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Exploratory Research Into Atypical N Heterocyclic Carbenes
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Book Synopsis Exploratory Research Into Atypical N-heterocyclic Carbenes by :
Download or read book Exploratory Research Into Atypical N-heterocyclic Carbenes written by and published by . This book was released on 2013 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this research is to create unique and highly functional N-heterocyclic carbene complexes that provide maximum catalytic features in close proximity to the metal centers. The N-heterocyclic carbenes created over the past 20 years have generally consisted of imidazole moieties substituted at both nitrogen atoms with alkyl and aryl substitutents. These typical N-heterocylic carbenes have presented many highly stable and tunable complexes used in catalysis, however, some beneficial features would be imparted on these N-heterocyclic carbenes if one of the alkyl and aryl substituted sites were allowed to remain un-substituted. These unique atypical protic N-heterocyclic carbenes allow for acid base chemistry to occur in close proximity to the metal center while simultaneously providing the tunable, highly sigma-donating features of a typical N-heterocyclic carbene. The research presented in this thesis explores the synthetic approach to atypical protic N-heterocyclic carbene ligand precursors as well as their complexation and subsequent catalytic capabilities. Two ligand precursor families were created: one consisting of an iodobenzene moiety attached to a tert-butyl imidazole group, and one in which a pyridine ring moiety is attached to a tert-butyl imidazole group. The iodobenzene group yielded two ligand precursors, 2a and 2b, both containing methylene spacers between the auxiliary moiety and tert-butyl groups. The pyridine-containing family consisted of 3a, where the tert-butyl imidazole was directly attached to the pyridine ring, and 3c, where the tert-butyl imidazole was attached to the ring by a methylene spacer. Attempts to complex the first ligand precursor family 2a and 2b were unsuccessful and lead to the synthesis of the pyridine analogues 3a and 3c which were successfully complexed to both iridium and rhodium metal centers yielding: Ir-Phos- 3a, Ir-Phos-3c, Ir-S0-3a, Ir-S1-3c, Rh-S0-3a, and Rh-S1-3c. Catalytic studies carried out with the six complexes above consisted of the oxidation of alcohols to their corresponding ketones. These catalytic tests revealed a higher degree of successful turnover with the 3c containing complexes. Crystallographic data suggests that bond angles and bond distances found in 3c containing complexes give inherent advantages to the 3c containing complexes due to the flex allowed by the methylene spacer. Additionally, catalytic comparisons of methylated analogues of 3c with the atypical protic 3c complexes showed a decrease in catalytic activity suggesting that the presences of the un-substituted nitrogen in close proximity to the metal center yields the predicted benefit of using atypical protic N-heterocyclic carbenes.
Book Synopsis 2-Oxoglutarate-Dependent Oxygenases by : Christopher J Schofield
Download or read book 2-Oxoglutarate-Dependent Oxygenases written by Christopher J Schofield and published by Royal Society of Chemistry. This book was released on 2015-05-06 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of the first examples of 2-oxoglutarate-dependent oxygenase-catalysed reactions in the 1960s, a remarkably broad diversity of alternate reactions and substrates has been revealed, and extensive advances have been achieved in our understanding of the structures and catalytic mechanisms. These enzymes are important agrochemical targets and are being pursued as therapeutic targets for a wide range of diseases including cancer and anemia. This book provides a central source of information that summarizes the key features of the essential group of 2-oxoglutarate-dependent dioxygenases and related enzymes. Given the numerous recent advances and biomedical interest in the field, this book aims to unite the latest research for those already working in the field as well as to provide an introduction for those newly approaching the topic, and for those interested in translating the basic science into medicinal and agricultural benefits. The book begins with four broad chapters that highlight critical aspects, including an overview of possible catalytic reactions, structures and mechanisms. The following seventeen chapters focus on carefully selected topics, each written by leading experts in the area. Readers will find explanations of rapidly evolving research, from the chemistry of isopenicillin N synthase to the oxidation mechanism of 5-methylcytosine in DNA by ten-eleven-translocase oxygenases.
Book Synopsis Contemporary Drug Synthesis by : Jie Jack Li
Download or read book Contemporary Drug Synthesis written by Jie Jack Li and published by John Wiley & Sons. This book was released on 2004-12-27 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.
Book Synopsis Modern Catalytic Methods for Organic Synthesis with Diazo Compounds by : Michael P. Doyle
Download or read book Modern Catalytic Methods for Organic Synthesis with Diazo Compounds written by Michael P. Doyle and published by Wiley-Interscience. This book was released on 1998-01-19 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: This much-needed resource brings together a wealth of procedures for the synthesis and practical use of diazocarbonyl compounds. It features methods for the preparation of important catalysts and for applications of diazocarbonyl compounds within each of the main transformation categories-including in-depth coverage of cyclopropanation, C-H and X-H insertion, Wolff rearrangement, ylide formation, aromatic cycloaddition and substitution, and many other useful reactions. Written by leading experts in the field, this book contains cutting-edge material on highly enantioselective transformations, and presents new ways of thinking about diazocarbonyl compounds and their applications, from donor-acceptor cyclopropanes in organic synthesis to macrocyclic cyclopropanation. Complete with illustrative examples of procedures in each chapter, clear diagrams, and a detailed bibliography, this practical reference gives readers the tools they need to put diazocarbonyl compounds to work for their own projects-an invaluable source of guidance for synthetic organic chemists, chemical scientists, and advanced students.
