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Fine Mapping Quantitative Trait Loci For Meat Quality Using Linkages And Linkage Disequilibrium Analyses
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Book Synopsis Fine-mapping Quantitative Trait Loci for Meat Quality Using Linkages and Linkage Disequilibrium Analyses by : Gelson Luís Dias Feijó
Download or read book Fine-mapping Quantitative Trait Loci for Meat Quality Using Linkages and Linkage Disequilibrium Analyses written by Gelson Luís Dias Feijó and published by . This book was released on 2007 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Davood Kolbehdari Publisher :Library and Archives Canada = Bibliothèque et Archives Canada ISBN 13 :9780494019061 Total Pages :120 pages Book Rating :4.0/5 (19 download)
Book Synopsis Fine Mapping of Quantitative Trait Loci (QTL) Using Linkage and Linkage Disequilibrium Analysis in Half-sib Designs [microform] by : Davood Kolbehdari
Download or read book Fine Mapping of Quantitative Trait Loci (QTL) Using Linkage and Linkage Disequilibrium Analysis in Half-sib Designs [microform] written by Davood Kolbehdari and published by Library and Archives Canada = Bibliothèque et Archives Canada. This book was released on 2004 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Quantitative Trait Loci Analysis in Animals by : Joel Ira Weller
Download or read book Quantitative Trait Loci Analysis in Animals written by Joel Ira Weller and published by Cabi. This book was released on 2001 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the theory and practice of methods for quantitative trait loci (QTL) detection and analysis, as well as marker assisted selection, in animal genetics and breeding. It is divided into 16 chapters: historical overview; principles of parameter estimation; random and fixed effects (the mixed model); experimental designs to detect QTL (generation of linkage disequilibrium); QTL parameter estimation for crosses between inbred lines; advanced statistical methods for QTL detection and parameter estimation; analysis of QTL as random effects; statistical power to detect QTL and parameter confidence interval; optimization of experimental designs; fine mapping of QTL; complete genome QTL scans (the problem of multiple comparisons); multiple trait QTL analysis; principles of selection index and traditional breeding programmes; marker-assisted selection (theory); marker-assisted selection (results of simulation studies); and marker-assisted introgression. The book is aimed at graduate students and research workers in quantitative genetics and animal breeding. There is an author index and a detailed subject index.
Book Synopsis Quantitative Trait Loci by : Nicola J. Camp
Download or read book Quantitative Trait Loci written by Nicola J. Camp and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Quantitative Trait Loci: Methods and Protocols, a panel of highly experienced statistical geneticists demonstrate in a step-by-step fashion how to successfully analyze quantitative trait data using a variety of methods and software for the detection and fine mapping of quantitative trait loci (QTL). Writing for the nonmathematician, these experts guide the investigator from the design stage of a project onwards, providing detailed explanations of how best to proceed with each specific analysis, to find and use appropriate software, and to interpret results. Worked examples, citations to key papers, and variations in method ease the way to understanding and successful studies. Among the cutting-edge techniques presented are QTDT methods, variance components methods, and the Markov Chain Monte Carlo method for joint linkage and segregation analysis.
Book Synopsis Modeling and Inferring Quantitative Trait Loci Using Linkage Disequilibrium in Natural Populations by :
Download or read book Modeling and Inferring Quantitative Trait Loci Using Linkage Disequilibrium in Natural Populations written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative trait loci (QTL) are those chromosome regions that contribute to variation of quantitative traits. Analysis of QTL is helpful for further study of molecular basis of the quantitative genetic variation. The discovery of highly abundant and dense polymorphic markers (e.g., single nucleotide polynorphisms, or SNPs) covering a whole genome provides an opportunity to localize QTL in a variety of populations. While classical linkage studies have a relatively limited resolution in QTL localization, the association mapping or linkage disequilibrium (LD) mapping approach can offer an alternative way for fine mapping of genes. Currently there are few LD methods available for QTL mapping in natural populations. Development of more efficient methods is still a challenging problem. In this thesis, we first review the LD approach for fine mapping of QTL in Chapter 1. Some basic issues in LD analysis and recent developments in LD methodology are discussed. Particular attention is paid to limitations and potential problems of these methods. This provides the motivation for the research in this thesis. Next, we explore Cockerham's genetic model (Cockerham, 1954) for quantitative traits in Chapter 2. A revised form of the Cockerham model is presented using some coding variables. The relationship between Cockerham model and some specific genetic models for designed experimental populations, such as backcross or F2, is then established. We study extensively the properties of QTL effects and partitions of various genetic variance components for these reduced models under both linkage equilibrium and linkage disequilibrium situations. A general multi-locus-two-allele model is also proposed that may serve as a basis for mapping QTL in natural populations. The main research of the thesis is on development of an exact multipoint likelihood approach to infer QTL in natural populations. In Chapter 3, we first generalize the formulation of the likelihood analysis for a polymorphic.
