Genetics Of Infectious Disease Susceptibility

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Genetics and Evolution of Infectious Diseases

Author : Michel Tibayrenc
Publisher : Elsevier
ISBN 13 : 0443288194
Total Pages : 1002 pages
Book Rating : 4.4/5 (432 download)

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Book Synopsis Genetics and Evolution of Infectious Diseases by : Michel Tibayrenc

Download or read book Genetics and Evolution of Infectious Diseases written by Michel Tibayrenc and published by Elsevier. This book was released on 2024-07-19 with total page 1002 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics and Evolution of Infectious Diseases, Third Edition discusses the evolving field of infectious diseases and their continued impact on the health of populations, especially in resource-limited areas of the world where they must confront the dual burden of death and disability due to infectious and chronic illnesses. Although substantial gains have been made in public health interventions for the treatment, prevention, and control of infectious diseases, in recent decades the world has witnessed the emergence of the human immunodeficiency virus (HIV) and the COVID-19 pandemic, increasing antimicrobial resistance, and the emergence of many new bacterial, fungal, parasitic, and viral pathogens. Fully updated and revised, this new edition presents the consequences of such diseases, the evolution of infectious diseases, the genetics of host-pathogen relationship, and the control and prevention strategies that are, or can be, developed. This book offers valuable information to biomedical researchers, clinicians, public health practitioners, decisions-makers, and students and postgraduates studying infectious diseases, microbiology, medicine, and public health that is relevant to the control and prevention of neglected and emerging worldwide diseases. - Takes an integrated approach to infectious diseases - Provides the latest developments in the field of infectious diseases - Focuses on the contribution of evolutionary and genomic studies for the study and control of transmissible diseases - Includes updated and revised contributions from leading authorities, along with six new chapters

Genetic Susceptibility to Infectious Diseases

Author : Richard A. Kaslow M.D.
Publisher : Oxford University Press
ISBN 13 : 019972122X
Total Pages : 464 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis Genetic Susceptibility to Infectious Diseases by : Richard A. Kaslow M.D.

Download or read book Genetic Susceptibility to Infectious Diseases written by Richard A. Kaslow M.D. and published by Oxford University Press. This book was released on 2008-03-03 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are commonly regarded as a distinct category, with different causes and patterns than chronic or genetic disease. But in fact there are many varieties of genetic susceptibility to infection, the subject of this book, which will be divided into three sections: 1) concepts and methods, 2) genes and pathophysiologic mechanisms, and 3) infectious agents and diseases. No currently plubished text on either genetics or infectious diseases focuses on the genetic aspects of the special relationship between host and pathogen in the way envisioned for Section 1. No other work on the selected genes regulating immunity deals as systematically with the sequence variation/function relationships most pertinent to infection as planned for Section 2. And no other book gives as meaningful a picture of how these genes operate in infectious disease as Section 3 will.

The Nramp Family

Author : Mathieu Cellier
Publisher : Springer Science & Business Media
ISBN 13 : 9780306478413
Total Pages : 226 pages
Book Rating : 4.4/5 (784 download)

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Book Synopsis The Nramp Family by : Mathieu Cellier

Download or read book The Nramp Family written by Mathieu Cellier and published by Springer Science & Business Media. This book was released on 2004-08-25 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first comprehensive volume on the "Nramp family", highlighting the physiological importance of Nramp proteins as metal transporters. The molecular knowledge of these membrane proteins is presented from an evolutionary perspective, considering Nramp cellular function and mechanism of transport in key model organisms. The pathological significance of Nramp genetic polymorphism is discussed with emphasis on metal homeostasis and microbial infection. The chapters were contributed by leading investigators, providing a timely state of the art book in this rapidly growing field. The Nramp Family will be useful to a broad community of scientists interested in metal transport and molecular biology. It will be of interest to the research audience in the broad fields of metal ions and molecular medicine.

Immunodeficient Rodents

Author : Institute of Laboratory Animal Resour
Publisher : Legare Street Press
ISBN 13 : 9781019453094
Total Pages : 0 pages
Book Rating : 4.4/5 (53 download)

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Book Synopsis Immunodeficient Rodents by : Institute of Laboratory Animal Resour

Download or read book Immunodeficient Rodents written by Institute of Laboratory Animal Resour and published by Legare Street Press. This book was released on 2023-07-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This informative guide provides a comprehensive overview of the biology and care of immunodeficient rodents, which are essential for the study of human diseases and the development of new treatments. It is an invaluable resource for scientists, veterinarians, and animal care professionals. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.

Assessing Genetic Risks

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309047986
Total Pages : 353 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Assessing Genetic Risks by : Institute of Medicine

Download or read book Assessing Genetic Risks written by Institute of Medicine and published by National Academies Press. This book was released on 1994-01-01 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Raising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.

