Enzyme Based Detoxification Of Organophosphorus Neurotoxic Pesticides And Chemical Warfare Agents

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Enzyme-based Detoxification of Organophosphorus Neurotoxic Pesticides and Chemical Warfare Agents

Author : Rory James Kern
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (61 download)

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Book Synopsis Enzyme-based Detoxification of Organophosphorus Neurotoxic Pesticides and Chemical Warfare Agents by : Rory James Kern

Download or read book Enzyme-based Detoxification of Organophosphorus Neurotoxic Pesticides and Chemical Warfare Agents written by Rory James Kern and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: There are some 15,000 known organophosphorus chemicals. Some of these OP's, including VX and paraoxon, demonstrate an acute neurotoxicity due to the inhibition of cholinergic enzymes. Organophosphorus chemical warfare agents and pesticide neurotoxins are subject to hydrolysis by OP degrading enzymes. To be useful as a bioremediation or anti-chemical warfare agent, the enzyme must be tailored for, and integrated into, a practical application platform. Several studies have established enzyme-based countermeasures, describing such diverse applications as decontaminating foams for surface remediation, encapsulating enzyme with liposome for in vivo therapy, enzyme attachments to surfaces for biosensors and development of a corn expression system for large-scale enzyme production. The goal of the research described here is to select, investigate and improve the operational potential of organophosphate-degrading enzymes including Organophosphorus Hydrolase (OPH, 3.1.8.1) and Organophosphorus Acid Anhydrolase (OPAA, 3.1.8.2). Using saturation kinetics, the catalytic efficiencies of these two major detoxification enzymes were characterized with substrates representing each class of OP neurotoxin, phosphotriester, phosphothioate and phosphofluoridate. OPH presents superior kinetic parameters with each OP class tested. Variants of OPH were created to increase the operational effectiveness of OP hydrolytic enzymes against phosphorothioates. An H254S/H257L mutation in the active site resulted in an improvement in the kinetics (kcat/KM) for the phosphorothioate, demeton-S. To screen potential vascular protection therapies, an in vitro protocol was developed to predict enzymatic effectiveness for protection of acetylcholinesterase from acute OP-inhibition. The protection abilities of the enzymes were directly related to their second order rate constants as inhibitory levels of OP are below the KM of the enzymes. Consideration of contaminant nature concentration and enzyme kinetic parameters, kcat and KM, is critical to understanding decontamination and effective use of enzyme technology. These technologies continue to develop and provide promising new decontamination tools for OP compounds.

Enzymatic Detoxification of Organophosphorus Pesticides, Fenamiphos and Malathion by Microbacterium Sp. MM1

Author : Logeshwaran Panneerselvan
Publisher :
ISBN 13 :
Total Pages : 172 pages
Book Rating : 4.:/5 (959 download)

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Book Synopsis Enzymatic Detoxification of Organophosphorus Pesticides, Fenamiphos and Malathion by Microbacterium Sp. MM1 by : Logeshwaran Panneerselvan

Download or read book Enzymatic Detoxification of Organophosphorus Pesticides, Fenamiphos and Malathion by Microbacterium Sp. MM1 written by Logeshwaran Panneerselvan and published by . This book was released on 2013 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organophosphorus compounds constitute the class of xenobiotic chemicals used in the production of plasticizers, air fuel ingredients, warfare agents and pesticides. Organophosphorus (OP) pesticides are generally used to control insect pests that can damage agriculture, horticulture, livestock and human health. Organophosphorus pesticides are generally neurotoxic in nature which causes paralysis, convulsions and ultimately the death of an organism. OP pesticides can result in lethal effects on non-target organisms like birds, animals, aquatic organisms and mammals including human beings. Indiscriminate and excessive production and usage of organophosphorus pesticides results in the contamination of ecosystems. Since OP pesticides are very toxic to aquatic organisms and wildlife, serious concerns about the environmental fate of these chemicals are increasing. Hence effective and safe decontamination strategies are needed for dealing with OP pesticide contamination. Microorganisms play a vital role in the decontamination of OP pesticides in that they utilize OP pesticides as carbon and energy sources and also as nutrient. Phosphotriesterases are enzymes comprising organophosphorus hydrolase, while methyl parathion hydrolase and organophosphorus acid anhydrolase produced by microbes are involved in the decontamination of OP pesticides. Hydrolysis of OP pesticides by the enzyme produced by microorganisms is a critical detoxification process. This study aimed to isolate, purify, identify and clone enzymes responsible for the hydrolysis of OP pesticides, fenamiphos and malathion.

