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Environmental Factors In Neurodegenerative Diseases
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Book Synopsis Environmental Factors in Neurodegenerative Diseases by :
Download or read book Environmental Factors in Neurodegenerative Diseases written by and published by Academic Press. This book was released on 2017-09-19 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental Factors in Neurodegenerative Diseases, Volume One addresses contemporary advances in neurotoxicology, with thematic volumes providing authoritative review articles on key issues in the field. Updates in this new volume include chapters on Air pollution and neurodegenerative diseases, Mercury and Parkinson's disease, Pesticides and PD: current evidence, Aluminum and neurodegeneration, Microglia and neurodegeneration, Dietary factors, Mitochondria in neurodegeneration, and Manganese and neurodegeneration. Edited by leading experts, volumes are designed as in-depth overviews of the latest topic developments that analyze the effect of varied chemical agents on the nervous system. It is an essential resource for researchers and graduate students alike. - Includes, in one single publication, a selection of comprehensive reviews devoted to neurotoxicology - Edited by high-profile, leading academics in the field, ensuring a quality publication for subscribers - Aims to widen the scope for participation by international contributors, researchers and editorial board members outside North America - Serves a broad audience of university faculty, researchers and students, as well as the industry, drug development companies and the government
Book Synopsis Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders by : Michael Aschner
Download or read book Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders written by Michael Aschner and published by Academic Press. This book was released on 2015-06-18 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders presents a state-of-the-art review of the effects of environmental contaminants on the development and degeneration of the human nervous system, brought together by world-leading experts in the field. Part One describes the adverse effects that the environment can have on neurological development, and how these effects may exhibit. Specific contaminants and their possible consequences of exposure are addressed (lead, methylmercury, alcohol), as well as specific disorders and the environmental factors associated with them, such as the effect of diet on attention deficit and hyperactivity disorders. Part Two tackles neurodegenerative disorders, specifically addressing their potential neurotoxic origins, and discussing the increasing interest in the effects that early exposure may have in later life. Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders is an invaluable reference for those professionals working in the fields of toxicology, environmental health and neuroscience. - Provides, for the first time, the cutting-edge theory of environmental impacts on both neurodegenerative and neurodevelopmental disorders - Written by an international selection of the world's foremost experts in the field of neurotoxicology - Full-colour throughout, providing accurate and illustrative examples of neurotoxic effects in action - An invaluable reference for those professionals working in the fields of toxicology, environmental health, and neuroscience
Book Synopsis Analysis of Genetic and Environmental Factors in Neurodegenerative Disease by : Marleshia Dorcell Hall
Download or read book Analysis of Genetic and Environmental Factors in Neurodegenerative Disease written by Marleshia Dorcell Hall and published by . This book was released on 2016 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: The incidence of neurodegenerative diseases including Parkinson's, Alzheimer's, and Huntington's disease is ever-increasing. Therefore, it is essential that we understand the mechanisms behind the pathology of these disorders. Extensive study has been conducted on the factors that play a role in these disorders. Through these studies, several pathways have been elucidated that further enlighten our understanding of these pathologies. However, many studies have been conducted on model systems that do not fully recapitulate all of the pathological hallmarks of these diseases. Additionally, a greater understanding into the interplay between multiple pathways has been lacking. Previously, we established a Drosophila model for Parkinson's disease that demonstrates that both genetic and environmental factors play a role in the susceptibility and resistance of the organism to neurodegenerative disease. The herbicide paraquat leads to degeneration of dopamine neurons and reduced mobility as is seen in Parkinson's patients. Using this model, we determined that an integration of the inflammatory and hypoxia pathways ensues whereby ingestion of paraquat induces the production of nitric oxide synthase (NOS) that is associated with hyper-branching of the trachea; this also occurs in adult Drosophila brains. Additionally, we have investigated the role of von Hippel Lindau (VHL), an E3 ubiquitin ligase that regulates the hypoxia response, in sensitivity to paraquat, induction of the inflammatory pathway, and neurodegeneration. We have found that loss of VHL along with exposure to paraquat leads to exacerbated survival truncation and movement abnormalities. Furthermore, Catsup protein levels (a negative regulator of dopamine biosynthesis) are altered in these mutants demonstrating a putative role for VHL in Catsup regulation. Here, we also show that a metabolite from the common soil bacteria Streptomyces venezuelae leads to decreased survival and loss of dopamine neurons and induction of NOS. Additionally, Îł-synuclein, a gene implicated in familial Parkinson's disease was studied to determine susceptibility to this bacterial metabolite. We found that expression of Îł-synuclein in flies leads to increased sensitivity and loss of dopamine neurons due to the toxic bacterial metabolite. Taken together, this work provides a mechanism behind the pathology of neurodegenerative diseases and signifies that both genetic and environmental factors play a role in the development and progression of these diseases. It also demonstrates that a dynamic interplay of pathways exists and provides avenues by which future therapeutics may be developed.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309683092 Total Pages :87 pages Book Rating :4.3/5 (96 download)
