Experimental and Modelling Study of Gerbil Middle Ear

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ISBN 13 :
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Book Synopsis Experimental and Modelling Study of Gerbil Middle Ear by : Nima Maftoon

Download or read book Experimental and Modelling Study of Gerbil Middle Ear written by Nima Maftoon and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "This thesis presents in vivo experimental measurements of vibrations on the surgically exposed tympanic membrane (TM) in the gerbil and a finite-element model of the gerbil middle ear. The TM is composed of the pars tensa and pars flaccida and is connected to the middle-ear bones via the manubrium of the malleus. Measurements were done on the pars flaccida and at several points along the manubrium and on the pars tensa using a laser Doppler vibrometer. Measurements were first done with a closed middle-ear cavity. The manubrial points show an increasing displacement magnitude from the lateral process toward the umbo, with the apparent axis of rotation shifting at high frequencies. Above 5 kHz, phase differences between points along the manubrium may indicate flexing in the manubrium. The simple low-frequency vibration pattern of the pars tensa breaks up at between 1.8 and 2.8 kHz.The effects of progressive opening of the middle-ear cavity were then explored. In all responses, opening the cavity causes an increase in the low-frequency magnitude and a shift of the main middle-ear resonance to lower frequencies, and introduces an antiresonance. However, opening the cavity has little or no effect on either the mode of vibration of the manubrium or the breakup frequency of the pars tensa. An identification method was developed for eliminating the effect of the antiresonance. It was validated and then applied to manubrial and pars-tensa responses. The finite-element model developed in this study uses a set of baseline parameters based primarily on a priori estimates from the literature. Responses from the model were validated against our measurements and against measurements from other groups. The responses of the model are mostly within the range of variability seen in the experimental data. A sensitivity analysis ranked the parameters of the model based on their effects on the model results." --

Vibrations of the Gerbil Middle Ear Under Quasi-static Pressures

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ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (134 download)

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Book Synopsis Vibrations of the Gerbil Middle Ear Under Quasi-static Pressures by : Orhun Kose

Download or read book Vibrations of the Gerbil Middle Ear Under Quasi-static Pressures written by Orhun Kose and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Tympanometry is a clinical test that records the response of the ear to sound during large air-pressure sweeps, to determine the status of the external and middle ear. The acoustical and mechanical response of the ear during this test is not well understood. To help improve our understanding, in this thesis we investigate the effects of quasi-static pressures on vibrations of the gerbil eardrum. Using a single-point laser Doppler vibrometer (LDV), the vibration magnitudes at several locations on the eardrum were measured. A pressurization cycle included decreasing the middle-ear pressure from 0 Pa to −2500 Pa, increasing it back to 0 Pa, increasing it to +2500 Pa, and then decreasing it back to 0 Pa. The acoustic input was a linear chirp ranging from 0.5 to 10 kHz. The first experimental study used a step-wise pressurization protocol in which the pressure was changed in 500-Pa increments and held constant for 10 s at each step. The low-frequency vibration magnitude decreased for both negative and positive pressures, with larger changes at smaller pressures; the magnitudes were smaller for negative middle-ear pressures than for the corresponding positive ones. At zero middle-ear pressure, as the frequency increased the vibration magnitude initially increased slightly up to a broad peak (R1), but as the pressure was made more negative the low-frequency vibration magnitude became constant with frequency and later decreased with frequency, and R1 shifted to slightly higher frequencies. R1 was visible at all locations for small pressures, and on the manubrium it was also visible for larger negative pressures. There was a magnitude dip around −1000 to −1500 Pa. A higher-frequency peak (R2) shifted gradually for large pressures, and was visible at all locations; it was seen as a cluster of peaks on the pars tensa. A small low-frequency peak at about 0.7 kHz was only visible on the pars flaccida. The overall vibration magnitude at the umbo was slightly higher than at mid-manubrium. The largest vibration magnitudes were observed on the posterior pars tensa. The frequency response on the pars flaccida was smooth near ambient pressure, similar to that at the umbo, but it changed rapidly when pressurized, already displaying a series of pronounced peaks and troughs by ±500 Pa.The second experimental study used a continuous pressure sweep instead of steps, with the same overall cycle duration as in the first study. The response behaviours were similar to those seen for pressure steps but many more details could be observed. For example, the magnitude dip started near R2 and then expanded quickly to frequencies below that peak. A trough on the posterior pars tensa, which shifted in a way similar to R2, appeared as a peak on the anterior pars tensa.A previous finite-element model, which simulated responses to both sounds and large quasi-static pressures, was further developed to accommodate both pressure steps and pressure sweeps. The simulation results were compared with our data and with data from other groups. The model replicates some of the experimentally observed behaviours but there are some discrepancies. Collectively these experimental and modelling studies will ultimately lead to being able to extract more information from tympanometry and thus to improvements in clinical decision making"--

