Fish Analysis For Drug And Chemicals Mediated Cellular Toxicity

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Fish Analysis for Drug and Chemicals Mediated Cellular Toxicity

Author : Ajit Kumar Saxena
Publisher : Springer Nature
ISBN 13 : 9811547009
Total Pages : 97 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Fish Analysis for Drug and Chemicals Mediated Cellular Toxicity by : Ajit Kumar Saxena

Download or read book Fish Analysis for Drug and Chemicals Mediated Cellular Toxicity written by Ajit Kumar Saxena and published by Springer Nature. This book was released on 2020-07-03 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive overview of drug and chemical cellular toxicity, especially concerning the effects of anticancer drugs (cyclophosphamide, methotrexate and phosphamidon) on chromosomes and proteins. It covers histological changes in rat testis during pre- and postnatal exposure to varied drug doses, along with laboratory findings on arsenic exposure and alcohol consumption producing neurological changes and deleterious effects on reproductive health in animals. The book offers essential information on the role of anticancer drug- / chemical-mediated toxicity in connection with genetic changes in the brain and reproductive health, making it a valuable guide for researchers working in the areas of cancer research, infertility, molecular diagnostics and modern drug discovery, at biochemical and toxicity laboratories, and in genetic predisposition and molecular biology in general.

Scientific Frontiers in Developmental Toxicology and Risk Assessment

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309070864
Total Pages : 348 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Scientific Frontiers in Developmental Toxicology and Risk Assessment by : National Research Council

Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-12-21 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Vascular Development

Author : Derek J. Chadwick
Publisher : John Wiley & Sons
ISBN 13 : 0470319429
Total Pages : 260 pages
Book Rating : 4.4/5 (73 download)

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Book Synopsis Vascular Development by : Derek J. Chadwick

Download or read book Vascular Development written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2007-08-20 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues. The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation. While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues. With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.

Drug Discovery Toxicology

Author : Yvonne Will
Publisher : John Wiley & Sons
ISBN 13 : 1119053390
Total Pages : 899 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Drug Discovery Toxicology by : Yvonne Will

Download or read book Drug Discovery Toxicology written by Yvonne Will and published by John Wiley & Sons. This book was released on 2016-03-22 with total page 899 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices

Translational Toxicology

Author : Claude L. Hughes
Publisher : Humana Press
ISBN 13 : 331927449X
Total Pages : 384 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Translational Toxicology by : Claude L. Hughes

Download or read book Translational Toxicology written by Claude L. Hughes and published by Humana Press. This book was released on 2016-03-23 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology—a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and potential translational toxicology therapeutics. The result is a compelling application of developmental toxicology in a new therapeutic discipline that is destined to become part of standard medical practice. Translational Toxicology: Defining a New Therapeutic Discipline is an essential text for regulatory authorities, scientists, and physicians who are concerned with environmental exposures, public health, nutrition, and pharmaceutical research and development. Basic science, epidemiological, and clinical investigators will also find this book a significant resource.

Xenobiotics in Fish

Author : D.J. Smith
Publisher : Springer Science & Business Media
ISBN 13 : 1461547032
Total Pages : 226 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Xenobiotics in Fish by : D.J. Smith

Download or read book Xenobiotics in Fish written by D.J. Smith and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aquaculture is rapidly becoming a major source of fish protein used to meet the nutritional needs of humans. As the aquaculture industry grows, exposure of farmed fish to environmental contaminants, and the need for chemical therapeutic agents for fish, will increase. This book is designed to bring together authorities worldwide on the regulation of environmental contaminants and food chemicals and researchers investigating the metabolism and disposition of foreign chemicals (xenobiotics) in fish species.

Toxicity Testing in the 21st Century

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309151732
Total Pages : 217 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Toxicity Testing in the 21st Century by : National Research Council

Download or read book Toxicity Testing in the 21st Century written by National Research Council and published by National Academies Press. This book was released on 2007-11-05 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.

