Frances Arnold

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Directed Evolution Library Creation

Author : Frances H. Arnold
Publisher : Humana Press
ISBN 13 : 9781617374715
Total Pages : 0 pages
Book Rating : 4.3/5 (747 download)

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Book Synopsis Directed Evolution Library Creation by : Frances H. Arnold

Download or read book Directed Evolution Library Creation written by Frances H. Arnold and published by Humana Press. This book was released on 2010-11-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological systems are very special substrates for engineering—uniquely the products of evolution, they are easily redesigned by similar approaches. A simple algorithm of iterative cycles of diversification and selection, evolution works at all scales, from single molecules to whole ecosystems. In the little more than a decade since the first reported applications of evolutionary design to enzyme engineering, directed evolution has matured to the point where it now represents the centerpiece of industrial biocatalyst development and is being practiced by thousands of academic and industrial scientists in com- nies and universities around the world. The appeal of directed evolution is easy to understand: it is conceptually straightforward, it can be practiced without any special instrumentation and, most important, it frequently yields useful solutions, many of which are totally unanticipated. Directed evolution has r- dered protein engineering readily accessible to a broad audience of scientists and engineers who wish to tailor a myriad of protein properties, including th- mal and solvent stability, enzyme selectivity, specific activity, protease s- ceptibility, allosteric control of protein function, ligand binding, transcriptional activation, and solubility. Furthermore, the range of applications has expanded to the engineering of more complex functions such as those performed by m- tiple proteins acting in concert (in biosynthetic pathways) or as part of mac- molecular complexes and biological networks.

Directed Enzyme Evolution

Author : Frances H. Arnold
Publisher : Springer Science & Business Media
ISBN 13 : 1592593968
Total Pages : 381 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Directed Enzyme Evolution by : Frances H. Arnold

Download or read book Directed Enzyme Evolution written by Frances H. Arnold and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Directed evolution comprises two distinct steps that are typically applied in an iterative fashion: (1) generating molecular diversity and (2) finding among the ensemble of mutant sequences those proteins that perform the desired fu- tion according to the specified criteria. In many ways, the second step is the most challenging. No matter how cleverly designed or diverse the starting library, without an effective screening strategy the ability to isolate useful clones is severely diminished. The best screens are (1) high throughput, to increase the likelihood that useful clones will be found; (2) sufficiently sen- tive (i. e. , good signal to noise) to allow the isolation of lower activity clones early in evolution; (3) sufficiently reproducible to allow one to find small improvements; (4) robust, which means that the signal afforded by active clones is not dependent on difficult-to-control environmental variables; and, most importantly, (5) sensitive to the desired function. Regarding this last point, almost anyone who has attempted a directed evolution experiment has learned firsthand the truth of the dictum “you get what you screen for. ” The protocols in Directed Enzyme Evolution describe a series of detailed p- cedures of proven utility for directed evolution purposes. The volume begins with several selection strategies for enzyme evolution and continues with assay methods that can be used to screen enzyme libraries. Genetic selections offer the advantage that functional proteins can be isolated from very large libraries s- ply by growing a population of cells under selective conditions.

Psychoanalytic Perspectives on Women and Their Experience of Desire, Ambition and Leadership

Author : Stephanie Brody
Publisher : Routledge
ISBN 13 : 1317551540
Total Pages : 188 pages
Book Rating : 4.3/5 (175 download)

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Book Synopsis Psychoanalytic Perspectives on Women and Their Experience of Desire, Ambition and Leadership by : Stephanie Brody