An Experimental Study of Middle-ear Vibrations in Gerbils

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ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (129 download)

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Book Synopsis An Experimental Study of Middle-ear Vibrations in Gerbils by : Shruti Nambiar

Download or read book An Experimental Study of Middle-ear Vibrations in Gerbils written by Shruti Nambiar and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

An Experimental Study of Middle-ear Vibrations in Gerbils

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ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (427 download)

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Book Synopsis An Experimental Study of Middle-ear Vibrations in Gerbils by : Nicolas Ellaham

Download or read book An Experimental Study of Middle-ear Vibrations in Gerbils written by Nicolas Ellaham and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Finite-element Modelling of the Gerbil Middle Ear

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ISBN 13 :
Total Pages : 242 pages
Book Rating : 4.:/5 (252 download)

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Book Synopsis Finite-element Modelling of the Gerbil Middle Ear by : Nidal Elkhouri

Download or read book Finite-element Modelling of the Gerbil Middle Ear written by Nidal Elkhouri and published by . This book was released on 2005 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Hearing loss is the third leading chronic disability after arthritis and hypertension, and the most frequent birth defect. Non-invasive diagnoses and middle-ear prostheses are often unsatisfactory, partly because of a lack of understanding of middle-ear mechanics. The focus of this thesis is to develop a 3-D finite-element model to quantify the mechanics of the gerbil middle ear. An MRM dataset with a voxel size of 45 &mgr;m, and an x-ray micro-CT dataset with a voxel size of 5 um, supplemented by histological images, are the basis for 3-D reconstruction and finite-element mesh generation. The eardrum model is based on moire shape measurements. The material properties of all the structures in the model are based on a priori estimates from the literature." --

An Experimental Study of Vibrations in the Gerbil Middle Ear Under Static Pressure

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ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (911 download)

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Book Synopsis An Experimental Study of Vibrations in the Gerbil Middle Ear Under Static Pressure by : Richard Shapiro

Download or read book An Experimental Study of Vibrations in the Gerbil Middle Ear Under Static Pressure written by Richard Shapiro and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "The Mongolian gerbil has become widely used in middle-ear research, because it is low in cost and its middle-ear structures are relatively accessible. This study presents the effects of static pressurization on the vibration response of the gerbil eardrum. A single-point laser Doppler vibrometer is used to acquire frequency responses in eight post mortem gerbil ears. Magnitudes of vibration are normalized with respect to sound pressure level measured near the eardrum and are presented over the range of 0.2 to 10 or 11 kHz. In each gerbil, measurements on the manubrium and on the pars tensa are presented using one of two pressurization protocols. For the unpressurized measurements the inter-specimen variability was small and measurements were more or less repeatable from cycle to cycle. Pressurized responses exhibited magnitude reductions at lower frequencies, then rose to a peak and exhibited sharp features at higher frequencies. As pressure increased, magnitudes decreased and the peak was shifted to higher frequencies. The eardrum break-up frequency was shifted beyond the frequency range of our measurements. On the manubrium we did not observe any viscoelastic or temporal changes. On the pars tensa, changes were observed from cycle to cycle but the reasons are not clear. Our results are compared with previous data in the literature. Understanding the vibration response of the eardrum to pressurization, as well as the roles of viscoelastic and temporal effects, will lead to a better understanding of clinical tympanometry, which is particularly important in infants where the response to tympanometry is not well understood." --

The Endolymphatic Sac of the Mongolian Gerbil

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ISBN 13 : 9789179005269
Total Pages : 34 pages
Book Rating : 4.0/5 (52 download)

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Book Synopsis The Endolymphatic Sac of the Mongolian Gerbil by : Maurizio Barbara

