Exploring the Current Landscape of Consumer Genomics

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Author :
Publisher : National Academies Press
ISBN 13 : 0309673038
Total Pages : 113 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Exploring the Current Landscape of Consumer Genomics by : National Academies of Sciences, Engineering, and Medicine

Download or read book Exploring the Current Landscape of Consumer Genomics written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-08-23 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Consumer genomics, encompassing both direct-to-consumer applications (i.e., genetic testing that is accessed by a consumer directly from a commercial company apart from a health care provider) and consumer-driven genetic testing (i.e., genetic testing ordered by a health care provider in response to an informed patient request), has evolved considerably over the past decade, moving from more personal utility-focused applications outside of traditional health care to interfacing with clinical care in nontraditional ways. As consumer genomics has increasingly intersected with clinical applications, discussions have arisen around the need to demonstrate clinical and analytical validity and clinical utility due to the potential for misinterpretation by consumers. Clinical readiness and interest for this information have presented educational and training challenges for providers. At the same time, consumer genomics has emerged as a potentially innovative mechanism for thinking about health literacy and engaging participants in their health and health care. To explore the current landscape of consumer genomics and the implications for how genetic test information is used or may be used in research and clinical care, the Roundtable on Genomics and Precision Health of the National Academies of Sciences, Engineering, and Medicine hosted a public workshop on October 29, 2019, in Washington, DC. Discussions included such topics as the diversity of participant populations, the impact of consumer genomics on health literacy and engagement, knowledge gaps related to the use of consumer genomics in clinical care, and regulatory and health policy issues such as data privacy and security. A broad array of stakeholders took part in the workshop, including genomics and consumer genomics experts, epidemiologists, health disparities researchers, clinicians, users of consumer genomics research applications, representatives from patient advocacy groups, payers, bioethicists, regulators, and policy makers. This publication summarizes the presentations and discussion of the workshop.

Exploring Personal Genomics

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Publisher : Oxford University Press
ISBN 13 : 0199644489
Total Pages : 265 pages
Book Rating : 4.1/5 (996 download)

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Book Synopsis Exploring Personal Genomics by : Joel T. Dudley

Download or read book Exploring Personal Genomics written by Joel T. Dudley and published by Oxford University Press. This book was released on 2013-01-03 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a novel inquiry-based approach to understanding and interpreting the practical, medical, and societal aspects of personal genomic information. It opens with an introduction to genomics and the issues surrounding the use of genomic data, and then discusses the potential applications of this data using real examples and data sets.

Achievements, Milestones and Challenges in Biomedical and Health Informatics

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Publisher : IOS Press
ISBN 13 : 1643683411
Total Pages : 244 pages
Book Rating : 4.6/5 (436 download)

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Book Synopsis Achievements, Milestones and Challenges in Biomedical and Health Informatics by : J. Mantas

Download or read book Achievements, Milestones and Challenges in Biomedical and Health Informatics written by J. Mantas and published by IOS Press. This book was released on 2022-11-23 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: The technological advances in Biomedical and Health Informatics (BMHI) in the last 4 decades could barely have been imagined when the field was in its infancy. At the time, computers were large and unwieldy, memory was measured in kilobytes, and the Internet was accessible only to people in the technology professions. How the world has changed. The skills of BMHI are now essential for everyone who participates in healthcare, from practitioners and researchers to administrators and patients. This book presents the 17 accepted papers of the International Symposium on Achievements, Milestones, and Challenges in Biomedical and Health Informatics (BMHI), held in Athens, Greece, on 29 October 2022. This event marks the retirement of Professor John Mantas, whose career in BMHI spans over 40 years, and a number of eminent colleagues from around the world were invited to present original review papers in their respective domains, not only to celebrate the work of Professor Mantas, but to review the achievements, milestones, and challenges of BMHI. Most of those presenting papers have worked in the field for decades, and their collective experience and wisdom highlights the accomplishments and limitations of the field. Each paper was peer reviewed by 3 independent reviewers before being thoroughly revised ensuring the high quality of the accepted papers. The book is dedicated to the entire BMHI community. It covers the achievements attained, the milestones reached, and the challenges which have been overcome or which have not been conquered, and provides knowledge and perspective for both learners and practitioners in the field.

