Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Phenolphthalein (CAS No. 77-09-8) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Feed Study)

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Publisher : DIANE Publishing
ISBN 13 : 1428988815
Total Pages : 364 pages
Book Rating : 4.4/5 (289 download)

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Book Synopsis Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Phenolphthalein (CAS No. 77-09-8) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Feed Study) by : J. K. Dunnick

Download or read book Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Phenolphthalein (CAS No. 77-09-8) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Feed Study) written by J. K. Dunnick and published by DIANE Publishing. This book was released on 2008-04 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phenolphthalein (PH) was commonly used as a laxative for most of the 20th cent. The use of PH in laxatives has decreased since 1997 when the FDA proposed to withdraw its classification as an OTC drug. PH has been previously evaluated in carcinogenecity studies in 1996. The major route of human exposure to PH is via ingestion, dermal contact, & inhalation of contaminated air originating from process units manufacturing the compound. In this study, the carcinogenic effects of PH were studied in the haploinsufficient p16Ink4a/p19Arf mouse model as an ongoing goal to seek model systems for toxicology & carcinogenesis studies, especially those that can provide mechanistic info. relative to understanding an agent¿s model of action. Illustrations.

Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Glycidol (CAS No. 556-52-5) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Gavage Study)

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Publisher : DIANE Publishing
ISBN 13 : 1437902243
Total Pages : 81 pages
Book Rating : 4.4/5 (379 download)

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Book Synopsis Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Glycidol (CAS No. 556-52-5) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Gavage Study) by : J. K. Dunnick

Download or read book Genetically Modified Model Report on Toxicology and Carcinogenesis Study of Glycidol (CAS No. 556-52-5) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (Gavage Study) written by J. K. Dunnick and published by DIANE Publishing. This book was released on 2008-06 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glycidol is used as a chemical intermediate in the pharmaceutical industry, as a stabilizer in the manufacture of vinyl polymers, and as an intermediate in the synthesis of glycerol, Glycidol ethers, and amines. Glycidol was nominated for carcinogenecity study by the Environmental Protection Agency (EPA). Glycidol was selected for study in the haploinsufficient p16Ink4a/p19Arf mouse because it was found to be carcinogenic in rats and mice in conventional 2-year rodent studies (NTP, 1990), but was negative in a study in p53+/- mice (Tennant et al., 1999). In this study, male and female mice received Glycidol (greater than 95% pure) by gavage for 40 weeks. Genetic toxicology studies were conducted in mouse peripheral blood erythrocytes. Illustrations.

NTP GMM.

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Publisher :
ISBN 13 :
Total Pages : 90 pages
Book Rating : 4.:/5 (9 download)

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Book Synopsis NTP GMM. by :

Download or read book NTP GMM. written by and published by . This book was released on 2005 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Processing Contaminants in Edible Oils

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Publisher : Elsevier
ISBN 13 : 1630670316
Total Pages : 212 pages
Book Rating : 4.6/5 (36 download)

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Book Synopsis Processing Contaminants in Edible Oils by :

Download or read book Processing Contaminants in Edible Oils written by and published by Elsevier. This book was released on 2015-08-15 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the current research on monochloropropanediol (MCPD) and glycidyl esters in edible oils. These potentially harmful contaminants are formed during the industrial processing of food oils during deodorization. The mechanisms of formation for these contaminants, as well as research identifying possible precursor molecules are reviewed. Strategies which have been used successfully to decrease the concentrations of these contaminants in edible oils are discussed, including the removal of precursor molecules before processing, modifications of deodorization protocol, and approaches for the removal of these contaminants after the completion of processing. Analytical strategies for accurate detection and quantitation of MCPD and glycidyl esters are covered, along with current information on their toxicological properties. This book serves as a single point of reference for the significant research related to these contaminants. Details the mechanisms of formation for these contaminants and research identifying possible precursor molecules Presents successful strategies to decrease the concentrations of these contaminants in edible oils Includes the analytical strategies for accurate detection and quantitation of the contaminants along with their toxicological properties.

Encyclopedia of Food Chemistry

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Publisher : Elsevier
ISBN 13 : 0128140453
Total Pages : 2217 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Encyclopedia of Food Chemistry by :

Download or read book Encyclopedia of Food Chemistry written by and published by Elsevier. This book was released on 2018-11-22 with total page 2217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Food Chemistry, Three Volume Set is the ideal primer for food scientists, researchers, students and young professionals who want to acquaint themselves with food chemistry. Well-organized, clearly written, and abundantly referenced, the book provides a foundation for readers to understand the principles, concepts, and techniques used in food chemistry applications. Articles are written by international experts and cover a wide range of topics, including food chemistry, food components and their interactions, properties (flavor, aroma, texture) the structure of food, functional foods, processing, storage, nanoparticles for food use, antioxidants, the Maillard and Strecker reactions, process derived contaminants, and the detection of economically-motivated food adulteration. The encyclopedia will provide readers with an introduction to specific topics within the wider context of food chemistry, as well as helping them identify the links between the various sub-topics. Offers readers a comprehensive understanding of food chemistry and the various connections between the sub-topics Provides an authoritative introduction for non-specialists and readers from undergraduate levels and upwards Meticulously organized, with articles structured logically based on the various elements of food chemistry

