Focal High Intensity Focused Ultrasound In The Treatment Of Non Metastatic Prostate Cancer

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Focal High Intensity Focused Ultrasound in the Treatment of Non-Metastatic Prostate Cancer

Author : Stephanie Guillaumier
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (116 download)

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Book Synopsis Focal High Intensity Focused Ultrasound in the Treatment of Non-Metastatic Prostate Cancer by : Stephanie Guillaumier

Download or read book Focal High Intensity Focused Ultrasound in the Treatment of Non-Metastatic Prostate Cancer written by Stephanie Guillaumier and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction This thesis will explore the adverse events, side--effect profile and efficacy of high intensity focused ultrasound to treat non--metastatic prostate cancer. I will look at the background of prostate cancer and how advances in the diagnostic pathway for prostate cancer, as well as the paradigm shifts in treatment for this disease, have defined the current treatment landscape for localized prostate cancer and how focal therapy fits in. Objectives The aim of this thesis is to evaluate the efficacy and medium--term outcomes of focal HIFU from a multicentre registry of over 600 cases treated over the last 10 years in the UK. In so doing, this thesis will explore the use of registries in defining novel treatments as a useful body of evidence that might be used to impact on standard care in the absence of randomized controlled studies which are difficult to conduct within surgical specialties. The future role of focal therapy and high intensity focused ultrasound will be discussed, providing insights into the evolution of this ablative therapy, and how it might take its place within the armamentarium of treatments available for localized prostate cancer. Results The multicenter academic focal HIFU registry demonstrates acceptable oncological control in men diagnosed with non--metastatic prostate cancer is achievable with acceptable o Conclusions The medium--term data presented in this thesis is the first of its kind and supports the contention that focal therapy has a role in decreasing the genito--urinary side--effects associated with standard whole--gland therapies. Trifecta status of leak--free, pad--free continence, erections sufficient for intercourse, and oncological control is achievable with focal HIFU with acceptable results. Ultimately, long--term data will be necessary, including 5 research into comparative effectiveness to further establish the future role of focal therapy in treating localized prostate cancer.

Focal Therapy of Prostate Cancer

Author : Stefan Thüroff
Publisher : Springer
ISBN 13 : 3319141600
Total Pages : 144 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Focal Therapy of Prostate Cancer by : Stefan Thüroff

Download or read book Focal Therapy of Prostate Cancer written by Stefan Thüroff and published by Springer. This book was released on 2015-03-20 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a 2015 state of the art update on the hot topic of focal prostate cancer therapy, which offers a means of preserving the prostate and avoiding major side-effects associated with conventional treatment strategies. In so doing, focal therapy meets the desire of many patients, especially those with low-risk disease, to avoid or postpone radical therapies in order to preserve quality of life. A wide range of aspects are covered, including the role of imaging-guided targeted biopsies, the pros and cons of surveillance in comparison with focal therapy, focal hemiablation and focal salvage therapy, multifocal therapies, focal cryotherapy. The potential role of various new diagnostic technologies as well as specific therapeutic devices as "Focal.One" robotic high-intensity focused ultrasound are explained. The authors are all international experts who are long-term proponents of non-invasive treatment of prostate cancer. "Focal Therapy of Prostate Cancer" will be an invaluable source of information for urologists, oncologists, radiation oncologists, and general practitioners, and also for patients wishing to learn more about this new treatment option.

Technical Aspects of Focal Therapy in Localized Prostate Cancer

Author : Eric Barret
Publisher : Springer
ISBN 13 : 2817804848
Total Pages : 252 pages
Book Rating : 4.8/5 (178 download)

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Book Synopsis Technical Aspects of Focal Therapy in Localized Prostate Cancer by : Eric Barret

Download or read book Technical Aspects of Focal Therapy in Localized Prostate Cancer written by Eric Barret and published by Springer. This book was released on 2015-01-29 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focal therapy is a promising option for selected patients who have localized low or intermediate-risk prostate cancer, providing a compelling alternative between active surveillance and radical therapies by targeting the index lesion and preserving as much tissue as possible. Numerous cohort studies have already investigated multiple focal techniques, such as cryotherapy, high-intensity focused ultrasound, brachytherapy, photodynamic therapy, laser therapy, irreversible electroporation and cyberknife methods, all of which have demonstrated positive oncological outcomes with 70 to 90 % negative follow-up biopsy. These various ablative techniques have produced only minor side-effects concerning urinary function, a low rate of erectile dysfunction, and have demonstrated a limited rectal toxicity. As a result, the primary end-point has now shifted and a new strategy needs to be established for patient follow-up and for defining treatment failure. Written by international experts in the field, this book is mainly focused on new techniques, all of which are amply illustrated. Technical Aspects of Focal Therapy in Localized Prostate Cancer will be of great practical value to all urologists and oncologists.

