Frontiers In Cerebral Vascular Biology

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Frontiers in Cerebral Vascular Biology

Author : Lester R. Drewes
Publisher : Springer Science & Business Media
ISBN 13 : 1461529204
Total Pages : 283 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Frontiers in Cerebral Vascular Biology by : Lester R. Drewes

Download or read book Frontiers in Cerebral Vascular Biology written by Lester R. Drewes and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past three decades, the cerebral vasculature and its role in blood-brain transport has been an increasingly active area of investigation and learning, particularly from an anatomical and physiological point of view. However, much less is known at the molecular and cellular level about the blood-brain barrier especially regarding the macromolecules responsible for transport, the roles played by vascular wall components (endothelial cell, pericyte, smooth muscle, basement membrane), and the mechanisms regulating brain vascular-specific protein expression and their molecular alterations during development and disease. Fundamental questions still unanswered include: What are the molecular constituents of brain endothelial cell tight junctions? What are the membrane proteins responsible for transport of specific substrates? What are the molecular signals that cause glucose transporter gene expression to be 20 to 100 times greater in brain endothelial cells in vivo than in vitro? What roles do pericytes, smooth muscle cells and basement membrane have in establishing or maintaining blood-brain transport characteristics? Are brain vascular transport systems responsible for edema following injury? Are transporter systems regulated via receptor-mediated events? Do hormones or neuromodulators regulate transporter expression? What is the molecular mechanism by which plasma proteins enter the extravascular space? Are transporters asymmetrically distributed between the luminal and abluminal endothelial cell membranes? Can prodrugs or pharmacologic agents be designed as substrate analogs and be delivered to the central nervous system via existing transporters or receptors? Can new and beneficial transporters be introduced into the brain vasculature?

National Library of Medicine Current Catalog

Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 1328 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)

Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1993 with total page 1328 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Brain Vascular Research

Author : Ana Clara Cristóvão
Publisher : Cambridge Scholars Publishing
ISBN 13 : 1527557235
Total Pages : 202 pages
Book Rating : 4.5/5 (275 download)

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Book Synopsis Advances in Brain Vascular Research by : Ana Clara Cristóvão

Download or read book Advances in Brain Vascular Research written by Ana Clara Cristóvão and published by Cambridge Scholars Publishing. This book was released on 2020-07-24 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain vasculature nurtures and regulates basic functions of the central nervous system (CNS), acting as a barrier against pathogens. This book provides in-depth and focused data on the characteristics, function and role of brain blood vessels in health and disease. It addresses topics such as vascular activity, cell-cell communication, and the role of the endothelium in the development of the most prevalent types of cerebrovascular disease, neurodegenerative disorders, cognitive impairment, and vascular abnormalities. It offers an updated view of the current state of microvascular biology and research, and thus supports the discovery of new therapeutic agents and procedures directed at several CNS disorders.

Current Catalog

Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 824 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Current Catalog by : National Library of Medicine (U.S.)

Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1993 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.

Frontiers in Cerebral Vascular Biology

Author : Lester R Drewes
Publisher :
ISBN 13 : 9781461529217
Total Pages : 310 pages
Book Rating : 4.5/5 (292 download)

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Book Synopsis Frontiers in Cerebral Vascular Biology by : Lester R Drewes

Download or read book Frontiers in Cerebral Vascular Biology written by Lester R Drewes and published by . This book was released on 1993-05-01 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neuroglia

Author : Helmut Kettenmann
Publisher : Oxford University Press, USA
ISBN 13 : 0199794596
Total Pages : 955 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis Neuroglia by : Helmut Kettenmann

Download or read book Neuroglia written by Helmut Kettenmann and published by Oxford University Press, USA. This book was released on 2013 with total page 955 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroglia, the third edition, is the long-awaited revision of the most highly regarded reference volume on glial cells. This indispensable edition has been completely revised, greatly enlarged, and enhanced with four-color figures throughout, all in response to the tremendous amount of new information that has accumulated since the previous edition seven years ago. Glial cells are, without doubt, the new stars in the neuroscience and neurology communities. Neglected in research for years, it is now evident that the brain only functions in a concerted action of all the cells, namely glia and neurons. Seventy one chapters comprehensively discuss virtually every aspect of normal glial cell anatomy, physiology, biochemistry and function, and consider the central roles of these cells in neurological diseases including stroke, Alzheimer disease, multiple sclerosis, Parkinson's disease, neuropathy, and psychiatric conditions. More than 20 new chapters have been added to accommodate the unprecedented growth of knowledge about the basic biology of glia and the sophisticated manner in which they partner with neurons in the course of normal brain function. Lavishly illustrated and meticulously edited, the third edition remains the most convenient and maximally useful reference available. This new edition is an essential reference for both newcomers to the field as well as established investigators. Neuroglia belongs on every neuroscientist's bookshelf and will be a great asset for educators and neurological clinicians as well.

