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Factors Influencing The Survival And Development Of Midbrain Dopaminergic Neurons In Vitro
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Book Synopsis Factors Influencing the Survival and Development of Midbrain Dopaminergic Neurons in Vitro by : Catherine Holmes
Download or read book Factors Influencing the Survival and Development of Midbrain Dopaminergic Neurons in Vitro written by Catherine Holmes and published by . This book was released on 1996 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Factors Influencing the Survival and Development of Midbrain Dopaminergic Nerons in Vitro by : Catherine Holmes
Download or read book Factors Influencing the Survival and Development of Midbrain Dopaminergic Nerons in Vitro written by Catherine Holmes and published by . This book was released on 1996 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Human Neural Stem Cells by : Leonora Buzanska
Download or read book Human Neural Stem Cells written by Leonora Buzanska and published by Springer. This book was released on 2018-09-12 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs.
Book Synopsis Basic Neurochemistry by : George J. Siegel
Download or read book Basic Neurochemistry written by George J. Siegel and published by Lippincott Raven. This book was released on 1999 with total page 1216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Illustrations by Lorie M. Gavulic, MFA Sponsored by the American Society for Neurochemistry.
Book Synopsis In Situ Hybridization by : D. G. Wilkinson
Download or read book In Situ Hybridization written by D. G. Wilkinson and published by Oxford University Press, USA. This book was released on 1998 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: In situ hybridization is used to reveal the location of specific nucleic acids sequences on chromosomes or in tissues. Visualization of the location of genes on chromosomes or of specific mRNAs or viruses in tissues is crucial for understanding the organization, regulation, and function of genes. It is a therefore a core technique in all areas of biomedical research. In Situ Hybridization: A Practical Approach 2/e is the second edition of one of the most successful Practical Approach books, published in 1992. Since the first edition was published, a number of important technical advances have been made. The new edition has been thoroughly updated to contain protocols detailing the major techniques of in situ hybridization currently in use: in situ hybridization to mRNA with oligonucleotide and RNA probes (radiolabelled and hapten labelled); analysis using light and electron microscopes; whole mount in situ hybridization; double detection of RNAs, and RNA plus protein; and fluorescent in situ hybridization to detect chromosomal sequences. The protocols are complemented by advice on strategies for successful results, descriptions of the theoretical basis of in situ hybridization and important new developments in gene expression databases. The procedures described are widely applicable to many systems. The use of in situ hybridization in PCR is covered in a separate volume: Herrington and O'Leary (Eds) PCR 3 - PCR in situ hybridization: A Practical Approach (OUP, 1997). All the authors have extensive practical experience of establishing reliable techniques of in situ hybridization. This book will be useful to all researchers at all levels who use in situ hybridization.
Book Synopsis Mouse Brain Development by : Andre M. Goffinet
Download or read book Mouse Brain Development written by Andre M. Goffinet and published by Springer Science & Business Media. This book was released on 2012-08-10 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of the molecular mechanisms involved in mammalian brain development remains limited. However, the last few years have wit nessed a quantum leap in our knowledge, due to technological improve ments, particularly in molecular genetics. Despite this progress, the available body of data remains mostly phenomenological and reveals very little about the grammar that organizes the molecular dictionary to articulate a pheno type. Nevertheless, the recent progress in genetics will allow us to contem plate, for the first time, the integration of observation into a coherent view of brain development. Clearly, this may be a major challenge for the next century, and arguably is the most important task of contemporary develop mental biology. The purpose of the present book is to provide an overview that syn thesizes up-to-date information on selected aspects of mouse brain devel opment. Given the format, it was not possible to cover all aspects of brain development, and many important subjects are missing. The selected themes are, to a certain extent, subjective and reflect the interests of the contributing authors. Examples of major themes that are not covered are peripheral nervous system development, including myelination, the development of the hippocampus and several other CNS structures, as well as the developmental function of some important morphoregulatory molecules.
Book Synopsis Development and Engineering of Dopamine Neurons by : Jeroen Pasterkamp
Download or read book Development and Engineering of Dopamine Neurons written by Jeroen Pasterkamp and published by Springer Science & Business Media. This book was released on 2009-12-16 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theneurotransmitter dopamine has just celebrated its 50thbirthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransm- ter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbraindopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization ofNurrl and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins, which have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminaldifferent- tion and finally maintenance of the mdDA neuronal pool.
Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Book Synopsis Handbook of Neurochemistry and Molecular Neurobiology by : Ramon Lim
Download or read book Handbook of Neurochemistry and Molecular Neurobiology written by Ramon Lim and published by Springer Science & Business Media. This book was released on 2006-09-18 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The Handbook is intended to be a service to the neuroscience community, to help in finding available and useful information, to point out gaps in our knowledge, and to encourage continued studies. It represents the valuable contributions of the many authors of the chapters and the guidance of the editors and most important, it represents support for research in this discipline. Based on the rapid advances in the years since the second edition."--Publisher's website.