Imaging and Focal Therapy of Early Prostate Cancer

Author : Thomas J. Polascik
Publisher : Springer
ISBN 13 : 3319499114
Total Pages : 475 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Imaging and Focal Therapy of Early Prostate Cancer by : Thomas J. Polascik

Download or read book Imaging and Focal Therapy of Early Prostate Cancer written by Thomas J. Polascik and published by Springer. This book was released on 2017-02-22 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text encompass an up-to-date, comprehensive review of the state-of-the-art for gland preserving therapies. Fully updated and revised, this text evaluates the scientific evidence for the evolving trend to treat intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and laser ablation, among others, is discussed in regard to their strengths and limitations as a therapeutic modality. Emphasis is placed on patient selection and outcomes utilizing both advanced imaging techniques and pathologic evaluation. Current and new approaches to image cancer foci within the prostate (multiparametric ultrasonography, multiparametric magnetic resonance image, etc) are presented along with various biopsy techniques, including robotics to map prostate cancer. Patient selection based on imaging and genomic classification, adjuvants to enhance therapy, treatment strategy, outcomes and patient centered concerns is discussed, providing an acceptable balance between cancer control and improved quality of life for patients. Written by experts in the field and lavishly illustrated with detailed line-art and photographs, Imaging and Focal Therapy of Early Prostate Cancer, Second Edition is designed as a comprehensive resource for urologists, radiation oncologists, medical oncologists, radiologists, uropathologists, molecular biologists, biomedical engineers, other clinicians –- residents, fellows, nurses and allied professionals -- and researchers with an interest in the diagnosis and novel treatment of prostate cancer. It will provide insight into the latest research and clinical applications of image-guided diagnosis and minimally invasive focal, gland-preserving treatment for prostate cancer.

MRI-Guided Focused Ultrasound Surgery

Author : Ferenc A. Jolesz
Publisher : CRC Press
ISBN 13 : 1420019937
Total Pages : 217 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis MRI-Guided Focused Ultrasound Surgery by : Ferenc A. Jolesz

Download or read book MRI-Guided Focused Ultrasound Surgery written by Ferenc A. Jolesz and published by CRC Press. This book was released on 2007-09-26 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: MRI-Guided Focused Ultrasound Surgery will be the first publication on this new technology, and will present a variety of current and future clinical applications in tumor ablation treatment. This source helps surgeons and specialists evaluate, analyze, and utilize MRI-guided focused ultrasound surgery - bridging the gap between phase 3 clinical tr

Focal Therapy in Prostate Cancer

Author : Hashim Uddin Ahmed
Publisher : John Wiley & Sons
ISBN 13 : 1405196491
Total Pages : 213 pages
Book Rating : 4.4/5 (51 download)

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Book Synopsis Focal Therapy in Prostate Cancer by : Hashim Uddin Ahmed

Download or read book Focal Therapy in Prostate Cancer written by Hashim Uddin Ahmed and published by John Wiley & Sons. This book was released on 2011-12-27 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively reviews the potential of focal therapy and discusses why the changing face of prostate cancer warrants a change in the way we treat men with the disease. It deals with the mechanisms by which disease can be localized within the gland and then the different technologies used for focal ablation. Bringing together eminent contributors in one accessible reference, this book introduces focal therapy to all urologists, oncologists, and radiologists who are involved in the treatment of men with prostate cancer.

