Equilibria And Kinetics Of Biological Macromolecules

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Equilibria and Kinetics of Biological Macromolecules

Author : Prof. Jan Hermans
Publisher : John Wiley & Sons
ISBN 13 : 1118733770
Total Pages : 411 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Equilibria and Kinetics of Biological Macromolecules by : Prof. Jan Hermans

Download or read book Equilibria and Kinetics of Biological Macromolecules written by Prof. Jan Hermans and published by John Wiley & Sons. This book was released on 2013-10-22 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progressively builds a deep understanding of macromolecular behavior Based on each of the authors' roughly forty years of biophysics research and teaching experience, this text instills readers with a deep understanding of the biophysics of macromolecules. It sets a solid foundation in the basics by beginning with core physical concepts such as thermodynamics, quantum chemical models, molecular structure and interactions, and water and the hydrophobic effect. Next, the book examines statistical mechanics, protein-ligand binding, and conformational stability. Finally, the authors address kinetics and equilibria, exploring underlying theory, protein folding, and stochastic models. With its strong emphasis on molecular interactions, Equilibria and Kinetics of Biological Macromolecules offers new insights and perspectives on proteins and other macromolecules. The text features coverage of: Basic theory, applications, and new research findings Related topics in thermodynamics, quantum mechanics, statistical mechanics, and molecular simulations Principles and applications of molecular simulations in a dedicated chapter and interspersed throughout the text Macromolecular binding equilibria from the perspective of statistical mechanics Stochastic processes related to macromolecules Suggested readings at the end of each chapter include original research papers, reviews and monographs, enabling readers to explore individual topics in greater depth. At the end of the text, ten appendices offer refreshers on mathematical treatments, including probability, computational methods, Poisson equations, and defining molecular boundaries. With its classroom-tested pedagogical approach, Equilibria and Kinetics of Biological Macromolecules is recommended as a graduate-level textbook for biophysics courses and as a reference for researchers who want to strengthen their understanding of macromolecular behavior.

Biomolecular Kinetics

Author : Clive R. Bagshaw
Publisher : CRC Press
ISBN 13 : 1351646664
Total Pages : 883 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Biomolecular Kinetics by : Clive R. Bagshaw

Download or read book Biomolecular Kinetics written by Clive R. Bagshaw and published by CRC Press. This book was released on 2017-10-04 with total page 883 pages. Available in PDF, EPUB and Kindle. Book excerpt: "a gem of a textbook which manages to produce a genuinely fresh, concise yet comprehensive guide" –Mark Leake, University of York "destined to become a standard reference.... Not just a ‘how to’ handbook but also an accessible primer in the essentials of kinetic theory and practice." –Michael Geeves, University of Kent "covers the entire spectrum of approaches, from the traditional steady state methods to a thorough account of transient kinetics and rapid reaction techniques, and then on to the new single molecule techniques" –Stephen Halford, University of Bristol This illustrated treatment explains the methods used for measuring how much a reaction gets speeded up, as well as the framework for solving problems such as ligand binding and macromolecular folding, using the step-by-step approach of numerical integration. It is a thoroughly modern text, reflecting the recent ability to observe reactions at the single-molecule level, as well as advances in microfluidics which have given rise to femtoscale studies. Kinetics is more important now than ever, and this book is a vibrant and approachable entry for anyone who wants to understand mechanism using transient or single molecule kinetics without getting bogged down in advanced mathematics. Clive R. Bagshaw is Emeritus Professor at the University of Leicester, U.K., and Research Associate at the University of California at Santa Cruz, U.S.A.

Energetics of Biological Macromolecules, Part D

Author : Jo M. Holt
Publisher : Elsevier
ISBN 13 : 0080497179
Total Pages : 315 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Energetics of Biological Macromolecules, Part D by : Jo M. Holt

Download or read book Energetics of Biological Macromolecules, Part D written by Jo M. Holt and published by Elsevier. This book was released on 2004-04-02 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the cooperative binding aspects of energetics in biological macromolecules. Methodologies such as NMR, small-angle scattering techniques for analysis, calorimetric analysis, fluorescence quenching, and time resolved FRET measurements are discussed. *Methods for Evaluating Cooperativity in a Dimeric Hemoglobin*Multiple-Binding of Ligands to a Linear Biopolymer*Fluorescence Quenching Methods to Study Protein-Nucleic Acid Interactions*Linked Equilibria in Biotin Repressor Function: Thermodynamic, Structural and Kinetic Analysis

Binding and Linkage

Author : Jeffries Wyman
Publisher : University Science Books
ISBN 13 : 9780935702569
Total Pages : 358 pages
Book Rating : 4.7/5 (25 download)

