Exploration of the Independent and Combined Effects of Energy and Estrogen on Bone Metabolism, Bone Structure, and Estimated Bone Strength in Young Exercising Women

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ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis Exploration of the Independent and Combined Effects of Energy and Estrogen on Bone Metabolism, Bone Structure, and Estimated Bone Strength in Young Exercising Women by : Emily Southmayd

Download or read book Exploration of the Independent and Combined Effects of Energy and Estrogen on Bone Metabolism, Bone Structure, and Estimated Bone Strength in Young Exercising Women written by Emily Southmayd and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Female Athlete Triad (Triad), a syndrome of low energy availability, menstrual dysfunction, and low bone mineral density (BMD), affects up to 60% of exercising girls and women. As such, understanding the physiology underlying the Triad is imperative in order to identify therapeutic targets and develop effective treatment strategies to prevent long-term health detriments in afflicted women. Bone health is a major clinical outcome of concern in female athletes and exercising women with the Triad, as bone loss or suboptimal peak bone mass development may predispose women to osteoporosis and related fractures later in life. To garner a better understanding of factors contributing to bone health and to inform guidelines for treatment targets in female athletes and exercising women with the Triad, this purpose of this dissertation was 1) to assess the unique and combined effects of energy status and estrogen status on volumetric BMD (vBMD), bone geometry, and estimated bone strength in exercising women, 2) to assess the unique and combined effects of energy status and estrogen status on bone turnover in exercising women, 3) to evaluate predictors of change in bone turnover dynamics across a 12-month nutritional intervention in women with exercise-associated menstrual disturbances, and 4) to determine if bone turnover dynamics at baseline impact BMD outcomes in women with exercise-associated menstrual disturbances participating in a nutritional intervention. Key findings of the studies that made up this dissertation implicate that energy status is a main driving factor dictating vBMD, bone geometry, estimated bone strength, and bone metabolism in exercising women. The results indicate that improving energetic status will not only improve bone turnover at the cellular level, but that bone turnover favoring bone formation over bone resorption will also predict improved BMD in the following year. The findings support the guidelines put forth by the Female Athlete Triad Coalition that endorse nutritional therapy as the first line of treatment for the Triad, as low energy availability is the root cause of the clinical sequelae, including menstrual dysfunction and compromised bone health.

The Impact of Estrogen Vs Energy Status on Bone Balance and Bone Turnover Rate in Young Exercising Women

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ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis The Impact of Estrogen Vs Energy Status on Bone Balance and Bone Turnover Rate in Young Exercising Women by : Andrew Philip Oneglia

Download or read book The Impact of Estrogen Vs Energy Status on Bone Balance and Bone Turnover Rate in Young Exercising Women written by Andrew Philip Oneglia and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Energy and estrogen deficiencies are detrimental to bone health in exercising women, but the significance of each independently has not been extensively examined, as energy and estrogen deficiency often occur simultaneously. The purpose of this study was to assess markers of bone formation (procollagen type I N-terminal propeptide) and resorption (serum C-terminal telopeptides) utilized in mathematical models of bone turnover to quantify how energy and estrogen status relate to indices of bone formation, bone resorption, the net balance of bone formation and resorption (bone balance), and bone turnover rate in 109 physically active, premenopausal women (18-35 years old). Energy status was assessed using total triiodothyronine (TT3) concentration; estrogen status was assessed using self-reported history of menses verified by prospective assessments of urinary estrone-1-glucuronide (E1G) and pregnanediol glucuronide (PdG). Participants were categorized as energy replete (EnR) or energy deficient (EnD) and estrogen replete (E2R) or estrogen deficient (E2D), resulting in four subgroups: EnR+E2R (n=37), EnR+E2D (n=18), EnD+E2R (n=22) and EnD+E2D (n=32). All groups were similar with respect to height and weight (p>0.05). Energy deficiency was associated with suppressed TT3 concentrations (67.11.4 ng/dL, p

Energy Restriction Effects on Estrogen Status and the Skeletal Response to Loading

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ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (761 download)

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Book Synopsis Energy Restriction Effects on Estrogen Status and the Skeletal Response to Loading by : Sibyl Nichole Swift