The Tumor

Author : John Grisham
Publisher : Focused Ultrasound Foundation
ISBN 13 : 1495179419
Total Pages : 66 pages
Book Rating : 4.4/5 (951 download)

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Book Synopsis The Tumor by : John Grisham

Download or read book The Tumor written by John Grisham and published by Focused Ultrasound Foundation. This book was released on 2015-03 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt: John Grisham says THE TUMOR is the most important book he has ever written. In this short book, he provides readers with a fictional account of how a real, new medical technology could revolutionize the future of medicine by curing with sound. THE TUMOR follows the present day experience of the fictional patient Paul, an otherwise healthy 35-year-old father who is diagnosed with a malignant brain tumor. Grisham takes readers through a detailed account of Paul’s treatment and his family’s experience that doesn’t end as we would hope. Grisham then explores an alternate future, where Paul is diagnosed with the same brain tumor at the same age, but in the year 2025, when a treatment called focused ultrasound is able to extend his life expectancy. Focused ultrasound has the potential to treat not just brain tumors, but many other disorders, including Parkinson’s, Alzheimer’s, hypertension, and prostate, breast and pancreatic cancer. For more information or to order a free hardcopy of the book, please visit The Focused Ultrasound Foundation’s website www.fusfoundation.org. Here you will find a video of Grisham on the TEDx stage with the Foundation’s chairman and a Parkinson’s patient who brings the audience to its feet sharing her incredible story of a focused ultrasound “miracle.” Readers will get a taste of the narrative they expect from Grisham, but this short book will also educate and inspire people to be hopeful about the future of medical innovation.

Handbook of Focal Therapy for Prostate and Renal Cancer

Author : Damian Greene
Publisher : JP Medical Ltd
ISBN 13 : 1909836117
Total Pages : 402 pages
Book Rating : 4.9/5 (98 download)

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Book Synopsis Handbook of Focal Therapy for Prostate and Renal Cancer by : Damian Greene

Download or read book Handbook of Focal Therapy for Prostate and Renal Cancer written by Damian Greene and published by JP Medical Ltd. This book was released on 2016-09-06 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer is the commonest cancer in men. Current treatments include surgery to remove the whole prostate or radiotherapy of the whole prostate. These radical treatments can treat the cancer effectively but often cause unwanted side effects. Meanwhile widespread screening with prostate-specific antigen has led to an increased diagnosis of localised prostate cancer; at the same time, widespread use of abdominal imaging has led to increased detection of renal masses. In response to demand for improved outcomes with reduced side effects, focal therapy has emerged as an important procedure in managing both prostate and renal cancers. It targets individual areas of cancer, reducing unwanted side effects and the amount of damage to collateral tissue. This new method of treatment has major advantages: it involves less radiation, the removal of less tissue and less time spent in hospital. Handbook of Focal Therapy for Prostate and Renal Cancer provides a comprehensive, timely review of targeted ablation methods to treat prostate and renal cancers. It describes the most effective techniques in current practice, with discussion of the selection criteria, ablation technologies and their limitations, and advice on the management of common side effects. The book opens with a summary of the principles of prostate and renal cancer treatment and the mechanisms of focal therapy. Separate sections on prostate and kidney follow, covering the role of focal therapy, side effects and their treatment and follow-up after targeted ablation. Written in a practical, clinically-oriented style, Handbook of Focal Therapy for Prostate and Renal Cancer is the ideal reference for urologists, radiologists and radiation oncologists wishing to employ the latest focal therapy techniques in the care of their patients.

Urological Pathology

Author : Mahul B. Amin
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1469857960
Total Pages : 2443 pages
Book Rating : 4.4/5 (698 download)

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Book Synopsis Urological Pathology by : Mahul B. Amin

Download or read book Urological Pathology written by Mahul B. Amin and published by Lippincott Williams & Wilkins. This book was released on 2013-11-14 with total page 2443 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge in the field of urologic pathology is growing at an explosive pace. Today’s pathologists, specialists, and residents require a comprehensive and authoritative text that examines the full range of urological diseases and their diagnosis. Written by recognized leaders and educators in the field, the text provides readers with a detailed understanding of all diagnostic aspects of urological disease. Inside this unique resource, readers will explore a broad spectrum of practical information—including etiology, diagnostic criteria, molecular markers, differential diagnosis, ancillary tests, and clinical management. This is sure to be the new definitive text for urological pathology!

