Frontiers In Molecular Pharming

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Frontiers in Molecular Pharming

Author : Muhammad Sarwar Khan
Publisher : Bentham Science Publishers
ISBN 13 : 981503667X
Total Pages : 413 pages
Book Rating : 4.8/5 (15 download)

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Book Synopsis Frontiers in Molecular Pharming by : Muhammad Sarwar Khan

Download or read book Frontiers in Molecular Pharming written by Muhammad Sarwar Khan and published by Bentham Science Publishers. This book was released on 2021-12-09 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advent of large-scale production and clinical trials of drugs developed through diverse production routes - involving viruses, microbes, plants, and animals - has increased the demand for an expanded capacity for pharmaceutical manufacturing. The production and purification of expressed proteins accounts for the bulk of the manufacturing costs for new therapeutics. Several pharmaceutical proteins have been synthesized by exploiting plant genetics allowing producers to override conventional approaches used to manufacture pharmaceuticals. The process of inserting a gene into a host organism for the purpose of harvesting a bioactive molecule for therapeutic use is known as molecular pharming. Frontiers in Molecular Pharming covers an array of topics relevant to understanding the structure, function, regulation, and mechanisms of action, biochemical significance, and usage of proteins and peptides as biomarkers, therapeutics, and vaccines for animals and humans. The contributions aim to highlight current progress in three areas, including system biology (in vivo characterization of proteins and peptides), molecular pharming for animals and molecular pharming for humans. The book gives special attention to computational biology tools, production platforms and fields (such as immunoinformatics) and applications of molecular pharming (such as veterinary therapeutics). A balance of theoretical concepts and practical applications is provided through 13 chapters. Frontiers in Molecular Pharming is an invaluable resource for students and researchers of biochemistry, molecular biology, and biotechnology. The book also serves as a springboard for understanding the process of how discoveries in protein and peptide research and its applications are coming to fruition.

Proceedings of ISPMF 2018 - Plant Molecular Farming

Author : Anneli Ritala
Publisher : Frontiers Media SA
ISBN 13 : 2889637948
Total Pages : 312 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Proceedings of ISPMF 2018 - Plant Molecular Farming by : Anneli Ritala

Download or read book Proceedings of ISPMF 2018 - Plant Molecular Farming written by Anneli Ritala and published by Frontiers Media SA. This book was released on 2020-06-16 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Plant Molecular Farming

Author : Kaiser Iqbal Wani
Publisher : Springer Nature
ISBN 13 : 3031127943
Total Pages : 83 pages
Book Rating : 4.0/5 (311 download)

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Book Synopsis Plant Molecular Farming by : Kaiser Iqbal Wani

Download or read book Plant Molecular Farming written by Kaiser Iqbal Wani and published by Springer Nature. This book was released on 2022-08-23 with total page 83 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular farming is a biotechnological approach that includes the genetic adjustment of agricultural products to create proteins and chemicals for profitable and pharmaceutical purposes. Plant molecular farming describes the manufacture of recombinant proteins and other biologically active product in plants. This approach depends on a genetic transformation of plants that can be accomplished by the methods of stable gene transfer, such as gene transfer to nuclei and chloroplasts, and unstable transfer methods like viral vectors. The requirement for recombinant proteins in terms of quality, quantity, and diversity is increasing exponentially This demand is traditionally met by recombinant protein construction technologies and the engineering of orthodox expression systems based on bacteria or mammalian cell cultures. However, majority of developing countries cannot afford the high costs of medicine derived from such existing methods. Hence, we need to produce not only the new drugs but also the cheaper versions of those already present in the market. Plant molecular farming is considered as a cost-effective technology that has grown and advanced tremendously over the past two decades. This book summarizes the advances and challenges of plant molecular farming for all those who are working on or have an interest in this rapidly emerging area of research.

