Flux Control In Biological Systems

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Flux Control in Biological Systems

Author : Ernst-Detlef Schulze
Publisher : Academic Press
ISBN 13 : 0323139426
Total Pages : 540 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Flux Control in Biological Systems by : Ernst-Detlef Schulze

Download or read book Flux Control in Biological Systems written by Ernst-Detlef Schulze and published by Academic Press. This book was released on 2012-12-02 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehending and modelling biomass production, nutrient, and water fluxes in biological systems requires understanding control mechanisms at various levels of organiztion. This new book, with 16 pages of four-colorplates, compares patterns and mechanisms of regulation-starting from enzyme reactions and ending at the population and ecosystem level. By doing so, the book investigates the general principles of how fluxes are adjusted and regulated. Such principles areessential for preparing effective models and for predicting human impacts on ecosystems. Flux Control in Biological Systems: From Enzymes to Populations and Ecosystems will be an essential personal library addition for student and professional environmental biologists, ecologists, physiologists, biochemists, botanists, microbiologists, soil scientists, and zoologists; as well as anyone who investigate patterns of matter and energy transfer in biological systems of different levels of complexity. * Presents the mechanisms of flux control * Explains the similarities of flux control at various levels of complexity and organization * Demonstrates how fluxes are adjusted in complex systems of interacting groups of organisms

Modeling Biological Systems with Cybernetic Control Laws and Steady State Flux Distributions

Author : Kritika Kashyap
Publisher :
ISBN 13 :
Total Pages : 78 pages
Book Rating : 4.:/5 (122 download)

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Book Synopsis Modeling Biological Systems with Cybernetic Control Laws and Steady State Flux Distributions by : Kritika Kashyap

Download or read book Modeling Biological Systems with Cybernetic Control Laws and Steady State Flux Distributions written by Kritika Kashyap and published by . This book was released on 2019 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolism is a process by which organisms extract energy from its environment to power itself. The interplay between cellular environment, nutrients present and the chemical reactions occurring within the organisms dictate the execution of metabolism. Single cell microbes, such as E. coli, P. putida and yeast, can be redesigned to be miniature chemical reactors that transform sugars and other carbon sources into biofuels. Enhancing bio-process conditions can stimulate the production of therapeutic proteins in mammalian cells. Hence, understanding the strategy of metabolism in organisms would help us build better technologies for controlling formation of end products like cell mass, biofuels,therapeutic proteins etc. Steady state flux analysis techniques have gained a lot of popularity in the field of systems biology due to successful qualitative analysis of large scale metabolic networks. This technique has been used to improve production of ethanol in Saccharomyces cerevisiae and lactic acid in Escherichia coli (E. coli), to name a few examples. Despite this success, its major shortcoming re-mains in providing quantitative measurements of metabolite profiles that can be further validated with experiments. Previous cybernetic models have accurately validated experimental results and described molecular processes governing metabolism, but their application is limited to small scale metabolic net-works. We have built a mathematical framework that combines solutions from steady state flux analysis with cybernetic principles to overcome the challenge of describing metabolic data for large scale metabolic networks. We have established computational models that can capture dynamic metabolic regulation in bacterial and mammalian cells. These models integrate chemical kinetics, mass balances, enzyme catalysis and stoichiometric laws to predict biology that can help us optimize cellular machinery towards bioproduct formation.

A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems

Author : Vishwesh V. Kulkarni
Publisher : Springer
ISBN 13 : 9401790477
Total Pages : 304 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems by : Vishwesh V. Kulkarni