Rational Design of Organophosphorus Hydrolase for the Degradation and Detection of Neurotoxic Pesticides and Chemical Warfare Agents

Download Rational Design of Organophosphorus Hydrolase for the Degradation and Detection of Neurotoxic Pesticides and Chemical Warfare Agents PDF Online Free

Author : Tony Elvern Reeves
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (191 download)

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Book Synopsis Rational Design of Organophosphorus Hydrolase for the Degradation and Detection of Neurotoxic Pesticides and Chemical Warfare Agents by : Tony Elvern Reeves

Download or read book Rational Design of Organophosphorus Hydrolase for the Degradation and Detection of Neurotoxic Pesticides and Chemical Warfare Agents written by Tony Elvern Reeves and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: It is critical to consider the balance between the catalytic capabilities of an enzyme and the inherent structural stability of the protein when developing enzymes for specific applications. Rational site directed mutagenesis has been used to explore the role of residues 254 and 257 in the global stability and catalytic specificities of organophosphorus hydrolase (OPH, EC 3.1.8.1). Substitution of residues H254 and H257, which are located near the active site, had a marked effect on both the global stability and substrate specificity of the enzyme. For example, the deltaGT for the double mutation Co2 H254R H257L (RL) enzyme variant was 19.6 kcal/mol, 5.7 kcal/mol less than that of the wild type enzyme. At the same time, the altered enzyme was catalytically more effective against VX and VR (Russian VX), as compared to the wild type enzyme. Limited proteolysis verified the importance of residues 254 and 257 for functional stability, evidenced by enhanced resistance to irreversible unfolding associated with thermal denaturation. It has been possible to construct third generation OPH variants, which are more stable than the wild type enzyme, with a 10 °C increase in the apparent melting temperature (TM app), yet retained desirable catalytic properties. It appeared that aromatic stacking and cation-pi interactions involving near active site residues not only affected activity but significantly contributed to the chemical and thermal stability of OPH. Rational design was used to develop an enzyme with an optimized orientation on a catalytically active biosensor surface. In these studies, lysine side chains located on the surface of OPH were used to create attachment sites to a surface plasmon resonance sensor resulting in an ensemble of enzyme orientations. Some of these orientations could be functionally restrictive if the active site is oriented toward the sensor surface. Substitution of a lysine near the active site resulted in 20% more activity with 53% less enzyme immobilized, thus increasing the specific activity of the decorated surface 2.5 fold.

State Secrets

Author : Vil S. Mirzayanov
Publisher : Outskirts Press
ISBN 13 : 9781432725662
Total Pages : 604 pages
Book Rating : 4.7/5 (256 download)

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Book Synopsis State Secrets by : Vil S. Mirzayanov

Download or read book State Secrets written by Vil S. Mirzayanov and published by Outskirts Press. This book was released on 2009 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The Mirzayanov case is an immediate legal litmus test of emerging Russian democracy. He is an individual in the true tradition of Andrei Sakharov, a man persecuted under the former regime for telling the truth, but now, rightfully, universally honored."--Dan Ellsberg, author.

Chemical Warfare Toxicology

Author : Franz Worek
Publisher :
ISBN 13 : 9781523104772
Total Pages : 325 pages
Book Rating : 4.1/5 (47 download)

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Book Synopsis Chemical Warfare Toxicology by : Franz Worek

Download or read book Chemical Warfare Toxicology written by Franz Worek and published by . This book was released on 2016 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an up-to-date treatise on the on-going research into the toxicology of chemical warfare agents, the diagnosis and verification of exposure, and the pre- and post-exposure treatment of poisoning.