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Book Synopsis Binding and Linkage by : Jeffries Wyman

Download or read book Binding and Linkage written by Jeffries Wyman and published by University Science Books. This book was released on 1990 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ligand-macromolecule interactions are of fundamental importance in the control of biological processes. This book applies the principles of linkage thermodynamics to polyfunctional macromolecular systems under equilibrium conditions, and describes the binding, linkage, and feedback phenomena that lead to control of complex metabolic processes. The first chapter sets out the different processes (conformational changes, changes in state of aggregation, phase changes) involving biological macromolecules which are affected by chemical variables (such as ligands) or physical variables (such as temperature and pressure). The general effects of ligands on micromolecular conformations and interactions are illustrated with specific examples from the respiratory proteins, electron-transport proteins, and nucleic acid binding proteins. Subsequent chapters develop these themes, and describe in detail how the mathematics of regulation and control can be applied to macromolecules in biological system.

Thermodynamics and Kinetics for the Biological Sciences

Author : Gordon G. Hammes
Publisher : Wiley-Interscience
ISBN 13 :
Total Pages : 192 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Thermodynamics and Kinetics for the Biological Sciences by : Gordon G. Hammes

Download or read book Thermodynamics and Kinetics for the Biological Sciences written by Gordon G. Hammes and published by Wiley-Interscience. This book was released on 2000-06-26 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gain a working knowledge of thermodynamics and kinetics with a minimum of mathematics-a guide for individuals in the biological sciences An understanding of thermodynamics and kinetics is essential for researchers investigating molecular phenomena in diverse disciplines, including bioorganic chemistry, medicinal chemistry, biochemistry, pharmaceuticals, and biology. The use of these physical chemistry tools in the biological sciences has exploded over the past fifteen years, but the majority of works on thermodynamics and kinetics require mathematical expertise beyond that of many researchers in the field. Presenting a highly accessible introduction to thermodynamics and kinetics, Thermodynamics and Kinetics for the Biological Sciences employs a minimum of mathematics, assuming only a basic calculus background, while treating a wide range of topics in a logical and easy-to-follow style. All principles and concepts are clearly illustrated through the use of relevant applications and examples from the biological sciences, and explanations are further enhanced with problems and up-to-date references. Written by a world-renowned authority on biochemical kinetics, this remarkable book also features an easy-to-understand statistical development of entropy and a more extensive coverage of chemical kinetics and ligand binding to macromolecules than is usually found in books of this kind. Readers will acquire a working knowledge of thermodynamics and kinetics that they can readily apply to biological systems and use for exploring the scientific literature.

Binding and Kinetics for Molecular Biologists

Author : James Andrew Goodrich
Publisher : CSHL Press
ISBN 13 : 0879697369
Total Pages : 188 pages
Book Rating : 4.8/5 (796 download)

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Book Synopsis Binding and Kinetics for Molecular Biologists by : James Andrew Goodrich

Download or read book Binding and Kinetics for Molecular Biologists written by James Andrew Goodrich and published by CSHL Press. This book was released on 2007 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook offers a practical guide to the principles of quantitative analysis in biological experiments. The material is primarily aimed at working molecular biologists, but the scope and clarity of presentation make it equally suitable as an introduction for students. Topics covered range from the basics â€” such as measuring the concentrations of macromolecules â€” through considerations of binding constants and the kinetics of molecular interactions. The book ends with a thorough consideration of data analysis.

Introduction to Macromolecular Binding Equilibria

Author : Charles P. Woodbury
Publisher : CRC Press
ISBN 13 : 1420052993
Total Pages : 272 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Introduction to Macromolecular Binding Equilibria by : Charles P. Woodbury

Download or read book Introduction to Macromolecular Binding Equilibria written by Charles P. Woodbury and published by CRC Press. This book was released on 2007-11-08 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macromolecules in the body form noncovalent associations, such as DNA-protein or protein-protein complexes, that control and regulate numerous cellular functions. Understanding how changes in the concentration and conformation of these macromolecules can trigger physiological responses is essential for researchers developing drug therapies to treat

Energetics of Biological Macromolecules, Part C

Author :
Publisher : Elsevier
ISBN 13 : 0080496784
Total Pages : 581 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Energetics of Biological Macromolecules, Part C by :