Download or read book A Systems Theoretic Approach to Systems and Synthetic Biology II: Analysis and Design of Cellular Systems written by Vishwesh V. Kulkarni and published by Springer. This book was released on 2014-07-03 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complexity of biological systems has intrigued scientists from many disciplines and has given birth to the highly influential field of systems biology wherein a wide array of mathematical techniques, such as flux balance analysis, and technology platforms, such as next generation sequencing, is used to understand, elucidate, and predict the functions of complex biological systems. More recently, the field of synthetic biology, i.e., de novo engineering of biological systems, has emerged. Scientists from various fields are focusing on how to render this engineering process more predictable, reliable, scalable, affordable, and easy. Systems and control theory is a branch of engineering and applied sciences that rigorously deals with the complexities and uncertainties of interconnected systems with the objective of characterising fundamental systemic properties such as stability, robustness, communication capacity, and other performance metrics. Systems and control theory also strives to offer concepts and methods that facilitate the design of systems with rigorous guarantees on these properties. Over the last 100 years, it has made stellar theoretical and technological contributions in diverse fields such as aerospace, telecommunication, storage, automotive, power systems, and others. Can it have, or evolve to have, a similar impact in biology? The chapters in this book demonstrate that, indeed, systems and control theoretic concepts and techniques can have a significant impact in systems and synthetic biology. Volume II contains chapters contributed by leading researchers in the field of systems and synthetic biology that concern modeling physiological processes and bottom-up constructions of scalable biological systems. The modeling problems include characterisation and synthesis of memory, understanding how homoeostasis is maintained in the face of shocks and relatively gradual perturbations, understanding the functioning and robustness of biological clocks such as those at the core of circadian rhythms, and understanding how the cell cycles can be regulated, among others. Some of the bottom-up construction problems investigated in Volume II are as follows: How should biomacromolecules, platforms, and scalable architectures be chosen and synthesised in order to build programmable de novo biological systems? What are the types of constrained optimisation problems encountered in this process and how can these be solved efficiently? As the eminent computer scientist Donald Knuth put it, "biology easily has 500 years of exciting problems to work on". This edited book presents but a small fraction of those for the benefit of (1) systems and control theorists interested in molecular and cellular biology and (2) biologists interested in rigorous modelling, analysis and control of biological systems.

Thermodynamics and Regulation of Biological Processes

Author : Ingolf Lamprecht
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110861194
Total Pages : 588 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Thermodynamics and Regulation of Biological Processes by : Ingolf Lamprecht

Download or read book Thermodynamics and Regulation of Biological Processes written by Ingolf Lamprecht and published by Walter de Gruyter GmbH & Co KG. This book was released on 2019-07-22 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: No detailed description available for "Thermodynamics and Regulation of Biological Processes".

Understanding the Dynamics of Biological Systems

Author : Werner Dubitzky
Publisher : Springer Science & Business Media
ISBN 13 : 1441979646
Total Pages : 249 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Understanding the Dynamics of Biological Systems by : Werner Dubitzky

Download or read book Understanding the Dynamics of Biological Systems written by Werner Dubitzky and published by Springer Science & Business Media. This book was released on 2011-01-07 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is intended as a communication platform to bridge the cultural, conceptual, and technological gap among the key systems biology disciplines of biology, mathematics, and information technology. To support this goal, contributors were asked to adopts an approach that appeals to audiences from different backgrounds.

The Nature of Biological Systems as Revealed by Thermal Methods

Author : Dénes Lörinczy
Publisher : Springer Science & Business Media
ISBN 13 : 9781402022180
Total Pages : 368 pages
Book Rating : 4.0/5 (221 download)

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Book Synopsis The Nature of Biological Systems as Revealed by Thermal Methods by : Dénes Lörinczy