Foundations of Behavior Genetics

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Publisher : Cambridge University Press
ISBN 13 : 1108858368
Total Pages : 443 pages
Book Rating : 4.1/5 (88 download)

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Book Synopsis Foundations of Behavior Genetics by : Scott F. Stoltenberg

Download or read book Foundations of Behavior Genetics written by Scott F. Stoltenberg and published by Cambridge University Press. This book was released on 2022-07-07 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: Foundations of Behavior Genetics provides a forward-looking introduction to this fascinating field. Written by an experienced teacher and researcher, this text focuses on concepts, methods, and findings that inform our understanding of heredity–behavior relations. The book's neuroscience perspective asks students to think about potential neural mechanisms involved in pathways from genes to behavior. While the text is primarily focused on human behavior genetics, it also emphasizes the importance of non-human animal models in experimental studies, as well as their evolutionary connections to humans. Part I covers the history of behavior genetics and the basics of non-molecular genetics; Part II discusses molecular genetics and neurogenetics; Part III addresses various behavioral disorders; and Part IV explores health, social behavior, and ethical implications. The text includes detailed chapter summaries, several “Check-up” questions after major sections that test student understanding, and recommended readings. Instructors are provided with a test bank of multiple-choice items and hi-res JPEGs of the many illustrations created for the book.

Textbook of Personalized Medicine

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Publisher : Springer Nature
ISBN 13 : 3030620808
Total Pages : 744 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Textbook of Personalized Medicine by : Kewal K. Jain

Download or read book Textbook of Personalized Medicine written by Kewal K. Jain and published by Springer Nature. This book was released on 2020-12-05 with total page 744 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is for personalized medicine as a prescription of specific treatments and therapeutics best suited for an individual and considers genetic as well as environmental factors that influence responses to therapy. Best approaches are described for integration of all available technologies for optimizing the therapy of individual patients. This comprehensive third edition covers the latest advances in personalized medicine and several chapters are devoted to various specialties, particulary cancer which is the largest area of application. The book discusses the development of personalized medicine and various players in it such as companies, academic institutions, the government, and the public as the consumer of healthcare. Additionally, the roles of bioinformatics, electronic health records, and digital technologies for personalized medicine are discussed. Textbook of Personalized Medicine, 3rd Edition serves as a convenient source of information for students at many levels and in a wide range of fields, including physicians, scientists, and decision makers in the biopharmaceutical and healthcare industries.

The Value of Genetic and Genomic Technologies

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Publisher : National Academies Press
ISBN 13 : 0309184991
Total Pages : 109 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Value of Genetic and Genomic Technologies by : Institute of Medicine

Download or read book The Value of Genetic and Genomic Technologies written by Institute of Medicine and published by National Academies Press. This book was released on 2010-11-29 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowing one's genetic disposition to a variety of diseases, including common chronic diseases, can benefit both the individual and society at large. The IOM's Roundtable on Translating Genomic-Based Research for Health held a workshop on March 22, 2010, to bring together diverse perspectives on the value of genetic testing, and to discuss its use in clinical practice.

Genomics of Rare Diseases

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Publisher : Academic Press
ISBN 13 : 0128204362
Total Pages : 316 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Genomics of Rare Diseases by : Claudia Gonzaga-Jauregui

Download or read book Genomics of Rare Diseases written by Claudia Gonzaga-Jauregui and published by Academic Press. This book was released on 2021-06-12 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomics of Rare Diseases: Understanding Disease Genetics Using Genomic Approaches, a new volume in the Translational and Applied Genomics series, offers readers a broad understanding of current knowledge on rare diseases through a genomics lens. This clear understanding of the latest molecular and genomic technologies used to elucidate the molecular causes of more than 5,000 genetic disorders brings readers closer to unraveling many more that remain undefined and undiscovered. The challenges associated with performing rare disease research are also discussed, as well as the opportunities that the study of these disorders provides for improving our understanding of disease architecture and pathophysiology. Leading chapter authors in the field discuss approaches such as karyotyping and genomic sequencing for the better diagnosis and treatment of conditions including recessive diseases, dominant and X-linked disorders, de novo mutations, sporadic disorders and mosaicism. Compiles applied case studies and methodologies, enabling researchers, clinicians and healthcare providers to effectively classify DNA variants associated with disease and patient phenotypes Discusses the main challenges in studying the genetics of rare diseases through genomic approaches and possible or ongoing solutions Explores opportunities for novel therapeutics Features chapter contributions from leading researchers and clinicians

