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Future Perspectives Of Gastric Cancer Treatment From Bench To Bedside
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Book Synopsis Future Perspectives of Gastric Cancer Treatment - From Bench to Bedside by : W. Yasui
Download or read book Future Perspectives of Gastric Cancer Treatment - From Bench to Bedside written by W. Yasui and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The highest rates of gastric cancer are observed in eastern Asia, South America and eastern Europe. More than half of all cases worldwide occur in eastern Asia. Distinguished experts in Asia have reviewed current topics and future perspectives for gastric cancer treatment in molecular pathology, tissue engineering, surgery and chemotherapy. Advances in diagnosis and treatment offer excellent long-term survival rates in the case of early cancer diagnosis, but the prognosis of advanced cancer still remains poor. A detailed understanding of molecular pathogenesis and the individual characteristics of gastric cancer and the development of new medical technologies and therapeutic agents help to provide personalized cancer care for patients of early and advanced cancer. For ongoing success, interactions and developments between bench and bedside as well as clinics and bench are crucial. This special issue is recommended for researchers, pathologists, surgeons, physicians and oncologists in the field of gastroenterology, who are interested in the current topics and future perspectives of molecular pathology, tissue engineering, surgery and chemotherapy of gastric cancer.
Book Synopsis Future Perspectives of Gastric Cancer Treatment by : Wataru Yasui
Download or read book Future Perspectives of Gastric Cancer Treatment written by Wataru Yasui and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The highest rates of gastric cancer are observed in eastern Asia, South America and eastern Europe. More than half of all cases worldwide occur in eastern Asia. Distinguished experts in Asia have reviewed current topics and future perspectives for gastric cancer treatment in molecular pathology, tissue engineering, surgery and chemotherapy. Advances in diagnosis and treatment offer excellent long-term survival rates in the case of early cancer diagnosis, but the prognosis of advanced cancer still remains poor. A detailed understanding of molecular pathogenesis and the individual characteristics of gastric cancer and the development of new medical technologies and therapeutic agents help to provide personalized cancer care for patients of early and advanced cancer. For ongoing success, interactions and developments between bench and bedside as well as clinics and bench are crucial. This special issue is recommended for researchers, pathologists, surgeons, physicians and oncologists in the field of gastroenterology, who are interested in the current topics and future perspectives of molecular pathology, tissue engineering, surgery and chemotherapy of gastric cancer.
Book Synopsis Gastric Cancer: Current Status and Future Perspectives by : Destiny Arthur
Download or read book Gastric Cancer: Current Status and Future Perspectives written by Destiny Arthur and published by . This book was released on 2020-09-08 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gastric cancer is the cancer, which develops in the lining of the stomach. Most stomach cancers are gastric carcinomas. Some of its early symptoms include upper abdominal pain, heartburn, nausea and loss of appetite. In its later stages, the cancer presents itself with yellowing of the skin and the whites of the eye, weight loss, vomiting and difficulty swallowing. More than 60% of gastric cancers are caused due to infection by Helicobacter pylori. If the cancer is detected and targeted early, it can be potentially cured. A gastroscopic exam involving the insertion of a fibre optic cable into the stomach, upper GI series and CT scanning of the abdomen can reveal gastric cancer. Treatments typically include a combination of radiation therapy, chemotherapy, targeted therapy and surgery. This book provides comprehensive insights into the current status and future perspectives of gastric cancer. It elucidates new techniques of assessment, diagnosis and management of gastric cancer in a multidisciplinary manner. Scientists and students actively engaged in oncology will find this book full of crucial and unexplored concepts.
Book Synopsis Future Perspectives in the Treatment of Incurable Gastric Cancer by : Yves Dittmar
Download or read book Future Perspectives in the Treatment of Incurable Gastric Cancer written by Yves Dittmar and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Future Perspectives in the Treatment of Incurable Gastric Cancer.
