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Formation Of Contiguous Stereogenic Quaternary Carbon Centers In Natural Products Synthesis
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Book Synopsis Formation of Contiguous Stereogenic Quaternary Carbon Centers in Natural Products Synthesis by : Emily Anne Peterson
Download or read book Formation of Contiguous Stereogenic Quaternary Carbon Centers in Natural Products Synthesis written by Emily Anne Peterson and published by . This book was released on 2005 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Total Synthesis of Natural Products by : Jie Jack Li
Download or read book Total Synthesis of Natural Products written by Jie Jack Li and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.
Book Synopsis The Pauson-Khand Reaction by : Ramon Rios Torres
Download or read book The Pauson-Khand Reaction written by Ramon Rios Torres and published by John Wiley & Sons. This book was released on 2012-03-01 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Pauson-Khand reaction is an important reaction in the field of organic chemistry. It involves the transition-metal catalysed cycloaddition of an alkyne, an alkene and carbon monoxide, to produce cyclopentenones. The importance of this reaction originates from its high value in transforming simple components into the synthetically useful cyclopentenone unit, in which a high degree of molecular complexity can be achieved in a single step, with impressive stereochemical and regiochemical control. The Pauson-Khand Reaction investigates the nature and many variations of this reaction. Topics covered include: the mechanisms of Pauson‐Khand-type reactions non chiral intramolecular and intermolecular versions of Pauson‐Khand reactions asymmetric Pauson‐Khand reaction using chiral auxiliaries the enantioselective Pauson‐Khand reaction Pauson‐Khand reactions catalysed by metals other than cobalt unconventional Pauson‐Khand reactions the Pauson‐Khand reaction in total synthesis Presenting a comprehensive overview of this fundamental reaction, The Pauson-Khand Reaction will find a place on the bookshelves of any organic or organometallic chemist.
Book Synopsis Quaternary Stereocenters by : Jens Christoffers
Download or read book Quaternary Stereocenters written by Jens Christoffers and published by John Wiley & Sons. This book was released on 2006-05-12 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling the gap in the literature, this book presents everything there is to know about this topic. By comprehensively covering the quaternary stereocenters found in a range of important and useful molecules in pharmaceutical and medicinal applications, as well as in thousands of natural products, the book provides the know-how chemists need to synthesize challenging molecules with numerous applications. A must for organic chemists in academia, the pharmaceutical industry and medicine. From the Contents: Important Natural Products Important Pharmaceuticals and Intermediates Aldol Reactions Michael Reactions and Conjugate Additions Cycloaddition Reactions Rearrangement Reactions Alkylation of Ketones and Imines Asymmetric Allylic Alkylation Asymmetric Cross Coupling and Heck Reactions Phase Transfer Catalysis Enzymatic Methods Radical Reactions
Book Synopsis Stereoselective Formation of All Carbon Quaternary Centers by : Erica Anne Tiong
Download or read book Stereoselective Formation of All Carbon Quaternary Centers written by Erica Anne Tiong and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Radicals in Synthesis III by : Markus Heinrich
Download or read book Radicals in Synthesis III written by Markus Heinrich and published by Springer Science & Business Media. This book was released on 2012-02-21 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Boron-Doped Diamond Electrodes for Electroorganic Chemistry, by Siegfried R. Waldvogel, Stamo Mentizi und Axel Kirste.- Modern Developments in Aryl Radical Chemistry, by Gerald Pratsch und Markus R. Heinrich.- Radical Additions to Chiral Hydrazones: Stereoselectivity and Functional Group Compatibility, by Gregory K. Friestad.- Hydrogen Atom Donors: Recent Developments, by Andreas Gansäuer, Lei Shi, Matthias Otte, Inga Huth, Antonio Rosales, Iris Sancho-Sanz, Natalia M. Padial und J. Enrique Oltra.- Radicals in Transition Metal Catalyzed Reactions? Transition Metal Catalyzed Radical Reactions? - A Fruitful Interplay Anyway Part 1. Radical Catalysis by Group 4 to Group 7 Elements, by Ullrich Jahn.- Radicals in Transition Metal Catalyzed Reactions? Transition Metal Catalyzed Radical Reactions? - A Fruitful Interplay Anyway Part 2. Radical Catalysis by Group 8 and 9 Elements, by Ullrich Jahn.- Radicals in Transition Metal Catalyzed Reactions? Transition Metal Catalyzed Radical Reactions?: A Fruitful Interplay Anyway Part 3: Catalysis by Group 10 and 11 Elements and Bimetallic Catalysis, by Ullrich Jahn.-
