Gap Junction Protocols

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Author :
Publisher : Methods in Molecular Biology
ISBN 13 : 9781493981106
Total Pages : 252 pages
Book Rating : 4.9/5 (811 download)

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Book Synopsis Gap Junction Protocols by : Mathieu Vinken

Download or read book Gap Junction Protocols written by Mathieu Vinken and published by Methods in Molecular Biology. This book was released on 2018-06-04 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Corrected statement of responsibility may be: edited by ...

Gap Junction Channels and Hemichannels

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Author :
Publisher : CRC Press
ISBN 13 : 9780367658441
Total Pages : 289 pages
Book Rating : 4.6/5 (584 download)

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Book Synopsis Gap Junction Channels and Hemichannels by : Taylor & Francis Group

Download or read book Gap Junction Channels and Hemichannels written by Taylor & Francis Group and published by CRC Press. This book was released on 2021-03-30 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gap junction channels are a group of intercellular channels expressed in tissues and organs to synchronize many physiological processes. A gap junction channel is formed by the docking of two hemichannels, and each hemichannel is a hexamer of connexins. The field of gap junction channel and hemichannel research has recently exploded and became one of the most active areas of cell biology. Numerous novel approaches and techniques have been developed, but there is no single book dedicated to the unique techniques and protocols employed for the research on these large pore channels. This book fills the gap and focuses on protocols, approaches and reviews of gap junction channels and connexin hemichannels. It will be a useful reference for graduate students, postdoctoral fellows and researchers. Anyone with an interest in gap junction channels and hemichannels will need this summary of state-of-the-art techniques and protocols.

Connexin Methods and Protocols

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1592590438
Total Pages : 495 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Connexin Methods and Protocols by : Roberto Bruzzone

Download or read book Connexin Methods and Protocols written by Roberto Bruzzone and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: Direct cell–cell communication is a common property of multicellular organisms that is achieved through membrane channels which are organized in gap junctions. The protein subunits of these intercellular channels, the connexins, form a multigene family that has been investigated in great detail in recent years. It has now become clear that, in different tissues, connexins speak several languages that control specific cellular functions. This progress has been made possible by the availability of new molecular tools and the improvement of basic techniques for the study of membrane channels, as well as by the use of genetic approaches to study protein function in vivo. More important, connexins have gained visibility because mutations in some connexin genes have been found to be linked to human genetic disorders. Connexin Methods and Protocols presents in detail a collection of te- niques currently used to study the cellular and molecular biology of connexins and their physiological properties. The field of gap junctions and connexin research has always been characterized by a multidisciplinary approach c- bining morphology, biochemistry, biophysics, and cellular and molecular biology. This book provides a series of cutting-edge protocols and includes a large spectrum of practical methods that are available to investigate the fu- tion of connexin channels. Connexin Methods and Protocols is divided into three main parts.

Gap Junctions

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Author :
Publisher : Elsevier
ISBN 13 : 9780762305995
Total Pages : 432 pages
Book Rating : 4.3/5 (59 download)

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Book Synopsis Gap Junctions by : E.L. Hertzberg

Download or read book Gap Junctions written by E.L. Hertzberg and published by Elsevier. This book was released on 2000-01-10 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective in editing this volume was twofold: to provide a reasoned overview of the field as well as to furnish one that provided this overview within the context of the intellectual boundaries of those who initially attempted to define the purview of gap junction research. The latter objective has been realized by selecting the topics for review in this volume. The former objective was achieved by securing the cooperation of leaders in their fields as chapter co-authors.

Gap Junctions

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Author :
Publisher : IOS Press
ISBN 13 : 9789051993745
Total Pages : 412 pages
Book Rating : 4.9/5 (937 download)

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Book Synopsis Gap Junctions by : Rudolf Werner

Download or read book Gap Junctions written by Rudolf Werner and published by IOS Press. This book was released on 1998 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph contains research articles from the leading laboratories around the world on gap junctions, the intercellular channels that allow communication between neighbouring cells. It describes the latest results in gap junctions research, the structural and functional characterization of cell-cell channels, the assembly and degradation of gap junctions, the expression and function of gap junctions in different tissues, knockout studies of gap junction genes, the regulation of connexin gene expression, and the functions of gap junctions in development and cancer. Any laboratory interested in intercellular communications and gap junction research will find this monograph an indispensable source of information and reference.

Connexin Hemichannels

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Author :
Publisher : Springer Nature
ISBN 13 : 1071638424
Total Pages : 206 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Connexin Hemichannels by : Fabio Mammano

Download or read book Connexin Hemichannels written by Fabio Mammano and published by Springer Nature. This book was released on with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Gap Junctions

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Author :
Publisher : Elsevier
ISBN 13 : 0444599843
Total Pages : 356 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Gap Junctions by : J.E. Hall

Download or read book Gap Junctions written by J.E. Hall and published by Elsevier. This book was released on 2012-12-02 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gap junctions are present in nearly all tissues, regardless of their embronic origin and have long been of great interest to scientists from many different disciplines. The international meeting on which this book is based brought together 157 scientists from 12 countries and almost as many scientific disciplines. The papers presented at the meeting were reviewed and updated prior to publication in this book. The seven parts of the book progress from general topics to the more specific ones (role of gap junctions in various tissues, regulation and biochemistry, and cancer).