Download or read book The Endolymphatic Sac of the Mongolian Gerbil written by Maurizio Barbara and published by . This book was released on 1988 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Development and Functional Role of Ligaments Within the Gerbil Middle Ear

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ISBN 13 :
Total Pages : 178 pages
Book Rating : 4.:/5 (13 download)

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Book Synopsis Development and Functional Role of Ligaments Within the Gerbil Middle Ear by : Eileen Yvonne Brister

Download or read book Development and Functional Role of Ligaments Within the Gerbil Middle Ear written by Eileen Yvonne Brister and published by . This book was released on 2021 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the relationship between structure and function in the middle ear is important for addressing congenital and acquired conductive hearing loss. The most direct way to investigate this relationship is to experimentally manipulate the anatomy, then measure function. However, knowledge of normal anatomy has not been well-established for the developing ear in model animals. The goals of this work are twofold: to investigate the relationship between structure and function of the ligaments in the middle ear, and to establish normal anatomical development in the gerbil ear, capitalizing on advanced imaging. This study first focused on the anterior mallear and posterior incudal ligaments in the gerbil ear. The attachments were severed, and the change in sound transmission was quantified using air-conduction and bone-conduction thresholds. Ears were imaged, and the change of the resting position of the ossicles was qualitatively discussed. Subsequently, gerbil middle ears 0-21 days after birth were imaged using synchrotron-based microtomography. Development was described qualitatively, and the dimensions, interior structure, and positional relationships of the ossicles were quantified.

The Middle Ear

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Publisher : Springer Science & Business Media
ISBN 13 : 1461465915
Total Pages : 320 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis The Middle Ear by : Sunil Puria

Download or read book The Middle Ear written by Sunil Puria and published by Springer Science & Business Media. This book was released on 2013-03-19 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The middle ear plays a vital role in the sense and sensitivity of hearing. Of the various characteristics that distinguish mammals from other vertebrates, several pertain specifically to the middle-ear system, such as the presence of three middle-ear bones and the four-layer composite structure of the tympanic membrane. The Middle Ear attempts to elucidate the role this system plays in sound transmission, as viewed from both scientific and clinical perspectives.

Finite-element Modelling of Middle-ear Vibrations Under Quasi-static Pressurization

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ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (119 download)

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Book Synopsis Finite-element Modelling of Middle-ear Vibrations Under Quasi-static Pressurization by : Dongfang Qian

Download or read book Finite-element Modelling of Middle-ear Vibrations Under Quasi-static Pressurization written by Dongfang Qian and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Early identification of hearing loss is important because if untreated it can lead to delayed language development and other difficulties. Current tools for newborn hearing screening are subject to excessively high false-positive rates. Tympanometry is a promising tool for improving screening tests by evaluating the condition of the middle ear, but it is poorly understood in newborns. Tympanometry involves large deformations, non-linear responses, viscoelastic (time-dependent) effects, and complex dynamic responses, which make it hard to model. A previous gerbil finite-element model developed in our lab was the first numerical simulation of tympanometry involving the simultaneous application of large quasi-static pressures and small sound pressures, and it succeeded in replicating some features of tympanometry. However, the model involved over-simplified anatomical details of the ossicles to reduce the computational cost. The goal of this study was to improve the model by adding a representation of the incudostapedial joint and its surrounding structures.The model employed a quasi-linear visco-hyperelastic model with several time constants in a Prony series. Material properties were taken from previous models and publications. The tympanic membrane was assumed to be homogeneous and nearly incompressible. The loads, combining high quasi-static pressures with low-amplitude sound pressures, both low-frequency pure tones and wideband chirps, reflected the conditions in tympanometry. The model was verified against our previous models, and validated against data from the literature and our recent laser vibrometry data for the pressurized gerbil middle ear. The model demonstrated experimentally and clinically observed features, including hysteresis and the asymmetry in the vibration amplitude between positive and negative static pressures.This numerical model will help us gain insight into how the middle ear responds to different stimuli and thus open up new approaches to the interpretation of tympanometric measurements"--

The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents

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Publisher : Academic Press
ISBN 13 : 0123809207
Total Pages : 1289 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents by : Mark A. Suckow