Genome-Wide Association Studies

Author : Tatsuhiko Tsunoda
Publisher : Springer Nature
ISBN 13 : 9811381771
Total Pages : 216 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Genome-Wide Association Studies by : Tatsuhiko Tsunoda

Download or read book Genome-Wide Association Studies written by Tatsuhiko Tsunoda and published by Springer Nature. This book was released on 2019-10-31 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the utility of genome-wide association studies (GWAS) in the era of next-generation sequencing and big data, identifies limitations and potential means of overcoming them, and looks to the future of GWAS and what may lay beyond. GWAS are among the most powerful tools for elucidating the genetic aspects of human and disease diversity. In Genome-Wide Association Studies, experts in the field explore in depth the impacts of GWAS on genomic research into a variety of common diseases, including cardiovascular, autoimmune, diabetic, cancer, and infectious diseases. The book will equip readers with a sound understanding both of the types of disease and phenotypes that are suited for GWAS and of the ways in which a road map resulting from GWAS can lead to the realization of personalized/precision medicine: functional analysis, drug seeds, pathway analysis, disease mechanism, risk prediction, and diagnosis.

Molecular and Quantitative Animal Genetics

Author : Hasan Khatib
Publisher : John Wiley & Sons
ISBN 13 : 1118677404
Total Pages : 336 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Molecular and Quantitative Animal Genetics by : Hasan Khatib

Download or read book Molecular and Quantitative Animal Genetics written by Hasan Khatib and published by John Wiley & Sons. This book was released on 2015-03-02 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal genetics is a foundational discipline in the fields of animal science, animal breeding, and veterinary sciences. While genetics underpins the healthy development and breeding of all living organisms, this is especially true in domestic animals, specifically with respect to breeding for key traits. Molecular and Quantitative Animal Genetics is a new textbook that takes an innovative approach, looking at both quantitative and molecular breeding approaches. The bookprovides a comprehensive introduction to genetic principles and their applications in animal breeding. This text provides a useful overview for those new to the field of animal genetics and breeding, covering a diverse array of topics ranging from population and quantitative genetics to epigenetics and biotechnology. Molecular and Quantitative Animal Genetics will be an important and invaluable educational resource for undergraduate and graduate students and animal agriculture professionals. Divided into six sections pairing fundamental principles with useful applications, the book's comprehensive coverage will make it an ideal fit for students studying animal breeding and genetics at any level.

Sex Hormones and Immunity to Infection

Author : Sabra L. Klein
Publisher : Springer Science & Business Media
ISBN 13 : 3642021557
Total Pages : 323 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis Sex Hormones and Immunity to Infection by : Sabra L. Klein

Download or read book Sex Hormones and Immunity to Infection written by Sabra L. Klein and published by Springer Science & Business Media. This book was released on 2009-10-22 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why sex matters Among human and nonhuman animals, the prevalence and intensity of infection typically is higher in males than females and may reflect differences in exposure as well as susceptibility to pathogens. Elevated immunity among females is a double-edged sword in which it is beneficial against infectious diseases but is detrimental in terms of increased development of autoimmune diseases. The present book critically reviews the evolutionary origin and the functional mechanisms responsible for sexual dimorphism in response to infection. It emphasizes the value of examining responses in both males and females to improve our understanding about host-pathogen interactions in both sexes. The contributors are experts in their specific disciplines which range from microbiology and immunology to genetics, pathology, and evolutionary biology. The book aims at bringing insight to the treatment and management of infectious diseases; it delineates areas where knowledge is lacking and highlights future avenues of research.

The Genetics of African Populations in Health and Disease

Author : Muntaser E. Ibrahim
Publisher : Cambridge University Press
ISBN 13 : 1107072026
Total Pages : 351 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis The Genetics of African Populations in Health and Disease by : Muntaser E. Ibrahim

Download or read book The Genetics of African Populations in Health and Disease written by Muntaser E. Ibrahim and published by Cambridge University Press. This book was released on 2019-12-19 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: A pioneering work that focuses on the unique diversity of African genetics, offering insights into human biology and genetic approaches.

Exploration of Host Genetic Factors associated with Malaria

Author : Tabish Qidwai
Publisher : Springer Nature
ISBN 13 : 9813347619
Total Pages : 174 pages
Book Rating : 4.8/5 (133 download)

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Book Synopsis Exploration of Host Genetic Factors associated with Malaria by : Tabish Qidwai

Download or read book Exploration of Host Genetic Factors associated with Malaria written by Tabish Qidwai and published by Springer Nature. This book was released on 2021-03-08 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is aimed to cover the role of genetic polymorphisms in human genes related to RBC disorders, metabolic enzymes, immune response, and cytoadherence in the susceptibility/resistance to malaria caused by Plasmodium falciparum. The chapters provide current information on the balancing trait and the significance of such traits in the malaria resistance. The book covers polymorphisms in the genes of the red blood cells-sickle cell anaemia; glucose-6-phosphate dehydrogenase deficiency and thalassemia that confer protection against malaria. In addition, the book explores selection of genetic variations in the human genome as genetic control mechanism against malaria in endemic regions. It also provides a comprehensive overview of the molecular epidemiology and natural selection of alleles in the genes which are associated with malaria, and presents description of the role of human genetic polymorphisms in malaria disease risk and disease outcome.

