Genome Instability

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Genome Stability

Author : Igor Kovalchuk
Publisher : Academic Press
ISBN 13 : 0323856802
Total Pages : 762 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Genome Stability by : Igor Kovalchuk

Download or read book Genome Stability written by Igor Kovalchuk and published by Academic Press. This book was released on 2021-07-17 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability research and outcomes for human disease Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair

Genome Stability

Author : Igor Kovalchuk
Publisher : Academic Press
ISBN 13 : 0128033452
Total Pages : 714 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Genome Stability by : Igor Kovalchuk

Download or read book Genome Stability written by Igor Kovalchuk and published by Academic Press. This book was released on 2016-09-03 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every species has to preserve the integrity of its genome to ensure faithful passage of genetic information to the progeny. At the same time, there are times during the life of the organism and population in general when a fine balance in genome stability and diversification has to be made to benefit the survival of the species. Genome Stability teaches the reader how various species maintain this fine balance in genome stability and genome diversification in response to their environments. Genome Stability covers a wide range of topics, including the genome stability of DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes and mammals. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability as well as changes in genome stability in response to aging. Finally, Genome Stability covers how epigenetic factors contribute to genome stability and how the species pass the memory of the encounters to the progeny, thus influencing the genome of the progeny in an indirect manner. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly-expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. Includes a collection of chapters on genome stability research from various kingdoms, including topics such as epigenetics and transgenerational effects Provides the first comprehensive coverage of the differences in the mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability and its effect on human diseases Explains how various species maintain the fine balance in genome stability and genome diversification in response to their environments

Genome Instability in Cancer Development

Author : Erich A. Nigg
Publisher : Springer Science & Business Media
ISBN 13 : 1402037643
Total Pages : 509 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Genome Instability in Cancer Development by : Erich A. Nigg

Download or read book Genome Instability in Cancer Development written by Erich A. Nigg and published by Springer Science & Business Media. This book was released on 2006-01-14 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinogenesis. These important findings not only explain the occurrence of certain hereditary tumours, but they also set the stage for the development of anti-cancer drugs that specifically target activated oncogenes. However, in spite of tremendous progress towards the elucidation of key signalling pathways involved in carcinogenesis, most cancers continue to elude currently available therapies. This stands as a reminder that “cancer” is an extraordinarily complex disease: although some cancers of the haematopoietic system show only a limited number of characteristic chromosomal aberrations, most solid tumours display a myriad of genetic changes and considerable genetic heterogeneity. This is thought to reflect a trait commonly referred to as ‘genome instability’, so that no two cancers are ever likely to display the exact same genetic alterations. Numerical and structural chromosome aberrations were recognised as a hallmark of human tumours for more than a century. Yet, the causes and consequences of these aberrations still remain to be fully understood. In particular, the question of how genome instability impacts on the development of human cancers continues to evoke intense debate.

New Research on Genomic Instability

Author : Eleanor J. Gloscow
Publisher : Nova Publishers
ISBN 13 : 9781600213205
Total Pages : 312 pages
Book Rating : 4.2/5 (132 download)

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Book Synopsis New Research on Genomic Instability by : Eleanor J. Gloscow

Download or read book New Research on Genomic Instability written by Eleanor J. Gloscow and published by Nova Publishers. This book was released on 2007 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many cancer biologists now believe that genomic instability not only initiates carcinogenesis, but also allows the tumour cell to become metastatic and evade drug toxicity. The loss of stability of the genome is becoming accepted as one of the most important aspects of carcinogenesis. One of the hallmarks of the cancer cell is the inherent instability of its genome. This book presents important research in this exciting field.

Genome Stability and Human Diseases

Author : Heinz-Peter Nasheuer
Publisher : Springer Science & Business Media
ISBN 13 : 9048134714
Total Pages : 346 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Genome Stability and Human Diseases by : Heinz-Peter Nasheuer

Download or read book Genome Stability and Human Diseases written by Heinz-Peter Nasheuer and published by Springer Science & Business Media. This book was released on 2009-12-11 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting ‘bottlenecks’ in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations. This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The chapters give insights into the newest development of the genome stability and human diseases and bring the current understanding of the mechanisms leading to chromosome instability and their potential for clinical impact to the reader.

