Author : Emily Southmayd
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (11 download)
Book Synopsis Exploration of the Independent and Combined Effects of Energy and Estrogen on Bone Metabolism, Bone Structure, and Estimated Bone Strength in Young Exercising Women by : Emily Southmayd
Download or read book Exploration of the Independent and Combined Effects of Energy and Estrogen on Bone Metabolism, Bone Structure, and Estimated Bone Strength in Young Exercising Women written by Emily Southmayd and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Female Athlete Triad (Triad), a syndrome of low energy availability, menstrual dysfunction, and low bone mineral density (BMD), affects up to 60% of exercising girls and women. As such, understanding the physiology underlying the Triad is imperative in order to identify therapeutic targets and develop effective treatment strategies to prevent long-term health detriments in afflicted women. Bone health is a major clinical outcome of concern in female athletes and exercising women with the Triad, as bone loss or suboptimal peak bone mass development may predispose women to osteoporosis and related fractures later in life. To garner a better understanding of factors contributing to bone health and to inform guidelines for treatment targets in female athletes and exercising women with the Triad, this purpose of this dissertation was 1) to assess the unique and combined effects of energy status and estrogen status on volumetric BMD (vBMD), bone geometry, and estimated bone strength in exercising women, 2) to assess the unique and combined effects of energy status and estrogen status on bone turnover in exercising women, 3) to evaluate predictors of change in bone turnover dynamics across a 12-month nutritional intervention in women with exercise-associated menstrual disturbances, and 4) to determine if bone turnover dynamics at baseline impact BMD outcomes in women with exercise-associated menstrual disturbances participating in a nutritional intervention. Key findings of the studies that made up this dissertation implicate that energy status is a main driving factor dictating vBMD, bone geometry, estimated bone strength, and bone metabolism in exercising women. The results indicate that improving energetic status will not only improve bone turnover at the cellular level, but that bone turnover favoring bone formation over bone resorption will also predict improved BMD in the following year. The findings support the guidelines put forth by the Female Athlete Triad Coalition that endorse nutritional therapy as the first line of treatment for the Triad, as low energy availability is the root cause of the clinical sequelae, including menstrual dysfunction and compromised bone health.