Optical Imaging of Brain Function and Metabolism

Author : Ulrich Dirnagl
Publisher : Springer Science & Business Media
ISBN 13 : 148992468X
Total Pages : 290 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Optical Imaging of Brain Function and Metabolism by : Ulrich Dirnagl

Download or read book Optical Imaging of Brain Function and Metabolism written by Ulrich Dirnagl and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: • . . . . At last the doctor will be freed from the tedious interpretation of screens and photographs. Instead, he will examine and scan through his patient directly. Wearing optical-shutter spectacles and aiming a pulsed laser torch, he will be able to peer at the beating heart, study the movement of a joint or the flexing of a muscle, press on suspect areas to see how the organs beneath respond, check that pills have been correctly swallowed or that an implant is savely in place, and so on. A patient wearing white cotton or nylon clothes that scatter but hardly absorb light, may not even have to undress . . . . •. David Jones, Nature (1990) 348:290 Optical imaging of the brain is a rapidly growing field of heterogenous techniques that has attracted considerable interest recently due to a number of theoretical advantages in comparison with other brain imaging modalities: it uses non ionizing radiation, offers high spatial and temporal resolution, and supplies new types of metabolic and functional information. From a practical standpoint it is important that bedside examinations seem feasible and that the implementations will be considerably less expensive compared with competing techniques. In October 1991, a symposium was held at the Eibsee near Garmisch, Germany to bring together the leading scientists in this new field.

The Cerebral Circulation

Author : Marilyn J. Cipolla
Publisher : Biota Publishing
ISBN 13 : 1615047239
Total Pages : 82 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis The Cerebral Circulation by : Marilyn J. Cipolla

Download or read book The Cerebral Circulation written by Marilyn J. Cipolla and published by Biota Publishing. This book was released on 2016-07-28 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.

Endothelial Cell Culture

Author : Roy Bicknell
Publisher : Cambridge University Press
ISBN 13 : 9780521559904
Total Pages : 156 pages
Book Rating : 4.5/5 (599 download)

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Book Synopsis Endothelial Cell Culture by : Roy Bicknell

Download or read book Endothelial Cell Culture written by Roy Bicknell and published by Cambridge University Press. This book was released on 1996-09-28 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the Handbooks in Practical Animal Cell Biology is to provide practical workbooks for those involved in primary cell culture. Each volume addresses a different cell lineage, and contains an introductory section followed by individual chapters on the culture of specific differentiated cell types. The authors of each chapter are leading researchers in their fields and use their first-hand experience to present reliable techniques in a clear and thorough manner. Endothelial Cell Culture contains chapters on endothelial cells derived from 1) lung, 2) bone marrow, 3) brain, 4) mammary glands, 5) skin, 6) adipose tissue, 7) female reproductive system, and 8) synovium.

Metals and Oxidative Damage in Neurological Disorders

Author : James R. Connor
Publisher : Springer Science & Business Media
ISBN 13 : 1489901973
Total Pages : 383 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Metals and Oxidative Damage in Neurological Disorders by : James R. Connor

Download or read book Metals and Oxidative Damage in Neurological Disorders written by James R. Connor and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to bring together scientists and clinicians interested in oxidative injury in the nervous system but whose approaches to investigation and treatment design vary widely. Indeed the goal of this book is to show that the investiga tive approaches and potential therapeutic interventions perhaps do not vary as widely as some may think. I think that the readers of this book will not read it from front to back, but will pick chapters of interest. Thus, the chapters are organized to contain information that is essential to understanding basic aspects of oxidative injury, and thus have some redundancy. However, within the context of each chapter the reader should hopefully find impetus and direction to go on to another chapter. The book is divided into three seetions. The first section contains reviews of metals and their role in generating oxidative injury. lron is considered in three of these chapters because of its relative abundance in the brain and its potency in inducing free radicals. The second section focuses on mechanisms by which the brain attempts to protect itself from oxidative injury. Some of these mechanisms have the potential to be protective in some situations and potentiaIly damaging in others. The third section contains the clinicaI diseases in which oxidative injury is known to contribute to the pathogenic process. This seetion ends with a chapter on antioxidant therapeutic strate gies in neurological disorders.

