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Author : Alan William Cuthbert
Publisher : Urban & Schwarzenberg
ISBN 13 :
Total Pages : 208 pages
Book Rating : 4.3/5 (91 download)
Download or read book Amiloride and Epithelial Sodium Transport written by Alan William Cuthbert and published by Urban & Schwarzenberg. This book was released on 1979 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : N.K. Wills
Publisher : Springer Science & Business Media
ISBN 13 : 9400914954
Total Pages : 366 pages
Book Rating : 4.4/5 (9 download)
Download or read book Epithelial Transport written by N.K. Wills and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building from general principles, the authors clearly explain the fundamental role of epithelia in plasma electrolyte and water balance. Emphasis is placed on experimental approaches and methodology. A comprehensive glossary of terms is included.
Author : Kirk L. Hamilton
Publisher : Springer Nature
ISBN 13 : 3030527808
Total Pages : 563 pages
Book Rating : 4.0/5 (35 download)
Download or read book Basic Epithelial Ion Transport Principles and Function written by Kirk L. Hamilton and published by Springer Nature. This book was released on 2020-11-26 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. As the authors show, these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their contribution to maintaining homeostasis. Readers will be introduced to the fundamentals of ion transport in terms of function, modelling, regulation, structure and pharmacology. This is the first of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on basic fundamentals of epithelial transport physiology. There is a range of chapters dedicated to specific aspects of epithelial ion transport and cell function. Accordingly, the authors discuss techniques used to determine epithelial function, principles of epithelia transport, polarization of epithelial cells, mathematical modelling of epithelial ion transport, protein folding of ion channels, degradation epithelial ion channels, fundamentals of epithelial sodium, potassium and chloride transport, fundamentals of bicarbonate secretion, volume regulation, and microRNA regulation of epithelial channels and transporters. Given its scope, Volume 1 offers a valuable resource for physiology students, scientists and clinicians alike.
Author :
Publisher : Academic Press
ISBN 13 : 0080585183
Total Pages : 425 pages
Book Rating : 4.0/5 (85 download)
Download or read book Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity written by and published by Academic Press. This book was released on 1999-05-04 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels, their regulation and involvement in normal and pathophysiological situations. Summarizes current state of amiloride-sensitive sodium channel field Analyzes structure-function of epithelial sodium channels Discusses immunolocalization of epithelial sodium channels Examines hormonal regulation of sodium channels Discusses sodium channels in lymphocytes, kidney, and lung Considers mechanosensitivity of sodium channels Provides ideas on sodium channels and disease
Author : R. Greger
Publisher : Springer Science & Business Media
ISBN 13 : 3642732852
Total Pages : 329 pages
Book Rating : 4.6/5 (427 download)
Download or read book NaCl Transport in Epithelia written by R. Greger and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: After the pioneering studies by Ussing and co-workers, studies of epithelial Nael transport have come a long way. The first phase of the phenomenological description of the cell as a black box has been follow ed by studies of cellular mechanisms, the interplay of the different trans port components, and the mechanisms of regulation. A broad spectrum of methods has been applied to many epithelia in a variety of species. For the individual epithelia transport schemes have been proposed, and, at this point I think it is appropriate to take a pause and search for elements common to several epithelia. This aspect triggered the publica tion of this book, and in fact the various chapters emphasize that the funetional eomponents, expressed in the various epithelia, are not in finite in number, but they occur in epithelia which are separated in evolu tion by several hundred million years. The authors come both from the field of veterinary and human physiology as weIl as from biology. In my opinion, the close contacts and eollaborations between physiologists and biologists have been essential for the progress in this field. I wish to thank all authors for their con tributions, and I hope that the reader will appreciate this collection of up to date reviews on epithelia in nonvertebrates and vertebrates.
Author : Haibi Hu
Publisher :
ISBN 13 :
Total Pages : 182 pages
Book Rating : 4.:/5 (223 download)
Download or read book Regulation of Epithelial Sodium Transport in Mouse Cortical Collecting Duct Cells written by Haibi Hu and published by . This book was released on 2001 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ayus Corcia
Publisher :
ISBN 13 :
Total Pages : 130 pages
Book Rating : 4.:/5 (884 download)
Download or read book Epithelial Sodium Transport written by Ayus Corcia and published by . This book was released on 1981 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kirk L. Hamilton
Publisher : Springer Nature
ISBN 13 : 3030554546
Total Pages : 1247 pages
Book Rating : 4.0/5 (35 download)
Download or read book Studies of Epithelial Transporters and Ion Channels written by Kirk L. Hamilton and published by Springer Nature. This book was released on 2021-03-04 with total page 1247 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses unique ion channels and transporters that are located within epithelial tissues of various organs including the kidney, intestine, pancreas and respiratory tract. The authors will show, that each of these channels and transporters play crucial roles in transepithelial ion and fluid transport across epithelia and their responsibility in maintaining homeostasis. The reader gains an understanding of the fundamentals of epithelial ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the third of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. The focus of this volume lies with different ion channel and transporter families. Additionally, this volume benefits from pharmaceutical contributors and their insights into recent pre-clinical drug discovery efforts and results from clinical trials. Overall, these chapters offer a more thorough coverage of individual epithelial ion channels and transporters from the 1st Edition, along with eleven new chapters. That makes Volume 3 an insightful contribution for physiology students, scientists and clinicians.