Book Synopsis Industrial Biocatalysis by : Peter Grunwald
Download or read book Industrial Biocatalysis written by Peter Grunwald and published by CRC Press. This book was released on 2014-12-11 with total page 1201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biocatalysis has become an essential tool in the chemical industry and is the core of industrial biotechnology, also known as white biotechnology, making use of biocatalysts in terms of enzymes or whole cells in chemical processes as an alternative to chemical catalysts. This shift can be seen in the many areas of daily life where biocatalysts-with
Download or read book Organocatalysis written by Manfred Reetz and published by Springer Science & Business Media. This book was released on 2008-05-27 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an excellent overview on state-of-the-art of modern organocatalysis. It presents the contributions from leading experts, with backgrounds in academia and industry, to an Ernst Schering Research Foundation Symposium held in April 2007. It will be of interest to those who want a general overview of the topic, but also to those who want to learn more about the state-of-the-art, current trends and perspectives in this highly dynamic field of research.
Book Synopsis Equal Access for Students with Disabilities by : Lisa M. Meeks, PhD
Download or read book Equal Access for Students with Disabilities written by Lisa M. Meeks, PhD and published by Springer Publishing Company. This book was released on 2020-11-28 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: Note to Readers: Publisher does not guarantee quality or access to any included digital components if book is purchased through a third-party seller. A vital resource for ensuring students with disabilities have access to appropriate, legal, and necessary accommodations Now in its second edition, this book on disability inclusion in the health sciences remains the most comprehensive, critically and legally informed guidance available to health science programs. Grounded in the ADA, case law, and OCR determinations, this seminal text delivers information that is translatable to daily practice. The second edition focuses on disability as a welcome form of diversity, with concomitant changes to language and approach that promote disability inclusion. New chapters and updates on topics including technical standards; a new appendix to guide faculty communication; and revised advice throughout, provide faculty, student affairs and disability professionals with the most up-to-date practices. The text delivers updated legal guidance and case references, assistance in benchmarking office policies and practices, new case studies, and a review chapter for teaching and assessing learning. New examples impart the best decision-making practices, describe what to do when things go awry, and discuss how to avoid problems by implementing strong accessibility-focused policies. Written by noted educators and practitioners at prestigious health science schools, this text is backed by years of practice and expertise. It is written in an easy-to-read, engaging manner that makes disability inclusion and disability law accessible to all. New to the Second Edition: Focus on the importance of fully-inclusive education for health care practitioners Real-world informed case studies that demonstrate best practices New and updated advice highlighting recent legal decisions New chapter on technical standards Updated guidance to inform office policies and practices Chapter specific review questions for teaching and self-assessment Expanded discussion of clinical accommodations Updated guides for high stakes exams, including new personal statement prompts Communication guide for faculty Key Features: Addresses all aspects of disability, including disability law, for students in health science settings Delivers information directly applicable to practice Accessibly written by esteemed and experienced practitioners and educators Includes easy-to-follow flowcharts Supports professional development in an affordable format
Book Synopsis Comprehensive and Molecular Phytopathology by : Yuri Dyakov
Download or read book Comprehensive and Molecular Phytopathology written by Yuri Dyakov and published by Elsevier. This book was released on 2007-01-09 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a collection of information on successive steps of molecular ‘dialogue’ between plants and pathogens. It additionally presents data that reflects intrinsic logic of plant-parasite interactions. New findings discussed include: host and non-host resistance, specific and nonspecific elicitors, elicitors and suppressors, and plant and animal immunity. This book enables the reader to understand how to promote or prevent disease development, and allows them to systematize their own ideas of plant-pathogen interactions. * Offers a more extensive scope of the problem as compared to other books in the market* Presents data to allow consideration of host-parasite relationships in dynamics and reveals interrelations between pathogenicity and resistance factors* Discusses beneficial plant-microbe interactions and practical aspects of molecular investigations of plant-parasite relationships* Compares historical study of common and specific features of plant immunity with animal immunity
Book Synopsis Computers in Chemistry by : Ajit J. Thakkar
Download or read book Computers in Chemistry written by Ajit J. Thakkar and published by Springer. This book was released on 1973-06-12 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Masters Theses in the Pure and Applied Sciences by : Wade H. Shafer
Download or read book Masters Theses in the Pure and Applied Sciences written by Wade H. Shafer and published by Springer. This book was released on 1985-03 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Masters Theses in the Pure and Applied Sciences was first conceived, published, and disseminated by the Center for Information and Numerical Data Analysis and Synthesis (CINDAS) * at Purdue University in 1 957, starting its coverage of theses with the academic year 1955. Beginning with Volume 13, the printing and dissemination phases of the activity were transferred to University Microfilms/Xerox of Ann Arbor, Michigan, with the thought that such an arrangement would be more beneficial to the academic and general scientific and technical community. After five years of this joint undertaking we had concluded that it was in the interest of all con cerned if the printing and distribution of the volumes were handled by an interna tional publishing house to assure improved service and broader dissemination. Hence, starting with Volume 18, Masters Theses in the Pure and Applied Sciences has been disseminated on a worldwide basis by Plenum Publishing Cor poration of New York, and in the same year the coverage was broadened to include Canadian universities. All back issues can also be ordered from Plenum. We have reported in Volume 28 (thesis year 1 983) a total of 10,661 theses titles from 26 Canadian and 197 United States universities. We are sure that this broader base for these titles reported will greatly enhance the value of this important annual reference work. While Volume 28 reports theses submitted in-1983, on occasion, certain univer sities do report theses submitted in previous years but not reported at the time.