Book Synopsis Mayo Clinic Medical Neurosciences by : Eduardo E. Benarroch
Download or read book Mayo Clinic Medical Neurosciences written by Eduardo E. Benarroch and published by Oxford University Press. This book was released on 2017-11-06 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully updated and revised according to student feedback, the sixth edition of Mayo Clinic Medical Neurosciences: Organized by Neurologic System and Level provides a systematic approach to anatomy, physiology, and pathology of the nervous system inspired by the neurologist's approach to solving clinical problems. This volume has 4 sections: 1) an overview of the neurosciences necessary for understanding anatomical localization and pathophysiologic characterization of neurologic disorders; 2) an approach to localizing lesions in the 7 longitudinal systems of the nervous system; 3) an approach to localizing lesions in the 4 horizontal levels of the nervous system; and 4) a collection of clinical problems. This book provides the neuroscience framework to support the neurologist in a clinical setting and is also a great resource for neurology and psychiatry board certifications. This is the perfect guide for all medical students and neurology, psychiatry, and physical medicine residents at early stages of training. New to This Edition - A chapter devoted to multiple-choice questions for self-assessment - Discussion of emerging concepts in molecular, cellular, and system neurosciences - New chapters on emotion and consciousness systems - Incorporation of new discoveries in neuroimaging and an appendix for tables of medications commonly used to treat neurologic disorders
Book Synopsis Functional Neural Transplantation by : Stephen B. Dunnett
Download or read book Functional Neural Transplantation written by Stephen B. Dunnett and published by Lippincott Williams & Wilkins. This book was released on 1994 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Restorative Therapies in Parkinson's Disease by : Patrik Brundin
Download or read book Restorative Therapies in Parkinson's Disease written by Patrik Brundin and published by Springer Science & Business Media. This book was released on 2006-08-31 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this exciting and timely book new approaches to repairing the parkinsonian brain are described by leading experts. Never in history has there been greater hope that novel experimental therapies can support significant restoration of brain function. This book gives an overview of the current state-of-the-art research for brain repair, what the challenges are and an indication of what research can provide for the next generation of people with Parkinson’s disease. The comprehensive chapters are geared to an audience of neuroscientists, neurologists, neurosurgeons and anyone interested in how findings in the research laboratory can effectively be transferred to the clinic.
Book Synopsis Chemical Factors in Neural Growth, Degeneration and Repair by : C. Bell
Download or read book Chemical Factors in Neural Growth, Degeneration and Repair written by C. Bell and published by Elsevier. This book was released on 1996-12-17 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an up-to-date survey of current thinking concerning the actions of chemical factors in the regulation of neuronal behaviour under normal and pathological conditions. The book is divided into four sections, dealing with chemical factors involved with the formation of axon pathways, factors involved with neuronal survival and specialization during normal development, factors involved in normal maintenance and repair of adult neurons and, finally, factors that have been implicated as mediators of degenerative changes in neurological and neuropsychiatric disorders.
Book Synopsis Growth Factors as Drugs for Neurological and Sensory Disorders by : Gregory R. Bock
Download or read book Growth Factors as Drugs for Neurological and Sensory Disorders written by Gregory R. Bock and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Degeneration of sensory receptors or of the nerves innervating them leads to a sensory deficit. Various strategies have been tried for promoting regrowth of sensory receptors, particularly in the eye and ear. The latest data from experimental studies in animals are presented in the book including applications of BDNF and CNTF in the eye and epidermal growth factor in the ear.
Book Synopsis Developmental Neurobiology by : Greg Lemke
Download or read book Developmental Neurobiology written by Greg Lemke and published by Academic Press. This book was released on 2010-05-22 with total page 771 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developmental Neuroscience is one of the six core disciplines in Neuroscience, and yet no single volume, non-textbook reference exists on the market that provides researchers with more in-depth, high-level information on developmental neurobiology. Currently, anyone interested in the field at a higher level must sift through review articles published frequently and the more specific handbooks that focus on aspects of development rather than the field as a whole. This reference is the first of its kind to fill this need. It pulls together the relevant articles on the topic from the 10-volume Encyclopedia of Neuroscience (Academic Press, 2008) and serves as an affordable and immediate resource for scientists, postdocs, graduate students with an interest beyond the basic textbook materials on the subject. The first and only comprehensive, single-volume reference for developmental neuroscience that goes beyond the basic textbook information The 93 chapters cover topics ranging from cell fate determination, path finding, synapse generation, neural stem cells, to neurodegeneration and regeneration, carefully selected from the Encyclopedia of Neuroscience by one of the great developmental neuroscientists, Greg Lemke The best researchers in the field provide their conclusions in the context of the latest experimental results
Book Synopsis Phylogeny and Development of Catecholamine Systems in the CNS of Vertebrates by : Wilhelmus J. A. Smeets
Download or read book Phylogeny and Development of Catecholamine Systems in the CNS of Vertebrates written by Wilhelmus J. A. Smeets and published by Cambridge University Press. This book was released on 1994-10-13 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: A thorough analysis of catecholamine systems in a wide range of vertebrates by experts. The book will be of interest to researchers and postgraduates of neuroscience, neurobiology, zoology, medicine and physiology.
Book Synopsis Genetic Influences on Neural and Behavioral Functions by : Donald W. Pfaff
Download or read book Genetic Influences on Neural and Behavioral Functions written by Donald W. Pfaff and published by CRC Press. This book was released on 1999-07-27 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Utilizing the flood of information derived from the Human Genome Project and corresponding efforts to elucidate the mouse genome, Genetic Influences on Neural and Behavioral Functions provides a scholarly catalog, organized logically, of relations between the expression of specific genes, nerve cell biology and behavior, normal and abnormal, in animals AND humans. Sample topics include genes in relation to schiziphrenia, panic disorder, epilepsy, alcoholism, sleep, eating disorders, and more.
