Exposure Science In The 21st Century

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Exposure Science in the 21st Century

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309264685
Total Pages : 210 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Exposure Science in the 21st Century by : National Research Council

Download or read book Exposure Science in the 21st Century written by National Research Council and published by National Academies Press. This book was released on 2012-10-28 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the use of personal products to our consumption of food, water, and air, people are exposed to a wide array of agents each day-many with the potential to affect health. Exposure Science in the 21st Century: A Vision and A Strategy investigates the contact of humans or other organisms with those agents (that is, chemical, physical, and biologic stressors) and their fate in living systems. The concept of exposure science has been instrumental in helping us understand how stressors affect human and ecosystem health, and in efforts to prevent or reduce contact with harmful stressors. In this way exposure science has played an integral role in many areas of environmental health, and can help meet growing needs in environmental regulation, urban and ecosystem planning, and disaster management. Exposure Science in the 21st Century: A Vision and A Strategy explains that there are increasing demands for exposure science information, for example to meet needs for data on the thousands of chemicals introduced into the market each year, and to better understand the health effects of prolonged low-level exposure to stressors. Recent advances in tools and technologies-including sensor systems, analytic methods, molecular technologies, computational tools, and bioinformatics-have provided the potential for more accurate and comprehensive exposure science data than ever before. This report also provides a roadmap to take advantage of the technologic innovations and strategic collaborations to move exposure science into the future.

Using 21st Century Science to Improve Risk-Related Evaluations

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309453518
Total Pages : 201 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Using 21st Century Science to Improve Risk-Related Evaluations by : National Academies of Sciences, Engineering, and Medicine

Download or read book Using 21st Century Science to Improve Risk-Related Evaluations written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-02-16 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, several large-scale United States and international programs have been initiated to incorporate advances in molecular and cellular biology, -omics technologies, analytical methods, bioinformatics, and computational tools and methods into the field of toxicology. Similar efforts are being pursued in the field of exposure science with the goals of obtaining more accurate and complete exposure data on individuals and populations for thousands of chemicals over the lifespan; predicting exposures from use data and chemical-property information; and translating exposures between test systems and humans. Using 21st Century Science to Improve Risk-Related Evaluations makes recommendations for integrating new scientific approaches into risk-based evaluations. This study considers the scientific advances that have occurred following the publication of the NRC reports Toxicity Testing in the 21st Century: A Vision and a Strategy and Exposure Science in the 21st Century: A Vision and a Strategy. Given the various ongoing lines of investigation and new data streams that have emerged, this publication proposes how best to integrate and use the emerging results in evaluating chemical risk. Using 21st Century Science to Improve Risk-Related Evaluations considers whether a new paradigm is needed for data validation, how to integrate the divergent data streams, how uncertainty might need to be characterized, and how best to communicate the new approaches so that they are understandable to various stakeholders.

Toxicity Testing in the 21st Century

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309151732
Total Pages : 217 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Toxicity Testing in the 21st Century by : National Research Council

Download or read book Toxicity Testing in the 21st Century written by National Research Council and published by National Academies Press. This book was released on 2007-11-05 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.

Identifying and Reducing Environmental Health Risks of Chemicals in Our Society

Author : Robert Pool
Publisher :
ISBN 13 : 9780309301152
Total Pages : 0 pages
Book Rating : 4.3/5 (11 download)

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Book Synopsis Identifying and Reducing Environmental Health Risks of Chemicals in Our Society by : Robert Pool

Download or read book Identifying and Reducing Environmental Health Risks of Chemicals in Our Society written by Robert Pool and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "On November 7-8, 2013, the Institute of Medicine's Roundtable on Environmental Health Sciences, Research, and Medicine held a workshop to discuss approaches related to identifying and reducing potential environmental public health risks to new and existing industrial chemicals present in society. Industrial chemicals include chemicals used in industrial processes or commercial products, not including those found in food, pesticides, or pharmaceuticals. Identifying and Reducing Environmental Health Risks of Chemicals in Our Society is a summary and synthesis of the presentations and discussions that took place during the two days of the workshop. The workshop examined successes and areas for improvement within current regulatory programs for assessing industrial chemical safety, frameworks for chemical prioritization to inform targeted testing and risk management strategies, concepts of sustainability and green chemistry that support the design and use of safer alternatives, and efforts to reduce the risk of chemicals in our society."--Publisher's description.