Download or read book The Nature of Biological Systems as Revealed by Thermal Methods written by Dénes Lörinczy and published by Springer Science & Business Media. This book was released on 2004-07-20 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Nature of Biological Systems as Revealed by Thermal Methods is a guide for experiments using thermal methods. The Editor has used his many years of experience to create a unique resource that will enable others with a less mathematical background, to realize the beauty and power of this tool and to gain a better understanding of biological problems. Biological calorimetry (and of course thermal analysis) is of increasing interest and is not covered thoroughly in other resources. The methods presented are macroscopic, for the rather inhomogeneous material (micromethods are often not possible or not pertinent). This book will help beginners in the field of thermal analysis or calorimetry understand the principles of thermodynamics being applied to biological systems. Biological systems are highly organized and very complex. The water and the different types of weak interactions among the macromolecules make the interpretation of thermal events very difficult. This book includes examples how to handle such problems. The Nature of Biological Systems as Revealed by Thermal Methods is unique in that it: -has a broad spectrum, from molecules and biochemistry, tissues, and food, to whole organisms; -combines practical problems (food processing, quality control, thermal denaturation of proteins, plants and small insects, etc.) with concrete solutions and interpretation; -provides practical strategies and tools without "dry physics and mathematics"; -initiates the application of thermal methods in new fields (e.g. medicine); -forces the reader to go into more detail of thermodynamics and thermal techniques; -simplifies communication between biologists, medical doctors and experts of thermal analysis. The book is an invaluable resource for anyone interested in thermodynamics, including practising professionals applying thermal methods to biological problems; researchers and graduate students beginning work using thermal methods; and specialists of thermal analysis starting work on biological problems. In addition, this book will be a useful resource for libraries and institutes as the only book covering quantitative thermal analysis of biological systems.

A Systems Theoretic Approach to Systems and Synthetic Biology I: Models and System Characterizations

Author : Vishwesh V. Kulkarni
Publisher : Springer
ISBN 13 : 9401790418
Total Pages : 338 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis A Systems Theoretic Approach to Systems and Synthetic Biology I: Models and System Characterizations by : Vishwesh V. Kulkarni

Download or read book A Systems Theoretic Approach to Systems and Synthetic Biology I: Models and System Characterizations written by Vishwesh V. Kulkarni and published by Springer. This book was released on 2014-07-03 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complexity of biological systems has intrigued scientists from many disciplines and has given birth to the highly influential field of systems biology wherein a wide array of mathematical techniques, such as flux balance analysis, and technology platforms, such as next generation sequencing, is used to understand, elucidate, and predict the functions of complex biological systems. More recently, the field of synthetic biology, i.e., de novo engineering of biological systems, has emerged. Scientists from various fields are focusing on how to render this engineering process more predictable, reliable, scalable, affordable, and easy. Systems and control theory is a branch of engineering and applied sciences that rigorously deals with the complexities and uncertainties of interconnected systems with the objective of characterising fundamental systemic properties such as stability, robustness, communication capacity, and other performance metrics. Systems and control theory also strives to offer concepts and methods that facilitate the design of systems with rigorous guarantees on these properties. Over the last 100 years, it has made stellar theoretical and technological contributions in diverse fields such as aerospace, telecommunication, storage, automotive, power systems, and others. Can it have, or evolve to have, a similar impact in biology? The chapters in this book demonstrate that, indeed, systems and control theoretic concepts and techniques can have a significant impact in systems and synthetic biology. Volume I provides a panoramic view that illustrates the potential of such mathematical methods in systems and synthetic biology. Recent advances in systems and synthetic biology have clearly demonstrated the benefits of a rigorous and systematic approach rooted in the principles of systems and control theory - not only does it lead to exciting insights and discoveries but it also reduces the inordinately lengthy trial-and-error process of wet-lab experimentation, thereby facilitating significant savings in human and financial resources. In Volume I, some of the leading researchers in the field of systems and synthetic biology demonstrate how systems and control theoretic concepts and techniques can be useful, or should evolve to be useful, in order to understand how biological systems function. As the eminent computer scientist Donald Knuth put it, "biology easily has 500 years of exciting problems to work on". This edited book presents but a small fraction of those for the benefit of (1) systems and control theorists interested in molecular and cellular biology and (2) biologists interested in rigorous modelling, analysis and control of biological systems.

