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Genetic Analysis Of Myosin Light Chain 2 Function In Drosophila Melanogaster
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Book Synopsis Muscle Development in Drosophilia by : Helen Sink
Download or read book Muscle Development in Drosophilia written by Helen Sink and published by Springer Science & Business Media. This book was released on 2006-02-02 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: The different aspects of muscle development are considered from cellular, molecular and genetic viewpoints, and the text is supported by black/white and color illustrations. The book will appeal to those studying muscle development and muscle biology in any organism.
Book Synopsis Myofibrillogenesis by : Dipak K. Dube
Download or read book Myofibrillogenesis written by Dipak K. Dube and published by Springer Science & Business Media. This book was released on 2001-10-19 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myofibrillogenesis has been studied extensively over the last 100 years. Until recently, we have not had a comprehensive understanding of this fundamental process. The emergence of new technologies in molecular and cellular biology, combined with classical embryology, have started to unravel some of the complexities of myofibril assembly in striated muscles. In striated muscles, the contractile proteins are arranged in a highly ordered three dimensional lattice known as the sarcomere. The assembly of a myofibril involves the precise ordering of several proteins into a linear array of sarcomeres. Multiple isoforms in many of these proteins further complicate the process, making it difficult to define the precise role of each component. This volume has been compiled as a comprehensive reference on myofibrillogenesis. In addition, the book includes reviews on myofibrillar disarray under various pathological conditions, such as familial hypertrophic cardiomyopathy (FHC), and incorporates a section on the conduction system in the heart. Much of the information in this volume has not been described elsewhere. Presented in a manner to be of value to students and teachers alike, "Myofibrillogenesis" will be an invaluable reference source for all in the fields of muscle biology and heart development.
Book Synopsis Behavioral Genetics of the Fly (Drosophila Melanogaster) by : Josh Dubnau
Download or read book Behavioral Genetics of the Fly (Drosophila Melanogaster) written by Josh Dubnau and published by Cambridge University Press. This book was released on 2014-06-26 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive portrayal of the behaviour genetics of the fruit fly (Drosophila melanogaster) and the methods used in these studies.
Book Synopsis Regulation of Smooth Muscle Contraction by : Robert S. Moreland
Download or read book Regulation of Smooth Muscle Contraction written by Robert S. Moreland and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sixth Annual Graduate Hospital Research Symposium REGULATION OF SMOOTH MUSCLE PROGRESS IN SOLVING THE PUZZLE Every so often a scientific conference comes at a time when everyone has new and exciting information, when old "dogmas" do not seem to be as well established, and when speakers and participants alike are ready to challenge interpretations of old and new experimental data. This was such a conference. What turns on a smooth muscle cell? The precise answer to this question has eluded scientists for much longer than I have been involved in the field. We know that an increase in cytosolic calcium is necessary and we know that phosphorylation of the 20 kDa myosin light chain is an important step in the process. We do not know if other processes are necessary for the initiation and lor maintenance of a smooth muscle contraction nor do we know if other processes modulate the regulation of contraction. The goal of the symposium on which this volume is based was to explore the most current hypotheses for the answers to these questions. I believe that after reading the chapters included in this volume, you will agree that this goal was achieved. The importance of calcium and calmodulin dependent myosin light chain phosphoryla tion in the regulation of smooth muscle contraction was reinforced by many presentations. However, the status of myosin light chain phosphorylation as a simple calcium dependent switch came under serious suspicion.
