Genome And Proteome In Oncology

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Genome and Proteome in Oncology

Author : Fotini Tzortzatou Stathopoulou
Publisher : Nova Publishers
ISBN 13 : 9781594542855
Total Pages : 384 pages
Book Rating : 4.5/5 (428 download)

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Book Synopsis Genome and Proteome in Oncology by : Fotini Tzortzatou Stathopoulou

Download or read book Genome and Proteome in Oncology written by Fotini Tzortzatou Stathopoulou and published by Nova Publishers. This book was released on 2005 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nature of cancer disease, its probable causes, and the molecular and cellular mechanisms through which malignant tumours develop, have only recently begun to be understood in any appreciable detail. Cancer is fundamentally a disease of the genome, arising from dynamic changes occurring within DNA during the lifetime of the cell e.g. deletions, amplifications, point mutations, translocations, that can occur in any cell and that may interact in a variety of cellular pathways. The imbalance in the interplay between genetic and environmental factors can initiate malignancy. The determination of the human genome sequence is acclaimed as one of the great achievements made possible by the rapid progress in the available molecular biology tools achieved during the last few years. The sequence of the human genome promises to unveil invaluable information useful for the development of novel approaches in the diagnosis and treatment of cancer disease. This book includes part of the work of international experts on the most up-to-date developments of various aspects of research on genome and proteome in oncology. The scientists suggest that the genetic key to human complexity lies not in the number of genes but in how gene parts are used to build different products in a process of the mRNA transcript called alternative splicing.

Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy

Author : Herbert B. Newton
Publisher : Academic Press
ISBN 13 : 0128121017
Total Pages : 852 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy by : Herbert B. Newton

Download or read book Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy written by Herbert B. Newton and published by Academic Press. This book was released on 2018-03-28 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first edition—mainly in the areas of molecular biology and molecular therapeutics, as well as in the maturation of immunotherapy approaches (e.g., vaccines). This updated edition has a new, primary focus on multidisciplinary molecular methods, and is broadened to include the latest cutting-edge molecular biology, therapeutics, immunobiology and immunotherapy approaches. As the first comprehensive book to address the molecular research into these concepts, users will find it to be an invaluable resource on the topics discussed. - Provides the most up-to-date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics for the treatment of brain tumors - Broadly appeals to anyone interested in neuro-oncology and the treatment of brain tumors - Features updated chapters on molecular biology, molecular therapeutics, maturation of immunotherapy approaches, and a focus on multidisciplinary molecular methods - Includes a new section on the basic science of immunology, as well as thorough updates on the use of vaccine technology and immunotherapy for the treatment of brain tumors

Evolution of Translational Omics

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309224187
Total Pages : 354 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Evolution of Translational Omics by : Institute of Medicine

Download or read book Evolution of Translational Omics written by Institute of Medicine and published by National Academies Press. This book was released on 2012-09-13 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.

Genomics, Proteomics, and Metabolomics

Author : Babak Arjmand
Publisher : Springer Nature
ISBN 13 : 3030277275
Total Pages : 208 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Genomics, Proteomics, and Metabolomics by : Babak Arjmand

Download or read book Genomics, Proteomics, and Metabolomics written by Babak Arjmand and published by Springer Nature. This book was released on 2019-11-14 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides thorough coverage of high-throughput OMICs technologies for the monitoring of stem cells and regenerative medicine. Specific topics covered include the genomics, proteomics, and metabolomics aspects of regenerative medicine, metabolic profiling of mesenchymal stem cells, genome profiling of mesenchymal stem cells, OMICs monitoring of stem cell-derived exosomes, stem cell proteomics, lipidomics, OMICs profiling of cancer (stem) cells, and finally ethical considerations of OMICs-based investigations. Chapters are authored by world-renowned scientists who have valuable expertise in the field of OMICs and regenerative medicine. Genomics, Proteomics, and Metabolomics: Stem Cells Monitoring in Regenerative Medicine, part of Springer’s Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers, clinicians, biologists, biochemists, and pharmaceutical experts conducting research in the fields of stem cell biology, molecular aspects of stem cell research, tissue engineering, regenerative medicine, cellular therapy, OMICs, bioinformatics, and ethics.