Food safety in the context of limited food availability

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Publisher : Food & Agriculture Org. [Author] [Author]
ISBN 13 : 925138777X
Total Pages : 128 pages
Book Rating : 4.2/5 (513 download)

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Book Synopsis Food safety in the context of limited food availability by : Food and Agriculture Organization of the United Nations

Download or read book Food safety in the context of limited food availability written by Food and Agriculture Organization of the United Nations and published by Food & Agriculture Org. [Author] [Author]. This book was released on 2024-05-24 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipid-based nutrient supplements (LNS) and ready-to-use therapeutic food (RUTF) are used to prevent and treat malnutrition in children. [Author] They are often produced in regions experiencing food insecurity and include edible oils obtained from oleaginous seeds or fruits that must be refined to remove undesirable substances and ensure adequate shelf-life for the product. [Author] However, the formation of the heat-induced contaminants 3-monochloropropane-1,2-diol (3-MCPD) fatty acid esters and glycidyl fatty acid esters (GEs) may occur during the refining process of edible oils. [Author] 3-MCPD and its fatty acid esters are present in many other foodstuffs and most of the total lifetime exposure is attributed to foods other than LNS/RUTF. [Author] While the only Codex standard developed for 3-MCPD is for liquid condiments containing acid hydrolyzed vegetable proteins, no Codex standards are available for GEs. [Author] This publication provides an overview of risk assessments for 3-MCPD and GEs previously performed by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), European Food Safety Authority (EFSA) and other authorities, based on chronic exposure. [Author] The use of LNS/RUTF is intended to be of finite duration and confined to a specific life stage. [Author] The aim of this report was to provide an assessment to characterize the risk of less-than-lifetime exposure to 3-MCPD (including 3-MCPD fatty acid esters) and GEs via LNS/RUTF in the context of limited food availability. [Author] The thresholds identified herein for concentrations of 3-MCPD and glycidol equivalents in LNS/RUTF products are considered to represent a level of exposure that is of low concern for human health. [Author]

NTP Report on the Toxicology and Carcinogenesis Study of Phenolphthalein (CAS No. 77-09-8) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (feed Study)

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Publisher :
ISBN 13 :
Total Pages : 86 pages
Book Rating : 4.:/5 (241 download)

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Book Synopsis NTP Report on the Toxicology and Carcinogenesis Study of Phenolphthalein (CAS No. 77-09-8) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (feed Study) by : National Toxicology Program (U.S.)

Download or read book NTP Report on the Toxicology and Carcinogenesis Study of Phenolphthalein (CAS No. 77-09-8) in Genetically Modified Haploinsufficient P16Ink4a/p19Arf Mice (feed Study) written by National Toxicology Program (U.S.) and published by . This book was released on 2007 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mutagenic Impurities

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Publisher : John Wiley & Sons
ISBN 13 : 1119551218
Total Pages : 548 pages
Book Rating : 4.1/5 (195 download)

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Book Synopsis Mutagenic Impurities by : Andrew Teasdale

Download or read book Mutagenic Impurities written by Andrew Teasdale and published by John Wiley & Sons. This book was released on 2022-02-15 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn to implement effective control measures for mutagenic impurities in pharmaceutical development In Mutagenic Impurities: Strategies for Identification and Control, distinguished chemist Andrew Teasdale delivers a thorough examination of mutagenic impurities and their impact on the pharmaceutical industry. The book incorporates the adoption of the ICH M7 guideline and focuses on mutagenic impurities from both a toxicological and analytical perspective. The editor has created a primary reference for any professional or student studying or working with mutagenic impurities and offers readers a definitive narrative of applicable guidelines and practical, tested solutions. It demonstrates the development of effective control measures, including chapters on the purge tool for risk assessment. The book incorporates a discussion of N-Nitrosamines which was arguably the largest mutagenic impurity issue ever faced by the pharmaceutical industry, resulting in the recall of Zantac and similar drugs resulting from N-Nitrosamine contamination. Readers will also benefit from the inclusion of: A thorough introduction to the development of regulatory guidelines for mutagenic and genotoxic impurities, including a historical perspective on the development of the EMEA guidelines and the ICH M7 guideline An exploration of in silico assessment of mutagenicity, including use of structure activity relationship evaluation as a tool in the evaluation of the genotoxic potential of impurities A discussion of a toxicological perspective on mutagenic impurities, including the assessment of mutagenicity and examining the mutagenic and carcinogenic potential of common synthetic reagents Perfect for chemists, analysts, and regulatory professionals, Mutagenic Impurities: Strategies for Identification and Control will also earn a place in the libraries of toxicologists and clinical safety scientists seeking a one-stop reference on the subject of mutagenic impurity identification and control.