Download or read book The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents written by Mark A. Suckow and published by Academic Press. This book was released on 2012-01-09 with total page 1289 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a single volume, comprehensive book sanctioned by the American College of Laboratory Animal Medicine (ACLAM), covering the rabbit, guinea pig, hamster, gerbil and other rodents often used in research. This well illustrated reference includes basic biology, anatomy, physiology, behavior, infectious and noninfectious diseases, husbandry and breeding, common experimental methods, and use of the species as a research model. It is a resource for advancements in the humane and responsible care of: rabbit, guinea pig, hamster, gerbil, chinchilla, deer mouse, kangaroo rat, cotton rat, sand rat, and degu Includes up-to-date, common experimental methods. Organized by species for easy access during bench research.

Finite-element Modelling of the Human Middle Ear Based on X-ray Micro-computed Tomography and Doppler Optical Coherence Tomography in the Same Ear

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ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (111 download)

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Book Synopsis Finite-element Modelling of the Human Middle Ear Based on X-ray Micro-computed Tomography and Doppler Optical Coherence Tomography in the Same Ear by : Xuan Wang

Download or read book Finite-element Modelling of the Human Middle Ear Based on X-ray Micro-computed Tomography and Doppler Optical Coherence Tomography in the Same Ear written by Xuan Wang and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "The middle ear plays a critical role in transferring sound into the inner ear. The vibration patterns of the tympanic membrane (TM) and ossicles have been investigated by many groups but, particularly at high frequencies, are still not well understood. Computational modelling of the middle ear offers a pathway toward a better understanding of the mechanical function of these structures. The tuning and validation of such models require accurate anatomical and mechanical experimental data, but such data usually come from populations of ears and little is known about how differences in individual anatomy and material properties affect middle-ear function. In this study we created a finite-element (FE) numerical model of a middle ear and validated it against vibration measurements from the same ear.A real-time phase-sensitive Doppler optical coherence tomography (OCT) system was used to measure the vibrations of both the TM and the ossicles of a human temporal bone at a stimulation frequency of 500 Hz. The measured vibration pattern of the TM showed a maximal displacement in the posterior region and a smaller maximum in the anterior region. The experimental data also showed smaller displacements on the ossicles, while the cochlear promontory appeared immobile as expected.A 3-D X-ray micro-computed tomography (microCT) scan was acquired for the same ear. A FE model of the middle ear was built using a combination of locally developed and other free and open-source software. The geometry was based on semi-automatic segmentation of the microCT images, and material properties were based on previous studies. A sensitivity analysis was performed to analyze the relative importance of the various parameters. The Doppler OCT images, masked by B-mode OCT images to reduce noise, were also segmented and the resulting 3-D model was transformed to Cartesian coordinates and aligned with the microCT-based model.Two FE solvers (Code_Aster and SAP IV) were used as part of the verification process. The simulated vibration patterns from the different solvers were compared with the measured Doppler-mode OCT velocity data and with data from the literature. The simulation results match well with the shape of the measured vibration pattern of the TM at 500 Hz. Co-registration of OCT and microCT for individual ears is a viable approach for building and validating FE models. If extended to clinical CT scans, this process could lead to patient-specific models and improved diagnosis of pathological changes in the middle ear. The process of creating FE models for the middle ear would need to be streamlined for clinical applications." --

Handbook of Animal Models of Infection

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Publisher : Academic Press
ISBN 13 : 0080533558
Total Pages : 1169 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Handbook of Animal Models of Infection by : Merle A. Sande

Download or read book Handbook of Animal Models of Infection written by Merle A. Sande and published by Academic Press. This book was released on 1999-05-28 with total page 1169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Animal Models of Infection is a complete revision of a three-volume text that was published in 1986. It incorporates the major advances in the field during the past decade, in particular those concerning molecular biological procedures and new models that have been developed. It focuses on both methods and techniques, which makes it an essential and comprehensive reference as well as a benchtop manual. The Handbook will help investigators save time and effort in formulating an approach to test a new potential therapeutic agent or combination of agents for in vivo efficacy and to position the therapy for specific infections where it may have therapeutic promise. The book is divided into five sections; the first covering the general methodologies, followed by sections describing experimental bacterial, mycotic, parasitic, and viral infections. Discusses ethical and safety aspects in an introductory background section Covers principles of animal care and current techniques appropriate for the use of animal models of infection Details a wide range of animals including rodents, rabbits, cats, and primates Provides hands-on descriptions of how to set up the model Discusses the major advantages and limitations of each model Ensures full coverage of bacterial, fungal, viral, and parasitic infections