Plant Molecular Farming for the Production of Next-Generation Vaccines and Biologics – Prospects and Challenges

Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832545661
Total Pages : 140 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Plant Molecular Farming for the Production of Next-Generation Vaccines and Biologics – Prospects and Challenges by :

Download or read book Plant Molecular Farming for the Production of Next-Generation Vaccines and Biologics – Prospects and Challenges written by and published by Frontiers Media SA. This book was released on 2024-03-11 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are still a major threat to public health. The vaccine remains the most important and safer way of combating infectious diseases. Therefore, there is an urgent need to look for new ways of vaccine generation that can cut down production costs and processing time. The development of rDNA technology allows the expression and purification of proteins in unlimited quantity, thus opening an avenue for the development of protein-based vaccines as a prophylactic measure against infectious diseases. Recombinant therapeutic proteins derived from biological sources, including mammalian cells, microorganisms, suspension cultures, or genetically modified organisms by employing biotechnological processes, are widely used in clinical applications, especially for the treatment and prevention of human or veterinary infections. Since the development of human insulin by utilizing recombinant DNA technology in E. coli in the 1980s, the recombinant therapeutic protein production field has significantly grown and gained major attention. Plant molecular farming, the production of biologics in plant cells or transgenic plants, could offer a cost-effective adaptable strategy to produce biologics, particularly in low-resource settings. Molecular farming-based strategies could provide an alternative strategy to traditional biologics or vaccine production, enabling rapid development, effective deployment, and safe administration of vaccines. The concept of PMF was initially documented three decades back when recombinant growth hormone was produced in tobacco and sunflower plants. Even with such a long history of significant advantages and several proof-of-concept studies, very few plant-derived therapeutic products have been clinically translated. However, the recent progress around the approval of the plant-based biopharmaceutical ZMapp by the FDA, Medicago’s COVID-19 vaccine by Health Canada, and the safety of a few plant-derived vaccines in clinical trials have displayed the potential of a plant platform for biopharmaceutical production. Furthermore, constant efforts are being made with respect to the optimization of expression techniques, downstream processing, and defining standard guidelines for plant products to make an impact of plant-derived products on an array of applications.

Engineering the Plant Factory for the Production of Biologics and Small-Molecule Medicines

Author : Domenico De Martinis
Publisher : Frontiers Media SA
ISBN 13 : 2889450511
Total Pages : 379 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Engineering the Plant Factory for the Production of Biologics and Small-Molecule Medicines by : Domenico De Martinis

Download or read book Engineering the Plant Factory for the Production of Biologics and Small-Molecule Medicines written by Domenico De Martinis and published by Frontiers Media SA. This book was released on 2017-04-27 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant gene transfer achieved in the early ‘80s paved the way for the exploitation of the potential of gene engineering to add novel agronomic traits and/or to design plants as factories for high added value molecules. For this latter area of research, the term "Molecular Farming" was coined in reference to agricultural applications in that major crops like maize and tobacco were originally used basically for pharma applications. The concept of the “green biofactory” implies different advantages over the typical cell factories based on animal cell or microbial cultures already when considering the investment and managing costs of fermenters. Although yield, stability, and quality of the molecules may vary among different heterologous systems and plants are competitive on a case-to-case basis, still the “plant factory” attracts scientists and technologists for the challenging features of low production cost, product safety and easy scale up. Once engineered, a plant is among the cheapest and easiest eukaryotic system to be bred with simple know-how, using nutrients, water and light. Molecules that are currently being produced in plants vary from industrial and pharmaceutical proteins, including medical diagnostics proteins and vaccine antigens, to nutritional supplements such as vitamins, carbohydrates and biopolymers. Convergence among disciplines as distant as plant physiology and pharmacology and, more recently, as omic sciences, bioinformatics and nanotechnology, increases the options of research on the plant cell factory. “Farming for Pharming” biologics and small-molecule medicines is a challenging area of plant biotechnology that may break the limits of current standard production technologies. The recent success on Ebola fighting with plant-made antibodies put a spotlight on the enormous potential of next generation herbal medicines made especially in the name of the guiding principle of reduction of costs, hence reduction of disparities of health rights and as a tool to guarantee adequate health protection in developing countries.

Plant Transformation via Agrobacterium Tumefaciens

Author : Phetole Mangena
Publisher : CRC Press
ISBN 13 : 1000638154
Total Pages : 244 pages
Book Rating : 4.0/5 (6 download)

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Book Synopsis Plant Transformation via Agrobacterium Tumefaciens by : Phetole Mangena