Book Synopsis Quantitative Trait Loci Analysis in Animals by : Joel Ira Weller
Download or read book Quantitative Trait Loci Analysis in Animals written by Joel Ira Weller and published by CABI. This book was released on 2009 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Trait Loci (QTL) is a topic of major agricultural significance for efficient livestock production. This book covers various statistical methods that have been used or proposed for detection and analysis of QTL and marker-and gene-assisted selection in animal genetics and breeding.
Book Synopsis High Resolution Linkage and Association Study of Quantitative Trait Loci by : Jeesun Jung
Download or read book High Resolution Linkage and Association Study of Quantitative Trait Loci written by Jeesun Jung and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: As a large number of single nucleotide polymorphisms (SNPs) and microsatellite markers are available, high resolution mapping employing multiple markers or multiple allele markers is an important step to identify quantitative trait locus (QTL) of complex human disease. For many complex diseases, quantitative phenotype values contain more information than dichotomous traits do. Much research has been done on conducting high resolution mapping using information of linkage and linkage disequilibrium. The most commonly employed approaches for mapping QTL are pedigree-based linkage analysis and population-based association analysis. As one of the methods dealing with multiple alleles markers, mixed models are developed to work out family-based association study with the information of transmitted allele and nontransmitted allele from one parent to offspring. For multiple markers, variance component models are proposed to perform association study and linkage analysis simultaneously. Linkage analysis provides suggestive linkage based on a broad chromosome region and is robust to population admixtures. One the other hand, allelic association due to linkage disequilibrium (LD) usually operates over very short genetic distance, but is affected by population stratification. Combining both approaches plays a synergistic role in overcoming their limitations and in increasing the efficiency and effectiveness of gene mapping.
Book Synopsis Quantitative Trait Loci and Genes Affecting Beef Tenderness by : Lei-Yao Chang
Download or read book Quantitative Trait Loci and Genes Affecting Beef Tenderness written by Lei-Yao Chang and published by . This book was released on 2012 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tenderness is one of the major meat quality factors that affects the intent of consumers to re-purchase beef. Both genetic and non-genetic factors affect the quantitative trait of tenderness. Among the genetic factors, polymorphisms in key genes, such as the myostatin (MSTN) and calpain 1(CAPN1), play important roles on tenderness. However, these genes do not explain all the genetic variation associated with tenderness. The aim of this study was to discover additional genes associated with tenderness to help integrate genetic information into beef cattle breeding programmes and meat quality assurance programmes, such as Meat Standards Australia, and produce high quality tender meat for consumers. Discovery of such genes should also aid in the understanding of mechanisms underlying tenderness. Backcross QTL mapping progeny based on crosses between two extreme Bos Taurus breeds (Limousin and Jersey) were used in the study. There were four new traits created for the QTL mapping and association studies. Two of the traits (wbld_adjusted and wbst_adjusted) were based on Warner-Bratzler (WB) shear force measurements from the M. longissimus dorsi (LD) and M. semitendinosus (ST) muscles and were derived from a multi-variate mixed model in which the environmental effects, myostatin F94L genotype effect, ageing day effect and the interaction effects were accounted for. The adjusted shear force traits offered a more accurate prediction for average tenderness. The other new trait was the amount of ageing per 25 days (called "ageing rate" herein) for the two