Toxicology of Organophosphate and Carbamate Compounds

Author : Ramesh C Gupta
Publisher : Academic Press
ISBN 13 : 0080543103
Total Pages : 781 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Toxicology of Organophosphate and Carbamate Compounds by : Ramesh C Gupta

Download or read book Toxicology of Organophosphate and Carbamate Compounds written by Ramesh C Gupta and published by Academic Press. This book was released on 2011-04-28 with total page 781 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text/reference book provides the most comprehensive coverage of anticholinesterase compounds (Organophosphates and Carbamates), which constitute the largest number of chemicals that are primarily used as insecticides in agriculture, industry, and around the home/garden. Some OPs (nerve agents) have been used in chemical warfare and terrorist attacks, while some OPs and CMs have been recommended as therapeutic agents in human medicine as well as in veterinary medicine. Many chemicals of both classes are extremely toxic and lack selectivity, thus their inadvertent/accidental use continues to pose a threat to human and animal health, aquatic systems and wildlife. These anticholinesterase agents produce a variety of toxicological effects in target and nontarget organs. In light of this complexicity, this multi-authored book is written by the well known scientists from many countries. The book is organized into nine sections, with a total of 49 chapters, to provide in-depth knowledge on various aspects of OP and CM compounds, including their use, classification, mechanism-based toxicity, and prophylactic and therapeutic measurements. Several chapters are written with special emphasis to cover timely topics, such as chemical warfare agents, physiologically-based pharmacokinetic modeling, structure and function of cholinesterases, paraoxonase, carboxylesterases; developmental neurotoxicity, the intermediate syndrome, oxidative stress, endocrine disruption, and DNA damage/gene expression and carcinogenesis. Section-VI with 5 chapters is specifically devoted to risk assessment, and safety and regulatory guidelines for pesticides. Describes everything you need to know about Organophosphates and Carbamates Extensively covers pesticides, nerve agents, therapeutic drugs, and flame retardants Describes epidemiology of the world's major disasters involving Organophosphates and Carbamates Covers animal, human, aquatic, and wildlife toxicity of Anticholinesterases Insights into in-depth cholinergic and noncholinergic mechanisms of toxicity Describes recent advancements in cholinesterases, paraoxonases, carboxylesterases, oxidative stress, endocrine disruption, cardiac and pulmonary toxicity, and carcinogenesis Provides in vitro and in vivo models for neurotoxicity testing Integrates knowledge of studies in lab animals and humans Offers risk/safety assessment and national/international guidelines for permissible levels of pesticide residues Describes management of Anticholinesterase poisoning in humans

Cholinesterases and Anticholinesterase Agents

Author : George B. Koelle
Publisher : Springer Science & Business Media
ISBN 13 : 3642998755
Total Pages : 1228 pages
Book Rating : 4.6/5 (429 download)

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Book Synopsis Cholinesterases and Anticholinesterase Agents by : George B. Koelle

Download or read book Cholinesterases and Anticholinesterase Agents written by George B. Koelle and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 1228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the anticholinesterase (anti-ChE) agents have only limited applica tions in therapy, and from the viewpoint of practical significance they are more appropriately classified as toxic compounds or insecticides than as drugs, in their capacity of pharmacological tools they have few equals. The concept of neuro humoral transmission was originally established largely from experiments in which physostigmine, or eserine, was employed to protect acetylcholine (ACh), the trans mitter of the cholinergic nerves, from rapid hydrolytic destruction by acetyl cholinesterase (AChE) and other cholinesterases (ChE's). Since then, a great num ber of additional reversible and irreversible anti-ChE agents also have been indis pensable in studies of synaptic and neuroeffector transmission, and of other physiological processes. At the same time, there is practically no other class of compounds for which a mechanism of pharmacological action can be described in such concrete biochemical and physiological terms. Consequently, it is not sur prising that a huge literature has developed on these several closely interdependent topics. The assembling anrl proper correlation of this material for the present volume has taken the collaborative efforts of over two dozen . investigators. It iR believed that their contributions to this end will prove invaluable to future in vestigators in providing a ready, inclusive source of established information, in defining areas where further studies are indicated, and in preventing unnecessary duplication of past work. How well these aims have been accomplished will be for time and the reader to judge.