Download or read book Psychoanalytic Perspectives on Women and Their Experience of Desire, Ambition and Leadership written by Stephanie Brody and published by Routledge. This book was released on 2019-04-08 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psychoanalytic Perspectives on Women and Their Experience of Desire, Ambition and Leadership considers how these factors can be understood, nurtured, or thwarted and the subsequent impact on women’s identity, authority and satisfaction. Psychoanalysis has long struggled with its ideas about women, about who they are, how to work with them, and how to respect and encourage what women want. This book argues that psychoanalytic theory and practice must evolve to maintain its relevance in a volatile landscape. Each section of the book begins with a chapter that reviews contemporary ideas regarding women, as well as psychoanalytic history, gender bias, and societal norms and deficits. Three composite clinical stories allow our distinguished contributors to discuss the contexts within which individual experience can be affected, and the role that clinical work may have to mobilize and advance passion and vitality. In their discussions, the interplay of clinical psychoanalysis, sociopolitical context, and understanding of gender, combine to offer a unique perspective, built on decades of scholarship, personal experience, and clinical expertise. Psychoanalytic Perspectives on Women and Their Experience of Desire, Ambition and Leadership will serve as a reference for all psychoanalysts and psychoanalytic psychotherapists as well as gender studies scholars interested in the progress of psychoanalytic theory regarding women in the 21st century. Contributors to this book include: Rosemary Balsam, Brenda Bauer, Andrea Celenza, Diane Elise, Adrienne Harris, Dorothy Holmes, Nancy Kulish, Vivian Pendar, Dionne Powell, and Arlene Richards.

Frances Farmer

Author : William Arnold
Publisher :
ISBN 13 : 9780515051247
Total Pages : 212 pages
Book Rating : 4.0/5 (512 download)

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Book Synopsis Frances Farmer by : William Arnold

Download or read book Frances Farmer written by William Arnold and published by . This book was released on 1979 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Arnoldian

Author :
Publisher :
ISBN 13 :
Total Pages : 230 pages
Book Rating : 4.P/5 (18 download)

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Book Synopsis The Arnoldian by :

Download or read book The Arnoldian written by and published by . This book was released on 1988 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Directed Molecular Evolution of Proteins

Author : Susanne Brakmann
Publisher : Wiley-VCH
ISBN 13 : 9783527304233
Total Pages : 0 pages
Book Rating : 4.3/5 (42 download)

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Book Synopsis Directed Molecular Evolution of Proteins by : Susanne Brakmann

Download or read book Directed Molecular Evolution of Proteins written by Susanne Brakmann and published by Wiley-VCH. This book was released on 2002-04-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural selection created optimal catalysts. However, optimal performance of enzyme catalysis does not necessarily refer to maximum reaction rate. Rather, it may be a compromise between specificity, rate, stability, and other chemical constraints that makes enzymes capable of catalyzing reactions under mild conditions and with high substrate specificity, accompanied by high regio- and enantioselectivity. The book presented here focuses on the directed evolution of proteins, which has established itself as a powerful method for designing enzymes showing new substrate specificities. It includes a comprehensive repertoire of techniques for producing combinatorial enzyme libraries, while the functional gene expression in a suitable host helps in selecting the appropriate structure, making fast screening a necessity. This book illustrates both the theoretical background as well as the potential of this interesting method in practice - which is becoming ever more important even in classical organic synthesis!

The Washingtons. Volume 1

Author : Justin Glenn
Publisher : Savas Publishing
ISBN 13 : 194066926X
Total Pages : 1223 pages
Book Rating : 4.9/5 (46 download)

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Book Synopsis The Washingtons. Volume 1 by : Justin Glenn

Download or read book The Washingtons. Volume 1 written by Justin Glenn and published by Savas Publishing. This book was released on 2014-06-11 with total page 1223 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the initial volume of a comprehensive history that traces the “Presidential line” of the Washingtons. Volume one begins with the immigrant John Washington who settled in Westmoreland Co., Va., in 1657, married Anne Pope, and was the great-grandfather of President George Washington. This volume continues the story of John and Anne’s family for a total of seven generations, collecting over 5,000 direct descendants. Future volumes will trace eight more generations with a total of over 63,000 descendants. Although structured in a genealogical format for the sake of clarity, this is no bare bones genealogy but a true family history with over 1,200 detailed biographical narratives. These in turn strive to convey the greatness of the family that produced not only The Father of His Country but many others, great and humble, who struggled to build that country. The Washingtons includes the time-honored John Wright line which in recent years has been challenged largely on the basis of DNA evidence. Volumes one and two will form a set, with a cumulative bibliography appearing at the end of volume 2. Volume two will highlight the most notable descendants and spouses from the later volumes, including such luminaries as General George S. Patton, the author Shelby Foote, and the actor Lee Marvin. All of the volumes, now estimated at fourteen in all, are virtually complete and are scheduled for release over the course of the next year.