Gap Junctions in Development and Disease

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Publisher : Springer Science & Business Media
ISBN 13 : 9783540261568
Total Pages : 312 pages
Book Rating : 4.2/5 (615 download)

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Book Synopsis Gap Junctions in Development and Disease by : Elke Winterhager

Download or read book Gap Junctions in Development and Disease written by Elke Winterhager and published by Springer Science & Business Media. This book was released on 2005-07-19 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Communication between cells via intercellular channels – gap junctions – appears essential to certain developmental processes and appropriate organ function. Gap Junctions in Development and Disease aims to describe the molecular events underlying impaired development and disease. Beginning with a comprehensive review of various mouse and human genes encoding the channel-forming connexins, later chapters describe several connexin mutations associated with human diseases such as hereditary deafness and female infertility. Erroneous signaling mediated by the interaction of mutant connexins with other proteins, thought to be responsible for dysfunction of organs such as heart, muscle, brain, skin, lens, placenta, and endocrine tissue in both mice and men, is also addressed. Although the question of why some mutations in gap-junction proteins lead to specific phenotypes remains to be answered, the reviews in this book provide an intriguing insight into the future direction of this research field.

Gap Junctions: Molecular Basis of Cell Communication in Health and Disease

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Author :
Publisher : Academic Press
ISBN 13 : 9780080585208
Total Pages : 648 pages
Book Rating : 4.5/5 (852 download)

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Book Synopsis Gap Junctions: Molecular Basis of Cell Communication in Health and Disease by :

Download or read book Gap Junctions: Molecular Basis of Cell Communication in Health and Disease written by and published by Academic Press. This book was released on 1999-12-22 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first gap junction protein (connexin) was cloned over a decade ago, more than a dozen connexin genes have been cloned. Consequently, a wealth of information on the molecular basis of gap junctional communication has been accumulated. This book pays tribute to this exciting era in the history of cell communication research by documenting the great strides made in this field as a result of the merging of biophysics and molecular biology, two of the most powerful approaches to studying the molecular basis of membrane channel behavior. Twenty-eight comprehensive chapters, authored by internationally recognized leaders in the field, discuss the biophysical, physiological, and molecular characteristics of cell-to-cell communication via gap junctions. Key aspects of molecular structure, formation, gating, conductance, and permeability of vertebrate and invertebrate gap junction channels are highlighted. In addition, a number of chapters focus on recent discoveries that implicate connexin mutations and alterations of gap junctional communication in the pathogenesis of several diseases, including the X-linked Charcot Marie Tooth demyelinating disease, some forms of inherited sensorineural deafness, malignant transformation, cardiac malformations and arrhythmia, eye lens cataract, and Chagas' disease.

Gap Junction-Mediated Intercellular Signalling in Health and Disease

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 0470515597
Total Pages : 296 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis Gap Junction-Mediated Intercellular Signalling in Health and Disease by : Gail Cardew

Download or read book Gap Junction-Mediated Intercellular Signalling in Health and Disease written by Gail Cardew and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gap junctions are key elements in communication between cells in multicellular organisms. It is clear that their activity is essential for normal embryonic development and normal function in adult organs, although the individual roles of the proteins that form the channels (connexins) are not yet fully understood. The last few years have seen considerable progress in this field and exciting new issues concerning gap junctional intercellular communication are being raised. Perturbed gap junction activity is beginning to be linked to certain pathologies, e.g. mutations in the major connexin of the heart have been found in human patients suffering from visceroatrial heterotaxia syndrome and mutations in the gene encoding another connexin have been found in patients with Charcot-Marie-Tooth disease. This book is the first to highlight the recent progress in understanding gap junction structure and to discuss the specific roles of individual connexins. It features contributions from an interdisciplinary group of experts who review the role of gap junctions in the heart, the retina and lens, the auditory system, the reproductive system, and in cell proliferation and cancer. The book will appeal to people interested in cell and molecular biology, embryonic development, neurobiology, cardiology, gynaecology and oncology.

Cardiovascular Gap Junctions

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Author :
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805580770
Total Pages : 307 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Cardiovascular Gap Junctions by : Stefan Dhein

Download or read book Cardiovascular Gap Junctions written by Stefan Dhein and published by Karger Medical and Scientific Publishers. This book was released on 2006-01-01 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, gap junction research in the cardiovascular system has considerably improved the understanding of cardiac function and the vasculature in health and disease. The present book focuses on the communication of intercellular gap junctions in

Cardiac Gap Junctions

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Author :
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805565674
Total Pages : 155 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Cardiac Gap Junctions by : Stefan Dhein

Download or read book Cardiac Gap Junctions written by Stefan Dhein and published by Karger Medical and Scientific Publishers. This book was released on 1998-01-01 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides an overview of what is currently known about cardiac gap junctions. An introduction into the various aspects of activation propogation and coupling in the heart is followed by a detailed description of the structure and diversity of gap junctions.