Book Synopsis Future Perspectives in the Treatment of Incurable Gastric Cancer by : Yves Dittmar
Download or read book Future Perspectives in the Treatment of Incurable Gastric Cancer written by Yves Dittmar and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Hyperthermic Oncology from Bench to Bedside by : Satoshi Kokura
Download or read book Hyperthermic Oncology from Bench to Bedside written by Satoshi Kokura and published by Springer. This book was released on 2016-06-07 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive work broadens readers' understanding of the rudimentary mechanism of the anti-cancer effect of hyperthermia. It also presents state-of-the-art clinical outcomes by hyperthermia treatment of cancer. In the past few decades, basic and clinical research have shown through in vitro experiments that hyperthermia inhibits epithelial-mesenchymal transition (EMT), resulting in the prevention of metastasis. It also has been learned that hyperthermia shows its superior benefit when applied in combination with radiation therapy, chemotherapy, or various immunotherapies as treatments of several types of carcinoma. The chapters here from expert contributors describe the details of their research for each type of cancer. This book provides not only an overview and the current status of hyperthermia but also its future perspectives. Therefore this volume will greatly benefit oncologists, radiologists and radiology technologists, and chemotherapists who are involved in immunotherapy for all kinds of cancer.
Download or read book Tumor Organoids written by Shay Soker and published by Humana Press. This book was released on 2017-10-20 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.
Book Synopsis Immunotherapy of Hepatocellular Carcinoma by : Tim F. Greten
Download or read book Immunotherapy of Hepatocellular Carcinoma written by Tim F. Greten and published by Springer. This book was released on 2018-08-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.
Book Synopsis Angiogenesis blockade for the treatment of gastrointestinal cancer by : Zhigang Bai
Download or read book Angiogenesis blockade for the treatment of gastrointestinal cancer written by Zhigang Bai and published by Frontiers Media SA. This book was released on 2023-03-07 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Natural Products and Nano-Formulations in Cancer Chemoprevention by : Shiv Kumar Dubey
Download or read book Natural Products and Nano-Formulations in Cancer Chemoprevention written by Shiv Kumar Dubey and published by CRC Press. This book was released on 2023-02-27 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers various aspects of cancer chemoprevention, including an overview of chemoprevention in the process of tumorigenesis; the roles of various phytochemicals, functional foods, and dietary interventions in disease prevention; and techniques such as cancer stem cell targeting, nano-formulations, and so forth. The nutrigenomic and epigenetic effects of natural products at the molecular and genetic levels are also covered alongside their potential for additive and synergistic effect, as well as overcoming drug resistance. The key selling features of the book are as follows: Discusses holistic and comprehensive areas of chemoprevention Includes diverse techniques, such as cancer stem cell targeting, nano-formulations, and nanotechnology-based drug delivery systems Introduces various mechanisms involved in prevention of the diseases, including targeting cancer stem cells Reviews various aspects which can reduce the toxicity and cost of treatment of diseases by alternative medicine Explores various sources, mechanisms, and ways to develop cancer chemopreventive agents with minimal toxicity compared to traditional cancer therapy drugs This book is focused on researchers and graduate students in drug delivery and formulation, nanobiotechnology, cancer chemoprevention, prevention, and therapeutics.