Download or read book Plant Transformation via Agrobacterium Tumefaciens written by Phetole Mangena and published by CRC Press. This book was released on 2022-09-01 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant Transformation via Agrobacterium Tumefaciens compiles fundamental and specific information and procedures involving in vitro soybean transformation, which forms the basis for the Agrobacterium-mediated genetic manipulation of soybean using plant tissue culture. This method serves as one of the most preferred, reliable and cost-effective mechanism of transgene expression in both leguminous recalcitrant species and non-legume crops. The technology is favoured due to its simplicity, feasibility and high transformation rates that are so far achieved mostly in monocot plants and a few dicot genotypes. This book provides a comprehensive review of plant transformation which remains necessary for many researchers who are still facing protocol-related hurdles. Among some of the major topics covered in Plant Transformation via Agrobacterium Tumefaciens are the history and discovery of Agrobacterium bacterium, longstanding challenges causing transformation inefficiencies, types and conditions of explants, development of transgenic plants for stress resistance, and the role of transgenic plants on animal/human health, including the environment. Plant Transformation via Agrobacterium Tumefaciens helps the reader to understand how soybean, like many other orphan legume crops, faces the risk of overexploitation which may render the currently available varieties redundant and extinct should its narrow gene pool not improve. Plant transformation serves as a key technique in improving the gene pool, while developing varieties that are drought tolerant, have enhanced nutritional value, pest resistant and reduce the destruction by disease causing microorganims. This book is an essential foundation tool that is available for researchers and students to reinforce the application of Agrobacterium-mediated genetic transformation in soybean.

Stress-responsive Factors and Molecular Farming in Medicinal Plants

Author : Divya Singh
Publisher : Springer Nature
ISBN 13 : 9819944805
Total Pages : 380 pages
Book Rating : 4.8/5 (199 download)

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Book Synopsis Stress-responsive Factors and Molecular Farming in Medicinal Plants by : Divya Singh

Download or read book Stress-responsive Factors and Molecular Farming in Medicinal Plants written by Divya Singh and published by Springer Nature. This book was released on 2023-10-18 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume brings out a comprehensive collection of changes from cellular to molecular levels in medicinal plants under extreme environments. The focus of this book is to address the molecular changes in medicinal plants under different abiotic stresses. Medicinal plants are regarded as rich resources of components that can be used for drug development in the pharmaceutical industry. A few medicinal plants are considered vital sources of nutrients and solicited for their therapeutic properties. Therefore, it is essential to understand medicinal plants' interaction under abiotic stresses as compounds obtained from these plants play an important role in human health. This book is of interest to students, teachers, researchers, scientists, medicinal plant experts, and policymakers. Also, the book provides study material for undergraduate and graduate students of botany, environmental sciences, medicinal and aromatic plants, biochemistry, and biotechnology. National and international scientists working in the area of medicinal plants, drug development, and policymakers will also find this a useful read

Applications of Plant Molecular Farming

Author : Chittaranjan Kole
Publisher : Springer Nature
ISBN 13 : 9819701767
Total Pages : 704 pages
Book Rating : 4.8/5 (197 download)

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Book Synopsis Applications of Plant Molecular Farming by : Chittaranjan Kole

Download or read book Applications of Plant Molecular Farming written by Chittaranjan Kole and published by Springer Nature. This book was released on with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Farming

Author : Jean-Pierre Toutant
Publisher : Editions Quae
ISBN 13 : 9782738009531
Total Pages : 332 pages
Book Rating : 4.0/5 (95 download)

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Book Synopsis Molecular Farming by : Jean-Pierre Toutant

Download or read book Molecular Farming written by Jean-Pierre Toutant and published by Editions Quae. This book was released on 2001 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Encyclopedia of Biotechnology in Agriculture and Food

Author : Dennis R. Heldman
Publisher : CRC Press
ISBN 13 : 1351452479
Total Pages : 1152 pages
Book Rating : 4.3/5 (514 download)

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Book Synopsis Encyclopedia of Biotechnology in Agriculture and Food by : Dennis R. Heldman