Book Synopsis Inventing Reactions by : Lukas J. Gooßen
Download or read book Inventing Reactions written by Lukas J. Gooßen and published by Springer. This book was released on 2012-10-30 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: Barry Trost: Transition metal catalyzed allylic alkylation.- Jeffrey W. Bode: Reinventing Amide Bond Formation.- Naoto Chatani and Mamoru Tobisu: Catalytic Transformations Involving the Cleavage of C-OMe Bonds.- Gregory L. Beutner and Scott E. Denmark: The Interplay of Invention, Observation and Discovery in the Development of Lewis Base Activation of Lewis Acids for Catalytic Enantioselective Synthesis.- David R. Stuart and Keith Fagnou: The Discovery and Development of a Palladium(II)-Catalyzed Oxidative Cross-Coupling of Two Unactivated Arenes.- Lukas Gooßen and Käthe Gooßen: Decarboxylative Cross-Coupling Reactions.- A. Stephen K. Hashmi: Gold-Catalyzed Organic Reactions.- Ben List: Developing Catalytic Asymmetric Acetalizations.- Steven M. Bischof, Brian G. Hashiguchi, Michael M. Konnick, and Roy A. Periana: The De NovoDesign of CH Bond Hydroxylation Catalysts.- Benoit Cardinal-David, Karl A. Scheidt: Carbene Catalysis: Beyond the Benzoin and Stetter Reactions.- Kenso Soai and Tsuneomi Kawasaki: Asymmetric autocatalysis of pyrimidyl alkanol.- Douglas C. Behenna and Brian M. Stoltz: Natural Products as Inspiration for Reaction Development: Catalytic Enantioselective Decarboxylative Reactions of Prochiral Enolate Equivalents. Hisashi Yamamoto: Acid Catalysis in Organic Synthesis.
Book Synopsis Domino Reactions in Organic Synthesis by : Lutz F. Tietze
Download or read book Domino Reactions in Organic Synthesis written by Lutz F. Tietze and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt: Domino reactions enable you to build complex structures in one-pot reactions without the need to isolate intermediates- a dream comes true. In this book, the well-respected expert, Professor Lutz Tietze, summarizes the possibilities of this reaction type - an approach for an efficiant, economically benificial and ecological benign synthesis. A definite must for every organic chemist.
Book Synopsis Total Synthesis of (±)-Maoecrystal V by : Jianxian Gong
Download or read book Total Synthesis of (±)-Maoecrystal V written by Jianxian Gong and published by Springer. This book was released on 2014-07-08 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this thesis, the author describes the total synthesis of natural product Maoecrystal V in detail. In the first part of the thesis, the author introduces the research background and reviews the research progress in total synthesis of Maoecrystal V. In the second part, the author develops a novel and concise approach for the stereo selective construction of the tetracyclic model system of Maoecrystal V. The model system is accomplished in 8 steps with 20% yield. In the third part, the author describes the first successful total synthesis of Maoecrystal V and investigates four strategies for constructing the key tetrahydrofuran oxa-bridge skeleton. The total synthesis starts from a known compound and is accomplished in 17 steps with 1.2% yield. The successful total synthesis of Maoecrystal V will contribute to the development of efficient synthetic strategies for natural products and other compounds with complex structures.
Book Synopsis Asymmetric Dearomatization Reactions by : Shu-Li You
Download or read book Asymmetric Dearomatization Reactions written by Shu-Li You and published by John Wiley & Sons. This book was released on 2016-09-13 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive account of the rapidly growing field of asymmetric dearomatization reactions with a focus on catalytic methods. It introduces the concept of dearomatization and describes recent progress in asymmetric reaction procedures with different catalyst systems, such as organocatalysts, transition metal catalysts, and enzymes. Chapters on dearomatizations of electron-deficient aromatic rings, dearomatization reactions via transition metal-catalyzed cross-couplings as well as dearomatization strategies in the synthesis of complex natural products are also included. Written by pioneers in the field, this is a highly valuable source of information not only for professional synthetic chemists in academia and industry but also for all those are interested in asymmetric methodologies and organic synthesis in general.