Deriving Drug Discovery Value from Large-Scale Genetic Bioresources

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Author :
Publisher : National Academies Press
ISBN 13 : 030944778X
Total Pages : 115 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Deriving Drug Discovery Value from Large-Scale Genetic Bioresources by : National Academies of Sciences, Engineering, and Medicine

Download or read book Deriving Drug Discovery Value from Large-Scale Genetic Bioresources written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-12-02 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: The process of discovering and developing a new drug or therapy is extremely costly and time consuming, and recently, it has been estimated that the creation of a new medicine costs on average more than $2 billion and takes 10 years to reach patients. The challenges associated with bringing new medicines to market have led many pharmaceutical companies to seek out innovative methods for streamlining their drug discovery research. One way to increase the odds of success for compounds in the drug development pipeline is to adopt genetically guided strategies for drug discovery, and recognizing the potential benefits of collecting genetic and phenotypic information across specific populations, pharmaceutical companies have started collaborating with healthcare systems and private companies that have curated genetic bioresources, or large databases of genomic information. Large-scale cohort studies offer an effective way to collect and store information that can be used to assess geneâ€"environment interactions, identify new potential drug targets, understand the role of certain genetic variants in the drug response, and further elucidate the underlying mechanisms of disease onset and progression. To examine how genetic bioresources could be used to improve drug discovery and target validation, the National Academies of Sciences, Engineering, and Medicine hosted a workshop in March 2016. Participants at the workshop explored the current landscape of genomics-enabled drug discovery activities in industry, academia, and government; examined enabling partnerships and business models; and considered gaps and best practices for collecting population data for the purpose of improving the drug discovery process. This publication summarizes the presentations and discussions from the workshop.

Landscape Genetics

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Publisher : John Wiley & Sons
ISBN 13 : 1118525299
Total Pages : 298 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis Landscape Genetics by : Niko Balkenhol

Download or read book Landscape Genetics written by Niko Balkenhol and published by John Wiley & Sons. This book was released on 2015-11-09 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: LANDSCAPE GENETICS: CONCEPTS, METHODS, APPLICATIONS LANDSCAPE GENETICS: CONCEPTS, METHODS, APPLICATIONS Edited by Niko Balkenhol, Samuel A. Cushman, Andrew T. Storfer, Lisette P. Waits Landscape genetics is an exciting and rapidly growing field, melding methods and theory from landscape ecology and population genetics to address some of the most challenging and urgent ecological and evolutionary topics of our time. Landscape genetic approaches now enable researchers to study in detail how environmental complexity in space and time affect gene flow, genetic drift, and local adaptation. However, learning about the concepts and methods underlying the field remains challenging due to the highly interdisciplinary nature of the field, which relies on topics that have traditionally been treated separately in classes and textbooks. In this edited volume, some of the leading experts in landscape genetics provide the first comprehensive introduction to underlying concepts, commonly used methods, and current and future applications of landscape genetics. Consistent with the interdisciplinary nature of the field, the book includes textbook-like chapters that synthesize fundamental concepts and methods underlying landscape genetics (Part 1), chapters on advanced topics that deserve a more in-depth treatment (Part 2), and chapters illustrating the use of concepts and methods in empirical applications (Part 3). Aimed at beginning landscape geneticists and experienced researchers alike, this book will be helpful for all scientists and practitioners interested in learning, teaching, and applying landscape genetics.

An Examination of Emerging Bioethical Issues in Biomedical Research

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Author :
Publisher : National Academies Press
ISBN 13 : 0309676630
Total Pages : 133 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis An Examination of Emerging Bioethical Issues in Biomedical Research by : National Academies of Sciences, Engineering, and Medicine

Download or read book An Examination of Emerging Bioethical Issues in Biomedical Research written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-09-10 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: On February 26, 2020, the Board on Health Sciences Policy of the National Academies of Sciences, Engineering, and Medicine hosted a 1-day public workshop in Washington, DC, to examine current and emerging bioethical issues that might arise in the context of biomedical research and to consider research topics in bioethics that could benefit from further attention. The scope of bioethical issues in research is broad, but this workshop focused on issues related to the development and use of digital technologies, artificial intelligence, and machine learning in research and clinical practice; issues emerging as nontraditional approaches to health research become more widespread; the role of bioethics in addressing racial and structural inequalities in health; and enhancing the capacity and diversity of the bioethics workforce. This publication summarizes the presentations and discussions from the workshop.

Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies

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Publisher : Academic Press
ISBN 13 : 0128137657
Total Pages : 431 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies by : Sorin Hostiuc

Download or read book Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies written by Sorin Hostiuc and published by Academic Press. This book was released on 2018-08-07 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies offers thorough discussions on preconception carrier screening, genetic engineering and the use of CRISPR gene editing, mitochondrial gene replacement therapy, sex selection, predictive testing, secondary findings, embryo reduction and the moral status of the embryo, genetic enhancement, and the sharing of genetic data. Chapter contributions from leading bioethicists and clinicians encourage a global, holistic perspective on applied challenges and the moral questions relating the implementation of genetic reproductive technology. The book is an ideal resource for practitioners, regulators, lawmakers, clinical researchers, genetic counselors and graduate and medical students. As the Human Genome Project has triggered a technological revolution that has influenced nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, prenatal genetic testing, and gene therapy, this book presents a timely resource. Provides practical analysis of the ethical issues raised by cutting-edge techniques and recent advances in prenatal and reproductive genetics Contains contributions from leading bioethicists and clinicians who offer a global, holistic perspective on applied challenges and moral questions relating to genetic and genomic reproductive technology Discusses preconception carrier screening, genetic engineering and the use of CRISPR gene editing, mitochondrial gene replacement therapy, ethical issues, and more

Artificial Intelligence in Healthcare

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Publisher : Academic Press
ISBN 13 : 0128184396
Total Pages : 385 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Artificial Intelligence in Healthcare by : Adam Bohr

Download or read book Artificial Intelligence in Healthcare written by Adam Bohr and published by Academic Press. This book was released on 2020-06-21 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Artificial Intelligence (AI) in Healthcare is more than a comprehensive introduction to artificial intelligence as a tool in the generation and analysis of healthcare data. The book is split into two sections where the first section describes the current healthcare challenges and the rise of AI in this arena. The ten following chapters are written by specialists in each area, covering the whole healthcare ecosystem. First, the AI applications in drug design and drug development are presented followed by its applications in the field of cancer diagnostics, treatment and medical imaging. Subsequently, the application of AI in medical devices and surgery are covered as well as remote patient monitoring. Finally, the book dives into the topics of security, privacy, information sharing, health insurances and legal aspects of AI in healthcare. Highlights different data techniques in healthcare data analysis, including machine learning and data mining Illustrates different applications and challenges across the design, implementation and management of intelligent systems and healthcare data networks Includes applications and case studies across all areas of AI in healthcare data

Cancer Principles and Practice of Oncology: Handbook of Clinical Cancer Genetics

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Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1469833883
Total Pages : 348 pages
Book Rating : 4.4/5 (698 download)

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Book Synopsis Cancer Principles and Practice of Oncology: Handbook of Clinical Cancer Genetics by : Ellen Matloff

Download or read book Cancer Principles and Practice of Oncology: Handbook of Clinical Cancer Genetics written by Ellen Matloff and published by Lippincott Williams & Wilkins. This book was released on 2013-03-25 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical, user-friendly guidebook will allow the clinician to search under disease site for the hereditary cancer syndromes relevant for his/her patient's cancer. For example, a gynecologist oncologist whose patient has ovarian cancer can turn to the Ovary chapter and quickly read a summary of all of the hereditary cancer syndromes that include ovarian cancer. She can learn the questions she should be asking when expanding that patient's personal and family history, which genes are most relevant, whether to refer that patient on for genetic counseling and testing, and how to manage that patient long-term if the patient is mutation positive or negative. The same holds true for the practicing oncologist, surgeon, urologist, endocrinologist, gynecologist, primary care physician, physician's assistant, advanced practice nurse and any other clinician seeing a patient who has had cancer. This guidebook also contains an overview article on genetic counseling and testing and several in depth articles on issues that are up and coming in the field of hereditary cancer.