muscles, calculated as the difference between natural log shear force values after 1 and 26 days ageing. Quantitative trait loci (QTL) mapping for these traits indicated there were 2 QTL (92 cM on BTA 5 and 52 cM on BTA 29) for adjusted shear force of the LD muscle, 3 QTL (96 cM on BTA 5, 36 cM on BTA 18 and 52 cM on BTA 29) for adjusted shear force of the ST muscle, 2 QTL (40 cM on BTA 4 and 0 cM on BTA 13) for ageing rate of the LD muscle and 2 QTL (48 cM on BTA 1 and 44 cM on BTA 19) for ageing rate of the ST muscle. Twelve candidate genes were selected for further study based on their physiological functions and the QTL mapping results from herein and elsewhere. Twenty DNA variants in these candidate genes were chosen for the association studies. The analyses were conducted with and without three known tenderness related gene variants (MSTN F94L, CAPN1-SNP316 and CAPN1-SNP530). Variants in the candidate genes were discovered to be significantly associated with traits related to tenderness, most of which were muscle specific effects. Of note, the effects of CAPN1-SNP316 were muscle specific. The heterozygous genotype (GC) of CAPN1-SNP316 had the opposite effect on LD and ST muscles in that the G allele was dominant for the LD but recessive for the ST. Another variant of large effect, MYO1G-SNP2 (myosin 1G), showed an effect on ageing rate of the LD muscle but not the ST muscle. Importantly, however, the interactions between gene variants frequently explained more of the genetic variation than the individual variants. For example, the interaction between the candidate gene variant SNIP1-SNP3 (Smad nuclear interacting protein 1) and the CAPN1-SNP316 explained more of the variation in the adjusted shear force of the ST muscle than CAPN1-SNP316 alone (9.5% vs. 5.2%). The studies also suggest that tenderness is not always affected by the genes that change the muscle weight or collagen content (eg. insulin-like growth factor 1). In fact, the results indicate that the effect of the myostatin gene on tenderness is not caused by the increased muscle mass or collagen changes associated with the myostatin F94L variant. Instead, most of the effect of myostatin on tenderness may be explained by a change in the muscle fibre types which affects calpain activity.
Book Synopsis Designing Experiments for Mapping Quantitative Trait Loci in Segregating Animal Populations by : Fengxing Du
Download or read book Designing Experiments for Mapping Quantitative Trait Loci in Segregating Animal Populations written by Fengxing Du and published by . This book was released on 1999 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Dissection of Complex Traits by : Andrew H. Paterson
Download or read book Molecular Dissection of Complex Traits written by Andrew H. Paterson and published by CRC Press. This book was released on 2019-09-17 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past 10 years, contemporary geneticists using new molecular tools have been able to resolve complex traits into individual genetic components and describe each such component in detail. Molecular Dissection of Complex Traits summarizes the state of the art in molecular analysis of complex traits (QTL mapping), placing new developments in thi
Book Synopsis Mapping Quantitative Trait Loci Using Linkage and Linkage Disequilibria with Selective Genotyping by : Lu Tong Duc
Download or read book Mapping Quantitative Trait Loci Using Linkage and Linkage Disequilibria with Selective Genotyping written by Lu Tong Duc and published by . This book was released on 2003 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Multiple Trait Analysis for Genetic Mapping of Quantitative Trait Loci for Carcass and Beef Quality by : Ali Esmailizadeh Koshkoih
Download or read book Multiple Trait Analysis for Genetic Mapping of Quantitative Trait Loci for Carcass and Beef Quality written by Ali Esmailizadeh Koshkoih and published by . This book was released on 2006 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The general goal of the present work was to map QTL (quantitative trait loci) for economically important traits in beef cattle.