Book Synopsis Forming Quaternary Carbons Using Photoredox Catalysis and Applications in Total Synthesis by : Gregory Lawrence Lackner
Download or read book Forming Quaternary Carbons Using Photoredox Catalysis and Applications in Total Synthesis written by Gregory Lawrence Lackner and published by . This book was released on 2016 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Chapter 1, the development of tert-alkyl N-phthalimidoyl oxalates as precursors for generating tertiary carbon radicals and forming quaternary carbons is discussed. The coupling of these radical precursors with conjugate acceptors is determined to be farily general with respect to both oxalate and alkene coupling partners. Studies that elucidate the mechanism of the coupling reaction are also presented. The mechanism of radical termination is found to be directly influenced by the stoichiometric reductant additive included in the reaction.In Chapter 2, a bimolecular radical fragment coupling is employed as a key step to complete the total syntheses of several trans-clerodane diterpenoid natural products as well as one ent-halimane diterpenoid natural product. In this context, the tertiary radical is optimally generated from an (N-acyloxy)phthalimide substrate rather than the corresponding tert-alkyl N-phthalimidoyl oxalate.In Chapter 3, a photoredox-catalyzed radical coupling is used to stereoselectively construct the central C8--C14 bond of the rearranged spongian diterpene macfarlandin C. An allylic phosphate displacement and intramolecular carbonyl-ene cyclization enable a robust enantioselective synthesis of the decalin fragment. The unexpected intramolecular cyclization of an alkoxycarbonyl radical derived from the (8S)-oxalate prompts a revised synthetic approach targeting the (8R)-oxalate radical precursor, which couples efficiently with (S)-5-methoxyfuran-2-one. Two synthetic routes to the bicyclic lactone moiety of macfarlandin C are investigated on a simple model substrate. These attempts are ultimately foiled by the difficulty in forming a cis-alpha, beta-disubstituted butyrolactone that bears a quaternary substituent at the beta-position.
Book Synopsis Principles and Applications of Asymmetric Synthesis by : Guo-Qiang Lin
Download or read book Principles and Applications of Asymmetric Synthesis written by Guo-Qiang Lin and published by John Wiley & Sons. This book was released on 2003-05-29 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Asymmetric synthesis remains a challenge to practicing scientistsas the need for enantiomerically pure or enriched compoundscontinues to increase. Over the last decade, a large amount ofliterature has been published in this field. Principles andApplications of Asymmetric Synthesis consolidates and evaluates themost useful methodologies into a one-volume resource for theconvenience of practicing scientists and students. Authored by internationally renowned scientists in the field, thisreliable reference covers more than 450 reactions and includesimportant stoichiometric as well as catalytic asymmetric reactions.The first chapter reviews the basic principles, commonnomenclature, and analytical methods, and the remainder of the bookis organized according to reaction type. The text examines suchtopics as: Carbon-carbon bond formations involving carbonyls, enamines,imines, and enolates Asymmetric C-O bond formations including epoxidation,dihydroxylation, and aminohydroxylation Asymmetric synthesis using the Diels-Alder reaction and othercyclizations Applications to the total synthesis of natural products Use of enzymes in asymmetric synthesis Practicing chemists in the pharmaceutical, fine chemical, andagricultural professions as well as graduate students will findthat Principles and Applications of Asymmetric Synthesis affordscomprehensive and current coverage.
Book Synopsis Asymmetric catalysis by : Michael P. Doyle
Download or read book Asymmetric catalysis written by Michael P. Doyle and published by JAI Press(NY). This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second volume in a series covering research advances in the field of catalytic processes.