Human Genetics and Genomics

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Publisher : John Wiley & Sons
ISBN 13 : 1118537661
Total Pages : 280 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis Human Genetics and Genomics by : Bruce R. Korf

Download or read book Human Genetics and Genomics written by Bruce R. Korf and published by John Wiley & Sons. This book was released on 2012-11-19 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fourth edition of the best-selling textbook, Human Genetics and Genomics, clearly explains the key principles needed by medical and health sciences students, from the basis of molecular genetics, to clinical applications used in the treatment of both rare and common conditions. A newly expanded Part 1, Basic Principles of Human Genetics, focuses on introducing the reader to key concepts such as Mendelian principles, DNA replication and gene expression. Part 2, Genetics and Genomics in Medical Practice, uses case scenarios to help you engage with current genetic practice. Now featuring full-color diagrams, Human Genetics and Genomics has been rigorously updated to reflect today’s genetics teaching, and includes updated discussion of genetic risk assessment, “single gene” disorders and therapeutics. Key learning features include: Clinical snapshots to help relate science to practice ‘Hot topics’ boxes that focus on the latest developments in testing, assessment and treatment ‘Ethical issues’ boxes to prompt further thought and discussion on the implications of genetic developments ‘Sources of information’ boxes to assist with the practicalities of clinical research and information provision Self-assessment review questions in each chapter Accompanied by the Wiley E-Text digital edition (included in the price of the book), Human Genetics and Genomics is also fully supported by a suite of online resources at www.korfgenetics.com, including: Factsheets on 100 genetic disorders, ideal for study and exam preparation Interactive Multiple Choice Questions (MCQs) with feedback on all answers Links to online resources for further study Figures from the book available as PowerPoint slides, ideal for teaching purposes The perfect companion to the genetics component of both problem-based learning and integrated medical courses, Human Genetics and Genomics presents the ideal balance between the bio-molecular basis of genetics and clinical cases, and provides an invaluable overview for anyone wishing to engage with this fast-moving discipline.

Genetics, Disability and the Law

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Publisher : Cambridge University Press
ISBN 13 : 1108509274
Total Pages : 335 pages
Book Rating : 4.1/5 (85 download)

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Book Synopsis Genetics, Disability and the Law by : Aisling de Paor

Download or read book Genetics, Disability and the Law written by Aisling de Paor and published by Cambridge University Press. This book was released on 2017-09-21 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: While advances in science and technology bring many advantages, we must not ignore the harm that they can cause. Rapid changes in genetic testing are a prime example, and indicators can now help to detect, address and treat diseases. However, in this new study, Aisling de Paor examines how genetic testing is also being used for non-medical reasons, for example for work opportunities and insurance coverage. Genetics, Disability and the Law is the first book of its kind to substantively consider an EU-level response to the use of genetic information. de Paor discusses how to help genetic and scientific research to evolve and grow, how to enhance public confidence in research, and how to control it so that it recognises our values and fundamental human rights. An understudied but vitally important topic, de Paor's work provides a valuable and timely contribution to the field of disability rights.

Knowing New Biotechnologies

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Publisher : Routledge
ISBN 13 : 1317691504
Total Pages : 217 pages
Book Rating : 4.3/5 (176 download)

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Book Synopsis Knowing New Biotechnologies by : Matthias Wienroth

Download or read book Knowing New Biotechnologies written by Matthias Wienroth and published by Routledge. This book was released on 2015-02-20 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: The areas of personal genomics and citizen science draw on – and bring together – different cultures of producing and managing knowledge and meaning. They also cross local and global boundaries, are subjects and objects of transformation and mobility of research practices, evaluation and multi-stakeholder groups. Thirdly, they draw on logics of ‘convergence’: new links between, and new kinds of, stakeholders, spaces, knowledge, practices, challenges and opportunities. This themed collection of essays from nationally and internationally leading scholars and commentators advances and widens current debates in Science and Technology Studies and in Science Policy concerning ‘converging technologies’ by complementing the customary focus on technical aspirations for convergence with the analysis of the practices and logics of scientific, social and cultural knowledge production that constitute contemporary technoscience. In case studies from across the globe, contributors discuss the ways in which science and social order are linked in areas such as direct-to consumer genetic testing and do-it-yourself biotechnologies. Organised into thematic sections, ‘Knowing New Biotechnologies’ explores: • ways of understanding the dynamics and logics of convergences in emergent biotechnologies • governance and regulatory issues around technoscientific convergences • democratic aspects of converging technologies – lay involvement in scientific research and the co-production of biotechnology and social and cultural knowledge.

Assessing Genetic Risks

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Author :
Publisher : National Academies Press
ISBN 13 : 0309047986
Total Pages : 353 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Assessing Genetic Risks by : Institute of Medicine

Download or read book Assessing Genetic Risks written by Institute of Medicine and published by National Academies Press. This book was released on 1994-01-01 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Raising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.