Genetically Modified Model Report on Toxicology and Carcinogeneticity Studies of Dichloroacetic Acid (CAS No. 79-43-6) in Genetically Modified (FVB Tb. ACV Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenecity Studies of Dichloroacetic Acid in Genetically Modified [B6. 129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water Studies)

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ISBN 13 : 9781422315200
Total Pages : 167 pages
Book Rating : 4.3/5 (152 download)

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Book Synopsis Genetically Modified Model Report on Toxicology and Carcinogeneticity Studies of Dichloroacetic Acid (CAS No. 79-43-6) in Genetically Modified (FVB Tb. ACV Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenecity Studies of Dichloroacetic Acid in Genetically Modified [B6. 129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water Studies) by : G. A. Boorman

Download or read book Genetically Modified Model Report on Toxicology and Carcinogeneticity Studies of Dichloroacetic Acid (CAS No. 79-43-6) in Genetically Modified (FVB Tb. ACV Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenecity Studies of Dichloroacetic Acid in Genetically Modified [B6. 129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water Studies) written by G. A. Boorman and published by . This book was released on 2007-08-01 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dichloroacetic acid was nominated for study by the EPA because of its widespread occurrence in drinking water as a byproduct of water disinfection using chlorination. It was also nominated because dicholoroacetic acid is the most studied representative of the class of haloacetic acids & has been shown to cause liver tumors in both rats & mice. Haloacetic acids are second only to trihalomethanes as a family of disinfection byproducts found in many drinking water supplies. Dichloroacetic acid is one of several disinfection byproducts being evaluated to determine whether genetically modified mouse models can serve as a more rapid & cost-effective means of evaluating & ranking potential hazards of disinfection byproducts. Illustrations.

NTP Report on the Toxicology Studies of Dichloroacetic Acid (CAS No. 79-43-6) in Genetically Modified (FVB Tg. AC Hemizygous) Mice (dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (drinking Water Studies)

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Book Synopsis NTP Report on the Toxicology Studies of Dichloroacetic Acid (CAS No. 79-43-6) in Genetically Modified (FVB Tg. AC Hemizygous) Mice (dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (drinking Water Studies) by :

Download or read book NTP Report on the Toxicology Studies of Dichloroacetic Acid (CAS No. 79-43-6) in Genetically Modified (FVB Tg. AC Hemizygous) Mice (dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (drinking Water Studies) written by and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

NTP Technical Report on the Toxicology Studies of Dichloroacetic Acid (CAS No. 79-43-6) in Genetically Modified (FVB Tg. AC Hemizygous) Mice (dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (drinking Water Studies)

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Book Synopsis NTP Technical Report on the Toxicology Studies of Dichloroacetic Acid (CAS No. 79-43-6) in Genetically Modified (FVB Tg. AC Hemizygous) Mice (dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (drinking Water Studies) by :

Download or read book NTP Technical Report on the Toxicology Studies of Dichloroacetic Acid (CAS No. 79-43-6) in Genetically Modified (FVB Tg. AC Hemizygous) Mice (dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (drinking Water Studies) written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

NTP Report on the Toxicology Studies of Dichloroacetic Acid (CAS NO. 79-43-6) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53]

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Book Synopsis NTP Report on the Toxicology Studies of Dichloroacetic Acid (CAS NO. 79-43-6) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53] by : Gary A Boorman

Download or read book NTP Report on the Toxicology Studies of Dichloroacetic Acid (CAS NO. 79-43-6) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53] written by Gary A Boorman and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genetically Modified Model Report on Toxicology Studies of Bromodichloromethane (CAS No. 75-27-4) in Genetically Modified (FVB Tb. AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6. 129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies)

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ISBN 13 : 9781422315224
Total Pages : 227 pages
Book Rating : 4.3/5 (152 download)

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Book Synopsis Genetically Modified Model Report on Toxicology Studies of Bromodichloromethane (CAS No. 75-27-4) in Genetically Modified (FVB Tb. AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6. 129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies) by : G. A. Boorman