Book Synopsis Development of a Spiroalkylation Method for the Stereoselective Construction of [alpha]-Quaternary Carbons, Its Application to the Total Synthesis of (R)-puraquinoic Acid, and Efforts Towards HDAC/HIV-1 Protease Hybrid Inhibitors by : Adam Elmehriki
Download or read book Development of a Spiroalkylation Method for the Stereoselective Construction of [alpha]-Quaternary Carbons, Its Application to the Total Synthesis of (R)-puraquinoic Acid, and Efforts Towards HDAC/HIV-1 Protease Hybrid Inhibitors written by Adam Elmehriki and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "[alpha]-Quaternary carbon stereocentres are a common yet challenging motif encountered in the synthesis of many organic molecules, ranging from natural products to molecules employed in medicinal chemistry endeavours. Herein, cyclic [alpha]-quaternary carbon stereocentres were prepared from biselectrophilic substrates and an easily prepared chiral bicyclic sulfonyl lactam. This was achieved in two steps by spiroalkylation, employing biphasic reaction conditions with a phase-transfer catalyst, followed by reduction and alkylation with a series of alkyl halide electrophiles. The products of this method were isolated in good yields with high levels of diastereoselectivity. Additionally, the methodology was employed in the enantioselective total synthesis of (R)-puraquinonic acid for a late-stage installation of the [alpha]-quaternary carbon stereocentre. This enabled the shortest total synthesis of (R)-puraquinonic acid to date, an eight-pot sequence providing an overall yield of 14%.Inspired by reports indicating that inhibition of histone deacetylase (HDAC) promotes reactivation of latent HIV reservoirs, a set of molecules were conceived and prepared which possessed both HDAC and HIV protease inhibitory activity. It was expected that such hybrid inhibitors could provide a means to clear HIV reservoirs by directly inhibiting viral protease function upon reactivation of latent HIV. The design of hybrid inhibitors was based on the known HDAC inhibitor vorinostat and the HIV-1 protease inhibitor darunavir. Initial biological testing proved that molecules of this design maintain their HDAC inhibitory function despite structural modifications made to incorporate HIV-1 protease inhibitory activity. Unfortunately, while the inhibitory activity against cytosolic HDAC6 of one hybrid inhibitor was comparable to the positive control (vorinostat) it was found to be over six-fold less potent against the desired nuclear target, HDAC3"--
Book Synopsis Total Synthesis of Bioactive Natural Products by : Goutam Brahmachari
Download or read book Total Synthesis of Bioactive Natural Products written by Goutam Brahmachari and published by Elsevier. This book was released on 2019-04-27 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background that outlines the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approximately 100 of the most promising bioactive agents. Taking a logical, user-friendly approach, the systematic name, compound class, structure, natural source, pharmaceutical potential and synthetic routes for each structure are detailed, with clear illustrations throughout, making this book an essential and practical guide for anyone working with both synthesis and natural products. - Provides individual outlines for the total synthesis of approximately 100 bioactive natural molecules - Outlines each step of the process in detail, with full experimental information supported by extensive schemes - Includes retrosynthetic analyses, reaction sequences and stereochemically crucial steps for each molecule
Book Synopsis Modern Carbonyl Chemistry by : Junzo Otera
Download or read book Modern Carbonyl Chemistry written by Junzo Otera and published by John Wiley & Sons. This book was released on 2008-11-21 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: The carbonyl group is undoubtedly one of the most important functional groups in organic chemistry, both in its role as reactive center for synthesis or derivatisation and as crucial feature for special structural or physiological properties. Vast and profound progress has been made in all aspects modern carbonyl chemistry. These achievements are, however, rather dispersed in the literature and it is often not easy for the researcher obtain a comprehensive overview of a relevant topic. Modern Carbonyl Chemistry overcomes this inconvenience by collating the information for appropriate themes. In this work internationally renowned experts and leaders in the field have surveyed recent aspects and modern features in carbonyl chemistry, such as cascade-reactions, one-pot-syntheses, recognition, or site differentiation.
Book Synopsis N-Heterocyclic Carbenes in Organocatalysis by : Akkattu T. Biju
Download or read book N-Heterocyclic Carbenes in Organocatalysis written by Akkattu T. Biju and published by John Wiley & Sons. This book was released on 2019-01-07 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Summarizing the emerging field of N-heterocyclic carbenes used in organocatalysis, this is an excellent overview of the synthesis and applications of NHCs focusing on carbon-carbon and carbon-heteroatom bond formation. Alongside comprehensive coverage of the synthesis, characteristics and applications, this handbook and ready reference also includes chapters on NHCs for polymerization reactions and natural product synthesis.
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