The Regulation of Cellular Systems

Author : Reinhart Heinrich
Publisher : Springer Science & Business Media
ISBN 13 : 1461311616
Total Pages : 387 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis The Regulation of Cellular Systems by : Reinhart Heinrich

Download or read book The Regulation of Cellular Systems written by Reinhart Heinrich and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is no doubt that nowadays, biology benefits greatly from mathematics. In particular, cellular biology is, besides population dynamics, a field where tech niques of mathematical modeling are widely used. This is reflected by the large number of journal articles and congress proceedings published every year on the dynamics of complex cellular processes. This applies, among others, to metabolic control analysis, where the number of articles on theoretical fundamentals and experimental applications has increased for about 15 years. Surprisingly, mono graphs and textbooks dealing with the modeling of metabolic systems are still exceptionally rare. We think that now time is ripe to fill this gap. This monograph covers various aspects of the mathematical description of enzymatic systems, such as stoichiometric analysis, enzyme kinetics, dynamical simulation, metabolic control analysis, and evolutionary optimization. We believe that, at present, these are the main approaches by which metabolic systems can be analyzed in mathematical terms. Although stoichiometric analysis and enzyme kinetics are classical fields tracing back to the beginning of our century, there are intriguing recent developments such as detection of elementary biochemical syn thesis routes and rate laws for the situation of metabolic channeling, which we have considered worth being included. Evolutionary optimization of metabolic systems is a rather new field with promising prospects. Its goal is to elucidate the structure and functions of these systems from an evolutionary viewpoint.

Systems Biology

Author : Fred Boogerd
Publisher : Elsevier
ISBN 13 : 0080475272
Total Pages : 361 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Systems Biology by : Fred Boogerd

Download or read book Systems Biology written by Fred Boogerd and published by Elsevier. This book was released on 2007-03-20 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems biology is a vigorous and expanding discipline, in many ways a successor to genomics and perhaps unprecedented in its combination of biology with a great many other sciences, from physics to ecology, from mathematics to medicine, and from philosophy to chemistry. Studying the philosophical foundations of systems biology may resolve a longer standing issue, i.e., the extent to which Biology is entitled to its own scientific foundations rather than being dominated by existing philosophies. * Answers the question of what distinguishes the living from the non-living* An in-depth look to a vigorous and expanding discipline, from molecule to system* Explores the region between individual components and the system

Systems Biology

Author : Source Wikipedia
Publisher : University-Press.org
ISBN 13 : 9781230644851
Total Pages : 68 pages
Book Rating : 4.6/5 (448 download)

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Book Synopsis Systems Biology by : Source Wikipedia

Download or read book Systems Biology written by Source Wikipedia and published by University-Press.org. This book was released on 2013-09 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Pages: 66. Chapters: Gene regulatory network, Synthetic biology, Metabolomics, Two-hybrid screening, Flux balance analysis, Metabolic network modelling, Cell signaling, SBML, List of systems biology research groups, Ionomics, Biopunk, Modelling biological systems, Metabolic control analysis, Interactome, Minimum Information Required in the Annotation of Models, Genenetwork, Dynamic energy budget, Protein-protein interaction, Society for Mathematical Biology, STRING, Systems Biology Ontology, List of omics topics in biology, Cytoscape, Cellular model, Metabolome, BioModels Database, Interactomics, Systems Biology Graphical Notation, Wagner's gene network model, DAVID, GenMAPP, The Proteolysis Map, International q-bio Conference on Cellular Information Processing, Luxembourg Centre for Systems Biomedicine, Manchester Centre for Integrative Systems Biology, KEGG, Phenome, Minimum Information About a Simulation Experiment, Biochemical systems theory, Simulated growth of plants, Biological systems engineering, Gemini Somatics, NCI-Nature Pathway Interaction Database, Biosimulation, Metallome, BioPAX, Regulome, Institute for Systems Biology, Living systems, Molecular Systems Biology, List of systems biology conferences, Network theory of aging, List of systems biology visualization software, BISC, Extrapolation based molecular systems biology, ChemProt, Systems immunology, Department of Systems Biology, Human ecosystem, Systems Biology Ireland, Protein-DNA interaction, Centre for Plant Integrative Biology, ESIGNET Project, BMC Systems Biology, Interaction network, Interferomics, Metabolic flux analysis, Metabolite pool.