Download or read book Energy Restriction Effects on Estrogen Status and the Skeletal Response to Loading written by Sibyl Nichole Swift and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Moderate energy restriction in young, exercising women attenuates the positive effects of exercise on bone density. Studies have shown that in the absence of adequate levels of circulating estrogen, there may not be enough functional estrogen receptor-a (ER-a) to respond adequately to loading. The experiment described in this document is significant because this model has not been explored under conditions of energy restriction (EnR) which are known to reduce circulating estrogen levels; it has been tested only in ovariectomized animals. The central hypothesis of this research is that reductions in estrogen due to EnR limit the ability of bone to respond to mechanical loading (LOAD) through a down-regulation of ER-a. Study one determined which nutrient's (calcium or energy) restriction ( -40 percent) had the greatest negative effects on the skeletal integrity of exercising female rats and whether exercise (EX) could mitigate these deleterious changes. EnR caused detrimental effects in many of the structural properties of bone; however EX attenuated losses in cancellous bone. Study two ascertained whether EX maintained cancellous bone mass in female rats subjected to graded EnR ( -20 or -40 percent) and whether changes in endocrine factors were related. EX preserved cancellous bone volume and osteoblast activity under both levels of EnR, in addition to total body lean mass and bone mineral content. A similar maintenance of serum insulin-like growth factor and estradiol occurred in the EX EnR(40 percent) group suggesting that these changes may be related to the protective effects of EX. Study three determined the effects of 40 percent EnR on bone formation rate to LOAD in young adult female rats and tracked alterations in ovarian function (estradiol). Although higher than non-loaded animals, the response of bone to LOAD in EnR animals was dampened in comparison to energy-replete animals. The experiments described in this document are significant because these are the first experiments to explore the relationship between EnR and estrogen levels on cancellous bone response to LOAD. This is particularly important for physically active, energy restricted women because cancellous bone in these women will not experience the same effects of loading which can increase their risk for developing osteoporosis.

Translational Studies Into the Effects of Exercise on Estimated Bone Strength

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ISBN 13 :
Total Pages : 394 pages
Book Rating : 4.:/5 (934 download)

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Book Synopsis Translational Studies Into the Effects of Exercise on Estimated Bone Strength by : Alyssa M. Weatherholt

Download or read book Translational Studies Into the Effects of Exercise on Estimated Bone Strength written by Alyssa M. Weatherholt and published by . This book was released on 2015 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanical loading associated with exercise is known to benefit bone health; however, most studies explore exercise benefits on bone mass independent of bone structure and strength. The purpose of this dissertation is to explore the response of the skeleton to exercise across the translational divide between animal- and human-based studies, with a particular emphasis on exercise-induced changes in bone structure and estimated strength. To explore the skeletal benefits of exercise, models were used wherein loading is introduced unilaterally to one extremity. Unilateral exercise enables the contralateral, non-exercised extremity to be used as an internal control site for the influences of systemic factors, such as genetics and circulating hormones. In study 1, a dose response between load magnitude and tibial midshaft cortical bone adaptation was observed in mice that had their right tibia loaded in axial compression at one of three load magnitudes for 3 d/wk over 4 weeks. In study 2, the ability of peripheral quantitative computed tomography to provide very good prediction of midshaft humerus mechanical properties with good short-term precision in human subjects was demonstrated. In study 3, collegiate-level jumping (long and/or high jump) athletes were shown to have larger side-to-side differences in tibial midshaft structure and estimated strength between their jump and lead legs than observed in non-jumping athletes. In study 4, prepubertal baseball players followed for 12 months were shown to gain more bone mass, structure and estimated strength in their throwing arm relative to their nonthrowing arm over the course of 12 months. These cumulative data using a combination of experimental models ranging from animal to cross-sectional and longitudinal human models demonstrate the ability of the skeleton to adapt its structure and estimated strength to the mechanical loading associated with exercise. Study of these models in future work may aid in optimizing skeletal responses to exercise.