Genotoxic Impurities

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Publisher : John Wiley & Sons
ISBN 13 : 0470934751
Total Pages : 455 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Genotoxic Impurities by : Andrew Teasdale

Download or read book Genotoxic Impurities written by Andrew Teasdale and published by John Wiley & Sons. This book was released on 2011-03-29 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines genotoxic impurities and their impact on the pharmaceutical industry. Specific sections examine this from both a toxicological and analytical perspective. Within these sections, the book defines appropriate strategies to both assess and ultimately control genotoxic impurities, thus aiding the reader to develop effective control measures. An opening section covers the development of guidelines and the threshold of toxicological concern (TTC) and is followed by a section on safety aspects, including safety tests in vivo and vitro, and data interpretation. The second section addresses the risk posed by genotoxic impurities from outside sources and from mutagens within DNA. In the final section, the book deals with the quality perspective of genotoxic impurities focused on two critical aspects, the first being the analysis and the second how to practically evaluate the impurities.

Handbook of Carcinogenic Potency and Genotoxicity Databases

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Publisher : CRC Press
ISBN 13 : 9781439810644
Total Pages : 840 pages
Book Rating : 4.8/5 (16 download)

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Book Synopsis Handbook of Carcinogenic Potency and Genotoxicity Databases by : Lois Swirsky Gold

Download or read book Handbook of Carcinogenic Potency and Genotoxicity Databases written by Lois Swirsky Gold and published by CRC Press. This book was released on 1996-11-26 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique new reference contains the Carcinogenic Potency Database (CPDB), which analyzes results of decades of animal cancer tests, including all Technical Reports of the National Toxicology Program (NTP) and the general published literature. A guide to the literature of animal cancer tests, the CPDB includes references to each published experiment and never-before published analyses. For each of 5,000 long-term experiments on 1,300 chemicals, the user-friendly format includes data on the species, strain, and sex of the test animal; features of experimental protocol such as the route of administration, duration of dosing, dose levels, and duration of the experiment; histopathology and tumor incidence; the shape of the dose-response curve; published author's opinion about the carcinogenicity at each site; and reference to the original publication of the test results. In addition, a measure of carcinogenic potency, the TD50, its statistical significance and confidence limits, are given for each tumor site. An overview is provided of earlier publication updates, such as positivity rates, reproducibility, interspecies extrapolation, and ranking possible carcinogenic hazards. The book also includes a summary of the NTP genetic toxicity test results on 1,500 chemicals, which are referenced to the original publications, including the Salmonella (Ames) test, L5178Y mouse lymphoma cell mutation test, chromosome aberration and sister chromatid exchange tests in cultured Chinese hamster ovary cells, and the sex-linked recessive lethal mutation test in Drosophila melanogaster. An index with chemicals listed by CAS number allows cross referencing between the carcinogenicity and genotoxicity databases, making data easy to find.

Some industrial chemicals and dyestuffs : this publication represents the views and expert opinions of an IARC working group on the evaluation of the carcinogenic risk of chemicals to humans which met in Lyon, 13-20 October 1981

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Publisher :
ISBN 13 : 9789283212294
Total Pages : 0 pages
Book Rating : 4.2/5 (122 download)

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Book Synopsis Some industrial chemicals and dyestuffs : this publication represents the views and expert opinions of an IARC working group on the evaluation of the carcinogenic risk of chemicals to humans which met in Lyon, 13-20 October 1981 by :

Download or read book Some industrial chemicals and dyestuffs : this publication represents the views and expert opinions of an IARC working group on the evaluation of the carcinogenic risk of chemicals to humans which met in Lyon, 13-20 October 1981 written by and published by . This book was released on 1982 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of Carcinogen Testing

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Publisher : William Andrew Inc.
ISBN 13 : 9780815513568
Total Pages : 856 pages
Book Rating : 4.5/5 (135 download)

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Book Synopsis Handbook of Carcinogen Testing by : Harry A. Milman

Download or read book Handbook of Carcinogen Testing written by Harry A. Milman and published by William Andrew Inc.. This book was released on 1994-01-01 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1961 the National Cancer Institute initiated a program to conduct bioassays of selected compounds to determine whether they might be carcinogens. Although some similarities continue with the program as it was in 1961, there are many more differences. Since 1985 when the first edition of this book appeared, these differences have been substantial enough to merit an updated version. This updated edition will provide the reader with an overview of how to proceed with the various tests and how the data are eventually used for regulatory decisions.