Download or read book Encyclopedia of Biotechnology in Agriculture and Food written by Dennis R. Heldman and published by CRC Press. This book was released on 2010-07-21 with total page 1152 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Biotechnology in Agriculture and Food provides users with unprecedented access to nearly 200 entries that cover the entire food system, describing the concepts and processes that are used in the production of raw agricultural materials and food product manufacturing. So that users can locate the information they need quickly without having to flip through pages and pages of content, the encyclopedia avoids unnecessary complication by presenting information in short, accessible overviews. Addresses Environmental Issues & Sustainability in the Context of 21st Century Challenges Edited by a respected team of biotechnology experts, this unrivaled resource includes descriptions and interpretations of molecular biology research, including topics on the science associated with the cloning of animals, the genetic modification of plants, and the enhanced quality of foods. It discusses current and future applications of molecular biology, with contributions on disease resistance in animals, drought-resistant plants, and improved health of consumers via nutritionally enhanced foods. Uses Illustrations to Communicate Essential Concepts & Visually Enhance the Text This one-of-a-kind periodical examines regulation associated with biotechnology applications—with specific attention to genetically modified organisms—regulation differences in various countries, and biotechnology’s impact on the evolution of new applications. The encyclopedia also looks at how biotechnology is covered in the media, as well as the biotechnology/environment interface and consumer acceptance of the products of biotechnology. Rounding out its solid coverage, the encyclopedia discusses the benefits and concerns about biotechnology in the context of risk assessment, food security, and genetic diversity. ALSO AVAILABLE ONLINE This Taylor & Francis encyclopedia is also available through online subscription, offering a variety of extra benefits for both researchers, students, and librarians, including: Citation tracking and alerts Active reference linking Saved searches and marked lists HTML and PDF format options For more information, visit Taylor & Francis Online or contact us to inquire about subscription options and print/online combination packages. US: (Tel) 1.888.318.2367 / (E-mail) [email protected] International: (Tel) +44 (0) 20 7017 6062 / (E-mail) [email protected] Dennis R. Heldman speaks about his work on the CRC Press YouTube Channel.

Tools & Techniques of Plant Molecular Farming

Author : Chittaranjan Kole
Publisher : Springer Nature
ISBN 13 : 9819948592
Total Pages : 422 pages
Book Rating : 4.8/5 (199 download)

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Book Synopsis Tools & Techniques of Plant Molecular Farming by : Chittaranjan Kole

Download or read book Tools & Techniques of Plant Molecular Farming written by Chittaranjan Kole and published by Springer Nature. This book was released on 2023-11-22 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book is an in-depth compilation of recent tools and techniques, concepts and strategies used globally in plant molecular farming (PMF) for the cost-effective bulk production of recombinant proteins, secondary metabolites, and other biomolecules. The book presents an overview of success stories of PMF applications from developing countries to address poverty, achieve zero hunger, good health and well-being, thus achieving the UN SDGs 1, 2, and 3. The book deep dives into recent extraction and downstream processing methodologies, its co-existence with conventional agriculture, global governance and finally opportunities, challenges, and future perspectives in plant molecular farming. It focuses on plastid/chloroplast transformation (transplastomics) and its application in plant molecular farming. The books highlight recent advances in genome editing, synthetic biology, glycosylation and glyco-engineering for improved plant molecular farming by marker-free and tissue-specific systems via cisgenic and transgenic crops. In depth discussions on biosafety issues and bio-containment strategies have also been included. The book has 15 chapters authored by globally leading experts on the subject, presenting opportunities & challenges for bio-industrial researchers and entrepreneurs. It is useful to researchers, industrialists, entrepreneurs, policy planners, academician, and students across the disciplines.

Molecular Farming in Plants: Recent Advances and Future Prospects

Author : Aiming Wang
Publisher : Springer Science & Business Media
ISBN 13 : 9400722176
Total Pages : 284 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Molecular Farming in Plants: Recent Advances and Future Prospects by : Aiming Wang

Download or read book Molecular Farming in Plants: Recent Advances and Future Prospects written by Aiming Wang and published by Springer Science & Business Media. This book was released on 2011-10-14 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular farming in plants is a relatively young subject of sciences. As plants can offer an inexpensive and convenient platform for the large-scale production of recombinant proteins with various functions, the driven force from the giant market for recombinant protein pharmaceuticals and industrial enzymes makes this subject grow and advance very quickly. To summarize recent advances, current challenges and future directions in molecular farming, international authorities were invited to write this book for researchers, teachers and students who are interested in this subject. This book, with the focus on the most advanced cutting-edge breakthroughs, covers all the essential aspects of the field of molecular farming in plants: from expression technologies to downstream processing, from products to safety issues, and from current advances and holdups to future developments.