Our Gohman Story

Author : Charlie Kunkel and Roy Evans
Publisher : AuthorHouse
ISBN 13 : 1481739190
Total Pages : 349 pages
Book Rating : 4.4/5 (817 download)

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Book Synopsis Our Gohman Story by : Charlie Kunkel and Roy Evans

Download or read book Our Gohman Story written by Charlie Kunkel and Roy Evans and published by AuthorHouse. This book was released on 2013-07-08 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book shares the stories of 65 Gohman ancestors who grew up next to the Mississippi River in Central Minnesota. They are the third-generation members of the Gohman family that immigrated from Lower Saxony, Germany, to the United States in 1843 and migrated from Cincinnati to Minnesota in 1855. The first and second generations are introduced briefly. The lives of the Third-Generation spanned a period from 1868 to 1991, an amazing 123 years. Generally engaged as farmers, they were diverse personalities who responded to life experiences in diverse ways. They lived through times of both great prosperity and deep poverty. They experienced two world wars and dramatically changing technology. This generation of the Gohman family thrived as they adapted to the changes in their lives from the horse and buggy times to the days of the jet plane.

Lorenzo Goes to Hollywood

Author : Edward Arnold
Publisher :
ISBN 13 :
Total Pages : 320 pages
Book Rating : 4.:/5 (6 download)

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Book Synopsis Lorenzo Goes to Hollywood by : Edward Arnold

Download or read book Lorenzo Goes to Hollywood written by Edward Arnold and published by . This book was released on 1940 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Decendents of Wyatt Arnold

Author :
Publisher : Turner Publishing Company
ISBN 13 : 1563114747
Total Pages : 456 pages
Book Rating : 4.5/5 (631 download)

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Download or read book Decendents of Wyatt Arnold written by and published by Turner Publishing Company. This book was released on 1998-06-15 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Directed Enzyme Evolution: Advances and Applications

Author : Miguel Alcalde
Publisher : Springer
ISBN 13 : 3319504134
Total Pages : 286 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Directed Enzyme Evolution: Advances and Applications by : Miguel Alcalde

Download or read book Directed Enzyme Evolution: Advances and Applications written by Miguel Alcalde and published by Springer. This book was released on 2017-02-14 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on some of the most significant advances in enzyme engineering that have been achieved through directed evolution and hybrid approaches. On the 25th anniversary of the discovery of directed evolution, this volume is a tribute to the pioneers of this thrilling research field, and at the same time provides a comprehensive overview of current research and the state of the art. Directed molecular evolution has become the most reliable and robust method to tailor enzymes, metabolic pathways or even whole microorganisms with improved traits. By mirroring the Darwinian algorithm of natural selection on a laboratory scale, new biomolecules of invaluable biotechnological interest can now be engineered in a manner that surpasses the boundaries of nature. The volume is divided into two sections, the first of which provides an update on recent successful cases of enzyme ensembles from different areas of the biotechnological spectrum, including tryptophan synthases, unspecific peroxygenases, phytases, therapeutic enzymes, stereoselective enzymes and CO2-fixing enzymes. This section also provides information on the directed evolution of whole cells. The second section of the book summarizes a variety of the most applicable methods for library creation, together with the future trends aimed at bringing together directed evolution and in silico/computational enzyme design and ancestral resurrection.

