The Billion-Dollar Molecule

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Author :
Publisher : Simon and Schuster
ISBN 13 : 143912681X
Total Pages : 480 pages
Book Rating : 4.4/5 (391 download)

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Book Synopsis The Billion-Dollar Molecule by : Barry Werth

Download or read book The Billion-Dollar Molecule written by Barry Werth and published by Simon and Schuster. This book was released on 2013-08-20 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Join journalist Barry Werth as he pulls back the curtain on Vertex, a start-up pharmaceutical company, and witness firsthand the intense drama being played out in the pioneering and hugely profitable field of drug research. Founded by Joshua Boger, a dynamic Harvard- and Merck-trained scientific whiz kid, Vertex is dedicated to designing—atom by atom—both a new life-saving immunosuppressant drug, and a drug to combat the virus that causes AIDS. You will be hooked from start to finish, as you go from the labs, where obsessive, fiercely competitive scientists struggle for a breakthrough, to Wall Street, where the wheeling and dealing takes on a life of its own, as Boger courts investors and finally decides to take Vertex public. Here is a fascinating no-holds-barred account of the business of science, which includes an updated epilogue about the most recent developments in the quest for a drug to cure AIDS.

Tacrolimus Ointment

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3662102099
Total Pages : 285 pages
Book Rating : 4.6/5 (621 download)

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Book Synopsis Tacrolimus Ointment by : T. Ruzicka

Download or read book Tacrolimus Ointment written by T. Ruzicka and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic breakthroughs in medicine are usually accompanied by a wealth of data. Often they result in a change of disease treatment paradigms. Tacrolimus ointment is the first in the new class of steroid-free Topical Immunomodulators (TIMs), and as such represents the first true breakthrough since the introduction of topical steroids more than 50 years ago for the treatment of T-cell mediated inflammatory skin diseases such as atopic dermatitis. This book gives an easy-to-read overview of the discovery and the development of Tacrolimus ointment for the treatment of atopic dermatitis. Summarising the largest clinical trial program ever conducted in dermatology for a new treatment with more than 13000 patients, it offers a detailed insight into the efficacy and safety profile of Tacrolimus ointment. Based on this large body of data and extensive personal experience, the authors offer practical and hands-on guidance for the physician as to when and how to use Tacrolimus ointment in daily practice.

Current Pharmaceutical Design

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Author :
Publisher :
ISBN 13 :
Total Pages : 130 pages
Book Rating : 4./5 ( download)

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Book Synopsis Current Pharmaceutical Design by :

Download or read book Current Pharmaceutical Design written by and published by . This book was released on 1995-08 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Current Pharmaceutical Design

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Author :
Publisher :
ISBN 13 :
Total Pages : 130 pages
Book Rating : 4./5 ( download)

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Book Synopsis Current Pharmaceutical Design by :

Download or read book Current Pharmaceutical Design written by and published by . This book was released on 1995-08 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Current Pharmaceutical Design

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Author :
Publisher :
ISBN 13 :
Total Pages : 130 pages
Book Rating : 4./5 ( download)

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Book Synopsis Current Pharmaceutical Design by :

Download or read book Current Pharmaceutical Design written by and published by . This book was released on 1995-08 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Current Pharmaceutical Design

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Author :
Publisher :
ISBN 13 :
Total Pages : 130 pages
Book Rating : 4./5 ( download)

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Book Synopsis Current Pharmaceutical Design by :

Download or read book Current Pharmaceutical Design written by and published by . This book was released on 1995-08 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Transplantation and Replacement of Thoracic Organs

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 0585342873
Total Pages : 793 pages
Book Rating : 4.5/5 (853 download)

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Book Synopsis The Transplantation and Replacement of Thoracic Organs by : D.K. Cooper

