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Etude Des Reseaux Biologiques A Grande Echelle Par Modelisation Statique Et Resolution Des Contraintes
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Book Synopsis Étude Des Réseaux Biologiques À Grande Échelle Par Modélisation Statique Et Résolution Des Contraintes by : Carito Guziolowski
Download or read book Étude Des Réseaux Biologiques À Grande Échelle Par Modélisation Statique Et Résolution Des Contraintes written by Carito Guziolowski and published by . This book was released on 2010 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: To this date many approaches exist that model a genetic regulatory network in order to elucidate the dynamics of the system. These methods focus, however, mainly on small-scale regulatory models. In this thesis we use a formal approach over qualitative large-scale regulatory networks, that models the equilibrium shift of the cell molecules between two steady states. We test the coherency between the network topology and gene expression data, by using a general interaction logical causal rule. The outputs of our approach are to measure the consistency of our data, diagnose inconsistent regions of the network with respect to the experimental data, and infer the qualitative variation of new network molecules. Our method reasons over the whole network of interactions using eefficient algorithms based either on decision diagrams, dependency graphs, or answer set programming. We proposed programs and bioinformatic tools that, based on these efficient implementations, automatize this reasoning. We validated this approach using the transcriptional networks of E. coli and S. cerevisiae, and the signaling network of the EWS-FLI1 human oncogene. Our main results were: (1) high prediction accuracy of the shifts of the network molecules, (2) effective manual and automatic corrections of the model and/or data, (3) automatic inference of the role of transcription factors, and (4) automatic reasoning over the causes that influence important phenotypes on a signaling network. All in all, we provided a methodology that can be applied to complete regulatory networks built at different molecular levels, by exploiting the constantly increasing high-throughput outputs.
Book Synopsis Modélisation grande échelle de réseaux biologiques by : Philippe Veber
Download or read book Modélisation grande échelle de réseaux biologiques written by Philippe Veber and published by . This book was released on 2007 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Les techniques de biologie moléculaire haut-débit permettent de mesurer un grand nombre de variables simultanément. Nous abordons la question de leur intégration : comment combiner les différentes sources dans un modèle et en tirer des conclusions pertinentes ? Nous introduisons un critère de consistance entre un modèle graphique des régulations cellulaires et des données de déplacement d'équilibre. Nous montrons ensuite comment l'utiliser pour obtenir des prédictions ou proposer des corrections en cas d'incompatibilité. Ces différentes tâches impliquent la résolution de contraintes à variables sur domaines finis, pour lesquelles nous proposons deux approches complémentaires. L'utilisation de ces techniques est illustrée avec des données réelles sur la bactérie E. coli et sur la levure. Nous montrons enfin, sur ces données, comment notre critère de consistance nous permet d'arriver à des prédictions robustes, ainsi que des corrections pertinentes du modèle étudié.
Download or read book Neural Networks written by Gérard Dreyfus and published by Springer Science & Business Media. This book was released on 2005-11-25 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural networks represent a powerful data processing technique that has reached maturity and broad application. When clearly understood and appropriately used, they are a mandatory component in the toolbox of any engineer who wants make the best use of the available data, in order to build models, make predictions, mine data, recognize shapes or signals, etc. Ranging from theoretical foundations to real-life applications, this book is intended to provide engineers and researchers with clear methodologies for taking advantage of neural networks in industrial, financial or banking applications, many instances of which are presented in the book. For the benefit of readers wishing to gain deeper knowledge of the topics, the book features appendices that provide theoretical details for greater insight, and algorithmic details for efficient programming and implementation. The chapters have been written by experts and edited to present a coherent and comprehensive, yet not redundant, practically oriented introduction.
Book Synopsis Numerical Methods for Partial Differential Equations by : Sandip Mazumder
Download or read book Numerical Methods for Partial Differential Equations written by Sandip Mazumder and published by Academic Press. This book was released on 2015-12-01 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerical Methods for Partial Differential Equations: Finite Difference and Finite Volume Methods focuses on two popular deterministic methods for solving partial differential equations (PDEs), namely finite difference and finite volume methods. The solution of PDEs can be very challenging, depending on the type of equation, the number of independent variables, the boundary, and initial conditions, and other factors. These two methods have been traditionally used to solve problems involving fluid flow. For practical reasons, the finite element method, used more often for solving problems in solid mechanics, and covered extensively in various other texts, has been excluded. The book is intended for beginning graduate students and early career professionals, although advanced undergraduate students may find it equally useful. The material is meant to serve as a prerequisite for students who might go on to take additional courses in computational mechanics, computational fluid dynamics, or computational electromagnetics. The notations, language, and technical jargon used in the book can be easily understood by scientists and engineers who may not have had graduate-level applied mathematics or computer science courses. Presents one of the few available resources that comprehensively describes and demonstrates the finite volume method for unstructured mesh used frequently by practicing code developers in industry Includes step-by-step algorithms and code snippets in each chapter that enables the reader to make the transition from equations on the page to working codes Includes 51 worked out examples that comprehensively demonstrate important mathematical steps, algorithms, and coding practices required to numerically solve PDEs, as well as how to interpret the results from both physical and mathematic perspectives
Book Synopsis Interaction and Market Structure by : Domenico Delli Gatti
Download or read book Interaction and Market Structure written by Domenico Delli Gatti and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a collection of essays which examine how the properties of aggregate variables are influenced by the actions and interactions of heterogenous individuals in different economic contexts. The common denominator of the essays is a critique of the representative agent hypothesis. If this hypothesis were correct, the behaviour of the aggregate variable would simply be the reproduction of individual optimising behaviour. In the methodology of the hard sciences, one of the achievements of the quantum revolution has been the rebuttal of the notion that aggregate behaviour can be explained on the basis of the behaviour of a single unit: the elementary particle does not even exist as a single entity but as a network, a system of interacting units. In this book, new tracks in economics which parallel the developments in physics mentioned above are explored. The essays, in fact are contributions to the analysis of the economy as a complex evolving system of interacting agents.