Microbial Diversity in the Genomic Era

Author : Surajit Das
Publisher : Academic Press
ISBN 13 : 0128148500
Total Pages : 715 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Microbial Diversity in the Genomic Era by : Surajit Das

Download or read book Microbial Diversity in the Genomic Era written by Surajit Das and published by Academic Press. This book was released on 2018-09-20 with total page 715 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial Diversity in the Genomic Era presents insights on the techniques used for microbial taxonomy and phylogeny, along with their applications and respective pros and cons. Though many advanced techniques for the identification of any unknown bacterium are available in the genomics era, a far fewer number of the total microbial species have been discovered and identified to date. The assessment of microbial taxonomy and biosystematics techniques discovered and practiced in the current genomics era with suitable recommendations is the prime focus of this book. - Discusses the techniques used for microbial taxonomy and phylogeny with their applications and respective pros and cons - Reviews the evolving field of bacterial typing and the genomic technologies that enable comparative analysis of multiple genomes and the metagenomes of complex microbial environments - Provides a uniform, standard methodology for species designation

Systems Biology of Cancer

Author : Sam Thiagalingam
Publisher : Cambridge University Press
ISBN 13 : 0521493390
Total Pages : 597 pages
Book Rating : 4.5/5 (214 download)

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Book Synopsis Systems Biology of Cancer by : Sam Thiagalingam

Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Data Mining for Genomics and Proteomics

Author : Darius M. Dziuda
Publisher : John Wiley & Sons
ISBN 13 : 0470593407
Total Pages : 348 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis Data Mining for Genomics and Proteomics by : Darius M. Dziuda

Download or read book Data Mining for Genomics and Proteomics written by Darius M. Dziuda and published by John Wiley & Sons. This book was released on 2010-07-16 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Data Mining for Genomics and Proteomics uses pragmatic examples and a complete case study to demonstrate step-by-step how biomedical studies can be used to maximize the chance of extracting new and useful biomedical knowledge from data. It is an excellent resource for students and professionals involved with gene or protein expression data in a variety of settings.

Mammography and Beyond

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309171318
Total Pages : 311 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Mammography and Beyond by : National Research Council

Download or read book Mammography and Beyond written by National Research Council and published by National Academies Press. This book was released on 2001-07-23 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each year more than 180,000 new cases of breast cancer are diagnosed in women in the U.S. If cancer is detected when small and local, treatment options are less dangerous, intrusive, and costly-and more likely to lead to a cure. Yet those simple facts belie the complexity of developing and disseminating acceptable techniques for breast cancer diagnosis. Even the most exciting new technologies remain clouded with uncertainty. Mammography and Beyond provides a comprehensive and up-to-date perspective on the state of breast cancer screening and diagnosis and recommends steps for developing the most reliable breast cancer detection methods possible. This book reviews the dramatic expansion of breast cancer awareness and screening, examining the capabilities and limitations of current and emerging technologies for breast cancer detection and their effectiveness at actually reducing deaths. The committee discusses issues including national policy toward breast cancer detection, roles of public and private agencies, problems in determining the success of a technique, availability of detection methods to specific populations of women, women's experience during the detection process, cost-benefit analyses, and more. Examining current practices and specifying research and other needs, Mammography and Beyond will be an indispensable resource to policy makers, public health officials, medical practitioners, researchers, women's health advocates, and concerned women and their families.

Targeted Therapies in Lung Cancer: Management Strategies for Nurses and Practitioners

Author : Marianne Davies
Publisher : Springer
ISBN 13 : 3030165507
Total Pages : 122 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Targeted Therapies in Lung Cancer: Management Strategies for Nurses and Practitioners by : Marianne Davies

Download or read book Targeted Therapies in Lung Cancer: Management Strategies for Nurses and Practitioners written by Marianne Davies and published by Springer. This book was released on 2019-07-16 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to educate nurses and advanced practice providers (APP’s) about known mutations, availability of targeted therapy and the management of patients with non-small cell lung cancer (NSCLC). It will educate nurses and practitioners about the scope of therapy to assure safe and effective lung cancer treatment. In this era of personalized medicine, nurses and APP’s are responsible for guiding patients from diagnosis through treatment. This starts with the identification of patients that can benefit from these therapies, the key role of biopsy acquisition (ie. what to test, when and how often) and treatment selection based on the mutation identified. Readers will learn about the mechanisms of action, administration, potential adverse side effects and unique management strategies for these targeted agents. Lung cancer continues to be the leading cause of cancer death in the United States and worldwide. Recent advances in the identification of specific oncogenic mutations that drive cancer development, growth and metastasis have led to major paradigm shifts in lung cancer treatment. Sophisticated methods are required to identify specific mutations at the time of diagnosis. This book explains how molecularly targeted therapies have been developed that target these drivers. To date, several tyrosine kinase inhibitors have been approved to target the epidermal growth factor receptor (EGFR), EML4-ALK ,ROS1 and BRAF. Most recently, immune checkpoint inhibitors have been approved with some indication that efficacy may be enhanced for patients who overexpress PD-L1. While some driver mutations have been identified, there is ongoing investigation into additional mutations. In the case of driver mutations, lung cancers will develop resistance to therapy. This book provides nurses and APP’s with the mechanisms of resistance that have been identified such as T790 mutation and many others in the EGFR mutation, and shows how the next level of drug development is focused on identifying mechanisms of resistance and development of new agents that overcome these mutations. With this book in hand, nurses and practitioners will be able to navigate patients through this ever expanding field of lung cancer treatment.