Download or read book The Transplantation and Replacement of Thoracic Organs written by D.K. Cooper and published by Springer Science & Business Media. This book was released on 2007-08-20 with total page 793 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is a great pleasure for me to contribute a few words as an achieved by many heart transplant centers and the ever improving results of lung transplantation and the functioning of mechanical introduction to the second edition of this volume, first published in 1990 when it was edited by David Cooper and Dimitri cardiac assist devices. Novitzky. The first edition was, in fact, a greatly expanded The current editors bring a wealth of expertise and experience version of an even earlier volume Heart Transplantation, edited to their task, and have blended together absolutely superb con by David Cooper and Robert Lanza and published in 1984. This tributions by many of the world's experts in their fields. This first work, authored by members of the medical staff of Groote comprehensive and highly readable volume documents the Schuur Hospital and the University of Cape Town Medical present 'state of the art' in the field of transplantation and School, was, I believe, the first volume reviewing this relatively replacement of thoracic organs. It provides an invaluable and un new field of medicine. paralleled source of information for those concerned with heart and lung medicine or surgery, and is essential reading for all who The present volume, therefore, continues the documentation of wish to keep abreast of developments in this field.

Spare Parts

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Publisher : Routledge
ISBN 13 : 135148852X
Total Pages : 292 pages
Book Rating : 4.3/5 (514 download)

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Book Synopsis Spare Parts by : Renee C. Fox

Download or read book Spare Parts written by Renee C. Fox and published by Routledge. This book was released on 2017-07-12 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spare Parts examines major developments in the field of organ replacement that occurred in the United States over the course of the 1980s and the beginning of the 1990s. It focuses upon significant medical and social changes in the transplantation of human organs and on the development and clinical testing of the Jarvik-7 artificial heart, with special emphasis on how these biomedical events were related to the political, economic, and social climate of American society. Part I examines the important biomedical advances and events in organ transplantation and their social and cultural concomitants. In Part II, the focus shifts to the story of the rise and fall of the Jarvik-7 artificial heart in the United States, its relation to American social institutions and cultural patterns, and its bearing on social control issues associated with therapeutic innovation and the patient-oriented clinical research it entails. Part III is a personal conclusion, which explains why the authors left the field of organ transplantation after so many years. Spare Parts is written in a narrative, ethnographic style, with thickly descriptive, verbatim, and atmospheric detail. The primary data it is based upon includes qualitative materials, collected via participant observation, interviews in a variety of medical milieu, and content analysis of medical journals, newspapers, and magazine articles, and a number of television transcripts. The new introduction provides an overview of some of the recent developments in transplantation and also underscores how tenacious many of the patterns associated with organ replacement have been. Spare Parts should be read by all medical professionals, sociologists, and historians.

Clinical Nephrotoxins

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 9401590885
Total Pages : 475 pages
Book Rating : 4.4/5 (15 download)

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Book Synopsis Clinical Nephrotoxins by : Marc E. de Broe

Download or read book Clinical Nephrotoxins written by Marc E. de Broe and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: GEORGE A. PORTER information is an international commodity whose The field of clinical nephrotoxicity involves toxins of interpretation and application are strongly influenced diverse origin and exposure. A significant contribution by both the cultural and ethnic background of the to this problem arises from registered and non-regis observer. The opportunity to share in the rich diversity tered drugs either prescribed or purchased over the of the international scientific community was a fun counter. Another major contributor comes from occu pational or industrial exposures. Each situation pre damental goal of this endeavor. To participate as sents the nephrologist with unique challenges con equals leads to mutual respect and peer appreciation. cerning diagnosis, confirrnation, and treatment includ The sharing of intellectual resources which such an ing limitation from future exposure. In selecting drugs effort fosters, should facilitate the advancement of for inclusions in this book the editors were guided by sound science. both frequency and current knowledge. For occupa Our approach to the field of nephrotoxicity is from tionall environmental exposures similar guidelines the perspective of a book which will be of value to the were applied. As one reviews the world's literature clinician. In this respect we have chosen compounds concerning nephrotoxicity two types of investigation wh ich are of current importance to the nephrologist and his/her patient rather than of historical interest.