Book Synopsis Faecal Sludge Management by : Linda Strande
Download or read book Faecal Sludge Management written by Linda Strande and published by IWA Publishing. This book was released on 2014-08-15 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is estimated that literally billions of residents in urban and peri-urban areas of Africa, Asia, and Latin America are served by onsite sanitation systems (e.g. various types of latrines and septic tanks). Until recently, the management of faecal sludge from these onsite systems has been grossly neglected, partially as a result of them being considered temporary solutions until sewer-based systems could be implemented. However, the perception of onsite or decentralized sanitation technologies for urban areas is gradually changing, and is increasingly being considered as long-term, sustainable options in urban areas, especially in low- and middle-income countries that lack sewer infrastructures. This is the first book dedicated to faecal sludge management. It compiles the current state of knowledge of the rapidly evolving field of faecal sludge management, and presents an integrated approach that includes technology, management, and planning based on Sandecs 20 years of experience in the field. Faecal Sludge Management: Systems Approach for Implementation and Operation addresses the organization of the entire faecal sludge management service chain, from the collection and transport of sludge, and the current state of knowledge of treatment options, to the final end use or disposal of treated sludge. The book also presents important factors to consider when evaluating and upscaling new treatment technology options. The book is designed for undergraduate and graduate students, and engineers and practitioners in the field who have some basic knowledge of environmental and/or wastewater engineering.
Book Synopsis Dynamique Non-linéaire Et Le Chaos by :
Download or read book Dynamique Non-linéaire Et Le Chaos written by and published by . This book was released on 1993 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Wind and Trees written by M. P. Coutts and published by Cambridge University Press. This book was released on 1995-08-24 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers wind behaviour, mechanical physiological responses of trees and forest management.
Book Synopsis Mammalian Synthetic Biology by : Jamie Davies
Download or read book Mammalian Synthetic Biology written by Jamie Davies and published by . This book was released on 2019-12-12 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written primarily for mid-to-upper level undergraduates, this primer will introduce students to topics at the forefront of the subject that are being applied to probe biological problems, or to address the most pressing issues facing society. These topics will include those that form thecornerstone of contemporary research, helping students to make the transition to active researcher.This primer introduces the challenges and opportunities of applying synthetic biological techniques to mammalian cells, tissues, and organisms. It covers the special features that make engineering mammalian systems different from engineering bacteria, fungi, and plants, and provides an overview ofcurrent techniques. A variety of cutting-edge examples illustrate the different purposes of mammalian synthetic biology, including pure biomedical research, drug production, tissue engineering, and regenerative medicine.
Book Synopsis The Mediterranean region under climate change by : Collectif
Download or read book The Mediterranean region under climate change written by Collectif and published by IRD Éditions. This book was released on 2018-11-19 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has been published by Allenvi (French National Alliance for Environmental Research) to coincide with the 22nd Conference of Parties to the United Nations Framework Convention on Climate Change (COP22) in Marrakesh. It is the outcome of work by academic researchers on both sides of the Mediterranean and provides a remarkable scientific review of the mechanisms of climate change and its impacts on the environment, the economy, health and Mediterranean societies. It will also be valuable in developing responses that draw on “scientific evidence” to address the issues of adaptation, resource conservation, solutions and risk prevention. Reflecting the full complexity of the Mediterranean environment, the book is a major scientific contribution to the climate issue, where various scientific considerations converge to break down the boundaries between disciplines.
Book Synopsis Global Burden of Disease and Risk Factors by : Alan D. Lopez
Download or read book Global Burden of Disease and Risk Factors written by Alan D. Lopez and published by World Bank Publications. This book was released on 2006-04-02 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strategic health planning, the cornerstone of initiatives designed to achieve health improvement goals around the world, requires an understanding of the comparative burden of diseases and injuries, their corresponding risk factors and the likely effects of invervention options. The Global Burden of Disease framework, originally published in 1990, has been widely adopted as the preferred method for health accounting and has become the standard to guide the setting of health research priorities. This publication sets out an updated assessment of the situation, with an analysis of trends observed since 1990 and a chapter on the sensitivity of GBD estimates to various sources of uncertainty in methods and data.