Author : George A. Gerencser
Publisher : Springer Science & Business Media
ISBN 13 : 1603272291
Total Pages : 493 pages
Book Rating : 4.6/5 (32 download)
Download or read book Epithelial Transport Physiology written by George A. Gerencser and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological cell membranes regulate the transfer of matter and information between the intracellular and extracellular compartments as basic survival and maintenance functions for an organism. This volume contains a series of reviews that are c- cerned with how epithelial plasma membranes regulate the transport of solutes between the intracellular and extracellular compartments of a cell. This book is also an attempt to analyze the molecular basis for the movement of various solutes across an epithelial cell membrane. This volume is devoted to a diversity of epithelial transport mechanisms in rep- sentative cell membranes of a variety of living things. The ?rst section of the book (Chapters 1–6) focuses on mechanisms of solute transport in epithelia of inver- brates. The last section which comprises ten chapters (Chapters 7–16) deals with solute transporters in epithelial cell membranes of vertebrates. It is hoped that with this particular ordering the reader can glean a telescopic view of the evolutionary history of the various epithelial solute transporters.
Author : Kirk L. Hamilton
Publisher : Springer
ISBN 13 : 1493933663
Total Pages : 1015 pages
Book Rating : 4.4/5 (939 download)
Download or read book Ion Channels and Transporters of Epithelia in Health and Disease written by Kirk L. Hamilton and published by Springer. This book was released on 2015-12-14 with total page 1015 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside. The individual chapters, written by leading scientists and clinicians, explore specific ion channels and transporters located in the epithelial tissues of the kidney, intestine, pancreas and respiratory tract, all of which play a crucial part in maintaining homeostasis. Further topics include the fundamentals of epithelial transport; mathematical modeling of ion transport; cell volume regulation; membrane protein folding and trafficking; transepithelial transport functions; and lastly, a discussion of transport proteins as potential pharmacological targets with a focus on the pharmacology of potassium channels.
Author : Kirk L. Hamilton
Publisher : Springer Nature
ISBN 13 : 3030553108
Total Pages : 390 pages
Book Rating : 4.0/5 (35 download)
Download or read book Ion Transport Across Epithelial Tissues and Disease written by Kirk L. Hamilton and published by Springer Nature. This book was released on 2020-12-12 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the unique ion channels and transporters found within the epithelial tissues of various organs, including the kidney, intestine, pancreas and respiratory tract. Authors focus on demonstrating the crucial roles that each of these channels and transporters play in transepithelial ion and fluid transport across epithelia, as well as in maintaining homeostasis. It allows readers to gain an understanding of the fundamentals of ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the second of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on a wide array of epithelial tissues and the use of organoids to study epithelial function. Furthermore, clinical researchers and basic scientists from various fields provide a medical perspective on the physiology of a number of tissues and organs of the body including the pancreas, intestine, sweat glands, mammary gland, inner ear epithelia, retinal pigment epithelia of the eye, choroid plexus, and the ectodermal epithelia in dental enamel formation. This volume aims to ‘round out’ the reader’s journey from basic science to the laboratory bench and clinical management of molecular diseases, making Volume 2 a must-read for students and scientists in the field of physiology, as well as for clinicians.
Download or read book Regulatory Mechanisms of Epithelial Sodium Channel written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Epithelial sodium channels (ENaC) are of immense importance, controlling Na+ transport across epithelia and thus playing a critical role in all aspects of fluid clearance as well as numerous other functions. Although extensive studies have been carried out to invistegate the regulation mechanism of ENaC, many questions still remain unclear. Therefore, we employed various techniques including electrophysiology and molecular biology approaches to investigate the mechanisms underlying the regulation of ENaCs by lipid metabolites, oxygen and mechanical stress. We have identified profound regulation mechanisms of ENaC in distal renal epithelial cells and vascular endothelial cells by lipid metabolites, heme and mechanical forces. Our results revealed a novel O\(_2\) sensitive regulation pathway of ENaC channels, in which hemeoxygenase acts as the O\(_2\) sensor and the substrate and product of which either inhibits or stimulates ENaC activity. This finding may eventually lead to novel clinic strategies in dealing with diseases e.g. renal failure, kidney reperfusion injury, hypertension, pulmonary edema and pre-clampsia. In addition, we, at the first time, have revealed that ENaC is functionally expressed in a variety of endothelial cells and is able to serve as mechano-transducing sensors in the vascular endothelial cells which play important roles in vascular physiology and pathology progresses.
Author : Mortimer Mordecai Civan
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 232 pages
Book Rating : 4.:/5 (45 download)
Download or read book Epithelial Ions and Transport written by Mortimer Mordecai Civan and published by John Wiley & Sons. This book was released on 1983 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Venkataramana K Sidhaye
Publisher : Academic Press
ISBN 13 : 0128038810
Total Pages : 277 pages
Book Rating : 4.1/5 (28 download)
Download or read book Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease written by Venkataramana K Sidhaye and published by Academic Press. This book was released on 2017-03-09 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. Provides a single source of information on lung epithelial junctions and transporters Discusses of the role of the epithelium in lung homeostasis and disease Includes capsule summaries of main conclusions as well as highlights of future directions in the field Covers the mechanistic basis for lung disease for a range of audiences
Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (141 download)
Download or read book Amiloride and Epithelial Sodium Transport written by and published by . This book was released on 1979 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Irene Schulz
Publisher :
ISBN 13 : 9783804721692
Total Pages : 188 pages
Book Rating : 4.7/5 (216 download)
Download or read book Epithelial Transport of Ions in Health and Disease written by Irene Schulz and published by . This book was released on 2004 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Stanley G. Schultz
Publisher : Raven Press (ID)
ISBN 13 :
Total Pages : 296 pages
Book Rating : 4.3/5 (91 download)
Download or read book Ion Transport by Epithelia written by Stanley G. Schultz and published by Raven Press (ID). This book was released on 1981 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