Understanding Racial and Ethnic Differences in Health in Late Life

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309165865
Total Pages : 184 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Understanding Racial and Ethnic Differences in Health in Late Life by : National Research Council

Download or read book Understanding Racial and Ethnic Differences in Health in Late Life written by National Research Council and published by National Academies Press. This book was released on 2004-09-08 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the population of older Americans grows, it is becoming more racially and ethnically diverse. Differences in health by racial and ethnic status could be increasingly consequential for health policy and programs. Such differences are not simply a matter of education or ability to pay for health care. For instance, Asian Americans and Hispanics appear to be in better health, on a number of indicators, than White Americans, despite, on average, lower socioeconomic status. The reasons are complex, including possible roles for such factors as selective migration, risk behaviors, exposure to various stressors, patient attitudes, and geographic variation in health care. This volume, produced by a multidisciplinary panel, considers such possible explanations for racial and ethnic health differentials within an integrated framework. It provides a concise summary of available research and lays out a research agenda to address the many uncertainties in current knowledge. It recommends, for instance, looking at health differentials across the life course and deciphering the links between factors presumably producing differentials and biopsychosocial mechanisms that lead to impaired health.

HLA and Disease Associations

Author : J.L. Tiwari
Publisher : Springer Science & Business Media
ISBN 13 : 1461385458
Total Pages : 492 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis HLA and Disease Associations by : J.L. Tiwari

Download or read book HLA and Disease Associations written by J.L. Tiwari and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human leukocyte antigen (HLA) or tissue types are the products of a rapidly developing field of knowledge within the last 20 years. In the early stages of the research many investigators suspected the existence of a complex series of transplantation antigens, but it was widely believed that these antigens would not be well-defined even in this century. Yet in the last two decades as many as 124 different HLA antigens determined by at least 7 very closely linked genes located on the short arm of chromosome 6 have been identified and subsequently agreed upon by an international nomenclature committee. 1 Extensive international collaboration fueled by the potential clinical application of these antigens to clinical transplantation has advanced the field rapidly. There were nine inter national histocompatibility workshops held during this period. Although iden tification of HLA antigens was of primary clinical importance in transplantation 2 and of great basic interest in human genetics and anthropology, a rather un expected bonus has been the determination that HLA antigens are associated with disease susceptibility to a greater extent than any other known genetic marker in man. In the past, many genetic polymorphisms have been suspected to be associated with diseases. The most extensively studied markers are blood groups, enzymes, and serum proteins. A comprehensive account of published studies, totalling approximately 1,000, of these markers is available in a book by Mourant et al.

The Genetic Basis of Common Diseases

Author : Richard A. King
Publisher : Oxford University Press
ISBN 13 : 0199747776
Total Pages : 1091 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis The Genetic Basis of Common Diseases by : Richard A. King

Download or read book The Genetic Basis of Common Diseases written by Richard A. King and published by Oxford University Press. This book was released on 2002-10-17 with total page 1091 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first edition of this highly acclaimed text was published in 1992, much new knowledge has been gained about the role of genetic factors in common adult diseases, and we now have a better understanding of the molecular processes involved in genetic susceptibility and diseases mechanisms. The second edition fully incorporates these advances. The entire book has been updated and twelve new chapters have been added. Most of these chapters deal with diseases such as gallstones, osteoporosis, osteoarthritis, skin cancer, other common skin diseases, prostate cancer and migraine headaches that are seen by all physicians. Others address the genetic and molecular basis of spondylarthropathies, lupus, hemochromatosis, IgA deficiency, mental retardation, hearing loss, and the role of mitochondrial variation in adult diseases. Chapters on the evolution of human genetic disease and on animal models add important background on the omplexities of these diseases. Unique clinical applications of genetics to common diseases are covered in the additional new chapters on genetic counseling, pharmacogenetics, and the genetic consequences of modern therapeutics.