Dioxins and Health

Author : A. Schecter
Publisher : Springer Science & Business Media
ISBN 13 : 1489914625
Total Pages : 718 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Dioxins and Health by : A. Schecter

Download or read book Dioxins and Health written by A. Schecter and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book originated in a series of cross-disciplinary conversations in the years 1984-1990 between the editor, who is a physician-researcher involved in clinical and laboratory research, and a dioxin toxicologist. During the years in which the conversations took place, an extraordinary amount of new scientific literature was published related to dioxins, defined for purposes of this text as the chlorinated dibenzo-p-dioxins, dibenzofurans, polychlorinated biphe nyls (PCB's) and other compounds that are structurally and toxicologically similar to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7 ,8-TCDD), the most extensively studied and most toxic of this group of chemicals. Dioxins also began to interest not only chemists and toxicologists, but also specialists from diverse disciplines such as wildlife and environmental science, immunology, neuroscience,public health, epidemiology, med icine, government, law, sociology, and journalism. Specialists from such varied disciplines, while familiar with their own literature, frequently did not have time to follow the dioxin literature outside their specialty area. In addition, each specialty had unique knowledge, methods, and perspectives. Cross disciplinary conversation was necessary, but all too frequently, specialists from the various disciplines did not speak the same language, resulting in misunderstanding.

OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 305: Bioaccumulation in Fish: Aqueous and Dietary Exposure

Author : OECD
Publisher : OECD Publishing
ISBN 13 : 9264185291
Total Pages : 72 pages
Book Rating : 4.2/5 (641 download)

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Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 305: Bioaccumulation in Fish: Aqueous and Dietary Exposure by : OECD

Download or read book OECD Guidelines for the Testing of Chemicals, Section 3 Test No. 305: Bioaccumulation in Fish: Aqueous and Dietary Exposure written by OECD and published by OECD Publishing. This book was released on 2012-10-02 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes a procedure for characterising the bioconcentration potential of substances in fish, using an aqueous (standard and minimised tests) or dietary exposure, under flow-through conditions (but semi-static regimes are ...

The Basic and Clinical Consequences of Genetic Disorders in Humans

Author : Ajit Kumar Saxena
Publisher : Cambridge Scholars Publishing
ISBN 13 : 1527588793
Total Pages : 172 pages
Book Rating : 4.5/5 (275 download)

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Book Synopsis The Basic and Clinical Consequences of Genetic Disorders in Humans by : Ajit Kumar Saxena

Download or read book The Basic and Clinical Consequences of Genetic Disorders in Humans written by Ajit Kumar Saxena and published by Cambridge Scholars Publishing. This book was released on 2022-12-19 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the basic concepts of genetics and heredity in human diseases. It discusses techniques like RT-PCR, karyotyping, DNA/RNA extraction, RFLP, DNA sequencing and electrophoresis, which will be helpful in clinical diagnostics for patients. The book also considers developmental anomalies and birth defects, as well as the potential for folate metabolism to act as a “risk factor” in genetic disorders.

Research Awards Index

Author :
Publisher :
ISBN 13 :
Total Pages : 1436 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis Research Awards Index by :

Download or read book Research Awards Index written by and published by . This book was released on 1985 with total page 1436 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Guidance for Assessing Chemical Contaminant Data for Use in Fish Advisories

Author : United States. Environmental Protection Agency. Office of Science and Technology
Publisher :
ISBN 13 :
Total Pages : 398 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Guidance for Assessing Chemical Contaminant Data for Use in Fish Advisories by : United States. Environmental Protection Agency. Office of Science and Technology

Download or read book Guidance for Assessing Chemical Contaminant Data for Use in Fish Advisories written by United States. Environmental Protection Agency. Office of Science and Technology and published by . This book was released on 1994 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Fish Physiology: Organic Chemical Toxicology of Fishes

Author : Keith B. Tierney
Publisher : Academic Press
ISBN 13 : 0123982553
Total Pages : 570 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Fish Physiology: Organic Chemical Toxicology of Fishes by : Keith B. Tierney

Download or read book Fish Physiology: Organic Chemical Toxicology of Fishes written by Keith B. Tierney and published by Academic Press. This book was released on 2013-12-04 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fish Physiology: Organic Chemical Toxicology of Fishes discusses the different types of organic chemical contaminants and their respective toxic effects in fish. The book also covers the detection of dissolved organic compounds and methods to assess organic toxicity. Substances addressed in this book include organometallics, hydrocarbons, endocrine disrupting compounds (EDCs), insecticides, herbicides, and pharmaceuticals. Fish are exposed to an ever-increasing array of organic chemicals that find their way into rivers and oceans. Some of these compounds are no longer being produced but nonetheless persist within the environment (persistent organic pollutants, or POPs). The exposure of fish to toxic organic compounds has potential impact on human, fish, and ecosystem health. Yet the regulations that govern environmental water quality vary worldwide, and compliance is never complete. This book provides a crucial resource on these issues for researchers in zoology, fish physiology, and related fields; applied researchers in environmental monitoring, conservation biology, and toxicology; and university-level students and instructors in these areas. Organized by type of toxic organic chemicals Includes metals, POPs, EDCs, herbicides, insecticides, and pharmaceuticals Measures toxicity in a variety of ways aside from lethality Probes the toxic effects of compound mixtures as well as single pollutants