Biodefence

Author : Sergey Mikhalovsky
Publisher : Springer Science & Business Media
ISBN 13 : 9400702191
Total Pages : 319 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Biodefence by : Sergey Mikhalovsky

Download or read book Biodefence written by Sergey Mikhalovsky and published by Springer Science & Business Media. This book was released on 2011-01-07 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on defence against biological warfare with an emphasis on applications of modern technologies and advanced materials in detection, health protection and medical treatment of the population. Specific topics include high-throughput sensitive detection methods, advanced nanostructured materials and techniques for external and internal protection of human health, as well as extracorporeal methods, adsorptive materials and bacteriophages decontaminating the human organism, and neutralising incorporated CBRN agents. The contributions describe recent developments in the field of biodefence aimed at protecting population against terrorism and terror related events. Broader approaches to reducing the impact of environmental pollution on human health and improving efficiency of medical treatment of patients with viral infections, poisoning and organ failure are also discussed.

Toxicological Profile for Pyrethrins and Pyrethroids

Author :
Publisher :
ISBN 13 :
Total Pages : 334 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Toxicological Profile for Pyrethrins and Pyrethroids by :

Download or read book Toxicological Profile for Pyrethrins and Pyrethroids written by and published by . This book was released on 2003 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Basic and Clinical Toxicology of Organophosphorus Compounds

Author : Mahdi Balali-Mood
Publisher : Springer Science & Business Media
ISBN 13 : 1447156250
Total Pages : 264 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Basic and Clinical Toxicology of Organophosphorus Compounds by : Mahdi Balali-Mood

Download or read book Basic and Clinical Toxicology of Organophosphorus Compounds written by Mahdi Balali-Mood and published by Springer Science & Business Media. This book was released on 2013-12-19 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains the chemistry of Organophosphorus compounds (OPs), their mechanism of toxicity and the history of OPs from their initial discovery to the development of new compounds such as Novichoks. It details the harmful effects to human health both as a result of acute and chronic OP exposure and the necessary clinical management of affected patients to reduce their toxic side effects. The book also explains the detrimental effect that OPs have had on the environment and the efforts being made to prevent this in the future. Finally, the book looks at the incidents where OPs have been used as chemical warfare agents. Basic and Clinical Toxicology of Organophosphorus Compounds aims to act as a comprehensive guide to all aspects of OPs and is a key resource for clinical toxicologists and related health professionals involved in the prevention, diagnosis and clinical management of OP patients, toxicologists and other scientists involved in research on OPs including regulatory issues and postgraduate students in Toxicology and related fields.

Handbook of Toxicology of Chemical Warfare Agents

Author : Ramesh C Gupta
Publisher : Academic Press
ISBN 13 : 0080922732
Total Pages : 1182 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Handbook of Toxicology of Chemical Warfare Agents by : Ramesh C Gupta

Download or read book Handbook of Toxicology of Chemical Warfare Agents written by Ramesh C Gupta and published by Academic Press. This book was released on 2009-04-02 with total page 1182 pages. Available in PDF, EPUB and Kindle. Book excerpt: This groundbreaking book covers every aspect of deadly toxic chemicals used as weapons of mass destruction and employed in conflicts, warfare and terrorism. Including findings from experimental as well as clinical studies, this one-of-a-kind handbook is prepared in a very user- friendly format that can easily be followed by students, teachers and researchers, as well as lay people. Stand-alone chapters on individual chemicals and major topics allow the reader to easily access required information without searching through the entire book.This is the first book that offers in-depth coverage of individual toxicants, target organ toxicity, major incidents, toxic effects in humans, animals and wildlife, biosensors, biomarkers, on-site and laboratory analytical methods, decontamination and detoxification procedures, prophylactic, therapeutic and countermeasures, and the role of homeland security. Presents a comprehensive look at all aspects of chemical warfare toxicology in one reference work. This saves researchers time in quickly accessing the very latest definitive details on toxicity of specific agents used in chemical warfare as opposed to searching through thousands of journal articles. Will include the most agent-specific information on the market Includes detailed coverage of the most exhaustive list of agents possibly used as chemical warfare agents in one source. Section 4: Agents That Can Be Used as Weapons of Mass Destruction ? 25 chapters long. Other books on the market only include a sample selection of specific agents. Offering all possible agents detailed under one cover makes this appealing to a wider audience and saves researchers time The Forward will be written by Dr. Tetsuo Satoh, Chiba University, Japan. He is one of the most respected, recognizable authorities on chemical warfare agents which will set the authoritative tone for the book Covers risk to humans, animals and the environment equally. Researchers involved in assessing the risks involved with a possible chemical warfare attack and those who are developing response plans to such attacks must look at not only the risks to human health but to our wildlife and environment as well. The holistic approach taken in this book ensures that the researchers have ready access to the details no matter which aspect of the effects of CWA's they might be concerned with