Book Synopsis Environmental Neuroscience by : National Academies of Sciences, Engineering, and Medicine
Download or read book Environmental Neuroscience written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2021-01-22 with total page 87 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans are potentially exposed to more than 80,000 toxic chemicals in the environment, yet their impacts on brain health and disease are not well understood. The sheer number of these chemicals has overwhelmed the ability to determine their individual toxicity, much less potential interactive effects. Early life exposures to chemicals can have permanent consequences for neurodevelopment and for neurodegeneration in later life. Toxic effects resulting from chemical exposure can interact with other risk factors such as prenatal stress, and persistence of some chemicals in the brain over time may result in cumulative toxicity. Because neurodevelopmental and neurodegenerative disorders - such as attention-deficit hyperactivity disorder and Parkinson's disease - cannot be fully explained by genetic risk factors alone, understanding the role of individual environmental chemical exposures is critical. On June 25, 2020, the National Academies of Sciences, Engineering, and Medicine's Forum on Neuroscience and Nervous System Disorders hosted a workshop to lay the foundation for future advances in environmental neuroscience. The workshop was designed to explore new opportunities to bridge the gap between what is known about the genetic contribution to brain disorders and what is known, and not known, about the contribution of environmental influences, as well as to discuss what is known about how genetic and environmental factors interact. This publication summarizes the presentation and discussion of the workshop.
Book Synopsis Behavioral Measures of Neurotoxicity by : National Research Council
Download or read book Behavioral Measures of Neurotoxicity written by National Research Council and published by National Academies Press. This book was released on 1990-02-01 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exposure to toxic chemicalsâ€"in the workplace and at homeâ€"is increasing every day. Human behavior can be affected by such exposure and can give important clues that a person or population is in danger. If we can understand the mechanisms of these changes, we can develop better ways of testing for toxic chemical exposure and, most important, better prevention programs. This volume explores the emerging field of neurobehavioral toxicology and the potential of behavior studies as a noninvasive and economical means for risk assessment and monitoring. Pioneers in this field explore its promise for detecting environmental toxins, protecting us from exposure, and treating those who are exposed.
Book Synopsis Imaging in Neurodegenerative Disorders by : Luca Saba
Download or read book Imaging in Neurodegenerative Disorders written by Luca Saba and published by Oxford University Press, USA. This book was released on 2015 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text summarizes the latest developments in imaging techniques and other new diagnostic methods as applied to the neurodegenerative disorders.
Book Synopsis Oxidative Stress and Neurodegenerative Disorders by : G. Ali Qureshi
Download or read book Oxidative Stress and Neurodegenerative Disorders written by G. Ali Qureshi and published by Elsevier. This book was released on 2007-03-22 with total page 795 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders.* Contains the latest information on the subject of neurodegenerative disorders* Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems
Book Synopsis Obesogenic Environmental Conditions Affect Neurodevelopment and Neurodegeneration by : Gustavo Pacheco-Lopez
Download or read book Obesogenic Environmental Conditions Affect Neurodevelopment and Neurodegeneration written by Gustavo Pacheco-Lopez and published by Frontiers Media SA. This book was released on 2021-09-23 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pathogenesis of Neurodegenerative Disorders by : Mark P. Mattson
Download or read book Pathogenesis of Neurodegenerative Disorders written by Mark P. Mattson and published by Springer Science & Business Media. This book was released on 2001-06-01 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the average life expectancy of many populations throughout the world increases, so to does the incidence of such age-related neurodegenerative disorders as Alzheimer's, Parkinson's, and Huntington's diseases. Rapid advances in our understanding of the molecular genetics and environmental factors that either cause or increase risk for age-related neurodegenerative disor ders have been made in the past decade. The ability to evaluate, at the cellular and molecular level, abnormalities in postmortem brain tissue from patients, when taken together with the development of valuable animal and cell-culture models of neurodegenerative disorders has allowed the identification of sequences of events within neurons that result in their demise in specific neurodegenerative disorders. Though the genetic and environmental factors that pro mote neurodegeneration may differ among disorders, shared biochemical cascades that will ultimately lead to the death of neurons have been identified. These cascades involve oxyradical production, aberrant regulation of cellular ion homeostasis and activation of a stereotyped sequence of events involving mitochondrial dysfunction and activa tion of specific proteases. Pathogenesis of Neurodegenerative Disorders provides a timely compilation of articles that encompasses fundamental mechanisms involved in neurodegenerative disorders. In addition, mechanisms that may prevent age-related neurodegenerative disorders are presented. Each chapter is written by an expert in the particular neurodegenerative disorder or mechanism or neuronal death discussed.