Nanoneuroscience and Nanoneuropharmacology

Author : Hari S. Sharma
Publisher : Elsevier
ISBN 13 : 0080962246
Total Pages : 261 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Nanoneuroscience and Nanoneuropharmacology by : Hari S. Sharma

Download or read book Nanoneuroscience and Nanoneuropharmacology written by Hari S. Sharma and published by Elsevier. This book was released on 2009-12-03 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents articles from the leading experts in the field in nanobiotechnology, providing students and researchers with a comprehensive review of the newly emerging area of neuroscience. All aspects of nanomaterials induced alteration in brain function are considered. Basic chapters on methods and ways to enhance nano-drug delivery into the brain are presented as well as chapters on functional and structural changes in the CNS, including gene expression and related issues. Particular attention is given to possible therapeutic advancement regarding nano-drug formulation and their role in neuroprotection.

Neural Metabolism In Vivo

Author : In-Young Choi
Publisher : Springer Science & Business Media
ISBN 13 : 1461417872
Total Pages : 1168 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Neural Metabolism In Vivo by : In-Young Choi

Download or read book Neural Metabolism In Vivo written by In-Young Choi and published by Springer Science & Business Media. This book was released on 2012-03-14 with total page 1168 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the preface: “Neural Metabolism In Vivo aims to provide a comprehensive overview of neurobiology by presenting the basic principles of up-to-date and cutting-edge technology, as well as their application in assessing the functional, morphological and metabolic aspects of the brain. Investigation of neural activity of the living brain via neurovascular coupling using multimodal imaging techniques extended our understanding of fundamental neurophysiological mechanisms, regulation of cerebral blood flow in connection to neural activity and the interplay between neurons, astrocytes and blood vessels. Constant delivery of glucose and oxygen for energy metabolism is vital for brain function, and the physiological basis of neural activity can be assessed through measurements of cerebral blood flow and consumption of glucose and oxygen.... This book presents the complex physiological and neurochemical processes of neural metabolism and function in response to various physiological conditions and pharmacological stimulations. Neurochemical detection technologies and quantitative aspects of monitoring cerebral energy substrates and other metabolites in the living brain are described under the “Cerebral metabolism of antioxidants, osmolytes and others in vivo” section. Altogether, the advent of new in vivo tools has transformed neuroscience and neurobiology research, and demands interdisciplinary approaches as each technology could only approximate a very small fraction of the true complexity of the underlying biological processes. However, translational values of the emerging in vivo methods to the application of preclinical to clinical studies cannot be emphasized enough. Thus, it is our hope that advances in our understanding of biochemical, molecular, functional and physiological processes of the brain could eventually help people with neurological problems, which are still dominated by the unknowns.” -- In-Young Choi and Rolf Gruetter

Mechanism of Myofilament Sliding in Muscle Contraction

Author : Haruo Sugi
Publisher : Springer Science & Business Media
ISBN 13 : 1461528720
Total Pages : 823 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Mechanism of Myofilament Sliding in Muscle Contraction by : Haruo Sugi

Download or read book Mechanism of Myofilament Sliding in Muscle Contraction written by Haruo Sugi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 823 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the entire proceedings of the symposium organized by one of us (H. S. ) on November 11 to 15, 1991 at Hakone, Japan, under the title of "Mechanism of Myofllament Sliding in Muscle Contraction. " Among various kinds of energy transduction mechanisms in biological systems, the mechanism of muscle contraction has been studied most intensively and extensively over many years. Since the monumental discovery by the two Huxleys and coworkers that muscle contraction results from relative sliding between the thick and thin myofilaments, attention of muscle investigators has been focused on the question, what makes the fllaments slide past one another. In response to the above question, A. F. Huxley and Simmons put forward a contraction model in 1971, in which globular heads of myosin (cross-bridges) extending from the thick fllament first attach to actin on the thin fllament, and then change their angle of attachment to actin (power stroke) leading to force generation or myofilament sliding until they detach from the thin fllament. The rocking cross-bridge contraction model seemed to be entirely consistent with the kinetic scheme of actomyosin ATPase published by Lymn and Taylor at the same time, thus giving a strong impression to the people concerned that the muscle contraction mechanism would soon be sorted out. In his review lecture in 1974, however, A. F.

Prodrugs

Author : Valentino Stella
Publisher : Springer Science & Business Media
ISBN 13 : 038749782X
Total Pages : 1447 pages
Book Rating : 4.3/5 (874 download)

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Book Synopsis Prodrugs by : Valentino Stella

Download or read book Prodrugs written by Valentino Stella and published by Springer Science & Business Media. This book was released on 2007-03-12 with total page 1447 pages. Available in PDF, EPUB and Kindle. Book excerpt: These volumes represent a comprehensive guide to prodrugs. They guide the reader through the current status of the prodrug concept and its many applications and highlight its many successes in overcoming formulation and delivery of problematic drugs. Replete with examples of approved and marketed prodrugs, these volumes introduce the topic to the novice as well as professional in the design of prodrugs.