Next Generation Agriculture: Understanding Plant Life for Food, Health and Energy

Author : Domenico De Martinis
Publisher : Frontiers Media SA
ISBN 13 : 2889660621
Total Pages : 247 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Next Generation Agriculture: Understanding Plant Life for Food, Health and Energy by : Domenico De Martinis

Download or read book Next Generation Agriculture: Understanding Plant Life for Food, Health and Energy written by Domenico De Martinis and published by Frontiers Media SA. This book was released on 2020-10-09 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Applications of Synthetic Biology in Health, Energy, and Environment

Author : Arshad, Muhammad
Publisher : IGI Global
ISBN 13 : 1668465787
Total Pages : 481 pages
Book Rating : 4.6/5 (684 download)

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Book Synopsis Applications of Synthetic Biology in Health, Energy, and Environment by : Arshad, Muhammad

Download or read book Applications of Synthetic Biology in Health, Energy, and Environment written by Arshad, Muhammad and published by IGI Global. This book was released on 2023-10-02 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: The application of genetic engineering techniques by redesigning and repurposing biological systems for novel biotechnical applications has paved the way for the field of synthetic biology. This field boosted the evolution and discovery of various novel technologies essential to the conquest of biological problems related to health, disease, the environment, and energy. The field of synthetic biology is growing rapidly, and further research is required. Applications of Synthetic Biology in Health, Energy, and Environment deliberates on principles and the advancement of synthetic biology and their translation in the fields of health, disease, energy, and the environment. Covering topics such as climate change, bioremediation, and smart drugs, this premier reference source is an excellent resource for students and educators of higher education, industrialists, medical professionals, hospital administrators, policymakers, environmental scientists, pharmacists, librarians, researchers, and academicians.

Improvement of Crop Plants for Industrial End Uses

Author : P. Ranalli
Publisher : Springer Science & Business Media
ISBN 13 : 1402054866
Total Pages : 533 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Improvement of Crop Plants for Industrial End Uses by : P. Ranalli

Download or read book Improvement of Crop Plants for Industrial End Uses written by P. Ranalli and published by Springer Science & Business Media. This book was released on 2007-05-16 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides concerns useful to promote an increase of the productivity of crops by using functional genomics. Fundamental thematics have been addressed: metabolic engineering, plant breeding tools, renewable biomass for energy generation, fibres and composites, and biopharmaceuticals. The gained know how is relevant to identify bottlenecks in the major production chains and to propose actions for moving these issues forward.

Recent Advances in Industrial Biochemistry

Author : Muhammad Zaffar Hashmi
Publisher : Springer Nature
ISBN 13 : 3031509897
Total Pages : 447 pages
Book Rating : 4.0/5 (315 download)

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Book Synopsis Recent Advances in Industrial Biochemistry by : Muhammad Zaffar Hashmi

Download or read book Recent Advances in Industrial Biochemistry written by Muhammad Zaffar Hashmi and published by Springer Nature. This book was released on with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Microbial Bioreactors for Industrial Molecules

Author : Sudhir P. Singh
Publisher : John Wiley & Sons
ISBN 13 : 1119874084
Total Pages : 516 pages
Book Rating : 4.1/5 (198 download)

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Book Synopsis Microbial Bioreactors for Industrial Molecules by : Sudhir P. Singh

Download or read book Microbial Bioreactors for Industrial Molecules written by Sudhir P. Singh and published by John Wiley & Sons. This book was released on 2023-06-07 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial Bioreactors for Industrial Molecules Harness the planet’s most numerous resources with this comprehensive guide Microorganisms constitute the invisible majority of all living creatures on Earth. They are found virtually everywhere on the planet, including in environments too extreme for any larger organisms to exist. They form a hugely significant resource whose potential value for human society cannot be overlooked. The creation of microorganism- based bioreactors for the industrial production of valuable biomolecules has the potential to revolutionize a range of industries and fields. Microbial Bioreactors for Industrial Molecules provides a comprehensive introduction to these bioresources. It covers all potential approaches to the use of microbial technology and the production of high-value biomolecules for the pharmaceutical, cosmetic, and agricultural industries, among others. The book’s rigorous detail and global, holistic approach to harnessing the power of the planetary microbiome make it an invaluable introduction to this growing area of research and production. Readers will also find: Detailed coverage of basic, applied, biosynthetic, and translational approaches to the use of microbial technology Discussion of industrially produced microbe-borne enzymes including invertase, lipase, keratinase, protease, and more Approaches for using microbial bioreactors to generate biofuels Microbial Bioreactors for Industrial Molecules is essential for scientists and researchers in microbiology and biotechnology, as well as for professionals in the biotech industries and graduate students studying the applications of the life sciences.