Methods for Measuring the Toxicity and Bioaccumulation of Sediment-associated Contaminants with Freshwater Invertebrates

Author :
Publisher :
ISBN 13 :
Total Pages : 150 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Methods for Measuring the Toxicity and Bioaccumulation of Sediment-associated Contaminants with Freshwater Invertebrates by :

Download or read book Methods for Measuring the Toxicity and Bioaccumulation of Sediment-associated Contaminants with Freshwater Invertebrates written by and published by . This book was released on 1994 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sediment contamination is a widespread environmental problem that can potentially pose a threat to a variety of aquatic ecosystems. The sediment test methods in this manual will be used by The United States Environmental Protection Agency (USEPA) to make decisions under a range of statutory authorities concerning such issues as: dredged material disposal, registration of pesticides and toxic substances, superfound site assessment, and assessment and cleanup of hazardous waste treatment, storage, and disposal facilities. The use of uniform sediment testing procedures by USEPA programs is expected to increase data accuracy and precision, facilitate test replication, increase the comparative value of test results, and ultimately, increase the efficiency of regulatory processes requiring sediment tests.

The Toxicology of Fishes

Author : Richard T. Di Giulio
Publisher : CRC Press
ISBN 13 : 0203647297
Total Pages : 1102 pages
Book Rating : 4.2/5 (36 download)

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Book Synopsis The Toxicology of Fishes by : Richard T. Di Giulio

Download or read book The Toxicology of Fishes written by Richard T. Di Giulio and published by CRC Press. This book was released on 2008-02-25 with total page 1102 pages. Available in PDF, EPUB and Kindle. Book excerpt: When looking for a book on fish toxicology, you might find one that discusses the biochemical and molecular aspects, or one that focuses aquatic toxicology in general. You can find resources that cover human and animal toxicology or ecotoxicology in general, but no up-to-date, comprehensive monograph devoted to the effects of chemical pollution on

Biochemical Toxicology

Author : Muharrem Ince
Publisher : BoD – Books on Demand
ISBN 13 : 178984696X
Total Pages : 232 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Biochemical Toxicology by : Muharrem Ince

Download or read book Biochemical Toxicology written by Muharrem Ince and published by BoD – Books on Demand. This book was released on 2020-07-29 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemical Toxicology - Heavy Metals and Nanomaterials provides an overview of biochemical contamination, nanomaterials and toxic metals, and measurement techniques. It explains and clarifies important studies and compares and develops new and groundbreaking measurement techniques in the fields of organic and inorganic pollution and nanoscience. It is highly recommended for professionals and readers interested in the environment and human health.

New Technologies for Toxicity Testing

Author : Michael Balls
Publisher : Springer Science & Business Media
ISBN 13 : 1461430550
Total Pages : 282 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis New Technologies for Toxicity Testing by : Michael Balls

Download or read book New Technologies for Toxicity Testing written by Michael Balls and published by Springer Science & Business Media. This book was released on 2012-03-22 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: The central theme running through this volume on New Technologies for Toxicity Testing is the development and application of advanced techniques for cell and tissue culture, as well as new markers and endpoints of toxicity, as alternatives to the traditional paradigm of relying on data from laboratory animal tests to undertake labelling and risk assessment. Of course, many of the techniques and methods described in this volume are in the early stages of development, and much work will be needed to ensure their further improvement, optimisation and validation. However, we are confident that this will be achieved and that, just as with the in vitro assays that were validated and granted regulatory acceptance over the last decade, these, and many other new, advanced methods, will likewise become part of the toxicologist’s improved toolbox for coping with increasingly stringent and numerous regulatory requirements and test chemicals, while placing less reliance on traditional testing paradigms.