Current and Future Immunosuppressive Therapies Following Transplantation

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 9401010056
Total Pages : 385 pages
Book Rating : 4.4/5 (1 download)

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Book Synopsis Current and Future Immunosuppressive Therapies Following Transplantation by : Giuseppe Remuzzi

Download or read book Current and Future Immunosuppressive Therapies Following Transplantation written by Giuseppe Remuzzi and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title provides a comprehensive and state-of-the-art summary of current and future immunosuppressive strategies in transplantation, with emphasis on the basic science mechanisms and clinical applicability of these strategies. The uniqueness of this book is the inclusion of up-to-date information on the basic mechanisms of actions of the immunosuppressive drugs as well as a summary of the clinical trials data and the potential use of these drugs in clinical organ transplantation. In addition to describing the various immunosuppressive strategies, the book has three special features, including immunosuppression in xenotransplantation, gene therapy approaches, and transplantation tolerance. A group of outstanding investigators have been assembled to write the chapters. The book is intended for the transplant professional and the specialist who wants to stay abreast of the current status of immunosuppression in organ transplantation. The book is also useful for basic scientists who work in the field of transplantation immunology.

The Study of FK 506 Metabolism in Rat Lives

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Author :
Publisher :
ISBN 13 :
Total Pages : 388 pages
Book Rating : 4.:/5 (58 download)

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Book Synopsis The Study of FK 506 Metabolism in Rat Lives by : Beatrice Yee-wa Tam Perotti

Download or read book The Study of FK 506 Metabolism in Rat Lives written by Beatrice Yee-wa Tam Perotti and published by . This book was released on 1994 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Transplant International

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Publisher : Springer Science & Business Media
ISBN 13 : 3662008181
Total Pages : 495 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Transplant International by : F. Mühlbacher

Download or read book Transplant International written by F. Mühlbacher and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: This supplement to TRANSPLANT International contains a most recent update of clinical and experimental research in transplantation and experiences with all modern immunosuppressive drugs, presented at the 7th Congress of the European Society of Organ Transplantation in Vienna in October 1995. The book has relevant information on clinical transplantation of kidneys, livers, hearts and pancreases as well as basic research data of immunbiology and organ preservation. More than 80% of the contributions were generated by respected European research institutions and therefore the book provides a comprehensive overview of European activities in transplantation research.

Heart Replacement

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 4431670203
Total Pages : 412 pages
Book Rating : 4.4/5 (316 download)

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Book Synopsis Heart Replacement by : Tetsuzo Akutsu

Download or read book Heart Replacement written by Tetsuzo Akutsu and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 5th International Symposium on Artificial Heart and Assist Devices was held in Tokyo on January 26 - 27, 1995, bringing together leading researchers and specialists from all over the world. The proceedings of the symposium presents the newest ideas and approaches in the field, and will be of special interest and relevance to all who are concerned with artificial organs, cardiovascular surgery, organ transplantation, biomaterials, and related disciplines. Reflecting the content of the symposium, the major topics in this volume include biocompatible material development, clinical use of assist devices, completely implantable devices, and heart transplantation. These are presented in the two main divisions of the book: The first consists of eight lectures by leading researchers, world-renowned in the field of the artificial heart. The second comprises more than 50 papers on such subjects as biomaterials, research and development of ventricular assist systems and the total artificial heart, and their use as a bridge to heart transplantation. An additional, special feature of the book is the inclusion of descriptions of exhibitions at the symposium, with photographs of all artificial heart devices and systems displayed by major laboratories and companies from around the world.