Download or read book Energetics of Biological Macromolecules, Part C written by and published by Elsevier. This book was released on 2000-08-09 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 323 of Methods in Enzymology is dedicated to the energetics of biological macromolecules. Understanding the molecular mechanisms underlying a biological process requires detailed knowledge of the structural relationships within the system and an equally detailed understanding of the energetic driving forces that control the structural interactions. This volume presents modern thermodynamic techniques currently being utilized to study the energetic driving forces in biological systems. It will be a useful reference source and textbook for scientists and students whose goal is to understand the energetic relationships between macromoleculer structures and biological functions. This volume supplements Volumes 259 and Volume 295 of Methods in Enzymology. Key Features * Probing Stability of Helical Transmembrane Proteins * Energetics of Vinca Alkaloid Interactions with Tubulin * Deriving Complex Ligand Binding Formulas * Mathematical Modeling of Cooperative Interactions in Hemoglobin * Analysis of Interactions of Regulatory Protein TyrR with DNA * Parsing Free Energy of Drug-DNA Interactions * Use of Fluorescence as Thermodynamics Tool

Essentials of Chemical Biology

Author : Andrew D. Miller
Publisher : John Wiley & Sons
ISBN 13 : 1118687833
Total Pages : 620 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Essentials of Chemical Biology by : Andrew D. Miller

Download or read book Essentials of Chemical Biology written by Andrew D. Miller and published by John Wiley & Sons. This book was released on 2013-05-03 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This excellent work fills the need for an upper-level graduate course resource that examines the latest biochemical, biophysical, and molecular biological methods for analyzing the structures and physical properties of biomolecules... This reviewer showed [the book] to several of his senior graduate students, and they unanimously gave the book rave reviews. Summing Up: Highly recommended..." CHOICE Chemical biology is a rapidly developing branch of chemistry, which sets out to understand the way biology works at the molecular level. Fundamental to chemical biology is a detailed understanding of the syntheses, structures and behaviours of biological macromolecules and macromolecular lipid assemblies that together represent the primary constituents of all cells and all organisms. The subject area of chemical biology bridges many different disciplines and is fast becoming an integral part of academic and commercial research. This textbook is designed specifically as a key teaching resource for chemical biology that is intended to build on foundations lain down by introductory physical and organic chemistry courses. This book is an invaluable text for advanced undergraduates taking biological, bioorganic, organic and structural chemistry courses. It is also of interest to biochemists and molecular biologists, as well as professionals within the medical and pharmaceutical industry. Key Features: A comprehensive introduction to this dynamic area of chemistry, which will equip chemists for the task of understanding and studying the underlying principles behind the functioning of biological macro molecules, macromolecular lipid assemblies and cells. Covers many basic concepts and ideas associated with the study of the interface between chemistry and biology. Includes pedagogical features such as: key examples, glossary of equations, further reading and links to websites. Clearly written and richly illustrated in full colour.

Molecular Biophysics

Author : M Volkenstein
Publisher : Elsevier
ISBN 13 : 0323144187
Total Pages : 634 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Molecular Biophysics by : M Volkenstein

Download or read book Molecular Biophysics written by M Volkenstein and published by Elsevier. This book was released on 2012-12-02 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biophysics presents the fundamental principles of biophysics and their application to the study of the physical properties of biological macromolecules. The merger of biology and physics involves the development of sophisticated instrumentation and the molecular approach to the study of life phenomena. This book is composed of nine chapters and begins with an overview of the thermodynamical aspects and chemical foundations of biophysics. These topics are followed by the physical aspects of macromolecules, with a particular emphasis on the biological functions, conformation, and hydrophobic interactions of proteins. The subsequent chapter describes the structural and electro-optical properties of biopolymers based on X-ray, optical, and spectroscopic analysis. The discussion then shifts to enzymes, their chemical kinetics, catalytic potential, and conformational and cooperative properties. The remaining chapters explore the physical aspects of nucleic acids and the biosynthesis of proteins. This book will prove useful to molecular biophysicists, biologists, physicists, and researchers in the fields of life sciences.

Enzyme Kinetics for Systems Biology

Author : Ambrosius Publishing
Publisher : Future Skill Software
ISBN 13 : 0982477309
Total Pages : 320 pages
Book Rating : 4.9/5 (824 download)

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Book Synopsis Enzyme Kinetics for Systems Biology by : Ambrosius Publishing

Download or read book Enzyme Kinetics for Systems Biology written by Ambrosius Publishing and published by Future Skill Software. This book was released on 2011-03-30 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces fundamental concepts in kinetics that relate to system biology. The text is suitable for junior/senior undergraduates and graduates who need access to information relevant to modeling biochemical pathways.