Drugs of Abuse, Immunity, and AIDS

Author : Pawel Migula
Publisher : Springer Science & Business Media
ISBN 13 : 1461529808
Total Pages : 284 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Drugs of Abuse, Immunity, and AIDS by : Pawel Migula

Download or read book Drugs of Abuse, Immunity, and AIDS written by Pawel Migula and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is based on the program of the Second International Conference on Drugs of Abuse, Immunity and AIDS, held in Clearwater Beach, FL in June 1992. The Conference was supported in part by the University of South Florida College of MediCine with financial assistance from the National Institute on Drug Abuse. The focus of this conference was the effects of drugs of abuse on immunity. It is now widely recognized that psychoactive drugs of abuse, including marijuana, cocaine, and opiates, as well as alcohol, have marked effects in an individual, including effects on their nervous system and behavior. In the past two decades, the scope of studies concerning the effects of some drugs of abuse have also involved investigations of alterations of various physiologic parameters including effects on the immune system. and the influence of such immune alterations on normal physiological responses. In this regard, participants in this Second International Conference provided newer information concerning both basic and clinical aspects of drugs of abuse and immunity, especially immunodeficiencies. In this regard, advances have been made in recent years concerning the nature and mechanisms whereby the immune system is regulated and the possible mechanisms by which drugs of abuse influence such immune systems. In particular, the emergence of psychoneuroimmunology as a new discipline the last decade has heightened interest in the immune responses influenced by psychoactive drugs. This has resulted in interdisciplinary investigations involving both clinical and basic scientists, including microbiologists, immunologists, physiologists, psychiatrists, oncologists, psychologists, etc.

New Concepts in the Pathogenesis of NIDDM

Author : Claes-Goran Östenson
Publisher : Springer Science & Business Media
ISBN 13 : 1461529107
Total Pages : 314 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis New Concepts in the Pathogenesis of NIDDM by : Claes-Goran Östenson

Download or read book New Concepts in the Pathogenesis of NIDDM written by Claes-Goran Östenson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM) has attracted the interest of our group during the last three decades. As early as 1969, a Nobel Symposium dealing with this topic was organized in Stockholm. This was followed in 1987 by a Nobel Conference devoted to the same subject. The main purpose of these meetings was to bring together the most distinguished scientists from all over the world and present theories on molecular and genetic mechanisms responsible for the development of glucose intolerance in NIDDM. This idea was followed also in the present symposium, "New Concepts in the Pathogenesis of NIDDM," organized with diabetologists from Toronto in Canada. Our purpose is to biannually organize international meetings covering important aspects of dia betes research, hoping that this type of interaction may result in new concepts and treat ment alternatives. For us, participating in this symposium in September 1992, the meeting in Stockholm was very stimulating and innovative. It is a special pleasure that almost all invited lecturers submitted manuscripts. Thus, the publication of the proceedings of the symposium makes it possible for all interested in diabetes research to share new ideas and findings presented at the meeting. Claes-G6ran Ostenson Suad Efendic Mladen V ranic v CONTENTS REGULATION OF INSULIN SECRETION Impaired Glucose-Induced Insulin Secretion: Studies in Animal Models with Spontaneous NIDDM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . C. -G. Ostenson, A. Khan, and S. Efendic Perturbation ofIslet Metabolism and Insulin Release in NIDDM. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 WJ. Malaisse 2 Regulation of Cytoplasmic Free Ca+ in Insulin-Secreting Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

The Underlying Molecular, Cellular and Immunological Factors in Cancer and Aging

Author : Stringer Sue Yang
Publisher : Springer Science & Business Media
ISBN 13 : 1461529263
Total Pages : 336 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis The Underlying Molecular, Cellular and Immunological Factors in Cancer and Aging by : Stringer Sue Yang

Download or read book The Underlying Molecular, Cellular and Immunological Factors in Cancer and Aging written by Stringer Sue Yang and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Background Cancer is a variety of malignancies generally associated with aging. As the overall health technology and health care delivery improved with the advances made in medicine and science in the United States, the life expectancy of the population also increased. The average life expectancy in the U. S. A. has increased from 49 years at the end of 1900 to 75 years today in 1990 (1-3). The population of 65 years and older that constituted 25. 5 million or 11. 3% of the total U. S. population in 1980(4) has now increased to 31. 1 million or 12. 5% of the population according to the 1990(5) census. As cancer diagnosis and treatment have improved, cancer mortality among patients under 55 has been significantly reduced within recent years *1; however, cancer incidence under 55 is still increasing at about 0. 4% per year (as compared to 1. 0% for all ages or 0. 6% for