Mammalian Toxicology

Author : Mohamed Abou-Donia
Publisher : John Wiley & Sons
ISBN 13 : 1119940419
Total Pages : 716 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Mammalian Toxicology by : Mohamed Abou-Donia

Download or read book Mammalian Toxicology written by Mohamed Abou-Donia and published by John Wiley & Sons. This book was released on 2015-05-04 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mammalian Toxicology surveys chemical agents and examines how such chemicals impact on human health, emphasizing the importance in minimizing environmental exposure to chemical and physical hazards in our homes, communities and workplaces through such media as contaminated water, soil and air. Starting with the basic principles on a wide range of toxic agents, this textbook describes how they enter the body, their mechanisms of action once inside, and strategies for diagnosis, prevention and treatment. Topics covered include: General principles of toxicology: pharmacological and toxicological principles underpinning the study of toxicology, risk assessments and mechanisms of cell death Disposition: routes of chemical exposures, entry into the body and various tissues, storage, metabolic biotransformation and elimination, with examples from various toxicants. Toxic agents: the occurrences, disposition in the body, health effects, toxic mechanisms, antidotes and treatments of a range of agents including pesticides, metals, solvents, gases, nanomaterials, food components and additives, pharmaceuticals, drugs of abuse, natural toxins, endocrine disruptors, radiation, and warfare weapons. Toxic effects: including neurotoxicity, developmental toxicity, immunotoxicity, teratogenecity, male and female reproductive toxicity, mutagenecity, carcinogenicity, pulmonary toxicity, cardiovascular toxicity, hepatotoxicity, gastrointestinal toxicity and cardiovascular toxicity Toxicology and society: epidemiological studies of chemical-induced diseases in human populations, and a vision for toxicology in the 21st century. Mammalian Toxicology is an essential primer for students of toxicology, biochemistry, biology, medicine and chemistry. It is also appropriate for professional toxicologists in research or regulatory affairs, and anyone who needs to understand the adverse effects of toxic agents on the human body.

Microbial Biotechnology

Author : Jayanta Kumar Patra
Publisher : Springer
ISBN 13 : 981106847X
Total Pages : 489 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Microbial Biotechnology by : Jayanta Kumar Patra

Download or read book Microbial Biotechnology written by Jayanta Kumar Patra and published by Springer. This book was released on 2018-02-07 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book, is a collection of 20 articles describing the recent advancements in the application of microbial technology for sustainable development of agriculture and environment. This book covers many aspects like agricultural nanotechnology, promising applications of biofuels production by algae, advancements and application of microbial keratinase, biocontrol agents, plant growth promoting rhizobacteria, bacterial siderophore, use of microbes in detoxifying organophosphate pesticides, bio-surfactants, biofilms, bioremediation degradation of phenol and phenolic compounds and bioprospecting of endophytes. This book intends to bring the latest research advancements and technologies in the area of microbial technology in one platform, providing the readers an up-to-date view on the area. This book would serve as an excellent reference book for researchers and students in the agricultural, environmental and microbiology fields.

Best Synthetic Methods

Author : Chris Timperley
Publisher : Newnes
ISBN 13 : 0080982247
Total Pages : 787 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Best Synthetic Methods by : Chris Timperley

Download or read book Best Synthetic Methods written by Chris Timperley and published by Newnes. This book was released on 2014-12-01 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt: Best Synthetic Methods: Organophosphorus (V) Chemistry provides systematic coverage of the most common classes of pentavalent organophosphorus compounds and reagents (including phosphonyl, phosphoryl, and organophosphates), and allows researchers an easy point of entry into this complex and economically important field. The book follows the Best Synthetic Methods format, containing practical methods, synthetic tips, and shortcuts. Where relevant, articles include toxicity data and historical context for the reactions. Typical analytical and spectroscopic data are also presented to enable scientists to identify key compound characteristics. The book is a valuable companion to research chemists in both academia and industry, summarizing the best practical methods (often originating in difficult-to-access, foreign-language primary literature) in one place. It is ideally suited for those working on industrial applications of these compounds, including insecticides, herbicides, flame retardants, and plasticizers. Includes a mixture of tried and tested, historical methods that are proven to work, alongside new methods to provide scientists with a quick, time-saving resource of reliable methods Includes tips and tricks to get reactions to work; important information often missing from other sources Includes key analytical data for compounds, so scientists have one handy resource to select, perform, and analyze the best reaction