Science for Environmental Protection

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309264898
Total Pages : 188 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Science for Environmental Protection by : National Research Council

Download or read book Science for Environmental Protection written by National Research Council and published by National Academies Press. This book was released on 2012-12-21 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: In anticipation of future environmental science and engineering challenges and technologic advances, EPA asked the National Research Council (NRC) to assess the overall capabilities of the agency to develop, obtain, and use the best available scientific and technologic information and tools to meet persistent, emerging, and future mission challenges and opportunities. Although the committee cannot predict with certainty what new environmental problems EPA will face in the next 10 years or more, it worked to identify some of the common drivers and common characteristics of problems that are likely to occur. Tensions inherent to the structure of EPA's work contribute to the current and persistent challenges faced by the agency, and meeting those challenges will require development of leading-edge scientific methods, tools, and technologies, and a more deliberate approach to systems thinking and interdisciplinary science. Science for Environmental Protection: The Road Ahead outlines a framework for building science for environmental protection in the 21st century and identified key areas where enhanced leadership and capacity can strengthen the agency's abilities to address current and emerging environmental challenges as well as take advantage of new tools and technologies to address them. The foundation of EPA science is strong, but the agency needs to continue to address numerous present and future challenges if it is to maintain its science leadership and meet its expanding mandates.

Science and Decisions

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309120462
Total Pages : 422 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Science and Decisions by : National Research Council

Download or read book Science and Decisions written by National Research Council and published by National Academies Press. This book was released on 2009-03-24 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Risk assessment has become a dominant public policy tool for making choices, based on limited resources, to protect public health and the environment. It has been instrumental to the mission of the U.S. Environmental Protection Agency (EPA) as well as other federal agencies in evaluating public health concerns, informing regulatory and technological decisions, prioritizing research needs and funding, and in developing approaches for cost-benefit analysis. However, risk assessment is at a crossroads. Despite advances in the field, risk assessment faces a number of significant challenges including lengthy delays in making complex decisions; lack of data leading to significant uncertainty in risk assessments; and many chemicals in the marketplace that have not been evaluated and emerging agents requiring assessment. Science and Decisions makes practical scientific and technical recommendations to address these challenges. This book is a complement to the widely used 1983 National Academies book, Risk Assessment in the Federal Government (also known as the Red Book). The earlier book established a framework for the concepts and conduct of risk assessment that has been adopted by numerous expert committees, regulatory agencies, and public health institutions. The new book embeds these concepts within a broader framework for risk-based decision-making. Together, these are essential references for those working in the regulatory and public health fields.

Using 21st Century Science to Improve Risk-Related Evaluations

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309453488
Total Pages : 201 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Using 21st Century Science to Improve Risk-Related Evaluations by : National Academies of Sciences, Engineering, and Medicine

Download or read book Using 21st Century Science to Improve Risk-Related Evaluations written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-03-16 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, several large-scale United States and international programs have been initiated to incorporate advances in molecular and cellular biology, -omics technologies, analytical methods, bioinformatics, and computational tools and methods into the field of toxicology. Similar efforts are being pursued in the field of exposure science with the goals of obtaining more accurate and complete exposure data on individuals and populations for thousands of chemicals over the lifespan; predicting exposures from use data and chemical-property information; and translating exposures between test systems and humans. Using 21st Century Science to Improve Risk-Related Evaluations makes recommendations for integrating new scientific approaches into risk-based evaluations. This study considers the scientific advances that have occurred following the publication of the NRC reports Toxicity Testing in the 21st Century: A Vision and a Strategy and Exposure Science in the 21st Century: A Vision and a Strategy. Given the various ongoing lines of investigation and new data streams that have emerged, this publication proposes how best to integrate and use the emerging results in evaluating chemical risk. Using 21st Century Science to Improve Risk-Related Evaluations considers whether a new paradigm is needed for data validation, how to integrate the divergent data streams, how uncertainty might need to be characterized, and how best to communicate the new approaches so that they are understandable to various stakeholders.