Bone Health and Osteoporosis

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Publisher :
ISBN 13 : 9781410219275
Total Pages : 0 pages
Book Rating : 4.2/5 (192 download)

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Book Synopsis Bone Health and Osteoporosis by : United States Public Health Service

Download or read book Bone Health and Osteoporosis written by United States Public Health Service and published by . This book was released on 2004-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first-ever Surgeon General's Report on bone health and osteoporosis illustrates the large burden that bone disease places on our Nation and its citizens. Like other chronic diseases that disproportionately affect the elderly, the prevalence of bone disease and fractures is projected to increase markedly as the population ages. If these predictions come true, bone disease and fractures will have a tremendous negative impact on the future well-being of Americans. But as this report makes clear, they need not come true: by working together we can change the picture of aging in America. Osteoporosis, fractures, and other chronic diseases no longer should be thought of as an inevitable part of growing old. By focusing on prevention and lifestyle changes, including physical activity and nutrition, as well as early diagnosis and appropriate treatment, Americans can avoid much of the damaging impact of bone disease and other chronic diseases. This Surgeon General's Report brings together for the first time the scientific evidence related to the prevention, assessment, diagnosis, and treatment of bone disease. More importantly, it provides a framework for moving forward. The report will be another effective tool in educating Americans about how they can promote bone health throughout their lives. This first-ever Surgeon General's Report on bone health and osteoporosis provides much needed information on bone health, an often overlooked aspect of physical health. This report follows in the tradition of previous Surgeon Generals' reports by identifying the relevant scientific data, rigorously evaluating and summarizing the evidence, and determining conclusions.

Optimizing Bone Mass and Strength

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Publisher : Karger Medical and Scientific Publishers
ISBN 13 :
Total Pages : 180 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Optimizing Bone Mass and Strength by : Robin M. Daly

Download or read book Optimizing Bone Mass and Strength written by Robin M. Daly and published by Karger Medical and Scientific Publishers. This book was released on 2007 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteoporosis and related fractures are a major public health problem globally. Although traditionally considered to be a disease affecting the elderly, increased recognition that osteoporosis may have its foundation early in life has stimulated substantial research interest into factors which can influence skeletal development, including both genetic and lifestyle factors. This book provides a summary and integrative review of the current state of knowledge of factors that influence the development of bone health during childhood and adolescence. The focus is on the role of physical activity for optimizing bone development. Other relevant topics that are reviewed include the influence of genetics, nutrition, and hormonal factors on skeletal development. In addition, there are expert views on practical lifestyle strategies and guidelines that can be adopted to optimize bone health and prevent fractures during growth. The book provides an excellent source of recent information for exercise specialists, pediatricians, nutritionists, biomedical researchers, health promotion worker and public health professionals.

The Female Athlete Triad

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Publisher : Springer
ISBN 13 : 148997525X
Total Pages : 187 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis The Female Athlete Triad by : Catherine M. Gordon

Download or read book The Female Athlete Triad written by Catherine M. Gordon and published by Springer. This book was released on 2014-10-28 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book of its kind to focus solely on the female athlete triad - its origins, its recognition, and most importantly, its management. Since the symptoms themselves cover a range of medical specialties, chapters are written by experts in a number of relevant fields - sports medicine, orthopedics, endocrinology, and pediatrics - with an eye toward overall care of the young female athlete. Additionally, each chapter includes suggestions on how to educate and communicate with young athletes and their parents, as well as trainers and coaches, on how to manage the illness outside of the direct clinical setting. The female athlete triad is often seen in sports where low body weight is emphasized, such as gymnastics, figure skating, and running, though it can appear in any sport or activity. The interrelated symptoms - eating disorders, amenorrhea, and low bone mass - exist on a spectrum of severity and are serious and potentially life-threatening if not properly treated. Psychological problems, in addition to medical ones, are not uncommon. The Female Athlete Triad: A Clinical Guide discusses all of these areas for a well-rounded and in-depth approach to the phenomenon and will be a useful reference for any clinician working with female athletes across the lifespan.

Nutrition and Bone Health

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Publisher : Springer
ISBN 13 : 1493920014
Total Pages : 737 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Nutrition and Bone Health by : Michael F. Holick

Download or read book Nutrition and Bone Health written by Michael F. Holick and published by Springer. This book was released on 2014-12-13 with total page 737 pages. Available in PDF, EPUB and Kindle. Book excerpt: This newly revised edition contains updated versions of all of the topics that were in the first edition and has been substantially expanded with an additional 5 chapters. Each chapter includes information from the most up-to-date research on how nutritional factors can affect bone health, written with an evidence-based focus and complete with comprehensive references for each subject. Nutrition and Bone Health, second edition covers all aspects of nutrition and the skeleton, from the history and fundamentals, to the effects of macronutrients, minerals, vitamins, and supplements, and even covers the effects of lifestyle, the different life stages, and nutrition-related disorders and secondary osteoporosis. New chapters include HIV & AIDs and the skeleton, celiac disease and bone health, and nutrition and bone health in space. Nutrition and Bone Health, second edition is a necessary resource for health care professionals, medical students, graduate students, dietitians, and nutritionists who are interested in how nutrition affects bone health during all stages of life.

