The Good, The Bad and The Ugly - 175+ Western Novels & Short Stories in One Edition' is an essential anthology for readers seeking to immerse themselves in the expansive world of Western literature. It offers a unique opportunity to traverse the wide-ranging landscapes of human emotion and adventure, curated through the lenses of masters in the genre. This collection is a treasure trove for students, scholars, and aficionados of American literature and history, promising a deeper appreciation of the Western ethos and its impact on American cultural identity. It beckons readers to explore the myriad of stories that paint a vivid tableau of the American West, a testament to the enduring legacy of its narratives.

Homelessness, Health, and Human Needs

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Author :
Publisher : National Academies Press
ISBN 13 : 0309038324
Total Pages : 257 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Homelessness, Health, and Human Needs by : Institute of Medicine

Download or read book Homelessness, Health, and Human Needs written by Institute of Medicine and published by National Academies Press. This book was released on 1988-02-01 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: There have always been homeless people in the United States, but their plight has only recently stirred widespread public reaction and concern. Part of this new recognition stems from the problem's prevalence: the number of homeless individuals, while hard to pin down exactly, is rising. In light of this, Congress asked the Institute of Medicine to find out whether existing health care programs were ignoring the homeless or delivering care to them inefficiently. This book is the report prepared by a committee of experts who examined these problems through visits to city slums and impoverished rural areas, and through an analysis of papers written by leading scholars in the field.

Social Isolation and Loneliness in Older Adults

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Author :
Publisher : National Academies Press
ISBN 13 : 0309671035
Total Pages : 317 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Social Isolation and Loneliness in Older Adults by : National Academies of Sciences, Engineering, and Medicine

Download or read book Social Isolation and Loneliness in Older Adults written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-05-14 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Social isolation and loneliness are serious yet underappreciated public health risks that affect a significant portion of the older adult population. Approximately one-quarter of community-dwelling Americans aged 65 and older are considered to be socially isolated, and a significant proportion of adults in the United States report feeling lonely. People who are 50 years of age or older are more likely to experience many of the risk factors that can cause or exacerbate social isolation or loneliness, such as living alone, the loss of family or friends, chronic illness, and sensory impairments. Over a life course, social isolation and loneliness may be episodic or chronic, depending upon an individual's circumstances and perceptions. A substantial body of evidence demonstrates that social isolation presents a major risk for premature mortality, comparable to other risk factors such as high blood pressure, smoking, or obesity. As older adults are particularly high-volume and high-frequency users of the health care system, there is an opportunity for health care professionals to identify, prevent, and mitigate the adverse health impacts of social isolation and loneliness in older adults. Social Isolation and Loneliness in Older Adults summarizes the evidence base and explores how social isolation and loneliness affect health and quality of life in adults aged 50 and older, particularly among low income, underserved, and vulnerable populations. This report makes recommendations specifically for clinical settings of health care to identify those who suffer the resultant negative health impacts of social isolation and loneliness and target interventions to improve their social conditions. Social Isolation and Loneliness in Older Adults considers clinical tools and methodologies, better education and training for the health care workforce, and dissemination and implementation that will be important for translating research into practice, especially as the evidence base for effective interventions continues to flourish.

New York Star

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Author :
Publisher :
ISBN 13 :
Total Pages : 556 pages
Book Rating : 4.:/5 (334 download)

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Book Synopsis New York Star by :

Download or read book New York Star written by and published by . This book was released on 1925 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: