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Epigenetic Regulation During Human Macrophage Differentiation And Polarization
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Book Synopsis Epigenetic Regulation During Human Macrophage Differentiation and Polarization by : Gokce Yildirim-Buharalioglu
Download or read book Epigenetic Regulation During Human Macrophage Differentiation and Polarization written by Gokce Yildirim-Buharalioglu and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The MIF Handbook by : Richard Bucala
Download or read book The MIF Handbook written by Richard Bucala and published by World Scientific. This book was released on 2012 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of the cytokine, macrophage migration inhibitory factor (MIF), in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well established. The aim of this handbook is to provide an authoritative volume covering all aspects of MIF, from basic molecular biology to structure-function relationships, pathophysiology, genetics, and drug development. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, cardiac physiology, and neurodevelopment. MIF's molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. Unique structural features of the protein, such as an intrinsic catalytic activity, and the continuing elucidation of its receptor-dependent mechanism of action offer attractive opportunities for therapeutic intervention. This volume will provide a comprehensive synthesis of the state of the art of MIF science.
Book Synopsis MIF Family Cytokines in Innate Immunity and Homeostasis by : Richard Bucala
Download or read book MIF Family Cytokines in Innate Immunity and Homeostasis written by Richard Bucala and published by Springer. This book was released on 2017-06-12 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, metabolism, and cellular stress responses. MIF’s molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. New family members, such as D-dopachrome tautomerase, or MIF-2, and the closely homologous genes encoding by parasites have been defined and are being functionally characterized. MIF directed therapies also are entering clinical testing and ultimately may be applied in a pharmacogenomics manner. This book provides a comprehensive synthesis of the state-of-the-art of MIF science. The intended audience are post-graduate students and researchers in inflammation, innate immunity, immunology, and immunopathology.
Book Synopsis Macrophages: Biology and Role in the Pathology of Diseases by : Subhra K. Biswas
Download or read book Macrophages: Biology and Role in the Pathology of Diseases written by Subhra K. Biswas and published by Springer. This book was released on 2014-11-12 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue micro environmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells. Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease-virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts provide state-of-the art knowledge of these cells in health and disease.
Book Synopsis Handbook on Immunosenescence by : Tamas Fulop
Download or read book Handbook on Immunosenescence written by Tamas Fulop and published by Springer Science & Business Media. This book was released on 2009-02-27 with total page 1693 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.
Book Synopsis Perinatal Stem Cells by : Anthony Atala
Download or read book Perinatal Stem Cells written by Anthony Atala and published by Academic Press. This book was released on 2018-06-14 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton’s jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury. In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry. Explores current clinical and pre-clinical application of stem cells derived from perinatal sources Offers detailed insight into sources of perinatal stem cells and their potential for disease treatment Discusses progress in the manufacturing, banking and clinical translation of perinatal stem cells Edited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells
Book Synopsis Chromatin and Disease by : Tapas K. Kundu
Download or read book Chromatin and Disease written by Tapas K. Kundu and published by Springer Science & Business Media. This book was released on 2007-05-04 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes a collection of articles with the broad theme of disease connection to chromatin structure and function. It elaborates on the molecular pharmacology of the drugs targeting chromatin structure and its components. The book contains up-to-date information about the chromatin structure and chromatin related diseases and drug functions. This work is the first endeavor to present different aspects encompassing the above theme.
Book Synopsis Epigenetic Regulation in Renal Development, Physiology and Disease by : Xiao-ming Meng
Download or read book Epigenetic Regulation in Renal Development, Physiology and Disease written by Xiao-ming Meng and published by Frontiers Media SA. This book was released on 2022-02-15 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Metabolism and Epigenetic Regulation: Implications in Cancer by : Tapas Kumar Kundu
Download or read book Metabolism and Epigenetic Regulation: Implications in Cancer written by Tapas Kumar Kundu and published by Springer Nature. This book was released on 2022-10-27 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic programs of individuals are key determinants for disease susceptibility and immune response. This book, edited by experts in the field, summarizes epigenetic signaling pathways that regulate metabolic programs associated with cancer and cancer-related secondary diseases. The first part of the book highlights key metabolic pathways that are implicated in cancer and provides a comprehensive overview on the carbohydrate, protein, lipid, amino- and nucleic acid metabolic pathways that are deregulated in cancer. Special attention is paid to the altered tumor micro-environment that is influenced by the metabolic milieu. Furthermore, the fundamental relationship between the cellular metabolic environment and cell death-mediated autophagy is discussed. The second part of the book covers our understanding of the fundamental epigenetic regulations that are implicated in controlling the metabolic programs in cancer cells. Many aspects of epigenetic regulation of non-coding RNAs as well as DNA/RNA methylation, which influencing metabolic homeostasis in cancer, are discussed in detail. Special emphasis is placed on the epigenetic regulation of the amino acid, glucose/carbohydrate metabolism and epigenetic regulation during hypoxia and its connection to cancer. Last but not least, the third part of the book covers small molecule modulators of histone modifying enzymes, which can be used as therapeutic tools. The readers learn about the cross-talk between epigenetics and immunometabolims, as well as the epigenetic regulation of oncometabolites to combat cancer. Given its scope, the book will appeal to a broad readership interested in epigenetic, cancer and metabolic research.