Author :Ludmila P. Filaretova Publisher :Karger Medical and Scientific Publishers ISBN 13 :3318021830 Total Pages :259 pages Book Rating :4.3/5 (18 download)
Book Synopsis Cell/Tissue Injury and Cytoprotection/Organoprotection in the Gastrointestinal Tract by : Ludmila P. Filaretova
Download or read book Cell/Tissue Injury and Cytoprotection/Organoprotection in the Gastrointestinal Tract written by Ludmila P. Filaretova and published by Karger Medical and Scientific Publishers. This book was released on 2012 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Up-to-date reviews on the mechanisms of gastrointestinal injury and protection In recent years, there have been significant advances both in understanding the mechanisms involved in gastrointestinal mucosal injury and protection, as well as in the development of successful strategies for prevention and treatment of gastrointestinal injury. Nevertheless, many people worldwide still suffer from gastrointestinal damage. This book contains contributions by an international panel of researchers in the form of up-to-date reviews on the mechanisms of gastrointestinal injury and protection. These are complemented by papers discussing how these new findings about cell/tissue injury and cytoprotection/organoprotection can be applied to the prevention and treatment of tissue damage in the gastrointestinal tract. Moreover, the publication includes a special chapter on Andre Robert, who has discovered the phenomenon of gastric cytoprotection. This publication will be of great interest for both basic and clinical researchers in gastroenterology and pharmacology, reviewing the advances made so far and pointing towards future developments.
Download or read book Biomedical Chemistry written by Nuno Vale and published by Walter de Gruyter GmbH & Co KG. This book was released on 2015-01-01 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical Chemistry provides readers with an understanding of how fundamental chemical concepts are used to combat some diseases. The authors explain the interdisciplinary relationship of chemistry with biology, physics, pharmacy and medicine. The results of chemical research can be applied to understand chemical processes in cells and in the body, and new methods for drug transportation. Also, basic chemical ideas and determination of disease etiology are approached by developing techniques to ensure optimum interaction between drugs and human cells. This Book is an excellent resource for students and researchers in health-related fields with frontier topics in medicinal and pharmaceutical chemistry, organic chemistry and biochemistry.
Book Synopsis Pathology and Genetics of Tumours of the Digestive System by : Lauri A. Aaltonen
Download or read book Pathology and Genetics of Tumours of the Digestive System written by Lauri A. Aaltonen and published by Oxford University Press, USA. This book was released on 2000 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative guide to the histological and genetic typing of human tumours of the digestive system. Prepared by 113 experts from 17 countries, the book covers neoplasms of the entire gastrointestinal tract, liver, biliary system, and exocrine pancreas. In view of their increasingly recognized importance, inherited tumour syndromes involving the digestive system are also described. Over 2200 references are included in this authoritative international tool. The book is organized according to ten groups of tumours. Each tumour is introduced with a concise definition and discussion of nomencl.
Book Synopsis Theranostics Approaches to Gastric and Colon Cancer by : Ganji Seeta Rama Raju
Download or read book Theranostics Approaches to Gastric and Colon Cancer written by Ganji Seeta Rama Raju and published by Springer Nature. This book was released on 2020-03-04 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the importance of understanding gastric and colon cancer metabolism in guiding diagnosis and drug discovery. It summarizes the correlation between adiponectin and matrix metalloproteinase with colorectal cancer. The book also evaluates the divergent role of hypoxia-inducible factor 1 in colorectal cancer growth and metastasis. After discussing the role of genetic polymorphisms in alcohol metabolizing enzymes and EPHX1 with the onset of colorectal cancer, it reviews the molecular mechanisms of chemoresistance in gastric cancer and novel therapeutic strategies to reverse the chemoresistance of tumors. In addition, the book explores the theranostic role of nanoparticles and therapeutic potential of phytochemicals with regard to colorectal cancer. Given its scope, the book offers a valuable guide for oncologists, academic researchers, pharmaceuticals practitioners, and students who are involved in research and treatment of cancer.