Proteome Research

Author : Marc R. Wilkins
Publisher : Springer Science & Business Media
ISBN 13 : 9783540627531
Total Pages : 270 pages
Book Rating : 4.6/5 (275 download)

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Book Synopsis Proteome Research by : Marc R. Wilkins

Download or read book Proteome Research written by Marc R. Wilkins and published by Springer Science & Business Media. This book was released on 1997 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to the proteome (K. L. Williams, D. F. Hochstrasser). Two-dimensional electrophoresis: the state of the art and future directions (B. R. Herbert, J.-C. Sanchez, L. Bini). large-scale comparative protein modeling ( M. C. Peitsch, N. Guex); Clinical and biomedical applications of proteomics (D. F. Hochstrasser). Biological applications of proteomics (K. L. Williams, V. Pallini). Conclusions (D. F. Hochstrasser, L. Williams). Index.

Genomics and Proteomics

Author : Devarajan Thangadurai
Publisher : CRC Press
ISBN 13 : 149872311X
Total Pages : 425 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Genomics and Proteomics by : Devarajan Thangadurai

Download or read book Genomics and Proteomics written by Devarajan Thangadurai and published by CRC Press. This book was released on 2015-06-09 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides scope and knowledge on advanced techniques and its applications into the modern fields of biotechnology-genomics and proteomics. In this book, different genomics and proteomics technologies and principles are examined. The fundamental knowledge presented in this book opens up an entirely new way of approaching DNA chip technology,

Introduction to Proteomics

Author : Agnieszka Kraj
Publisher : Wiley-Interscience
ISBN 13 : 9780470055359
Total Pages : 0 pages
Book Rating : 4.0/5 (553 download)

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Book Synopsis Introduction to Proteomics by : Agnieszka Kraj

Download or read book Introduction to Proteomics written by Agnieszka Kraj and published by Wiley-Interscience. This book was released on 2008-10-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Proteomics is written by seasoned researchers with years of practical experience. In addition to comprehensive discussions of the basic concepts, techniques, and applications of the subject, the text also includes an extensive glossary and a chapter containing laboratory exercises and protocols. While mass spectrometry is central to proteomics, the book discusses all of the analytical techniques a student is likely to need when faced with real-world problems, such as sample preparation, chromatographic and electrophoretic separation, micro-total analysis systems, and bioinformatics.

Functional Genomics and Proteomics

Author : Charles Malkoff
Publisher :
ISBN 13 : 9781682861226
Total Pages : 0 pages
Book Rating : 4.8/5 (612 download)

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Book Synopsis Functional Genomics and Proteomics by : Charles Malkoff

Download or read book Functional Genomics and Proteomics written by Charles Malkoff and published by . This book was released on 2016-05-31 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional genomics and proteomics play a crucial role in analysing available genetic data and gathering key information for further use. The book emphasizes on the dynamic aspects of genomics and proteomics such as regulation of genes, transcription, translation and protein-protein interactions, large scale protein structures, etc. Researches and case-studies included in this book attempt to provide methods, models and techniques to analyze and gather information from large pool of available genomic data of various organisms. This book provides a detailed explanation on structure determination and structural genomics. Students and researchers will find this book beneficial.

Tissue Proteomics

Author : Minnie M. Sarwal
Publisher : Humana
ISBN 13 : 9781493993048
Total Pages : 320 pages
Book Rating : 4.9/5 (93 download)

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Book Synopsis Tissue Proteomics by : Minnie M. Sarwal

Download or read book Tissue Proteomics written by Minnie M. Sarwal and published by Humana. This book was released on 2019-09-01 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a compilation of methods that detail improved protein and peptide sample preparation and identification. Chapters guide readers through methods for depletion of myofibril-associated proteins, peptide sample preparation in urinary proteomics, purification of targeted proteins from native tissues, fractionation strategies for protein analysis, and GeLC-MS as a sample preparation method for sample preparation for proteomics using minimal amount of tissue. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Tissue Proteomics: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field.