Bioreaction Engineering

Author : K. Schügerl
Publisher : Springer
ISBN 13 : 9783642597367
Total Pages : 604 pages
Book Rating : 4.5/5 (973 download)

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Book Synopsis Bioreaction Engineering by : K. Schügerl

Download or read book Bioreaction Engineering written by K. Schügerl and published by Springer. This book was released on 2012-01-19 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alongside presenting the fundamentals, this book reviews the state of the art of mathematical modeling and control of bioprocesses, while demonstrating the application in various biological systems important to industry. At the same time, the application of different types of models and control strategies are illustrated, taking into account the recent developments in reactor modeling. In addition to modeling and control, the metabolic flux analysis and the metabolic design and their application to bioprocesses are considered.

Thermodynamics and Control of Biological Free-energy Transduction

Author : Hans V. Westerhoff
Publisher : Elsevier Publishing Company
ISBN 13 :
Total Pages : 608 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Thermodynamics and Control of Biological Free-energy Transduction by : Hans V. Westerhoff

Download or read book Thermodynamics and Control of Biological Free-energy Transduction written by Hans V. Westerhoff and published by Elsevier Publishing Company. This book was released on 1987 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains a description of how quantitative notions from physics and chemistry may be applied to biological systems, in particular those involved in biological free energy transduction. Researchers in the fields of bioenergetics and biochemistry will find this volume to be an excellent, in-depth review of the subject and an invaluable source of information.

Transport Phenomena in Biological Systems

Author : George A. Truskey
Publisher : Prentice Hall
ISBN 13 : 0131569880
Total Pages : 889 pages
Book Rating : 4.1/5 (315 download)

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Book Synopsis Transport Phenomena in Biological Systems by : George A. Truskey

Download or read book Transport Phenomena in Biological Systems written by George A. Truskey and published by Prentice Hall. This book was released on 2009 with total page 889 pages. Available in PDF, EPUB and Kindle. Book excerpt: For one-semester, advanced undergraduate/graduate courses in Biotransport Engineering. Presenting engineering fundamentals and biological applications in a unified way, this text provides students with the skills necessary to develop and critically analyze models of biological transport and reaction processes. It covers topics in fluid mechanics, mass transport, and biochemical interactions, with engineering concepts motivated by specific biological problems.

Systems Biology

Author : Jens Nielsen
Publisher : John Wiley & Sons
ISBN 13 : 3527696172
Total Pages : 600 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Systems Biology by : Jens Nielsen

Download or read book Systems Biology written by Jens Nielsen and published by John Wiley & Sons. This book was released on 2017-03-15 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive coverage of the many different aspects of systems biology, resulting in an excellent overview of the experimental and computational approaches currently in use to study biological systems. Each chapter represents a valuable introduction to one specific branch of systems biology, while also including the current state of the art and pointers to future directions. Following different methods for the integrative analysis of omics data, the book goes on to describe techniques that allow for the direct quantification of carbon fluxes in large metabolic networks, including the use of 13C labelled substrates and genome-scale metabolic models. The latter is explained on the basis of the model organism Escherichia coli as well as the human metabolism. Subsequently, the authors deal with the application of such techniques to human health and cell factory engineering, with a focus on recent progress in building genome-scale models and regulatory networks. They highlight the importance of such information for specific biological processes, including the ageing of cells, the immune system and organogenesis. The book concludes with a summary of recent advances in genome editing, which have allowed for precise genetic modifications, even with the dynamic control of gene expression. This is part of the Advances Biotechnology series, covering all pertinent aspects of the field with each volume prepared by eminent scientists who are experts on the topic in question.

Systems Biology

Author : Lilia Alberghina
Publisher : Springer Science & Business Media
ISBN 13 : 9783540742692
Total Pages : 432 pages
Book Rating : 4.7/5 (426 download)

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Book Synopsis Systems Biology by : Lilia Alberghina

Download or read book Systems Biology written by Lilia Alberghina and published by Springer Science & Business Media. This book was released on 2007-10-04 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: For life to be understood and disease to become manageable, the wealth of postgenomic data now needs to be made dynamic. This development requires systems biology, integrating computational models for cells and organisms in health and disease; quantitative experiments (high-throughput, genome-wide, living cell, in silico); and new concepts and principles concerning interactions. This book defines the new field of systems biology and discusses the most efficient experimental and computational strategies. The benefits for industry, such as the new network-based drug-target design validation, and testing, are also presented.