Book Synopsis Molecular Genetic Analysis of Drosophila Melanogaster Paramyosin in Muscle Development, Structure, and Function by : Hongjun Liu
Download or read book Molecular Genetic Analysis of Drosophila Melanogaster Paramyosin in Muscle Development, Structure, and Function written by Hongjun Liu and published by . This book was released on 2003 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Paramyosin is a major structural component of invertebrate muscles. It forms thick filament cores with other proteins. The motor protein myosin assembles on the surface of the core to form functional thick filaments. To investigate the roles of paramyosin in thick filament assembly as well as muscle contraction, I functionally knocked out the Drosophila melanogaster paramyosin gene by mobilizing a P element localized in the promoter region. I found that homozygous paramyosin mutants die at the embryo stage. Using electron microscopy and confocal microscopy, I analyzed the phenotypic defects of a functional null allele prm1. I observed that, in the absence of paramyosin, thick filaments of embryo body wall muscles are abnormal and the striated pattern of myobibrils is disrupted. These results indicate that paramyosin is essential for thick filament assembly and myofibril formation. Surprisingly, the muscle pattern of paramyosin mutant embryos is also abnormal. Mutation of paramyosin causes random losses of muscle fibers. Using a marker for founder myoblasts and the DMEF2 antibody which recognizes all myoblasts, I proved that the muscle fiber loss is not due to defects in myoblast differentiation. Rather, it is caused by abnomal myoblast fusion. Using a paramyosin specific antibody, I revealed that paramyosin functions as a cytoplasmic protein before myofibril formation and is important for myoblast fusion. I further investigated the function of paramyosin phosphorylation in the NH2-terminal non-helical domain. I made transgenic flies in which 1, 3, or 4 phosphorylatable serine residues in this domain are substituted with alanines. I observed that mutations of paramyosin at these residues do not affect the ultrastructure of myofibrils. However, mutant flies with substitution at some specific sites are flight impaired. Mechanical studies of indirect flight muscle fibers revealed that the flight impairment is caused by reduced fiber stiffness and power output. These results indicate that paramyosin phosphorylation in the NH2-terminal domain is important for muscle contraction.
Book Synopsis Nature's Versatile Engine: by : Jim Vigoreaux
Download or read book Nature's Versatile Engine: written by Jim Vigoreaux and published by Springer Science & Business Media. This book was released on 2007-06-24 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods for Obtaining X-Ray Diffraction Patterns from Drosophila 198 Diffraction Patterns from Drosophila IFM 203 Concluding Remarks 211 Note Added in Proof 211 17. Functional and Ecological Effects of Isoform Variation in Insect Flight Muscle 214 James H. Marden Abstract 214 Introduction 215 Nature's Versatile Engine 215 The Underlying Genetics: An Underinflated Genome and a Hyperinflated Transcriptome and Proteome 216 Functional Effects of Isoform Variation 219 Alternative Splicing and the Generation of Combinatorial Complexity 220 Functional Consequences of Naturally Occurring Isoform Variation 220 18. Muscle Systems Design and Integration 230 Fritz- OlafLehmann Abstract 230 Power Requirements for Flight 230 Power Reduction 233 Power Constraints on Steering Capacity 234 Balancing Power and Control 236 Changes in Muscle Efficiency in Vivo 238 Concluding Remarks 239 From the Inside Out 19. Molecular Assays for Acto-Myosin Interactions 242 John C. Sparrow and Michael A. Geeves Abstract 242 Introduction 242 Myosin Purification and Preparation of the SI Fragment 243 Purification of Flight Muscle Actin 244 Assays of Myosin and Acto-Myosin 244 Major Conclusions Relating to the Enzymatic Properties of Insect Flight Muscle Acto-Myosin 247 Major Questions about Insect Flight Muscle Acto-Myosin Kinetics That Remain 249 20.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1999 with total page 1860 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Calcium Regulation of Cellular Function by :
Download or read book Calcium Regulation of Cellular Function written by and published by Academic Press. This book was released on 2000-04-01 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 30 examines the prominent role of calcium as an intracellular second messenger. Leading investigators review a wide variety of studies on how calcium enters and moves through cells, how it interacts with its many binding proteins, and how calcium and its intracellular receptor, calmodulin, control vital cellular processes. Coverage includes a detailed analysis of the mechanisms by which calcium bound to calmodulin regulates contractile proteins in smooth muscle cells. Close attention is given to the roles of calcium and calmodulin-dependent protein kinases and phosphatases in synaptic signal transduction, protein synthesis, gene expression, programmed cell death, activation of T-lymphocytes, and control of cell division cycles. Other chapters discuss studies using genetically manipulable nonmammalian organisms to further proble the functions of calcium and calmodulin.