Therapeutic Modulation of Cytokines

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Publisher : CRC Press
ISBN 13 : 9780849383816
Total Pages : 362 pages
Book Rating : 4.3/5 (838 download)

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Book Synopsis Therapeutic Modulation of Cytokines by : M. W. Bodmer

Download or read book Therapeutic Modulation of Cytokines written by M. W. Bodmer and published by CRC Press. This book was released on 1996-01-23 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytokines are peptide or protein cell-to-cell signaling molecules that play vital roles in normal cell and tissue homeostasis, as well as in responses to infectious agents. Because of their importance in virtually all forms of pathology, the pharmaceutical industry is devoting great effort to develop methods for the control of cytokine synthesis or action. This is the first volume to bring together experts from academia and the pharmaceutical industry to discuss problems and solutions in the therapeutic control of cytokines. An introductory section reviews the biology, physiology, and pathology of cytokines. Internationally recognized scientists then discuss the development of low molecular mass inhibitors, including inhibitors of cytokine convertases and oligonucleotide drugs. The potential use of natural inhibitors such as soluble receptors, interleukin-1 receptor antagonists, and anti-cytokine antibodies is detailed. This interesting book also covers intracellular signaling pathways induced by pro-inflammatory cytokines and the bio-modulatory activity of specific cytokines such as TGF-ß. Therapeutic Modulation of Cytokines will interest academic scientists in biochemistry, cell biology, pharmacology, and molecular biology and biological scientists in the pharmaceutical and biopharmaceutical industries.

Current Opinions in the Kyoto Cornea Club

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Author :
Publisher : Kugler Publications
ISBN 13 : 9789062991389
Total Pages : 126 pages
Book Rating : 4.9/5 (913 download)

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Book Synopsis Current Opinions in the Kyoto Cornea Club by : Kyoto Cornea Club. Meeting

Download or read book Current Opinions in the Kyoto Cornea Club written by Kyoto Cornea Club. Meeting and published by Kugler Publications. This book was released on 1997 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preface During the past two decades, a significant international research exchange has taken place in order to understand the pathobiology of corneal diseases, and to develop more sophisticated treatments. For this purpose, many Japanese cornea specialists have been abroad to the United States, the United Kingdom, etc., to perform collaborative works in basic and clinical cornea research. As a result, many original concepts and thoughts have been produced from Japan, and some of them are now accepted world wide. Further to promote the international exchange of current knowledge and research on corneas in both health and disease, the First Annual Meeting of the Kyoto Cornea Club was held in Kyoto City on December I and 2, 1995. The goal of this meeting was to provide each speaker's updated knowledge that would be of value to all active corneal researchers who are interested in 'state-of-the-art' information from Japan. To achieve this objective fully, 41 selected Japanese cornea specialists registered as active participants in this meeting. James D. Zieske, PhD, from Schepens Eye Research Institute and the Department of Ophthalmology at Harvard Medical School, Boston, MA, USA, and Tadatsugu Taniguchi, PhD, from the Department of Immunology, Faculty of Medicine, Tokyo University, Japan, participated as special guests at this meeting, and both gave plenary lectures. This volume was created to provide each speaker's current opinions on the subjects they presented at this meeting, and also to provide a scientific reference for cornea research. We hope that the first issue will serve as a useful source of current knowledge and insight on Japanese cornea research. We wish to thank all those whose administrative help and/or assistance has made this issue possible; Takakazu Morita of Santen Pharmaceutical Co. Ltd., Machiko Tsujino of PMSI Japan, Ltd., and Kugler Publications. Shigeru Kinoshita and Yuichi Ohashi

Cumulated Index Medicus

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Author :
Publisher :
ISBN 13 :
Total Pages : 1860 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1997 with total page 1860 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemotherapy and the Immune System

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Author :
Publisher : Cambridge University Press
ISBN 13 : 9780521448352
Total Pages : 116 pages
Book Rating : 4.4/5 (483 download)

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Book Synopsis Chemotherapy and the Immune System by : L. H. Chappell

Download or read book Chemotherapy and the Immune System written by L. H. Chappell and published by Cambridge University Press. This book was released on 1992 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: This specially commissioned text covers a range of topics relating to chemotherapy and the immune system.