Download or read book Genetically Modified Model Report on Toxicology Studies of Bromodichloromethane (CAS No. 75-27-4) in Genetically Modified (FVB Tb. AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6. 129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies) written by G. A. Boorman and published by . This book was released on 2007-08-01 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bromodichloromethane (BD) is a by-product of the chlorination of drinking water. It is formed by the halogen substitution & oxidation reactions of chlorine & naturally occurring organic matter (e.g., humic or fluvic acids) in water containing bromide. BD was nominated to the Nat. Toxicology Program for toxicology & carcinogenecity studies. Male & female Tb.AC hemizygous mice received bromodichloromethane (at least 99% pure) by dermal application for 26 or 39 weeks, in drinking water for 26 or 42 weeks, or by gavage for 26 or 41 weeks. p53 Haploinsufficient mice received BD in drinking water for 26 or 42 weeks or by gavage for 26 or 42 weeks. Genetic toxicology studies were conducted in mouse peripheral blood erythrocytes. Illustrations.

NTP Technical Report on the Toxicology Studies of Bromodichloromethane (CAS No. 75-27-4) in Genetically Modified (FVB Tg. AC Hemizygous) Mice (dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (drinking Water and Gavage Studies)

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Book Synopsis NTP Technical Report on the Toxicology Studies of Bromodichloromethane (CAS No. 75-27-4) in Genetically Modified (FVB Tg. AC Hemizygous) Mice (dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (drinking Water and Gavage Studies) by :

Download or read book NTP Technical Report on the Toxicology Studies of Bromodichloromethane (CAS No. 75-27-4) in Genetically Modified (FVB Tg. AC Hemizygous) Mice (dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (drinking Water and Gavage Studies) written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

NTP Report on the Toxicology Studies of Bromodichloromethane (CAS No. 75-27-4) in Genetically Modified (FVB Tg. AC Hemizygous) Mice (dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (drinking Water and Gavage Studies)

Download NTP Report on the Toxicology Studies of Bromodichloromethane (CAS No. 75-27-4) in Genetically Modified (FVB Tg. AC Hemizygous) Mice (dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (drinking Water and Gavage Studies) PDF Online Free

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Book Synopsis NTP Report on the Toxicology Studies of Bromodichloromethane (CAS No. 75-27-4) in Genetically Modified (FVB Tg. AC Hemizygous) Mice (dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (drinking Water and Gavage Studies) by :

Download or read book NTP Report on the Toxicology Studies of Bromodichloromethane (CAS No. 75-27-4) in Genetically Modified (FVB Tg. AC Hemizygous) Mice (dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (drinking Water and Gavage Studies) written by and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genetically Modified Model Report on Toxicology Studies of Allyl Bromide (CAS No. 106-95-6) in Genetically Modified (FVB Tb. AC Hemizygous) Mice and Carcinogenicity Studies of Allyl Bromide in Genetically Modified [B6. 129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Dermal and Gavage Studies)

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ISBN 13 : 9781437904802
Total Pages : 122 pages
Book Rating : 4.9/5 (48 download)

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Book Synopsis Genetically Modified Model Report on Toxicology Studies of Allyl Bromide (CAS No. 106-95-6) in Genetically Modified (FVB Tb. AC Hemizygous) Mice and Carcinogenicity Studies of Allyl Bromide in Genetically Modified [B6. 129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Dermal and Gavage Studies) by : J. K. Dunnick

Download or read book Genetically Modified Model Report on Toxicology Studies of Allyl Bromide (CAS No. 106-95-6) in Genetically Modified (FVB Tb. AC Hemizygous) Mice and Carcinogenicity Studies of Allyl Bromide in Genetically Modified [B6. 129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Dermal and Gavage Studies) written by J. K. Dunnick and published by . This book was released on 2008-10 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Allyl Bromide (AB) is a colorless to light yellow liquid with an unpleasant pungent odor. It is slightly soluble in water and miscible with alcohol, chloroform, ether, carbon disulfide, or carbon tet. Dangerous fire and explosion hazards occur when AB is exposed to heat, flame, or oxidizers; it also emits toxic bromide fumes when heated to decomposition. AB is used primarily as a starting material/chemical intermediate in organic synthesis and as an intermediate in the manufacture of polymers/resins, synthetic perfumes, pharmaceuticals, ag. chem., and other allyl compounds. It is also an insecticidal fumigant used in crop prot. Genetic toxicology studies were conducted in ¿Salmonella typhimurium¿ and mouse peripheral blood erythrocytes. Illus.