Book Synopsis Animal Models in Medicine and Biology by : Eva Tvrdá
Download or read book Animal Models in Medicine and Biology written by Eva Tvrdá and published by BoD – Books on Demand. This book was released on 2020-04-08 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thanks to animal models, our knowledge of biology and medicine has increased enormously over the past decades, leading to significant breakthroughs that have had a direct impact on the prevention, management and treatment of a wide array of diseases.This book presents a comprehensive reference that reflects the latest scientific research being done in a variety of medical and biological fields utilizing animal models. Chapters on Drosophila, rat, pig, rabbit, and other animal models reflect frontier research in neurology, psychiatry, cardiology, musculoskeletal disorders, reproduction, chronic diseases, epidemiology, and pain and inflammation management. Animal Models in Medicine and Biology offers scientists, clinicians, researchers and students invaluable insights into a wide range of issues at the forefront of medical and biological progress.
Download or read book Myosins written by James Sellers and published by OUP Oxford. This book was released on 1999-05-13 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myosins are a diverse superfamily of molecular motor proteins, which share the ability to reversibly bind actin and hydrolyse MgATP. They are capable of either translocating actin filaments or translocating vesicles or other cargo on fixed actin filaments. There are currently 15 distinct classes in the myosins superfamily, based on sequence homology. Myosin II and myosin I proteins are familiar and well studied; while Classes III-XV are less well characterized. All myosins examined to date are multimeric and appear to possess at least three functional domains, a head, neck, and tail. Myosins (second edition) explores the structure and functional properties of myosins, their regulation, and mutational analysis. It has been thoroughly updated since the first edition was published in 1995 including sections on the three additional classes defined by new sequences, information provided by the crystal structure of seven new Dicytostelium motor domains, and data from new techniques such as molecular imaging and tagging proteins with GFP 20. The three human diseases that are now known to be linked to mutations in different myosin heavy or light chains are also covered, including more than 50 mutations associated with hyperotrophic cardiomyopathy.
Download or read book Research Awards Index written by and published by . This book was released on 1987 with total page 834 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Genetics written by and published by Academic Press. This book was released on 1999-05-04 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Genetics increases its focus on modern human genetics and its relation to medicine with the merger of this long-standing serial with Molecular Genetic Medicine. This merger affirms the Academic Press commitment to publish important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Volume 39 of Advances in Genetics completes the trilogy of volumes authored by Dr. Igor Zhimulev of the Institute of Cytology and Genetics in Novosibirsk, Russia. This set comprises what is perhaps the most comprehensive collection of volumes dedicated to the study of polytene chromosomes. Volume 39 picks up where the previous two volumes, 34 and 37, left off. It covers the organization of genetic material in the morphological structures of the interphase chromosome, the chromomeres and the interchromomeric regions, and the structural changes occurring during the activation of the chomomeres, the puffs.
Book Synopsis Biology of Drosophila by : Milislav Demerec
Download or read book Biology of Drosophila written by Milislav Demerec and published by CSHL Press. This book was released on 1994 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biology of Drosophila was first published by John Wiley and Sons in 1950. Until its appearance, no central, synthesized source of biological data on Drosophila melanogaster was available, despite the fly's importance to science for three decades. Ten years in the making, it was an immediate success and remained in print for two decades. However, original copies are now very hard to find. This facsimile edition makes available to the fly community once again its most enduring work of reference.
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 1998 with total page 662 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Genetic, Molecular and Ultrastructural Characterization of Myosin Heavy Chain Mutations in Drosophila Melanogaster by : Patrick Thomas O'Donnell
Download or read book Genetic, Molecular and Ultrastructural Characterization of Myosin Heavy Chain Mutations in Drosophila Melanogaster written by Patrick Thomas O'Donnell and published by . This book was released on 1988 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biochemistry of Smooth Muscle Contraction by : Michael Barany
Download or read book Biochemistry of Smooth Muscle Contraction written by Michael Barany and published by Elsevier. This book was released on 1996-01-04 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: This valuable resource provides a systematic account of the biochemistry of smooth muscle contraction. As a comprehensive guide to this rapidly growing area of research, it covers the structure and characteristic properties of contractile and regulatory proteins, with special emphasis on their predicted function in the live muscle. Also included in this book are intermediate filament proteins, and desmin and vimentin, whose function in smooth muscle is unknown; and several enzymes involved in the phosphorylation-dephosphorylation of contractile and other proteins.
Book Synopsis Animal Anomalies by : Lewis I. Held, Jr
Download or read book Animal Anomalies written by Lewis I. Held, Jr and published by Cambridge University Press. This book was released on 2021-03-18 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highlights what we know about the pathways pursued by embryos and evolution, and stresses what we do not yet know.