New Research Opportunities in the Earth Sciences

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309219248
Total Pages : 132 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis New Research Opportunities in the Earth Sciences by : National Research Council

Download or read book New Research Opportunities in the Earth Sciences written by National Research Council and published by National Academies Press. This book was released on 2012-04-26 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 2001 National Research Council (NRC) report Basic Research Opportunities in Earth Science (BROES) described how basic research in the Earth sciences serves five national imperatives: (1) discovery, use, and conservation of natural resources; (2) characterization and mitigation of natural hazards; (3) geotechnical support of commercial and infrastructure development; (4) stewardship of the environment; and (5) terrestrial surveillance for global security and national defense. This perspective is even more pressing today, and will persist into the future, with ever-growing emphasis. Today's world-with headlines dominated by issues involving fossil fuel and water resources, earthquake and tsunami disasters claiming hundreds of thousands of lives and causing hundreds of billions of dollars in damages, profound environmental changes associated with the evolving climate system, and nuclear weapons proliferation and testing-has many urgent societal issues that need to be informed by sound understanding of the Earth sciences. A national strategy to sustain basic research and training of expertise across the full spectrum of the Earth sciences is motivated by these national imperatives. New Research Opportunities in the Earth Sciences identifies new and emerging research opportunities in the Earth sciences over the next decade, including surface and deep Earth processes and interdisciplinary research with fields such as ocean and atmospheric sciences, biology, engineering, computer science, and social and behavioral sciences. The report also identifies key instrumentation and facilities needed to support these new and emerging research opportunities. The report describes opportunities for increased cooperation in these new and emerging areas between EAR and other government agency programs, industry, and international programs, and suggests new ways that EAR can help train the next generation of Earth scientists, support young investigators, and increase the participation of underrepresented groups in the field.

Air Pollution Science for the 21st Century

Author : J. Austin
Publisher : Elsevier
ISBN 13 : 008052690X
Total Pages : 686 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Air Pollution Science for the 21st Century by : J. Austin

Download or read book Air Pollution Science for the 21st Century written by J. Austin and published by Elsevier. This book was released on 2002-10-31 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acid rain, photochemistry, long-range transport of pollutants, greenhouse gas emissions and aerosols have dominated tropospheric air pollution for the last 30 years of the 20th century. At the start of the 21st century, acid rain is subject to planned improvement in Europe and North America, but is still a growing problem in Asia. Tropospheric ozone is understood much better, but the problem is still with us, and desirable levels are difficult to achieve over continental Europe. The heterogeneous chemistry that is responsible for ozone depletion in the stratosphere is now reasonably clear, but there is on-going interest in the sources and sinks of CFC (chlorofluorocarbon) replacements in the troposphere. There is also increasing interest in indoor air quality, and the origin and health implications of atmospheric particles. Perhaps most important on a global perspective, intensive research has not yet determined the relationship between greenhouse gases, aerosols and surface temperature. The climactic implications of these are now more urgent than ever. This book, the first in the Developments in Environmental Science series, consists of a collection of authoritative reviews and essays on the science and application of air pollution research at the start of this new century.

Human Exposure to Environmental Chemicals (with DVD)

Author :
Publisher :
ISBN 13 : 9781536115239
Total Pages : 130 pages
Book Rating : 4.1/5 (152 download)

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Book Synopsis Human Exposure to Environmental Chemicals (with DVD) by :

Download or read book Human Exposure to Environmental Chemicals (with DVD) written by and published by . This book was released on 2011 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Undue Risk

Author : Jonathan D. Moreno
Publisher : Routledge
ISBN 13 : 1136605568
Total Pages : 394 pages
Book Rating : 4.1/5 (366 download)

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Book Synopsis Undue Risk by : Jonathan D. Moreno

Download or read book Undue Risk written by Jonathan D. Moreno and published by Routledge. This book was released on 2013-05-13 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the courtrooms of Nuremberg to the battlefields of the Gulf War, Undue Risk exposes a variety of government policies and specific cases, includingplutonium injections to unwilling hospital patients, and even the attempted recruitment of Nazi medical scientists bythe U.S. government after World War II.