The Osmotic Pressure of Biological Macromolecules

Author : M. P. Tombs
Publisher : Oxford University Press, USA
ISBN 13 :
Total Pages : 162 pages
Book Rating : 4.:/5 (44 download)

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Book Synopsis The Osmotic Pressure of Biological Macromolecules by : M. P. Tombs

Download or read book The Osmotic Pressure of Biological Macromolecules written by M. P. Tombs and published by Oxford University Press, USA. This book was released on 1974 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Multiple Equilibria in Proteins

Author : Jacinto Steinhardt
Publisher : Academic Press
ISBN 13 : 1483220303
Total Pages : 404 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Multiple Equilibria in Proteins by : Jacinto Steinhardt

Download or read book Multiple Equilibria in Proteins written by Jacinto Steinhardt and published by Academic Press. This book was released on 2014-06-28 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple Equilibria in Proteins covers the multiple interactions between small ions and molecules and a protein molecule. The book also deals with the physicochemical mechanisms of this interaction and the information about protein structure and the forces stabilizing that structure. The text discusses the mathematical description of complex formation, the thermodynamic analysis of binding data, and various theoretical models which can be used to describe the phenomena of small molecule-macromolecule interactions. The measurement of complex formation; the binding of neutral molecules; and hydrogen-ion equilibria are also considered. The book further tackles metal-ion binding; the binding of organic ions by proteins; as well as protein-protein interaction. Chemists and biochemists will find the book useful.

Dynamics and Kinetics in Structural Biology

Author : Keith Moffat
Publisher : John Wiley & Sons
ISBN 13 : 1119696305
Total Pages : 292 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Dynamics and Kinetics in Structural Biology by : Keith Moffat

Download or read book Dynamics and Kinetics in Structural Biology written by Keith Moffat and published by John Wiley & Sons. This book was released on 2023-10-19 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dynamics and Kinetics in Structural Biology Understand the latest experimental tools in structural biology with this pioneering work Structural biology seeks to understand the chemical mechanisms and functions of biological molecules, such as proteins, based on their atomic structures. Until recently, these structures have been studied only statically, using procedures which deliberately freeze atomic motion. However, freezing eliminates the rapid structural motions so essential to biological activity and function; the molecules are inactive. But with the recent development of X-ray free electron laser (XFEL) sources, efforts to conduct dynamic experiments have expanded using the principles of dynamics and kinetics to capture active biological molecules as they function. Dynamics and Kinetics in Structural Biology promotes the development of these experiments and their successful application. It grounds readers in the foundational principles of dynamics and kinetics; proceeds through extended discussions of experimental procedures and data analysis techniques; and explores experimental frontiers in structural dynamics. The book will aid researchers to gather and interpret cutting-edge data on the dynamic structure of biological molecules, under conditions where they retain their biological functions. Dynamics and Kinetics in Structural Biology offers readers: Authorship by founding figures in the field In-depth presentation of time-resolved X-ray crystallography, solution scattering, and more A pioneering contribution to a rapidly developing field of study Dynamics and Kinetics in Structural Biology is essential reading for graduate students, scientists, researchers and industry professionals engaged in structural studies of biological systems. Industry professionals considering dynamic studies in the development of new product lines will also benefit.

Molecular Biology

Author : Nancy Craig
Publisher : Oxford University Press
ISBN 13 : 0199658579
Total Pages : 945 pages
Book Rating : 4.1/5 (996 download)

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Book Synopsis Molecular Biology by : Nancy Craig

Download or read book Molecular Biology written by Nancy Craig and published by Oxford University Press. This book was released on 2014-05 with total page 945 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Molecular Biology' offers a fresh, distinctive approach to the study of molecular biology. With its focus on key principles, its emphasis on the commonalities that exist between the three kingdoms of life, and its integrated approach throughout, it is the perfect companion to any molecular biology course.

Kinetic Analysis of Macromolecules

Author : Kenneth Johnson
Publisher :
ISBN 13 : 9780198524939
Total Pages : 256 pages
Book Rating : 4.5/5 (249 download)

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Book Synopsis Kinetic Analysis of Macromolecules by : Kenneth Johnson

Download or read book Kinetic Analysis of Macromolecules written by Kenneth Johnson and published by . This book was released on 2003 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Biology

Author : Nancy L. Craig
Publisher : Oxford University Press, USA
ISBN 13 : 0198788657
Total Pages : 1018 pages
Book Rating : 4.1/5 (987 download)

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Book Synopsis Molecular Biology by : Nancy L. Craig

Download or read book Molecular Biology written by Nancy L. Craig and published by Oxford University Press, USA. This book was released on 2021-01-20 with total page 1018 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fresh, distinctive approach to the teaching of molecular biology. With its focus on key principles, its emphasis on the commonalities that exist between the three kingdoms of life, and its integrated coverage of experimental methods and approaches, Molecular Biology is the perfect companion to any molecular biology course.