Chemical Carcinogenesis

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Publisher : Springer Science & Business Media
ISBN 13 : 1617379956
Total Pages : 447 pages
Book Rating : 4.6/5 (173 download)

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Book Synopsis Chemical Carcinogenesis by : Trevor M. Penning

Download or read book Chemical Carcinogenesis written by Trevor M. Penning and published by Springer Science & Business Media. This book was released on 2011-03-03 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.

Toxicological Evaluation of Certain Veterinary Drug Residues in Food

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Publisher : World Health Organization
ISBN 13 : 9789241660532
Total Pages : 206 pages
Book Rating : 4.6/5 (65 download)

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Book Synopsis Toxicological Evaluation of Certain Veterinary Drug Residues in Food by : Joint FAO/WHO Expert Committee on Food Additives

Download or read book Toxicological Evaluation of Certain Veterinary Drug Residues in Food written by Joint FAO/WHO Expert Committee on Food Additives and published by World Health Organization. This book was released on 2005 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: The monographs in this volume summarize data on the veterinary drug residues that were evaluated toxicologically by the Committee, which included three antimicrobial agents (cefuroxime, flumequine and pirlimycin), two insecticides (cyhalothrin, and cypermethrin and alpha-cypermethrin) and one production aid (ractopamine). The Committee also evaluated the safety of low levels of the antimicrobial agent chloramphenicol in animal products. This volume and others in the WHO Food Additives Series contain information that is useful to those who produce and use food additives and veterinary drugs and those involved with controlling contaminants in food, government and food regulatory officers, industrial testing laboratories, toxicological laboratories, and universities.

Chemical Carcinogenesis

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Publisher : Springer Science & Business Media
ISBN 13 : 1468443348
Total Pages : 496 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Chemical Carcinogenesis by : Claudio Nicolini

Download or read book Chemical Carcinogenesis written by Claudio Nicolini and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: During October 18-30, 1981, the second course of the International School of Pure and Applied Biostructure, a NATO Advanced Study Institute, was held at the Ettore Majorana Center for Scientific Culture in Erice, Italy, co-sponsored by the International Union Against Cancer, the Italian League Against Cancer, the Italian Ministry of Public Education, the Italian Ministry of Scientific and Technological Research, the North Atlantic Treaty Organization, the Italian National Research Council, the Sicilian Regional Government and two pharmaceutical Companies (Zambeletti and Farmitalia). The subject of the course was "Chemical Carcino genesis" with participants selected world-wide from 18 different countries. It is now eminently clear that.the bulk of human cancers are related to one of several types of environmental exposure. Of the environmental hazards, chemicals are among the best characterized carcinogens. However, how chemicals induce cancer is still poorly understood. Because of the magnitude of the problem and the ob vious need for a much more critical scientific analysis of the process by which cancer is induced (carcinogenesis), it was highly desirable to expose a greater number of scientists with varying background to some of the latest thinking in chemical carcino genesis. The course had this as its major objective and the re sulting book does reflect it.

Evaluation of Certain Mycotoxins in Food

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Publisher : World Health Organization
ISBN 13 : 9789241209069
Total Pages : 80 pages
Book Rating : 4.2/5 (9 download)

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Book Synopsis Evaluation of Certain Mycotoxins in Food by : Joint FAO/WHO Expert Committee on Food Additives. Meeting

Download or read book Evaluation of Certain Mycotoxins in Food written by Joint FAO/WHO Expert Committee on Food Additives. Meeting and published by World Health Organization. This book was released on 2002 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report presents the conclusions of a joint expert committee convened to assess the risks associated with the consumption of food contaminated with specific mycotoxins. It contains a general discussion of the principles for evaluating mycotoxins in food, including those concerning analytical methods, sampling, data on food consumption and dietary intake, and prevention and control.

Safety Evaluation of Certain Contaminants in Food

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Publisher : WHO Food Additives
ISBN 13 : 9789241660631
Total Pages : 0 pages
Book Rating : 4.6/5 (66 download)

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Book Synopsis Safety Evaluation of Certain Contaminants in Food by : Joint FAO/WHO Expert Committee on Food Additives. Meeting

Download or read book Safety Evaluation of Certain Contaminants in Food written by Joint FAO/WHO Expert Committee on Food Additives. Meeting and published by WHO Food Additives. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The detailed monographs in this volume summarize the technical, analytical, dietary exposure and toxicological data on a number of contaminants in food: acrylamide, arsenic, deoxydivalenol, furan, mercury and perchlorate. This volume and others in the WHO Food Additives series contain information that is useful to those who produce and use food additives and veterinary drugs and those involved with controlling contaminants in food, government and food regulatory officers, industrial testing laboratories, toxicological laboratories and universities.