Book Synopsis Nutrition and Cardiometabolic Health by : Nathalie Bergeron
Download or read book Nutrition and Cardiometabolic Health written by Nathalie Bergeron and published by CRC Press. This book was released on 2017-11-10 with total page 781 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutrition plays a key role in prevention of cardiovascular disease, the leading cause of death worldwide. Diet influences a broad spectrum of cardiometabolic risk factors, notably a cluster including excess adiposity, dyslipidemia, impaired glucose metabolism and high blood pressure. In the face of the rapidly increasing incidence of obesity and diabetes, maintaining cardiometabolic health through adoption of a healthy lifestyle is a top public health priority. In this book, Nutrition and Cardiometabolic Health, international experts present state-of-the-art scholarly reviews of dietary and lifestyle effects on metabolic systems associated with cardiovascular health and disease. It covers a broad range of topics including biological and behavioral processes regulating food intake; lifestyle and surgical approaches to weight loss; nutritional considerations for optimal cardiometabolic health across the lifespan; the relationship of macronutrients, whole foods and dietary patterns to diabetes and cardiovascular disease; and diet as a modulator of gene expression, epigenetics and the gut microbiome and the relationship of these traits to disorders of metabolism. This book provides its readers with an authoritative view of the present state of knowledge of dietary effects on cardiometabolic health and will be of interest to nutrition and healthcare professionals alike.
Book Synopsis M1/M2 Macrophages: The Arginine Fork in the Road to Health and Disease by : Charles Dudley Mills
Download or read book M1/M2 Macrophages: The Arginine Fork in the Road to Health and Disease written by Charles Dudley Mills and published by Frontiers Media SA. This book was released on 2015-03-23 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophages have unique and diverse functions necessary for survival. And, in humans (and other species), they are the most abundant leukocytes in tissues. The Innate functions of macrophages that are best known are their unusual ability to either “Kill” or “Repair”. Since killing is a destructive process and repair is a constructive process, it was stupefying how one cell could exhibit these 2 polar – opposite functions. However, in the late 1980’s, it was shown that macrophages have a unique ability to enzymatically metabolize Arginine to Nitric Oxide (NO, a gaseous non – specific killer molecule) or to Ornithine (a precursor of polyamines and collagen for repair). The dual Arginine metabolic capacity of macrophages provided a functional explanation for their ability to kill or repair. Macrophages predominantly producing NO are called M1 and those producing Ornithine are called M2. M1 and M2 – dominant responses occur in lower vertebrates, and in T cell deficient vertebrates being directly driven by Damage and Pathogen Associated Molecular Patterns (DAMP and PAMP). Thus, M1 and M2 are Innate responses that protect the host without Adaptive Immunity. In turn, M1/M2 is supplanting previous models in which T cells were necessary to “activate” or “alternatively activate” macrophages (the Th1/Th2 paradigm). M1 and M2 macrophages were named such because of the additional key findings that these macrophages stimulate Th1 and Th2 – like responses, respectively. So, in addition to their unique ability to kill or repair, macrophages also govern Adaptive Immunity. All of the foregoing would be less important if M1 or M2 – dominant responses were not observed in disease. But, they are. The best example to date is the predominance of M2 macrophages in human tumors where they act like wound repair macrophages and actively promote growth. More generally, humans have become M2 – dominant because sanitation, antibiotics and vaccines have lessened M1 responses. And, M2 dominance seems the cause of ever - increasing allergies in developed countries. Obesity represents a new and different circumstance. Surfeit energy (e.g., lipoproteins) causes monocytes to become M1 dominant in the vessel walls causing plaques. Because M1 or M2 dominant responses are clearly causative in many modern diseases, there is great potential in developing the means to selectively stimulate (or inhibit) either M1 or M2 responses to kill or repair, or to stimulate Th1 or Th2 responses, depending on the circumstance. The contributions here are meant to describe diseases of M1 or M2 dominance, and promising new methodologies to modulate the fungible metabolic machinery of macrophages for better health.
Book Synopsis Epigenetics in Human Disease by : Trygve O Tollefsbol
Download or read book Epigenetics in Human Disease written by Trygve O Tollefsbol and published by Academic Press. This book was released on 2018-05-18 with total page 1112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics in Human Disease, Second Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. In addition to detailing the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, novel epigenetic approaches to treatment are also explored. Fully revised and up-to-date, this new edition discusses topics of current interest in epigenetic research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, and epigenetic mechanisms of imprinting disorders. Further sections explore online epigenetic tools and datasets, early-life programming of epigenetics in age-related diseases, the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer's disease, respiratory diseases, and many other human maladies. - Includes contributions from leading international investigators involved in translational epigenetic research and therapeutic applications - Integrates methods and applications with fundamental chapters on epigenetics in human disease, along with an evaluation of recent clinical breakthroughs - Presents side-by-side coverage of the basis of epigenetic diseases and treatment pathways - Provides a fully revised resource covering current developments, including stem cell epigenetic therapy, the bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, online epigenetic tools and datasets, and more
Book Synopsis The Cytokine Handbook by : Angus W. Thomson
Download or read book The Cytokine Handbook written by Angus W. Thomson and published by Gulf Professional Publishing. This book was released on 2003 with total page 878 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the molecules that induce and regulate immune responses. Expanded to two volumes, the scope of the book has been broadened to include a major emphasis on the clinical applications of cytokines. The early chapters discuss individual cytokines, chemokines and receptors. Additional chapters discuss the clinical implications and applications of cytokines, including cytokine gene transfer, antisense therapy and assay systems.