Book Synopsis Gastrointestinal Cancer Immunotherapy: from Drug Resistance Mechanisms to Overcoming Strategies by : Xiaofang Che
Download or read book Gastrointestinal Cancer Immunotherapy: from Drug Resistance Mechanisms to Overcoming Strategies written by Xiaofang Che and published by Frontiers Media SA. This book was released on 2023-06-15 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gastrointestinal (GI) cancers, including gastric cancer, colon cancer, liver cancer, esophageal cancer, and pancreatic cancer, seriously threaten the health of human beings worldwide with a high rate of morbidity and mortality. The clinical successes achieved with immune checkpoint inhibitors (ICIs) targeting PD-1/PD-L1 and CTLA-4 have opened a new cancer therapy era and brought new hope to cancer patients. However, the overall response rate (ORR) of ICI monotherapy in the non-selective population is only about 20%, in which some patients subsequently develop immunotherapy resistance. Moreover, the remaining 70-80% of patients displayed primary resistance to ICIs, and a few patients even experienced hyper progression disease (HPD). Although PD-L1 expression, mismatch repair deficient (MMRd), high tumor mutational burden (TMB-H) , high homologous recombination deficiency (HRD), and tumor infiltrated immune cells (TILs) are known as effective biomarkers for immunotherapy, growing studies have reported that ICIs could not improve the OS of all patients with PD-L1 expression higher than 50%, and the ORR of MSI-H patients was only about 60%, whereas some patients with low PD-L1 expression or MSS could still benefit from immunotherapy, indicating the complexity of ICI resistance. Therefore, it is of great importance and significance to explore the prediction biomarkers for primary or acquired immunotherapy resistance and elucidate their underlying molecular mechanisms and develop reversal strategies. Due to the multiple steps of the cancer immune cycle and complex immune microenvironment, any disorders of immune cell infiltration or T cell activation, such as lack of antigens and/or their presentation, lack of response to antigen presentation, and T cell priming, could contribute to ICI resistance. The combination with anti-angiogenesis therapy, radiotherapy, chemotherapy, and other ICIs has improved the efficacy of ICI therapy to some extent in the clinic. Although numerous studies related to ICI resistance were reported in GI cancers, due to the strong spatial/temporal heterogeneity and the complex immune microenvironment in different kinds of GI cancers and different individuals, many questions about ICI resistance and reversal strategies remain unsolved. The aim of this Research Topic is to provide a forum to exhibit the latest research achievement related to the exploration of biomarkers for immunotherapy resistance including HPD and the underlying molecular mechanisms, as well as the development of reversal strategies in GI cancers. We hope this Research Topic will lead to a better understanding of precision cancer immunotherapy and provide useful clues for clinical application to benefit more GI cancer patients with immunotherapy.
Book Synopsis Drug Repurposing in Cancer Therapy by : Kenneth K.W. To
Download or read book Drug Repurposing in Cancer Therapy written by Kenneth K.W. To and published by Academic Press. This book was released on 2020-07-29 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types
Book Synopsis SPEC - Colorectal Cancer: Disease and Advanced Drug Delivery Strategies, 12-Month Access, eBook by : Bhupendra Prajapati
Download or read book SPEC - Colorectal Cancer: Disease and Advanced Drug Delivery Strategies, 12-Month Access, eBook written by Bhupendra Prajapati and published by Elsevier. This book was released on 2023-11-19 with total page 619 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal Cancer: Disease and Advanced Drug Delivery Strategies examines the combined impact of basic clinical and medical treatments as well as recent advances in the field of colorectal cancer. With a strong focus towards colorectal cancer diagnosis, disease drug delivery, and diagnosis, the book also examines the Tumor microenvironment-responsive and site-specific nanoparticles for cancer theragnostics. In 16 chapters Colorectal Cancer: Disease and Advanced Drug Delivery Strategies not only provides the opportunity to understand and diagnose the disease, but it also describes screening methods, drugs including nano- and immunotherapy, and gives insight into the role of nanoparticles, lipids, and biomarkers in colorectal cancer. Content includes clinical trials in colorectal cancer research and disease models. This book directs researchers and clinicians how to better diagnose and treat colorectal cancer. Provides a wealth of information on the latest research and developments in the science and treatment of colorectal cancer Contains new and innovative ways to treat colorectal cancer Reflects on basic clinical and medical methods and recent advances in colorectal cancer science Gives specific details about how nanoparticles can be used to target cancer cells or cancer treatment Covers tumor microenvironment, their challenges, and opportunities in colorectal cancer research