Green Toxicology

Author : Alexandra Maertens
Publisher : Royal Society of Chemistry
ISBN 13 : 1839164409
Total Pages : 307 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Green Toxicology by : Alexandra Maertens

Download or read book Green Toxicology written by Alexandra Maertens and published by Royal Society of Chemistry. This book was released on 2022-02-01 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Green toxicology is an integral part of green chemistry. One of the key goals of green chemistry is to design less toxic chemicals. Therefore, an understanding of toxicology and hazard assessment is important for any chemist working in green chemistry, but toxicology is rarely part of most chemists' education. As a consequence, chemists lack the toxicological lens necessary to view chemicals in order to design safer substitutions. This book seeks to fill that gap and demonstrate how a basic understanding of toxicology, as well as the tools of in silico and in vitro toxicology, can be an integral part of green chemistry. R&D chemists, product stewards, and toxicologists who work in the field of sustainability, can all benefit from integrating green toxicology principles into their work. Topics include in silico tools for hazard assessment, toxicity testing, and lifecycle considerations, this book aims to act as a bridge between green toxicologists and green chemists.

Radon

Author : Ramesh Chandra Tiwari
Publisher :
ISBN 13 : 9781536167917
Total Pages : 330 pages
Book Rating : 4.1/5 (679 download)

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Book Synopsis Radon by : Ramesh Chandra Tiwari

Download or read book Radon written by Ramesh Chandra Tiwari and published by . This book was released on 2020-03-18 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the recent past, studies on radon and their progenies have drawn a lot of attention from the scientific community and researchers, due to their crucial role as a possible cause of cancer, monitoring radiation levels of nuclear installations and as a potential precursor parameter to seismic events. This book titled "Radon: Detection, Exposure and Control" has 19 chapters comprising of research contributions from across the globe namely; Brazil, Spain, Norway, Ireland, Russia, Taiwan (PRC), Iran, Egypt, Turkey, Saudi Arabia and several regions of India including the seismic zone-V, the second highest seismic zone in the world. This book is very useful to scholars pursuing post-graduate studies and research covering broad areas of applied sciences namely; geophysics, Earth science, geoscience, geochemistry and civil & geotechnical engineering. This book provides a mixed flavour of the recent trends in several types of research works related to detection, exposure and control of Radon (Rn222, Rn220) in a concise and interesting manner. This book contains several chapters dedicated to the radon measurement based radioactivity studies in rocks, over kimberlite pipes, inside soil and in open environments. The book also describes indoor radon gas concentration studies in schools and other working places including the assessment of health risk associated with it including radon exposure, its measurement and protection. In addition to the influence of regional and geophysical characteristics on the volumetric activity of radon, this book also contains the radon-based biometric characterization of person identification. Review articles on a detailed study of fault traces in Taiwan using soil gas geochemistry and the role of radon as precursor to earthquake have also been discussed including psychological perspective of radon risk and remediation. I feel confident that this book shall be extremely useful to the research community of science and engineering streams at large and do hope that they will find it extremely helpful to understand the mechanism and to conceive research problems with potential applications.

Exposure

Author : Robert Bilott
Publisher : Atria Books
ISBN 13 : 1501172824
Total Pages : 400 pages
Book Rating : 4.5/5 (11 download)

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Book Synopsis Exposure by : Robert Bilott

Download or read book Exposure written by Robert Bilott and published by Atria Books. This book was released on 2020-07-14 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: “For Erin Brockovich fans, a David vs. Goliath tale with a twist” (The New York Times Book Review)—the incredible true story of the lawyer who spent two decades building a case against DuPont for its use of the hazardous chemical PFOA, uncovering the worst case of environmental contamination in history—affecting virtually every person on the planet—and the conspiracy that kept it a secret for sixty years. The story that inspired Dark Waters, the major motion picture from Focus Features starring Mark Ruffalo and Anne Hathaway, directed by Todd Haynes. 1998: Rob Bilott is a young lawyer specializing in helping big corporations stay on the right side of environmental laws and regulations. Then he gets a phone call from a West Virginia farmer named Earl Tennant, who is convinced the creek on his property is being poisoned by runoff from a neighboring DuPont landfill, causing his cattle and the surrounding wildlife to die in hideous ways. Earl hasn’t even been able to get a water sample tested by any state or federal regulatory agency or find a local lawyer willing to take the case. As soon as they hear the name DuPont—the area’s largest employer—they shut him down. Once Rob sees the thick, foamy water that bubbles into the creek, the gruesome effects it seems to have on livestock, and the disturbing frequency of cancer and other health problems in the area, he’s persuaded to fight against the type of corporation his firm routinely represents. After intense legal wrangling, Rob ultimately gains access to hundreds of thousands of pages of DuPont documents, some of them fifty years old, that reveal the company has been holding onto decades of studies proving the harmful effects of a chemical called PFOA, used in making Teflon. PFOA is often called a “forever chemical,” because once in the environment, it does not break down or degrade for millions of years, contaminating the planet forever. The case of one farmer soon spawns a class action suit on behalf of seventy thousand residents—and the shocking realization that virtually every person on the planet has been exposed to PFOA and carries the chemical in his or her blood. What emerges is a riveting legal drama “in the grand tradition of Jonathan Harr’s A Civil Action” (Booklist, starred review) about malice and manipulation, the failings of environmental regulation; and one lawyer’s twenty-year struggle to expose the truth about this previously unknown—and still unregulated—chemical that we all have inside us.