Book Synopsis Computer Modelling for Nutritionists by : Mark Tomás Mc Auley
Download or read book Computer Modelling for Nutritionists written by Mark Tomás Mc Auley and published by Springer. This book was released on 2019-10-08 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book draws on Mark Mc Auley’s wealth of experience to provide an intuitive step-by-step guide to the modelling process. It also provides case studies detailing the creation of biological process models. Mark Mc Auley has over 15 years’ experience of applying computing to challenges in bioscience. Currently he is employed as a Senior Lecturer in Chemical Engineering at the University of Chester. He has published widely on the use of computer modelling in nutrition and uses computer modelling to both enhance and enrich the learning experience of the students that he teaches. He has taught computer modelling to individuals at a wide variety of levels and from different backgrounds, from undergraduate nutrition students to PhD and medical students.
Book Synopsis Isocyanide-based Multicomponent Reactions by : Jonathan G. Rudick
Download or read book Isocyanide-based Multicomponent Reactions written by Jonathan G. Rudick and published by Frontiers Media SA. This book was released on 2020-02-20 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Anion Sensing written by Eric V. Anslyn and published by Springer Science & Business Media. This book was released on 2005-05-06 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: with contributions by numerous experts
Book Synopsis In Defence of Rhetoric by : Brian Vickers
Download or read book In Defence of Rhetoric written by Brian Vickers and published by Oxford University Press, USA. This book was released on 1988 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: A spirited effort to restore the importance of rhetoric, this book examines its early development in the classical era, its triumph during the Renaissance, and its subsequent decline. While acknowledging rhetoric's general loss of prestige, the author asserts its value in modern times as an indispensable vehicle for style and thought in the work of Joyce, Orwell, Jarrell, and others, and concludes by surveying rhetoric's fragmentation and misapplication in the current critical theories of such thinkers as Jakobson and de Man.
Book Synopsis Phthalocyanines by : Leznoff, C. C. (Clifford C.)
Download or read book Phthalocyanines written by Leznoff, C. C. (Clifford C.) and published by New York : VCH, 1989-c1996.. This book was released on 1989 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Up-to-date and written by leading experts, this book is unique in a rapidly expanding field. It provides in-depth discussions and descriptions of the materials, electronic properties and applications of phthalocyanines. Aspects of phthalocyanines covered include * synthesis * polymer aspects * electronic spectroscopy * excited state chemistry and physics * chemical sensors * biological aspects (e.g. photodynamic therapy of cancer) The numerous tables, chemical structures, and references are particularly handy source materials for both the novice and experienced researcher and industrial practitioner interested in phthalocyanines.
Book Synopsis Antiepileptic Drug Discovery by : Alan Talevi
Download or read book Antiepileptic Drug Discovery written by Alan Talevi and published by Humana. This book was released on 2016-09-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thorough volume delves into antiepileptic drug discovery with a comprehensive collection of innovative approaches for the development of antiepileptic therapies, focusing on novel molecular targets for antiepileptic drugs, computer-aided approaches for the identification of new drug candidates, and therapeutic strategies to overcome refractory epilepsy. The last section illustrates the potential benefits that network pharmacology and rational drug repurposing could bring to the antiepileptic drug discovery community. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of detailed description and implementation advice to ensure results in the laboratory. Authoritative and practical, Antiepileptic Drug Discovery: Novel Approaches aims to provide medicinal chemists, pharmacologists, and other researchers with the tools need to further explore the study of pharmacoresistant epilepsy and the discovery of new antiepileptic drugs.