Americans of Royal Descent

Author : Charles Henry Browning
Publisher : Genealogical Publishing Com
ISBN 13 : 080630054X
Total Pages : 582 pages
Book Rating : 4.8/5 (63 download)

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Book Synopsis Americans of Royal Descent by : Charles Henry Browning

Download or read book Americans of Royal Descent written by Charles Henry Browning and published by Genealogical Publishing Com. This book was released on 1969 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: A standard work on royal genealogy, this collection contains nearly 200 pedigrees showing the lineal descent of hundreds of American families from the kings of England, Scotland, Ireland, Wales, and France. The data derives from authoritative reference works, from family histories, and from manuscript pedigrees held in both public and private repositories. The indexes contain references to upwards of 3,000 surnames, many with multiple entries. One need only trace a surname through a lineage to connect with the Blood Royal. (Earlier editions of this work are not necessarily superseded by the seventh edition, but the seventh is held to be the most authoritative, and is therefore the most popular.)

Not My Will

Author : Francena H. Arnold
Publisher : Moody Publishers
ISBN 13 : 1575676885
Total Pages : 269 pages
Book Rating : 4.5/5 (756 download)

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Book Synopsis Not My Will by : Francena H. Arnold

Download or read book Not My Will written by Francena H. Arnold and published by Moody Publishers. This book was released on 2002-07-01 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eleanor's secret love for Chad could mean losing her inheritance and giving up a life-long dream. Will she follow her own will, or make the hard choice to submit her life to Christ's leadership? Now available with a contemporary new look, Not My Will is a classic story of love, loss, and surrender, with more than 500,000 copies sold.

Thurman Arnold

Author : Spencer Weber Waller
Publisher : NYU Press
ISBN 13 : 0814794602
Total Pages : 455 pages
Book Rating : 4.8/5 (147 download)

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Book Synopsis Thurman Arnold by : Spencer Weber Waller

Download or read book Thurman Arnold written by Spencer Weber Waller and published by NYU Press. This book was released on 2005-12-01 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thurman Arnold (1891-1969) was a major iconoclast of American law and a great liberal of the 20th century. In this first biography of Arnold, Spencer Weber Waller traces Arnold's life from his birth in Laramie, Wyoming, and explores how his western upbringing influenced his distinctive views about law and power. After studying at Princeton and Harvard Law School, Arnold practiced law in Chicago, served in World War I, and eventually returned to Laramie, where he was a prominent practitioner, mayor, and state legislator in the 1920s. As the rise of national corporations began to destroy the local businesses that were the core of his legal practice, Arnold turned from the courtroom to the academy, most notably at Yale Law School, where he became one of the leading spokesmen for the legal realism movement. Arnold’s work attracted the attention of Franklin Roosevelt, who appointed him to head the Antitrust Division during the New Deal. He went on to establish Arnold, Fortas & Porter, which became the epitome of the modern Washington, DC law firm, and defended pro-bono hundreds of clients accused of Communist sympathies during the McCarthy era. One of the few individuals who shaped 20th century American law in so many of its facets, Arnold's biography is long overdue, and Waller honors his life and legacy with a book that is both vividly narrated and extensively researched.

Frances Arnold

Author : David R Chamberlin
Publisher : Independently Published
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.8/5 (833 download)

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Book Synopsis Frances Arnold by : David R Chamberlin