Basic Research Opportunities in Earth Science

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030907133X
Total Pages : 169 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Basic Research Opportunities in Earth Science by : National Research Council

Download or read book Basic Research Opportunities in Earth Science written by National Research Council and published by National Academies Press. This book was released on 2001-02-01 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic Research Opportunities in Earth Science identifies areas of high-priority research within the purview of the Earth Science Division of the National Science Foundation, assesses cross-disciplinary connections, and discusses the linkages between basic research and societal needs. Opportunities in Earth science have been opened up by major improvements in techniques for reading the geological record of terrestrial change, capabilities for observing active processes in the present-day Earth, and computational technologies for realistic simulations of dynamic geosystems. This book examines six specific areas in which the opportunities for basic research are especially compelling, including integrative studies of the near-surface environment (the "Critical Zone"); geobiology; Earth and planetary materials; investigations of the continents; studies of Earth's deep interior; and planetary science. It concludes with a discussion of mechanisms for exploiting these research opportunities, including EarthScope, natural laboratories, and partnerships.

Occupational Exposure and Health Risks

Author : Enrico Oddone
Publisher : Nova Science Publishers
ISBN 13 : 9781634850735
Total Pages : 0 pages
Book Rating : 4.8/5 (57 download)

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Book Synopsis Occupational Exposure and Health Risks by : Enrico Oddone

Download or read book Occupational Exposure and Health Risks written by Enrico Oddone and published by Nova Science Publishers. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite several improvements in risk assessment and exposure prevention, the occupational environment could expose workers to a wide variety of risk factors. Beside classical risk factors, such as chemical compounds, physical agents and biological agents, a group of "new risk factors has become more and more prevalent over the last few decades; psychosocial hazards in occupational environments and exposure to nanoparticles are flawless examples of these potential issues for workers' health. This book aims to address principal classical risk factors by dealing extensively with occupational respiratory diseases, cardiovascular diseases related to work, occupational cancers, and occupational risks for hypersensitivity. Additionally, it attempts to shed light on a deepened treatise of occupational hazards related to the development of neurodegenerative diseases, psychosocial ailments, and ergonomic risk factors, which could result in cumulative trauma disorders of the upper limb. The second part of this book provides some advice regarding specific risk factors or specific occupational exposures: health issues related to exposure to mechanical vibrations, pesticides, nanomaterials, and in a hospital environment were used as examples to deepen the risk assessment and the analysis of health hazards. The authors hope to paint a global picture of the principal risk factors in occupational medicine. Given these premises, this book is not aimed to be comprehensive, but rather to provide an introductive and robust base for facing several current issues in occupational medicine.

The Exposome

Author : Gary W Miller
Publisher : Elsevier
ISBN 13 : 0124172180
Total Pages : 118 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis The Exposome by : Gary W Miller

Download or read book The Exposome written by Gary W Miller and published by Elsevier. This book was released on 2013-11-16 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Exposome: A Primer is the first book dedicated to exposomics, detailing the purpose and scope of this emerging field of study, its practical applications and how it complements a broad range of disciplines. Genetic causes account for up to a third of all complex diseases. (As genomic approaches improve, this is likely to rise.) Environmental factors also influence human disease but, unlike with genetics, there is no standard or systematic way to measure the influence of environmental exposures. The exposome is an emerging concept that hopes to address this, measuring the effects of life-long environmental exposures on health and how these exposures can influence disease. This systematic introduction considers topics of managing and integrating exposome data (including maps, models, computation, and systems biology), "-omics"-based technologies, and more. Both students and scientists in disciplines including toxicology, environmental health, epidemiology, and public health will benefit from this rigorous yet readable overview.