NTP Technical Report on the Toxicology Study of Diisopropylcarbodiimide (CAS No. 693-13-0) in Genetically Modified (FVB Tg. AC Hemizygous) Mice and Carcinogenicity Study of Diisopropylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (dermal Studies)

Download NTP Technical Report on the Toxicology Study of Diisopropylcarbodiimide (CAS No. 693-13-0) in Genetically Modified (FVB Tg. AC Hemizygous) Mice and Carcinogenicity Study of Diisopropylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (dermal Studies) PDF Online Free

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ISBN 13 :
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Book Synopsis NTP Technical Report on the Toxicology Study of Diisopropylcarbodiimide (CAS No. 693-13-0) in Genetically Modified (FVB Tg. AC Hemizygous) Mice and Carcinogenicity Study of Diisopropylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (dermal Studies) by :

Download or read book NTP Technical Report on the Toxicology Study of Diisopropylcarbodiimide (CAS No. 693-13-0) in Genetically Modified (FVB Tg. AC Hemizygous) Mice and Carcinogenicity Study of Diisopropylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (dermal Studies) written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

NTP Report on the Toxicology Study of Diispropylcarbodiimide (CAS NO. 693-13-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Diispropylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice ((Dermal Studies)emizygous) Mice and Carcinogenicity Study of Diispropylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mi

Download NTP Report on the Toxicology Study of Diispropylcarbodiimide (CAS NO. 693-13-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Diispropylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice ((Dermal Studies)emizygous) Mice and Carcinogenicity Study of Diispropylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mi PDF Online Free

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ISBN 13 :
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Book Rating : 4.:/5 (135 download)

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Book Synopsis NTP Report on the Toxicology Study of Diispropylcarbodiimide (CAS NO. 693-13-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Diispropylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice ((Dermal Studies)emizygous) Mice and Carcinogenicity Study of Diispropylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mi by :

Download or read book NTP Report on the Toxicology Study of Diispropylcarbodiimide (CAS NO. 693-13-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Diispropylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice ((Dermal Studies)emizygous) Mice and Carcinogenicity Study of Diispropylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mi written by and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

NTP Report on the Toxicology Study of Diisopropylcarbodiimide (CAS No. 693-13-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Diisopropylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (dermal Studies)

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ISBN 13 :
Total Pages : 54 pages
Book Rating : 4.:/5 (144 download)

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Book Synopsis NTP Report on the Toxicology Study of Diisopropylcarbodiimide (CAS No. 693-13-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Diisopropylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (dermal Studies) by : National Toxicology Program (U.S.)

Download or read book NTP Report on the Toxicology Study of Diisopropylcarbodiimide (CAS No. 693-13-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Diisopropylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (dermal Studies) written by National Toxicology Program (U.S.) and published by . This book was released on 2007 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt:

NTP Report on the Toxicology Studies of Dicyclohexylcarbodiimide (CAS No. 538-75-0) in F344/N Rats, B6C3F1 Mice and Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Studyof Dicyclohexylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (dermal Studies)

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ISBN 13 :
Total Pages : 138 pages
Book Rating : 4.:/5 (177 download)

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Book Synopsis NTP Report on the Toxicology Studies of Dicyclohexylcarbodiimide (CAS No. 538-75-0) in F344/N Rats, B6C3F1 Mice and Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Studyof Dicyclohexylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (dermal Studies) by : National Toxicology Program (U.S.)

Download or read book NTP Report on the Toxicology Studies of Dicyclohexylcarbodiimide (CAS No. 538-75-0) in F344/N Rats, B6C3F1 Mice and Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Studyof Dicyclohexylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (dermal Studies) written by National Toxicology Program (U.S.) and published by . This book was released on 2007 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:

NTP Report on the Toxicology Studies of Dicyclohexylcarbodiimide (CAS NO. 538-75-0) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Dicyclohexylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Dermal Studies)

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ISBN 13 :
Total Pages : 138 pages
Book Rating : 4.:/5 (129 download)