Focal Therapy in Prostate Cancer

Author : Hashim Uddin Ahmed
Publisher : John Wiley & Sons
ISBN 13 : 1444346873
Total Pages : 213 pages
Book Rating : 4.4/5 (443 download)

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Book Synopsis Focal Therapy in Prostate Cancer by : Hashim Uddin Ahmed

Download or read book Focal Therapy in Prostate Cancer written by Hashim Uddin Ahmed and published by John Wiley & Sons. This book was released on 2011-10-19 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively reviews the potential of focal therapy and discusses why the changing face of prostate cancer warrants a change in the way we treat men with the disease. It deals with the mechanisms by which disease can be localized within the gland and then the different technologies used for focal ablation. Bringing together eminent contributors in one accessible reference, this book introduces focal therapy to all urologists, oncologists, and radiologists who are involved in the treatment of men with prostate cancer.

Focal High Intensity Focused Ultrasound for Prostate Cancer

Author : Fouad Aoun
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (115 download)

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Book Synopsis Focal High Intensity Focused Ultrasound for Prostate Cancer by : Fouad Aoun

Download or read book Focal High Intensity Focused Ultrasound for Prostate Cancer written by Fouad Aoun and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Focal High Intensity Focused Ultrasound for Prostate Cancer.

Image-Guided Cancer Therapy

Author : Damian E. Dupuy
Publisher : Springer
ISBN 13 : 9781441907509
Total Pages : 0 pages
Book Rating : 4.9/5 (75 download)

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Book Synopsis Image-Guided Cancer Therapy by : Damian E. Dupuy

Download or read book Image-Guided Cancer Therapy written by Damian E. Dupuy and published by Springer. This book was released on 2013-08-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Image-Guided Cancer Therapy: A Multidisciplinary Approach provides clinicians with in-depth coverage of the growing, dynamic field of interventional oncology. Combining the knowledge of expert editors and authors into one powerhouse reference, this book looks at tumor ablation, HIFU, embolic therapies, emerging technologies, and radiation therapy throughout the body (liver, bone, breast, gynecologic and prostate cancers, to name just a few) , and includes discussion of different imaging modalities. In the words of Peter Mueller, MD, author of the book’s Foreword: “... The senior authors are all world renowned experts in interventional oncology, which is another example of the high quality authorship and experience that is brought to this book. The later chapters discuss therapies that are simply not covered in any other source. Everyone who is doing or wants to do ablation therapies and interventional oncology will face a time when they will be asked to use their expertise in less used and less investigated areas. There is nowhere else where the reader can get information on the prostate, breast, and gynecologic areas, and especially pediatrics....This book is an outstanding contribution to the literature and will become a ‘must read’ for all physicians who are interested in Interventional Oncology.”

Therapeutic Ultrasound

Author : Jean-Michel Escoffre
Publisher : Springer
ISBN 13 : 3319225367
Total Pages : 459 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Therapeutic Ultrasound by : Jean-Michel Escoffre

Download or read book Therapeutic Ultrasound written by Jean-Michel Escoffre and published by Springer. This book was released on 2015-10-20 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights advances and prospects of a highly versatile and dynamic research field: Therapeutic ultrasound. Leading experts in the field describe a wide range of topics related to the development of therapeutic ultrasound (i.e., high intensity focused ultrasound, microbubble-assisted ultrasound drug delivery, low intensity pulsed ultrasound, ultrasound-sensitive nanocarriers), ranging from the biophysical concepts (i.e., tissue ablation, drug and gene delivery, neuromodulation) to therapeutic applications (i.e., chemotherapy, sonodynamic therapy, sonothrombolysis, immunotherapy, lithotripsy, vaccination). This book is an indispensable source of information for students, researchers and clinicians dealing with non-invasive image-guided ultrasound-based therapeutic interventions in the fields of oncology, neurology, cardiology and nephrology.

Focal Therapy Using High-intensity Focused Ultrasound for Localised Prostate Cancer

Author : National Institute for Health and Clinical Excellence (Great Britain)
Publisher :
ISBN 13 :
Total Pages : 6 pages
Book Rating : 4.:/5 (16 download)

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Book Synopsis Focal Therapy Using High-intensity Focused Ultrasound for Localised Prostate Cancer by : National Institute for Health and Clinical Excellence (Great Britain)

Download or read book Focal Therapy Using High-intensity Focused Ultrasound for Localised Prostate Cancer written by National Institute for Health and Clinical Excellence (Great Britain) and published by . This book was released on 2012 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Atlas of Ultrasonography in Urology, Andrology, and Nephrology