Book Synopsis How to Design Wastewater Systems for Local Conditions in Developing Countries by : David M. Robbins
Download or read book How to Design Wastewater Systems for Local Conditions in Developing Countries written by David M. Robbins and published by IWA Publishing. This book was released on 2014-03-15 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a practical handbook providing a step-by-step approach to the techniques used for characterizing wastewater sources and investigating sites where collection, treatment and reuse/disposal technologies will be installed. It is intended to help enable local implementation of on-site and decentralized wastewater management system (DWMS)for wide scale use in development settings. How to Design Wastewater Systems for Local Conditions in Developing Countries helps local service providers and regulatory officials make informed decisions through the use of tools, checklists and case studies. It includes a link to a web based community of on-site and decentralized wastewater professionals, which contains related tools and case studies. This handbook serves as a reference for training classes, certification programs, and higher education programs in civil and sanitary engineering. There is an increasing interest on the part of local government officials and private sector service providers to implement wastewater treatment systems to solve sanitation problems. The model presented in this handbook promotes activities that first generate data related to source and site conditions that represent critical inputs, and then applies this information to the technology selection process. Matching the most appropriate technologies to the specific needs of the wastewater project is the key that leads to long term sustainability. How to Design Wastewater Systems for Local Conditions in Developing Countries is an invaluable resource for public sector decision makers and private sector service providers in developing countries. It is also a useful text for students at engineering colleges in developing countries interested in taking a class that teaches the methods of decentralized wastewater management system (DWMS) development.
Book Synopsis Complexity Theory and the Philosophy of Education by : Mark Mason
Download or read book Complexity Theory and the Philosophy of Education written by Mark Mason and published by John Wiley & Sons. This book was released on 2009-02-23 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of scholarly essays, Complexity Theory and thePhilosophy of Education provides an accessible theoreticalintroduction to the topic of complexity theory while consideringits broader implications for educational change. Explains the contributions of complexity theory to philosophyof education, curriculum, and educational research Brings together new research by an international team ofcontributors Debates issues ranging from the culture of curriculum, to theimplications of work of key philosophers such as Foucault and JohnDewey for educational change Demonstrates how social scientists and social and educationpolicy makers are drawing on complexity theory to answer questionssuch as: why is it that education decision-makers are so resistantto change; how does change in education happen; and what does ittake to make these changes sustainable? Considers changes in use of complexity theory; developedprincipally in the fields of physics, biology, chemistry, andeconomics, and now being applied more broadly to the socialsciences and to the study of education
Book Synopsis Mathematics as a Service Subject by : A. G. Howson
Download or read book Mathematics as a Service Subject written by A. G. Howson and published by Cambridge University Press. This book was released on 1988-05-27 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on the 1987 International Commission on Mathematical Instruction conference, this volume comprises key papers on the role of mathematics in applied subjects.
Book Synopsis Conceptual Basis, Formalisations and Parameterization of the Stics Crop Model by : Nadine Brisson
Download or read book Conceptual Basis, Formalisations and Parameterization of the Stics Crop Model written by Nadine Brisson and published by Editions Quae. This book was released on 2009-01-19 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The STICS crop model has been developed since 1996 at INRA in collaboration with other research and technical institutes. The model syntheses, illustrates and concretizes an important part of the French agronomic knowledge as a point of view on the field and cropping systems working. The formalisations of the STICS crop model presented in this book can be considered as references used in the framework of crop sciences. The book arrangement relies on the way the model designs the crop-soil system functioning, each chapter being devoted to a set of important functions such as growth initiation, yield onset, water uptake, transformation of organic matter etc. One chapter deals with the cropping system and long term simulations and the final chapter is about the involvement of the user in terms of option choices and parameterization. If this book is mainly intended for scientists who use the STICS model, it can also be useful for agronomists, crop modellers, students and technicians looking for elementary formalizations of the crop-soil system functioning.
Book Synopsis Saints of the Atlas by : Ernest Gellner
Download or read book Saints of the Atlas written by Ernest Gellner and published by ACLS History E-Book Project. This book was released on 2008-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dynamic Behavior of Materials, Volume 1 by : Bo Song
Download or read book Dynamic Behavior of Materials, Volume 1 written by Bo Song and published by Springer. This book was released on 2015-10-23 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dynamic Behavior of Materials, Volume 1 represents the first of nine volumes of technical papers presented at the Society for Experimental Mechanics SEM 15th International Congress & Exposition on Experimental and Applied Mechanics, held at Costa Mesa, California, June 8-11, 2015. The full set of proceedings also includes volumes on: Challenges in Mechanics of Time Dependent Materials, Advancement of Optical Methods in Experimental Mechanics, Experimental and Applied Mechanics 16th International Symposium on MEMS and Nanotechnology, 5th International Symposium on the Mechanics of Biological Systems and Materials, International Symposium on the Mechanics of Composite and Multi-functional Materials, Fracture, Fatigue, Failure and Damage Evolution; and Residual Stress, Thermomechanics & Infrared Imaging, Hybrid Techniques and Inverse Problems.