Systems Biology in Practice

Author : Edda Klipp
Publisher : John Wiley & Sons
ISBN 13 : 352760488X
Total Pages : 486 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Systems Biology in Practice by : Edda Klipp

Download or read book Systems Biology in Practice written by Edda Klipp and published by John Wiley & Sons. This book was released on 2008-07-15 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting the main concepts, this book leads students as well as advanced researchers from different disciplines to an understanding of current ideas in the complex field of comprehensive experimental investigation of biological objects, analysis of data, development of models, simulation, and hypothesis generation. It provides readers with guidance on how a specific complex biological question may be tackled: - How to formulate questions that can be answered - Which experiments to perform - Where to find information in databases and on the Internet - What kinds of models are appropriate - How to use simulation tools - What can be learned from the comparison of experimental data and modeling results - How to make testable predictions. The authors demonstrate how mathematical concepts can illuminate the principles underlying biology at a genetic, molecular, cellular and even organism level, and how to use mathematical tools for analysis and prediction.

A Systems Theoretic Approach to Systems and Synthetic Biology I: Models and System Characterizations

Author : Vishwesh Kulkarni
Publisher : Springer
ISBN 13 : 9789401790406
Total Pages : 0 pages
Book Rating : 4.7/5 (94 download)

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Book Synopsis A Systems Theoretic Approach to Systems and Synthetic Biology I: Models and System Characterizations by : Vishwesh Kulkarni

Download or read book A Systems Theoretic Approach to Systems and Synthetic Biology I: Models and System Characterizations written by Vishwesh Kulkarni and published by Springer. This book was released on 2014-07-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complexity of biological systems has intrigued scientists from many disciplines and has given birth to the highly influential field of systems biology wherein a wide array of mathematical techniques, such as flux balance analysis, and technology platforms, such as next generation sequencing, is used to understand, elucidate, and predict the functions of complex biological systems. More recently, the field of synthetic biology, i.e., de novo engineering of biological systems, has emerged. Scientists from various fields are focusing on how to render this engineering process more predictable, reliable, scalable, affordable, and easy. Systems and control theory is a branch of engineering and applied sciences that rigorously deals with the complexities and uncertainties of interconnected systems with the objective of characterising fundamental systemic properties such as stability, robustness, communication capacity, and other performance metrics. Systems and control theory also strives to offer concepts and methods that facilitate the design of systems with rigorous guarantees on these properties. Over the last 100 years, it has made stellar theoretical and technological contributions in diverse fields such as aerospace, telecommunication, storage, automotive, power systems, and others. Can it have, or evolve to have, a similar impact in biology? The chapters in this book demonstrate that, indeed, systems and control theoretic concepts and techniques can have a significant impact in systems and synthetic biology. Volume I provides a panoramic view that illustrates the potential of such mathematical methods in systems and synthetic biology. Recent advances in systems and synthetic biology have clearly demonstrated the benefits of a rigorous and systematic approach rooted in the principles of systems and control theory - not only does it lead to exciting insights and discoveries but it also reduces the inordinately lengthy trial-and-error process of wet-lab experimentation, thereby facilitating significant savings in human and financial resources. In Volume I, some of the leading researchers in the field of systems and synthetic biology demonstrate how systems and control theoretic concepts and techniques can be useful, or should evolve to be useful, in order to understand how biological systems function. As the eminent computer scientist Donald Knuth put it, "biology easily has 500 years of exciting problems to work on". This edited book presents but a small fraction of those for the benefit of (1) systems and control theorists interested in molecular and cellular biology and (2) biologists interested in rigorous modelling, analysis and control of biological systems.