Gap Junction Channels and Hemichannels

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Author :
Publisher :
ISBN 13 : 9781315369396
Total Pages : 289 pages
Book Rating : 4.3/5 (693 download)

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Book Synopsis Gap Junction Channels and Hemichannels by : Donglin Bai

Download or read book Gap Junction Channels and Hemichannels written by Donglin Bai and published by . This book was released on 2017 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pattern Formation in Zebrafish

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Author :
Publisher : Springer
ISBN 13 : 9783642536670
Total Pages : 438 pages
Book Rating : 4.5/5 (366 download)

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Book Synopsis Pattern Formation in Zebrafish by : Lilianna Solnica-Krezel

Download or read book Pattern Formation in Zebrafish written by Lilianna Solnica-Krezel and published by Springer. This book was released on 2012-11-28 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authored by leading experts in the field, this book provides the first comprehensive overview of the mechanisms of early patterning and morphogenesis in zebrafish. It summarizes the current knowledge and the key questions for the next decade of research.

Gap Junctions in the Brain

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Publisher : Academic Press
ISBN 13 : 012415901X
Total Pages : 318 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Gap Junctions in the Brain by : Ekrem Dere

Download or read book Gap Junctions in the Brain written by Ekrem Dere and published by Academic Press. This book was released on 2012-08-30 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: In addition to chemical links across synapses, neurons can also form direct connections via electrical gap junctions. These channels play a key role in brain development and intercellular communication. Dere (pathophysiology of cerebral aging, U. Pierre et Marie Curie, Paris; AP-HP Hôpital Charles Foix, Centre de Recherche et Développement, Ivry-sur-Seine, France) introduces types of gap junctions, their structural aspects, expression patterns of connexins (transmembrane proteins), and gap junction-related diseases due to mutations in connexin genes. International researchers working in this emerging field discuss specific connexin genes and their mechanisms of action and function in the developing neocortx, behavior, and neurological and neuropsychiatric diseases. The text includes color and b&w illustrations including schematic representations and models. Academic Press is an imprint of Elsevier. Annotation ©2013 Book News, Inc., Portland, OR (booknews.com).

Intercellular Communication through Gap Junctions

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Author :
Publisher : Newnes
ISBN 13 : 0444599525
Total Pages : 474 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Intercellular Communication through Gap Junctions by : Y. Kanno

Download or read book Intercellular Communication through Gap Junctions written by Y. Kanno and published by Newnes. This book was released on 1995-02-09 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on intercellular communication through gap junctions has continued to expand, and the meeting on which this book is based brought together many scientists from many different countries and disciplines. In line with the objective of the meeting, this volume focuses on the biological meaning of intercellular communication through gap junctions in various organs. The most recent up-to-date findings have been included in this extensive volume, valuable to all those interested in this rapidly expanding field.

A Laboratory Guide to the Tight Junction

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Publisher : Academic Press
ISBN 13 : 0128226439
Total Pages : 422 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis A Laboratory Guide to the Tight Junction by : Jianghui Hou

Download or read book A Laboratory Guide to the Tight Junction written by Jianghui Hou and published by Academic Press. This book was released on 2020-04-24 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Laboratory Guide to the Tight Junction offers broad coverage of the unique methods required to investigate its characteristics. The methods are described in detail, including its biochemical and biophysical principles, step-by-step process, data analysis, troubleshooting, and optimization. The coverage includes various cell, tissue, and animal models. Chapter 1 provides the foundations of cell biology of tight junction. Chapter 2 covers the Biochemical approaches for paracellular channels and is followed by chapter 3 providing the Biophysical approaches. Chapter 4 describes and discusses Histological approaches for tissue fixation and preparation. Chapter 5 discusses Light microscopy, while chapter 6 presents Electron microscopic approaches. Chapter 7 covers Transgenic manipulation in cell cultures, including DNA and siRNA, Mutagenesis, and viral infection. Chapter 8 covers transgenic manipulation in mice, including: Knockout, Knockin, siRNA knockdown, GFP/LacZ reporter, and overexpression. The final chapter discusses the future developments of new approaches for tight junction research. Researchers and advanced students in bioscience working on topics of cell junction, ion channel and membrane protein will benefit from the described methods. Clinicians and pathologists interested in tissue barrier diseases will also benefit from the biochemical and biophysical characterization of tight junctions in organ systems, and their connection to human diseases. Provides consistent and detailed research methods Covers various cell, tissue and animal models Includes step-by-step guidance from beginner to sophisticated levels