Author : Pasquale Martino
Publisher : Springer
ISBN 13 : 3319407821
Total Pages : 710 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Atlas of Ultrasonography in Urology, Andrology, and Nephrology by : Pasquale Martino

Download or read book Atlas of Ultrasonography in Urology, Andrology, and Nephrology written by Pasquale Martino and published by Springer. This book was released on 2017-03-28 with total page 710 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the latest recommendations for ultrasound examination of the entire urogenital system, particularly in the male. The coverage encompasses the role of ultrasound in imaging of disorders of the kidneys, urinary tract, prostate, seminal vesicles, bladder, testes, and penis, including male infertility disorders. In addition, detailed consideration is given to intraoperative and interventional ultrasound and recently developed ultrasound techniques. Each chapter defines the purpose of and indications for ultrasound, identifies its benefits and limitations, specifies the technological standards for devices, outlines performance of the investigation, establishes the expected accuracy for differential diagnosis, and indicates the reporting method. Most of the recommendations are based on review of the literature, on previous recommendations, and on the opinions of the experts of the Imaging Working Group of the Italian Society of Urology (SIU) and the Italian Society of Ultrasound in Urology, Andrology, and Nephrology (SIEUN). The book will be of value for all physicians involved in the first-line evaluation of diseases of the renal/urinary system and male genital disorders.

High intensity focused ultrasound for prostate cancer

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (137 download)

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Book Synopsis High intensity focused ultrasound for prostate cancer by :

Download or read book High intensity focused ultrasound for prostate cancer written by and published by . This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The intent is to provide a list of sources and a summary of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. [...] This report will review evidence for the clinical and cost-effectiveness of HIFU for the treatment of prostate cancer and benign prostatic hypertrophy and guidelines associated with its use for both indications. [...] Health technology assessments Prostate cancer The first relevant HTA identified from the literature search was produced by the NHS R&D Health Technology Assessment Programme and reviewed the clinical and cost-effectiveness of new and emerging technologies for early, localized prostate cancer.4 A total of 15 technologies were included in the review including HIFU. [...] The authors remarked that they had some difficulty determining the absolute number of patients treated with HIFU because some of the articles appear to relate to the same study with different numbers of patients or different durations of follow-up. [...] Based on the available evidence, the authors did not make conclusions regarding the use of HIFU for the treatment of prostate cancer.

MR-Guided Pulsed High-Intensity Focused Ultrasound Enhancement of Gene Therapy Combined With Androgen Deprivation and Radiotherapy for Prostate Cancer Treatment

Download MR-Guided Pulsed High-Intensity Focused Ultrasound Enhancement of Gene Therapy Combined With Androgen Deprivation and Radiotherapy for Prostate Cancer Treatment PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 10 pages
Book Rating : 4.:/5 (64 download)

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Book Synopsis MR-Guided Pulsed High-Intensity Focused Ultrasound Enhancement of Gene Therapy Combined With Androgen Deprivation and Radiotherapy for Prostate Cancer Treatment by :

Download or read book MR-Guided Pulsed High-Intensity Focused Ultrasound Enhancement of Gene Therapy Combined With Androgen Deprivation and Radiotherapy for Prostate Cancer Treatment written by and published by . This book was released on 2009 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work is aimed to study MR guided high intensity focused ultrasound (MRgHIFU) enhancement of gene therapy for Prostate Cancer. The first statement of work is to determine if high intensity focused ultrasound (HIFU) increases the cellular uptake of AS-MDM2, AS-bcl-2 and AS-PKA, thereby suppressing MDM2, bcl-2 and PKA, respectively, in vivo. The tasks include (a) Characterization of the output of the focused ultrasound unit using MR guidance; (b) Determination of the uptake of AS-bcl-2 in orthotopically grown LNCaP tumors; (c) Determination of the timing of the reduction in MDM2 in orthotopically grown LNCaP tumors;(d) Statistical assessment of targeted antisense therapy on gene expression in tumor bearing mice. We performed phantom studies on characterization of the output of the focused ultrasound unit using MR guidance. The IACUC protocol has just been approved by the USAMRMC Animal Care and Use Review Office (ACURO) for the use of mice. Now we are able to perform the animal studies.