Glucocorticoid-induced Osteoporosis

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Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805572964
Total Pages : 213 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Glucocorticoid-induced Osteoporosis by : Andrea Giustina

Download or read book Glucocorticoid-induced Osteoporosis written by Andrea Giustina and published by Karger Medical and Scientific Publishers. This book was released on 2002 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteoporosis is one of the most clinically relevant disabling chronic disease encountered in clinical practice. A common cause of osteoporosis is glucocorticoid excess, as glucocorticoids may increase bone resorption, inhibit bone formation, have indirect actions on bone by decreasing intestinal calcium absorption and induce hypercalciuria. This book presents a comprehensive overview of the effects of glucocorticoids on bone metabolism and structure and on the diagnosis and treatment of glucocorticoid-induced osteoporosis. It aims at providing updated information on the pathogenesis, diagnosis and treatment of this often dramatic complication of glucocorticoid excess. Being one of the few publications completely devoted to glucocorticoid-induced osteoporosis it will heighten the awareness of specialists who prescribe glucocorticoids of the clinical relevance of this treatment complication. 'Glucocorticoid-Induced Osteoporosis' is addressed to clinical experts as well as to general practitioners who will both benefit from the comprehensive and integrative view of the management of patients exposed to glucocorticoids.

Educating the Student Body

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Publisher : National Academies Press
ISBN 13 : 0309283140
Total Pages : 503 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Educating the Student Body by : Committee on Physical Activity and Physical Education in the School Environment

Download or read book Educating the Student Body written by Committee on Physical Activity and Physical Education in the School Environment and published by National Academies Press. This book was released on 2013-11-13 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physical inactivity is a key determinant of health across the lifespan. A lack of activity increases the risk of heart disease, colon and breast cancer, diabetes mellitus, hypertension, osteoporosis, anxiety and depression and others diseases. Emerging literature has suggested that in terms of mortality, the global population health burden of physical inactivity approaches that of cigarette smoking. The prevalence and substantial disease risk associated with physical inactivity has been described as a pandemic. The prevalence, health impact, and evidence of changeability all have resulted in calls for action to increase physical activity across the lifespan. In response to the need to find ways to make physical activity a health priority for youth, the Institute of Medicine's Committee on Physical Activity and Physical Education in the School Environment was formed. Its purpose was to review the current status of physical activity and physical education in the school environment, including before, during, and after school, and examine the influences of physical activity and physical education on the short and long term physical, cognitive and brain, and psychosocial health and development of children and adolescents. Educating the Student Body makes recommendations about approaches for strengthening and improving programs and policies for physical activity and physical education in the school environment. This report lays out a set of guiding principles to guide its work on these tasks. These included: recognizing the benefits of instilling life-long physical activity habits in children; the value of using systems thinking in improving physical activity and physical education in the school environment; the recognition of current disparities in opportunities and the need to achieve equity in physical activity and physical education; the importance of considering all types of school environments; the need to take into consideration the diversity of students as recommendations are developed. This report will be of interest to local and national policymakers, school officials, teachers, and the education community, researchers, professional organizations, and parents interested in physical activity, physical education, and health for school-aged children and adolescents.

Clinical Gynecology

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Publisher : Cambridge University Press
ISBN 13 : 1107040396
Total Pages : 1127 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis Clinical Gynecology by : Eric J. Bieber

Download or read book Clinical Gynecology written by Eric J. Bieber and published by Cambridge University Press. This book was released on 2015-04-23 with total page 1127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.