Genome Stability

Author : James Haber
Publisher : Garland Science
ISBN 13 : 1317682319
Total Pages : 416 pages
Book Rating : 4.3/5 (176 download)

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Book Synopsis Genome Stability by : James Haber

Download or read book Genome Stability written by James Haber and published by Garland Science. This book was released on 2013-12-16 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome Stability: DNA Repair and Recombination describes the various mechanisms of repairing DNA damage by recombination, most notably the repair of chromosomal breaks. The text presents a definitive history of the evolution of molecular models of DNA repair, emphasizing current research. The book introduces the central players in recombination. An overview of the four major pathways of homologous recombinational repair is followed by a description of the several mechanisms of nonhomologous end-joining. Designed as a textbook for advanced undergraduate and graduate students with a molecular biology and genetics background, researchers and practitioners, especially in cancer biology, will also appreciate the book as a reference.

Genome Instability

Author : Marco Muzi-Falconi
Publisher :
ISBN 13 : 9781493973064
Total Pages : 663 pages
Book Rating : 4.9/5 (73 download)

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Book Synopsis Genome Instability by : Marco Muzi-Falconi

Download or read book Genome Instability written by Marco Muzi-Falconi and published by . This book was released on 2018 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents forty-two methods and protocols to analyze diverse aspects of genome instability. Chapters detail mutagenesis and repair, methods to quantify and analyze the properties of DNA double-strand breaks, profile replication, replication proteins strand-specifically, genome instability, fluorescence microscopic techniques, and genomic and proteomic approaches. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genome Instability: Methods and Protocols aims to provide a comprehensive resource for the discovery and analysis of the proteins and pathways that are critical for stable maintenance of the genome.

Genetic Instability and Tumorigenesis

Author : Michael B. Kastan
Publisher : Springer Science & Business Media
ISBN 13 : 3642605052
Total Pages : 189 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Genetic Instability and Tumorigenesis by : Michael B. Kastan

Download or read book Genetic Instability and Tumorigenesis written by Michael B. Kastan and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: M. B. KASTAN Cancer is a disease resulting from alterations of cellular genes which cause phe notypic changes in somatic cells. Usually, when we think about genetic diseases, we think about inheriting one or two abnormal genes from our parents and these gene abnormalities confer the disease phenotype. In contrast, in the majority of cancers, no such inherited gene abnormalities can be identified (which does not mean that they do not exist) and there is no obvious family history suggesting an inherited disease. The vast majority of genes which are altered in the cancer cells are not transmitted through the germ line, but rather become abnormal in somatic cells sometime during the lifetime of the individual. Thus, the critical question which arises is "how do these genetic changes occur in somatic cells?". Epidemiologic data suggest that exposure to environmental carcinogens con tributes to the genesis of at least 80% of all human cancers (DOLL and PETO 1981). Thus, it is natural to suspect that the genetic changes in somatic cells which con tribute to the transformed phenotype arise from DNA damage caused by such exposures. Therefore, understanding how cells respond to DNA-damaging agents is likely to be an important component of our understanding of the genesis of human tumors.

Systems Biology of Cancer

Author : Sam Thiagalingam
Publisher : Cambridge University Press
ISBN 13 : 0521493390
Total Pages : 597 pages
Book Rating : 4.5/5 (214 download)

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Book Synopsis Systems Biology of Cancer by : Sam Thiagalingam

Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Genome Instability: Old Problem, New Solutions

Author : Vivian Kahl
Publisher : Frontiers Media SA
ISBN 13 : 2889746917
Total Pages : 168 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Genome Instability: Old Problem, New Solutions by : Vivian Kahl

Download or read book Genome Instability: Old Problem, New Solutions written by Vivian Kahl and published by Frontiers Media SA. This book was released on 2022-03-15 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:

DNA Damage, Genome Stability and Human Disease

Author : Yuejin Hua
Publisher : Frontiers Media SA
ISBN 13 : 288974194X
Total Pages : 154 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis DNA Damage, Genome Stability and Human Disease by : Yuejin Hua

Download or read book DNA Damage, Genome Stability and Human Disease written by Yuejin Hua and published by Frontiers Media SA. This book was released on 2022-01-27 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mobile DNA II

Author : Nancy L. Craig
Publisher : Amer Society for Microbiology
ISBN 13 : 9781555812096
Total Pages : 1204 pages
Book Rating : 4.8/5 (12 download)

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Book Synopsis Mobile DNA II by : Nancy L. Craig

Download or read book Mobile DNA II written by Nancy L. Craig and published by Amer Society for Microbiology. This book was released on 2002 with total page 1204 pages. Available in PDF, EPUB and Kindle. Book excerpt: An extension of the original volume, reflecting the latest advances in understanding these elements. This title is published by the American Society for Microbiology Press and distributed by Taylor and Francis in rest of world territories.

Genome Instability and Transgenerational Effects

Author : Igor Kovalchuk
Publisher :
ISBN 13 : 9781608768318
Total Pages : 0 pages
Book Rating : 4.7/5 (683 download)

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Book Synopsis Genome Instability and Transgenerational Effects by : Igor Kovalchuk

Download or read book Genome Instability and Transgenerational Effects written by Igor Kovalchuk and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome stability of every species depends on complex interaction of predefined and environmentally induced genetic and epigenetic states. Predefined states consist of chromatin structure and cell metabolic processes such as DNA repair, radical scavenging and cell signalling, whereas induced states depend on interactions with the environment. Organisms are able to respond to a changing environment by various alterations in their somatic cells as well as in their germline and progeny. In this book, we will describe various phenomena associated with the maintenance of genome stability. These include genetic and epigenetic responses to various stresses in exposed cells and organisms, bystander and, bystander-like effects, transgenerational changes in genome stability and stress tolerance in bacteria, plants and animals.

Genome Instability

Author :
Publisher :
ISBN 13 :
Total Pages : 27 pages
Book Rating : 4.:/5 (437 download)

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Book Synopsis Genome Instability by :

Download or read book Genome Instability written by and published by . This book was released on 2002 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genomic Instability and Immortality in Cancer

Author : Enrico Mihich
Publisher : Springer Science & Business Media
ISBN 13 : 1461553652
Total Pages : 410 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Genomic Instability and Immortality in Cancer by : Enrico Mihich

Download or read book Genomic Instability and Immortality in Cancer written by Enrico Mihich and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the Eighth Annual Pezcoller Symposium held in Trento, Italy, June 17-19, 1996

Chromatin and Genomic Instability in Cancer

Author :
Publisher : Academic Press
ISBN 13 : 0323855628
Total Pages : 286 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Chromatin and Genomic Instability in Cancer by :

Download or read book Chromatin and Genomic Instability in Cancer written by and published by Academic Press. This book was released on 2021-09-08 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatin and DNA Repair in Cancer, Volume 364 in the International Review of Cell and Molecular Biology series reviews and details current advances in cell and molecular biology. Chapters in this new release cover Genomic Instability and metabolism in cancer, Histones variants and Histones modifications in cancer and Aging, DNA Double-stranded breaks Repair in Cancer, Reactive oxygen species and DNA damage response in cancer, Transcription-Associated DNA Breaks and Cancer: A Matter of DNA Topology, Mechanisms of Base Excision Repair: Its Significance to Human Health, and more. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of 9 years. This great resource ranks high amongst scientific journals dealing with cell biology. Publishes only invited review articles on selected topics Authored by established and active cell and molecular biologists, drawn from international sources Offers a wide range of perspectives on specific subjects

Aging of the Genome

Author : Jan Vijg
Publisher : OUP Oxford
ISBN 13 : 0191524581
Total Pages : 384 pages
Book Rating : 4.1/5 (915 download)

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Book Synopsis Aging of the Genome by : Jan Vijg

Download or read book Aging of the Genome written by Jan Vijg and published by OUP Oxford. This book was released on 2007-01-25 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.