Vibration Measurements on the Widely Exposed Gerbil Eardrum

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ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (841 download)

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Book Synopsis Vibration Measurements on the Widely Exposed Gerbil Eardrum by : Zinan He

Download or read book Vibration Measurements on the Widely Exposed Gerbil Eardrum written by Zinan He and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Hearing loss is one of the most common birth defects. Early identification of hearing loss is very important because even a mild hearing loss can seriously delay language development and compromise communication, educational and social capabilities. Tympanometry is a promising tool to identify conductive hearing loss through examining the eardrum responses. However, current clinical results are unsatisfactory due to our inadequate knowledge of the complex mechanics of the middle ear. The vibration pattern of the eardrum is a critical factor for understanding tympanometry and the underlying sound transmission in the middle ear. However, very few experimental studies have investigated the vibration patterns of the eardrum.This study involves in vivo measurements of gerbil eardrum vibrations using laser Doppler vibrometry. An experimental approach to widely expose the eardrum has been developed. This wider exposure allows measurements to be taken on a larger area ...

Cochlear Mechanics

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Publisher : S. Karger AG (Switzerland)
ISBN 13 : 9783805569880
Total Pages : 0 pages
Book Rating : 4.5/5 (698 download)

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Book Synopsis Cochlear Mechanics by : Frank Böhnke

Download or read book Cochlear Mechanics written by Frank Böhnke and published by S. Karger AG (Switzerland). This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This special issue collects our current knowledge of the mechanical processing of acoustic signals by the cochlea and its containing structures. Many workers in diverse disciplines in otology use the facts from cochlear mechanics for the interpretation of their results. Presented here for the first time is the development of a three-dimensional mechanical model of the curved cochlea including fluid-structure couplings. An important approach for future cochlear modeling is shown by the provision of geometrical data for the input of three-dimensional finite element models by microtomographic imaging. A remarkable article tries to demonstrate a connection between outer hair cell mechanics and the complex phenomenon of tinnitus and will be of special interest for stress engineers. Owing to its strong interdisciplinarity, this issue is not only intended for biophysicists, ENT clinicians and audiologists but also for radiologists, biomechanical engineers and computer engineers.

Biomechanics of the Musculo-Skeletal System

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Publisher : Chichester ; Toronto : J. Wiley
ISBN 13 :
Total Pages : 608 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Biomechanics of the Musculo-Skeletal System by : Benno M. Nigg

Download or read book Biomechanics of the Musculo-Skeletal System written by Benno M. Nigg and published by Chichester ; Toronto : J. Wiley. This book was released on 1994-09-06 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomechanics is the science that uses the first principles of physics for the study of the mechanics of biological systems. It touches on many areas of the natural sciences and ranges from investigations of the mechanisms of force production on the molecular level, to the optimization of the performance of athletes on the macroscopic level. In this text the authors provide a unique and comprehensive account of the mechanics of the neuro-musculoskeletal system. Geared towards students and researchers of biomechanics, the book covers key areas such as the properties of biomaterials, common measuring techniques and modelling.

Principles of Animal Research for Graduate and Undergraduate Students

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Publisher : Academic Press
ISBN 13 : 012802366X
Total Pages : 288 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Principles of Animal Research for Graduate and Undergraduate Students by : Mark A. Suckow

Download or read book Principles of Animal Research for Graduate and Undergraduate Students written by Mark A. Suckow and published by Academic Press. This book was released on 2016-11-16 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Animal Research is the first publication to offer a broad look at animal research science for a student, early researcher, or technician. Offering guidance for all aspects of the research experience, including the research and development of a thesis, model selection, experimental design, IACUC protocol preparation, and animal husbandry and technical procedural needs, the book is a necessary addition to every student, technician, and researcher’s education. Provides background material for students to understand the broader backdrop against which animal research is undertaken Includes ethical and regulatory information Covers commonly used animal models and the process to choose a model for biomedical research