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Book Synopsis NTP Report on the Toxicology Studies of Dicyclohexylcarbodiimide (CAS NO. 538-75-0) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Dicyclohexylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Dermal Studies) by :

Download or read book NTP Report on the Toxicology Studies of Dicyclohexylcarbodiimide (CAS NO. 538-75-0) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Dicyclohexylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Dermal Studies) written by and published by . This book was released on 2007 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: BACKGROUND: Dicyclohexylcarbodiimide is used as a stabilizing agent in elastics and fibers and for the chemical synthesis of peptides. We tested if dicyclohexylcarbodiimide could cause cancer in two different strains of genetically modified mice. METHODS: We applied solutions containing dicyclohexylcarbodiimide dissolved in ethanol to the backs of female Tg.AC hemizygous mice for 20 weeks and to female p53 haploinsufficient mice for 27 weeks. The daily doses were 0.75, 1.5, 3, 6, or 12 milligrams of dicyclohexylcarbodiimide per kilogram of body weight. Besides the skin where the solutions were applied, tissues from over 15 organs were examined for every animal. RESULTS: Exposure to dicyclohexylcarbodiimide caused inflammation and hyperplasia of the skin at the site of application in both strains of genetically modified mice. Female Tg.AC hemizygous mice given dicyclohexylcarbodiimide developed squamous cell papillomas of the skin at the site the chemical was applied. Female p53 haploinsufficient mice receiving dicyclohexylcarbodiimide did not have any increase in tumors related to the chemical. CONCLUSIONS: We conclude that dicyclohexylcarbodiimide caused cancer of the skin in female Tg.AC hemizygous mice but not in female p53 haploinsufficient mice.

NTP Report on the Toxicology Studies of Dicyclohexylcarbodiimide (CAS NO. 538-75-0) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Dicyclohexylcarbodiimide in Genetically Modified [B6.129-Tr]

Download NTP Report on the Toxicology Studies of Dicyclohexylcarbodiimide (CAS NO. 538-75-0) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Dicyclohexylcarbodiimide in Genetically Modified [B6.129-Tr] PDF Online Free

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Book Rating : 4.:/5 (135 download)

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Book Synopsis NTP Report on the Toxicology Studies of Dicyclohexylcarbodiimide (CAS NO. 538-75-0) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Dicyclohexylcarbodiimide in Genetically Modified [B6.129-Tr] by :

Download or read book NTP Report on the Toxicology Studies of Dicyclohexylcarbodiimide (CAS NO. 538-75-0) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Dicyclohexylcarbodiimide in Genetically Modified [B6.129-Tr] written by and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genetically Modified Model Report on Toxicology Studies of Dicyclohexylcarbodiimide and Carcinogenicity Study of Dicyclohexylcarbodiimide

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ISBN 13 : 9781422319789
Total Pages : 138 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Genetically Modified Model Report on Toxicology Studies of Dicyclohexylcarbodiimide and Carcinogenicity Study of Dicyclohexylcarbodiimide by : R. S. Chabra

Download or read book Genetically Modified Model Report on Toxicology Studies of Dicyclohexylcarbodiimide and Carcinogenicity Study of Dicyclohexylcarbodiimide written by R. S. Chabra and published by . This book was released on 2008-01 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dicyclohexylcarbodiimide is used in industry as a stabilizing agent, coupling agent, & condensing agent. Its widespread use during protein synthesis in the recombinant DNA industry & in the synthesis of polypeptides in the chemical & pharmaceutical industries provides an increasing potential for low-level human exposure. Dicyclohexylcarbodiimide was nominated for study as a key representative of the carbodiimide chemical class because of its acute toxicity & the absence of data on potential health effects. Under the conditions of this 27-week dermal study, there was no evidence of carcinogenic activity of dicyclohexylcarbodiimide in female p53 haplo-insufficient mice administered 0.75, 3, 6, or 12 mg/kg in ethanol. Female Tg.AC hemizygous mice dermally dosed with dicyclohexylcarbodiimide for 20 weeks had significantly increased incidences of squamous cell papilloma of the skin at the site of application. Non-neoplastic lesions noted at the site of application included chronic active inflammation & epidermal hyperplasia in female p53 haplo-insufficient mice & female Tg.AC hemizygous mice. Illus.