Download or read book Frances Arnold written by David R Chamberlin and published by Independently Published. This book was released on 2024-02-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frances Arnold: Pioneering the Future of Science Frances Arnold is a remarkable woman whose groundbreaking work has revolutionized the field of biotechnology. In this compelling book, readers will discover the incredible journey of a scientist and innovator who has defied all odds to become one of the most influential figures in her field. From her early days growing up in Pittsburgh to her groundbreaking research at the California Institute of Technology, Frances Arnold's story is one of determination, passion, and unwavering commitment to scientific discovery. Through her pioneering work in the field of directed evolution, Frances has transformed the way we approach the design of proteins and enzymes, opening up new possibilities for applications in medicine, industry, and environmental sustainability. Readers will get to know the woman behind the groundbreaking research as they follow Frances's journey from her early struggles to her awe-inspiring achievements. Along the way, they will gain a deep understanding of the scientific principles that have shaped her career and led to her groundbreaking discoveries. Frances Arnold's work has not only earned her numerous accolades and awards, including the Nobel Prize in Chemistry, but has also paved the way for a new era of scientific innovation. Through her pioneering spirit and relentless pursuit of knowledge, she has inspired countless others to push the boundaries of what is possible in the world of biotechnology and beyond. This book is a captivating and inspiring portrait of a true trailblazer, whose work has not only transformed the scientific landscape but has also helped to shape the future of humanity. Frances Arnold: Pioneering the Future of Science is a must-read for anyone interested in the remarkable story of a woman who has changed the world through her groundbreaking contributions to science.

Nineteenth Century Prose

Author :
Publisher :
ISBN 13 :
Total Pages : 664 pages
Book Rating : 4.:/5 (45 download)

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Download or read book Nineteenth Century Prose written by and published by . This book was released on 1988 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Washingtons. Volume 6, Part 2

Author : Justin Glenn
Publisher : Casemate Publishers
ISBN 13 : 1940669588
Total Pages : 1194 pages
Book Rating : 4.9/5 (46 download)

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Book Synopsis The Washingtons. Volume 6, Part 2 by : Justin Glenn

Download or read book The Washingtons. Volume 6, Part 2 written by Justin Glenn and published by Casemate Publishers. This book was released on 2014-09-05 with total page 1194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the sixth volume of Dr. Justin Glenn’s comprehensive history that traces the “Presidential line” of the Washingtons. Volume One began with the immigrant John Washington, who settled in Westmoreland Co., Va., in 1657, married Anne Pope, and became the great-grandfather of President George Washington. It continued the record of their descendants for a total of seven generations. Volume Two highlighted notable family members in the next eight generations of John and Anne Washington’s descendants. Volume Three traced the ancestry of the early Virginia members of this “Presidential Branch” back in time to the aristocracy and nobility of England and continental Europe. Volume Four resumed the family history where Volume One ended, and it contained Generation Eight of the immigrant John Washington’s descendants. Volume Five treated Generation Nine. Volume Six now presents Generation Ten, and it includes over 12,000 descendants. Future volumes will add generations eleven through fifteen, making a total of over 63,000 descendants. Although structured in a genealogical format for the sake of clarity, this is no bare bones genealogy but a true family history with over 1,200 detailed biographical narratives. These in turn strive to convey the greatness of the family that produced not only The Father of His Country but many others, great and humble, who struggled to build that country. ADVANCE PRAISE “I am convinced that your work will be of wide interest to historians and academics as well as members of the Washington family itself. Although the surname Washington is perhaps the best known in American history and much has been written about the Washington family for well over a century, it is surprising that no comprehensive family history has been published. Justin M. Glenn’s The Washingtons: A Family History finally fills this void for the branch to which General and President George Washington belonged, identifying some 63,000 descendants. This is truly a family history, not a mere tabulation of names and dates, providing biographical accounts of many of the descendants of John Washington who settled in Westmoreland County, Virginia, in 1657. . . . Each individual section is followed by extensive listings of published and manuscript sources supporting the information presented and errors of identification in previous publications are commented upon as appropriate.” John Frederick Dorman, editor of The Virginia Genealogist (1957-2006) and author of Adventurers of Purse and Person “Decades of reviewing Civil War books have left me surprised and delighted when someone applies exhaustive diligence to a topic not readily accessible. Dr. Glenn surely meets that standard with the meticulous research that unveils the Washington family in gratifying detail—many of them Confederates of interest and importance.” Robert K. Krick, author of The Smoothbore Volley that Doomed the Confederacy and Stonewall Jackson at Cedar Mountain