Genes, Behavior, and the Social Environment

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309133815
Total Pages : 384 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Genes, Behavior, and the Social Environment by : Institute of Medicine

Download or read book Genes, Behavior, and the Social Environment written by Institute of Medicine and published by National Academies Press. This book was released on 2006-11-07 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past century, we have made great strides in reducing rates of disease and enhancing people's general health. Public health measures such as sanitation, improved hygiene, and vaccines; reduced hazards in the workplace; new drugs and clinical procedures; and, more recently, a growing understanding of the human genome have each played a role in extending the duration and raising the quality of human life. But research conducted over the past few decades shows us that this progress, much of which was based on investigating one causative factor at a time—often, through a single discipline or by a narrow range of practitioners—can only go so far. Genes, Behavior, and the Social Environment examines a number of well-described gene-environment interactions, reviews the state of the science in researching such interactions, and recommends priorities not only for research itself but also for its workforce, resource, and infrastructural needs.

Polyomaviruses and Human Diseases

Author : Nasimul Ahsan
Publisher : Springer Science & Business Media
ISBN 13 : 0387329579
Total Pages : 383 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Polyomaviruses and Human Diseases by : Nasimul Ahsan

Download or read book Polyomaviruses and Human Diseases written by Nasimul Ahsan and published by Springer Science & Business Media. This book was released on 2007-06-25 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Science never solves apr oblem without creating ten more Geor ge Bernard Shaw How prophetic the above words prove to be when applied to the advances of 20th century medicine. Prior to Banting and Best, chnicians were unaware of the ravages of diabetes, patients simply wasted away and died. Following the purifica tion of insulin, clinicians now had to deal with diabetic retinopathy, diabetic neph ropathy and all the other complications of long-term diabetes. A little over 50 years ago, the first successful human kidney transplant was performed in Boston. The first 30 years of the experience had successes when compared to the alternative but were a constant struggle to get even 50% of the grafts from deceased donors to survive more than a year. However, the science continued to advance knowledge of the immune response. With this came more and increasingly powerful tools for the clinician. Suddenly, success rates of 80-90% at one year were attainable. With this success came new problems, new complications and clinicians now had to worry about the long-term consequences of their therapy as patients were surviving with functional grafts for extended periods. A particular infectious complication evolved with the application of ever more powerful immunosuppressant drugs. Astute clinicians noted that occasionally cellular rejections seemed to get worse with steroids. Despite their best efforts and the use of powerful drugs, patients lost their grafts to overwhelming interstitial infiltrates not seen before.

Applied Mathematical Ecology

Author : Simon A. Levin
Publisher : Springer Science & Business Media
ISBN 13 : 3642613179
Total Pages : 498 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Applied Mathematical Ecology by : Simon A. Levin

Download or read book Applied Mathematical Ecology written by Simon A. Levin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Autumn Course on Mathematical Ecology was held at the Intern ational Centre for Theoretical Physics in Trieste, Italy in November and December of 1986. During the four year period that had elapsed since the First Autumn Course on Mathematical Ecology, sufficient progress had been made in applied mathemat ical ecology to merit tilting the balance maintained between theoretical aspects and applications in the 1982 Course toward applications. The course format, while similar to that of the first Autumn Course on Mathematical Ecology, consequently focused upon applications of mathematical ecology. Current areas of application are almost as diverse as the spectrum covered by ecology. The topiys of this book reflect this diversity and were chosen because of perceived interest and utility to developing countries. Topical lectures began with foundational material mostly derived from Math ematical Ecology: An Introduction (a compilation of the lectures of the 1982 course published by Springer-Verlag in this series, Volume 17) and, when possible, progressed to the frontiers of research. In addition to the course lectures, workshops were arranged for small groups to supplement and enhance the learning experience. Other perspectives were provided through presentations by course participants and speakers at the associated Research Conference. Many of the research papers are in a companion volume, Mathematical Ecology: Proceedings Trieste 1986, published by World Scientific Press in 1988. This book is structured primarily by application area. Part II provides an introduction to mathematical and statistical applications in resource management.

Opportunistic Infections

Author : David S. Lindsay
Publisher : Springer Science & Business Media
ISBN 13 : 1402078463
Total Pages : 249 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Opportunistic Infections by : David S. Lindsay

Download or read book Opportunistic Infections written by David S. Lindsay and published by Springer Science & Business Media. This book was released on 2008-04-16 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Opportunistic Infections: Toxoplasma, Sarcocystis, and Microsporidia will focus on two important Genera of Apicomplexan parasites, Toxoplasma gondii and Sarcocystis species, and the medically important members of the Phylum Microsporida. We have been fortunate in obtaining excellent contributions from many experts in the field. Volumes in the "World Class Parasites" book series are written for researchers, students and scholars who enjoy reading about excellent research on problems of global significance. Each volume focuses on a parasite, or group of parasites, that has a major impact on human health, or agricultural productivity, and against which we have no satisfactory defense. The volumes are intended to supplement more formal texts that cover taxonomy, life cycles, morphology, vector distribution, symptoms and treatment. They integrate vector, pathogen and host biology and celebrate the diversity of approach that comprises modern parasitological research.