Neural Control of the Pituitary Gland

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Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (689 download)

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Book Synopsis Neural Control of the Pituitary Gland by : Geoffrey Wingfield Harris

Download or read book Neural Control of the Pituitary Gland written by Geoffrey Wingfield Harris and published by . This book was released on 1971 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Diagnosis and Management of Ovarian Disorders

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Publisher : Elsevier
ISBN 13 : 008049451X
Total Pages : 595 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Diagnosis and Management of Ovarian Disorders by : Albert Altchek

Download or read book Diagnosis and Management of Ovarian Disorders written by Albert Altchek and published by Elsevier. This book was released on 2003-09-04 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated second edition of Diagnosis and Management of Ovarian Disorders provides thorough, yet succinct insight into the ever-changing realm of ovarian disorders. It presents a novel multidisciplinary approach to the subject as described by clinicians, surgeons, pathologists, basic scientists and related medical researchers. Topics covered include reproductive technology, early diagnosis of ovarian cancer, and management of menopause among others. The breadth of information provided by this book will appeal to clinicians and researchers involved in the study and treatment of ovarian disorders.KEY FEATURES* Includes updated information on early diagnosis of ovarian cancer* Reviews new diagnostic techniques for ovarian disorders* Discusses latest information on reproductive technology* Presents translational treatment linking laboratory research with clinical medicine

Livestock's Long Shadow

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Publisher : Food & Agriculture Org.
ISBN 13 : 9789251055717
Total Pages : 418 pages
Book Rating : 4.0/5 (557 download)

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Book Synopsis Livestock's Long Shadow by : Henning Steinfeld

Download or read book Livestock's Long Shadow written by Henning Steinfeld and published by Food & Agriculture Org.. This book was released on 2006 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The assessment builds on the work of the Livestock, Environment and Development (LEAD) Initiative"--Pref.

Clinical Case Studies for the Family Nurse Practitioner

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Publisher : John Wiley & Sons
ISBN 13 : 1118277856
Total Pages : 432 pages
Book Rating : 4.1/5 (182 download)

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Book Synopsis Clinical Case Studies for the Family Nurse Practitioner by : Leslie Neal-Boylan

Download or read book Clinical Case Studies for the Family Nurse Practitioner written by Leslie Neal-Boylan and published by John Wiley & Sons. This book was released on 2011-11-28 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Case Studies for the Family Nurse Practitioner is a key resource for advanced practice nurses and graduate students seeking to test their skills in assessing, diagnosing, and managing cases in family and primary care. Composed of more than 70 cases ranging from common to unique, the book compiles years of experience from experts in the field. It is organized chronologically, presenting cases from neonatal to geriatric care in a standard approach built on the SOAP format. This includes differential diagnosis and a series of critical thinking questions ideal for self-assessment or classroom use.

Handbook of Sports Medicine and Science

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Publisher : John Wiley & Sons
ISBN 13 : 1118862201
Total Pages : 144 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Handbook of Sports Medicine and Science by : Margo Mountjoy

Download or read book Handbook of Sports Medicine and Science written by Margo Mountjoy and published by John Wiley & Sons. This book was released on 2014-10-06 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new International Olympic Committee (IOC) handbook covers the science, medicine and psycho-social aspects of females in sports at all levels of competition. Each chapter focuses on the specific issues that female athletes confront both on and off the field, such as bone health, nutritional recommendations, exercise/competition during menstruation and pregnancy, and much more. Fully endorsed by the IOC and drawing upon the experience of an international team of expert contributors, no other publication deals with the topic in such a concise and complete manner. The Female Athlete is recommended for all health care providers for women and girl athletes internationally for all sports and all levels of competition. It is a valuable resource for medical doctors, physical and occupational therapists, nutritionists, and sports scientists as well as coaches, personal trainers and athletes.

Skeletal Tissue Mechanics

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Publisher : Springer
ISBN 13 : 1493930028
Total Pages : 513 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Skeletal Tissue Mechanics by : R. Bruce Martin

Download or read book Skeletal Tissue Mechanics written by R. Bruce Martin and published by Springer. This book was released on 2015-10-29 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook describes the biomechanics of bone, cartilage, tendons and ligaments. It is rigorous in its approach to the mechanical properties of the skeleton yet it does not neglect the biological properties of skeletal tissue or require mathematics beyond calculus. Time is taken to introduce basic mechanical and biological concepts, and the approaches used for some of the engineering analyses are purposefully limited. The book is an effective bridge between engineering, veterinary, biological and medical disciplines and will be welcomed by students and researchers in biomechanics, orthopedics, physical anthropology, zoology and veterinary science. This book also: Maximizes reader insights into the mechanical properties of bone, fatigue and fracture resistance of bone and mechanical adaptability of the skeleton Illustrates synovial joint mechanics and mechanical properties of ligaments and tendons in an easy-to-understand way Provides exercises at the end of each chapter