Functional Proteomics

Author : Julie D. Thompson
Publisher : Humana Press
ISBN 13 : 9781588299710
Total Pages : 0 pages
Book Rating : 4.2/5 (997 download)

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Book Synopsis Functional Proteomics by : Julie D. Thompson

Download or read book Functional Proteomics written by Julie D. Thompson and published by Humana Press. This book was released on 2008-08-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the emerging field of proteomics continues to expand at an extremely rapid rate, the relative quantification of proteins, targeted by their function, becomes its greatest challenge. Complex analytical strategies have been designed that allow comparative analysis of large proteomes, as well as in depth detection of the core proteome or the interaction network of a given protein of interest. In Functional Proteomics: Methods and Protocols, expert researchers describe the latest protocols being developed to address the problems encountered in high-throughput proteomics projects, with emphasis on the factors governing the technical choices for given applications. The case studies within the volume focus on the following three crucial aspects of the experimental design: 1) the strategy used for the selection, purification and preparation of the sample to be analyzed by mass spectrometry, 2) the type of mass spectrometer used and the type of data to be obtained from it, and 3) the method used for the interpretation of the mass spectrometry data and the search engine used for the identification of the proteins in the different types of sequence data banks available. As a part of the highly successful Methods in Molecular BiologyTM series, the chapters compile step-by-step, readily reproducible laboratory protocols, lists of the necessary materials and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Functional Proteomics: Methods and Protocols is an ideal resource for all scientists pursuing this developing field and its multitudinous data.

Proteomics Data Analysis

Author : Daniela Cecconi
Publisher :
ISBN 13 : 9781071616413
Total Pages : 326 pages
Book Rating : 4.6/5 (164 download)

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Book Synopsis Proteomics Data Analysis by : Daniela Cecconi

Download or read book Proteomics Data Analysis written by Daniela Cecconi and published by . This book was released on 2021 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thorough book collects methods and strategies to analyze proteomics data. It is intended to describe how data obtained by gel-based or gel-free proteomics approaches can be inspected, organized, and interpreted to extrapolate biological information. Organized into four sections, the volume explores strategies to analyze proteomics data obtained by gel-based approaches, different data analysis approaches for gel-free proteomics experiments, bioinformatic tools for the interpretation of proteomics data to obtain biological significant information, as well as methods to integrate proteomics data with other omics datasets including genomics, transcriptomics, metabolomics, and other types of data. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detailed implementation advice that will ensure high quality results in the lab. Authoritative and practical, Proteomics Data Analysis serves as an ideal guide to introduce researchers, both experienced and novice, to new tools and approaches for data analysis to encourage the further study of proteomics.

LC-MS/MS in Proteomics

Author : Pedro R. Cutillas
Publisher : Humana Press
ISBN 13 : 9781607617815
Total Pages : 330 pages
Book Rating : 4.6/5 (178 download)

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Book Synopsis LC-MS/MS in Proteomics by : Pedro R. Cutillas

Download or read book LC-MS/MS in Proteomics written by Pedro R. Cutillas and published by Humana Press. This book was released on 2011-04-06 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the development of new quantitative strategies and powerful bioinformatics tools to cope with the analysis of the large amounts of data generated in proteomics experiments, liquid chromatography with tandem mass spectrometry (LC-MS/MS) is making possible the analysis of proteins on a global scale, meaning that proteomics can now start competing with cDNA microarrays for the analysis of whole genomes. In LC-MS/MS in Proteomics: Methods and Applications, experts in the field provide protocols and up-to-date reviews of the applications of LC-MS/MS, with a particular focus on MS-based methods of protein and peptide quantification and the analysis of post-translational modifications. Beginning with overviews of the use of LC-M/MS in protein analysis, the book continues with topics such as protocols for the analysis of post-translational modifications, with particular focus on phosphorylation and glycosylation, popular techniques for quantitative proteomics, such as multiple reaction monitoring, metabolic labelling, and chemical tagging, biomarker discovery in biological fluids, as well as novel applications of LC-MS/MS. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective subjects, lists of necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, LC-MS/MS in Proteomics: Methods and Applications presents the techniques and concepts necessary in order to aid proteomic practitioners in the application of LC-MS/MS to essentially any biological problem.