Book Synopsis Use of Linkage Disequilibrium for Quantitative Trait Loci Mapping in Livestock by : Honghua Zhao
Download or read book Use of Linkage Disequilibrium for Quantitative Trait Loci Mapping in Livestock written by Honghua Zhao and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Genome-wide QTL Mapping for Complex Traits in Pigs and Focusing Analysis on Fatness QTL on Porcine Chromosome X by : Junwu Ma
Download or read book Genome-wide QTL Mapping for Complex Traits in Pigs and Focusing Analysis on Fatness QTL on Porcine Chromosome X written by Junwu Ma and published by . This book was released on 2009 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aims of this thesis are to gain knowledge on genetic architecture of complex traits and on fine-scale structure of recombination rate variation in pigs. The first part of this thesis presents a genome-wide scan for quantitative trait loci (QTL) in a cross between White Duroc boars and Erhualian sows that was developed at Jiangxi Agricultural University (JXAU) in China. The mapping population comprised 750-1030 F2 individuals that were evaluated for a total of 80 traits related to carcass composition (17 traits), meat quality (58 traits) and ear traits (5 traits). In total, we identified 253 QTL for these traits, of which about half reached genome-wide significance level. Numerous QTL for these traits have been found on porcine chromosomes 4, 7, 8 and X. The greatest significance levels were found for a QTL affecting carcass length, head weight and ear weight on SSC7 in an interval of 3 cM (SW1856-S0666), which explained up to 50% of the phenotypic variance. White Duroc alleles at a majority of QTL detected were favorable for carcass composition, while favorable QTL alleles for meat quality originated from both White Duroc and Erhualian. INRA performed a genome scan to reveal QTL in a Large White × Meishan cross 8 years ago. Coincidently, both INRA and JXAU mapped strong QTL for fatness and muscling traits in a similar region of the porcine chromosome X (SSCX). Thus, both sides wished to collaborate to fine map the QTL...
Book Synopsis Quantitative Trait Loci (QTL) by : Scott A. Rifkin
Download or read book Quantitative Trait Loci (QTL) written by Scott A. Rifkin and published by Humana Press. This book was released on 2012-05-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last two decades advances in genotyping technology, and the development of quantitative genetic analytical techniques have made it possible to dissect complex traits and link quantitative variation in traits to allelic variation on chromosomes or quantitative trait loci (QTLs). In Quantitative Trait Loci (QTLs):Methods and Protocols, expert researchers in the field detail methods and techniques that focus on specific components of the entire process of quantitative train loci experiments. These include methods and techniques for the mapping populations, identifying quantitative trait loci, extending the power of quantitative trait locus analysis, and case studies. Written in the highly successful Methods in Molecular BiologyTM series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Quantitative Trait Loci (QTLs):Methods and Protocols aids scientists in the further study of the links between phenotypic and genotypic variation in fields from medicine to agriculture, from molecular biology to evolution to ecology.
Book Synopsis Power and Accuracy of Detecting Linkage Between Quantitative Trait Loci and Genetic Markers by : Zhiwu Zhang
Download or read book Power and Accuracy of Detecting Linkage Between Quantitative Trait Loci and Genetic Markers written by Zhiwu Zhang and published by . This book was released on 1998 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Bioinformatics in Aquaculture by : Zhanjiang (John) Liu
Download or read book Bioinformatics in Aquaculture written by Zhanjiang (John) Liu and published by John Wiley & Sons. This book was released on 2017-01-24 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioinformatics derives knowledge from computer analysis of biological data. In particular, genomic and transcriptomic datasets are processed, analysed and, whenever possible, associated with experimental results from various sources, to draw structural, organizational, and functional information relevant to biology. Research in bioinformatics includes method development for storage, retrieval, and analysis of the data. Bioinformatics in Aquaculture provides the most up to date reviews of next generation sequencing technologies, their applications in aquaculture, and principles and methodologies for the analysis of genomic and transcriptomic large datasets using bioinformatic methods, algorithm, and databases. The book is unique in providing guidance for the best software packages suitable for various analysis, providing detailed examples of using bioinformatic software and command lines in the context of real world experiments. This book is a vital tool for all those working in genomics, molecular biology, biochemistry and genetics related to aquaculture, and computational and biological sciences.
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