Book Synopsis Epigenetics Methods by : Trygve Tollefsbol
Download or read book Epigenetics Methods written by Trygve Tollefsbol and published by Academic Press. This book was released on 2020-07-08 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the field of epigenetics has grown significantly, driving new understanding of human developmental processes and disease expression, as well as advances in diagnostics and therapeutics. As the field of epigenetics continues to grow, methods and technologies have multiplied, resulting in a wide range of approaches and tools researchers might employ. Epigenetics Methods offers comprehensive instruction in methods, protocols, and experimental approaches applied in field of epigenetics. Here, across thirty-five chapters, specialists offer step-by-step overviews of methods used to study various epigenetic mechanisms, as employed in basic and translational research. Leading the reader from fundamental to more advanced methods, the book begins with thorough instruction in DNA methylation techniques and gene or locus-specific methylation analyses, followed by histone modification methods, chromatin evaluation, enzyme analyses of histone methylation, and studies of non-coding RNAs as epigenetic modulators. Recently developed techniques and technologies discussed include single-cell epigenomics, epigenetic editing, computational epigenetics, systems biology epigenetic methods, and forensic epigenetic approaches. Epigenetics methods currently in-development, and their implication for future research, are also considered in-depth. In addition, as with the wider life sciences, reproducibility across experiments, labs, and subdisciplines is a growing issue for epigenetics researchers. This volume provides consensus-driven methods instruction and overviews. Tollefsbol and contributing authors survey the range of existing methods; identify best practices, common themes, and challenges; and bring unity of approach to a diverse and ever-evolving field. Includes contributions by leading international investigators involved in epigenetic research and clinical and therapeutic application Integrates technology and translation with fundamental chapters on epigenetics methods, as well as chapters on more novel and advanced epigenetics methods Written at verbal and technical levels that can be understood by scientists and students alike Includes chapters on state-of-the-art techniques such as single-cell epigenomics, use of CRISPR/Cas9 for epigenetic editing, and epigenetics methods applied to forensics
Book Synopsis Macrophage Plasticity in Sterile and Pathogen-Induced Inflammation by : Ioannis Kourtzelis
Download or read book Macrophage Plasticity in Sterile and Pathogen-Induced Inflammation written by Ioannis Kourtzelis and published by Frontiers Media SA. This book was released on 2022-02-04 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cardiac Regeneration by : Masaki Ieda
Download or read book Cardiac Regeneration written by Masaki Ieda and published by Springer. This book was released on 2017-10-27 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.
Book Synopsis Epigenetic Regulation of Autophagy in Inflammatory Diseases by : Kai Wang
Download or read book Epigenetic Regulation of Autophagy in Inflammatory Diseases written by Kai Wang and published by Frontiers Media SA. This book was released on 2024-03-13 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics refers to changes in the expression of heritable genes or cellular phenotypes caused by regulating DNA methylation, histone modification, chromatin remodeling, and noncoding RNA expression, without altering the DNA sequence. It plays a critical role in the regulation of many physiological and pathological processes, such as inflammation, immunity, and tumor. In particular, many epigenetic modifiers have been found to affect innate cell development, infection, and inflammatory responses by regulating gene-specific expression. Epigenetic abnormalities often result in changes in gene expression and its function, which in turn promote the process of inflammation and even tumorigenesis. Autophagy is a highly conserved subcellular degradation process by which some damaged organelles, misfolded proteins, nucleic acids, and pathogenic microorganisms are digested to maintain homeostasis. Autophagy dysregulation has been implicated in multiple diseases, including inflammation, tumors, and neurodegenerative diseases. It is not only a cytoplasmic event, but also involved in the regulation of nuclear components, including histone modifications, microRNA, and transcription factors. Methyltransferase-mediated histone modifications (H3K9me2, H3R17me2, and H3K27me3), miRNAs, and DNA methylation catalyzed by DNA methyltransferase are the key nuclear factors involved in the regulation of autophagy. In addition, some autophagy-related genes (Atgs) promote or inhibit the autophagic process through epigenetic modifications, such as histone modifications and DNA methylation, affecting the occurrence and development of inflammatory diseases. Studying the role of epigenetic regulation of autophagy in inflammatory diseases may help identify novel drug targets and develop potential diagnostic and therapeutic approaches. Although the biological and clinical significance of epigenetic modification of autophagy has attracted more and more attention from researchers, this regulation is very complex and its role and mechanism in inflammatory diseases are still unclear.