Veterinary Toxicology for Australia and New Zealand

Author : Rosalind Dalefield
Publisher : Elsevier
ISBN 13 : 0127999124
Total Pages : 630 pages
Book Rating : 4.1/5 (279 download)

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Book Synopsis Veterinary Toxicology for Australia and New Zealand by : Rosalind Dalefield

Download or read book Veterinary Toxicology for Australia and New Zealand written by Rosalind Dalefield and published by Elsevier. This book was released on 2017-06-23 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: Veterinary Toxicology for Australia and New Zealand is a reference suited to the unique challenges of veterinary practice in Australia and New Zealand. Both streamlined and thorough in its coverage of poisons and treatments for those locations, this focused approach allows readers to quickly find relevant information that is presented in a concise and logical manner that is useful to clinicians. The authors draw upon a wealth of knowledge of the particularities of toxicology in Australia and New Zealand to present readers with the up-to-date information required to efficiently and effectively diagnose and treat their patients. Highlights toxins of specific concern in Australia and New Zealand Structures information in a logical way so that it can be located quickly Offers up-to-date information on current and emerging risks

Organophosphates

Author : Janice E. Chambers
Publisher : Academic Press
ISBN 13 :
Total Pages : 472 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis Organophosphates by : Janice E. Chambers

Download or read book Organophosphates written by Janice E. Chambers and published by Academic Press. This book was released on 1992-01-28 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume pulls together a wealth of up-to-date information on the toxicology of this diverse and ubiquitous class of insecticides. Leading experts review the reactivity of organophosphorus compounds with cholinesterase, as well as their metabolism and biological effects on humans and other nontarget organisms. The book not only covers the anticholinesterase actions of organophosphates, but also other, presumably independent, effects, such as teratogenicity, delayed neuropathy, immunotoxicity, and behavioral toxicity. Offers crucial overviews of chemical and biochemical reactivity and biological responsiveness of mainly nontarget organisms Reviews new developments in assessment of metabolism and disposition of organophosphorus compounds Examines organophosphorus compound-induced toxicity mediated by mechanisms other than inhibition of acetylcholinesterase Covers new research on differences in toxicity induced by the variety of organophosphorus Analyzes current controversies on the relevance of certain biochemical parameters in actual organophosphate toxicity in vivo

Handbook of Toxicology of Chemical Warfare Agents

Author : Ramesh C Gupta
Publisher : Academic Press
ISBN 13 : 0128190914
Total Pages : 1322 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Handbook of Toxicology of Chemical Warfare Agents by : Ramesh C Gupta

Download or read book Handbook of Toxicology of Chemical Warfare Agents written by Ramesh C Gupta and published by Academic Press. This book was released on 2020-03-31 with total page 1322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Toxicology of Chemical Warfare Agents, Third Edition, covers every aspect of deadly toxic chemicals used in conflicts, warfare and terrorism. Including findings from experimental as well as clinical studies, this essential reference offers in-depth coverage of individual toxicants, target organ toxicity, major incidents, toxic effects in humans, animals and wildlife, biosensors and biomarkers, on-site and laboratory analytical methods, decontamination and detoxification procedures, and countermeasures. Expanding on the second edition, Handbook of Toxicology of Chemical Warfare Agents has been completely updated, presenting the most recent advances in field. Brand new chapters include a new chapter on emergency preparedness, coverage of the chemical warfare agents used in Syria, the use of the Novichok agent in the UK, and more. Unites world-leading experts to bring you cutting-edge, agent-specific information on Chemical Warfare Agents (CWA) and their adverse effects on human and animal health, and the environment Provides you with all the information you need on CWA modes of action, detection, prevention, therapeutic treatment and countermeasures New to this edition: a full update to reflect the most recent advances in the field and new chapters on emergency preparedness, the chemical warfare agents used in Syria, and the use of the Novichok agent in the UK