Book Synopsis Advances in understanding the pathogenetic mechanisms of neurodevelopmental disorders and neurodegenerative disease - The environment as a putative risk factor by : Anna Maria Lavezzi
Download or read book Advances in understanding the pathogenetic mechanisms of neurodevelopmental disorders and neurodegenerative disease - The environment as a putative risk factor written by Anna Maria Lavezzi and published by Frontiers Media SA. This book was released on 2023-09-05 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodevelopmental disorders are generally influenced by genetic as well as intrauterine and extrauterine factors that affect the fetal-maternal environment and/or brain development that continues after birth. Specific genetic polymorphisms may increase susceptibility to environmental factors that alter the trajectory of brain development via diverse molecular mechanisms. In particular, the pre- and post-natal exposure to neurotoxic metals, pesticides, persistent organic pollutants, and other chemicals is increasingly recognized as involved in the pathogenesis of neurodevelopmental disorders, such as autism, deficiency attention/hyperactivity disorders, neurodegenerative disorders such as Parkinson's and Alzheimer's disease, chronic multiple sclerosis, and even fetal and infant death, including SIUDS (Sudden Unexplained Intrauterine Death Syndrome) and SIDS (Sudden Infant Death Syndrome).
Book Synopsis Neurodegeneration: From Genetics to Molecules by : Victoria Campos-Peña
Download or read book Neurodegeneration: From Genetics to Molecules written by Victoria Campos-Peña and published by Frontiers Media SA. This book was released on 2016-11-15 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic degenerative diseases are one of the major public health problems, particularly those affecting the nervous system. They are characterized by the degeneration of specific cell populations that include several pathologies which contribute significantly to morbidity and mortality in the elderly population. Therefore, in recent years, the study of neuroscience has gained significant importance. Most of these neurodegenerative disorders are the result of a complex interaction between genetic and environmental factors that generate progression and can even determine its severity. The presence of mutations in genes as LRRK2, SNCA, PARK7, PARK2 or PINK1 is associated with Parkinson's disease. Mutations in genes such as APP, PS1 and PS2 are associated with familial Alzheimer's disease; while HTT gene mutations are the cause of Huntington's disease. In most cases, this condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. It is known that these mutations can also alter the proteins function; however, it has not yet been possible to fully understand how some genetic changes cause the disease or influence the risk of developing these disorders. Most symptoms seen in these conditions occurs when specific nerve cells are damaged or die generating a loss in brain communication. Also many of these mutations generate aggregation of intracellular or extracellular proteins affecting cell function and eventually causing neuronal death. It is unclear whether the presence of these aggregates play an important role in nerve cell death during the development of neurodegenerative diseases, or if they are simply part of the response of cells to the disease. Other mutations affect the mitochondrial function generating alterations in energy production and promoting the formation of unstable molecules such as free radicals. Under normal conditions, the harmful effects caused by free radicals, are offset within the cell. However, in pathological conditions, the presence of mutations can alter this process by allowing the accumulation of radicals and damaging or killing cells. On the other hand, we also know that these diseases may not have a direct genetic component, thus, the study of sporadic type neurodegenerative diseases is much more complex. Histopathological lesions as well as the cellular and molecular alterations are generally indistinguishable from familial cases. For this reason, it is important to understand the genetic and molecular mechanisms associated with this type of pathologies. In this sense, this issue aims to understand the molecular processes that occur in the brain, and how these are influenced by the environment, genetics and behavior.
Book Synopsis Etiology of Parkinson's Disease by : Jonas H. Ellenberg
Download or read book Etiology of Parkinson's Disease written by Jonas H. Ellenberg and published by CRC Press. This book was released on 1995-03-01 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
Book Synopsis Environmental Contaminants and Neurological Disorders by : Muhammad Sajid Hamid Akash
Download or read book Environmental Contaminants and Neurological Disorders written by Muhammad Sajid Hamid Akash and published by Springer Nature. This book was released on 2021-05-17 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses how environmental pollutants are involved in the pathogenesis of neurological disorders, and covers specific mechanisms and risk factors, as well as the necessary strategies to reduce the adverse impacts of environmental pollutants on the human nervous system. With a collection of contributions from experts in environmental pollution, neurology and pharmaceutical chemistry, the book provides both an introduction to the pathogenesis of neurodegeneration, including the types and different classes of neurological disorders, and studies demonstrating the clear link between environmental contaminants (e.g. pesticides, smoking, mycotoxins, persistent organic pollutants (POP's), polychlorinated biphenyls, phthalates, nanomaterials) and the development of neurological disorders in vulnerable populations. The book fills in a gap in research on the topic by also covering state-of-the-art treatment strategies and mitigation measures for each type of pollutant. The book will be of interest to environmental scientists, pharmacologists, toxicologists, biochemists, biotechnologists, and food and drug regulatory organizations.
Book Synopsis Neurodegenerative Diseases by : Shamim I. Ahmad
Download or read book Neurodegenerative Diseases written by Shamim I. Ahmad and published by Springer Science & Business Media. This book was released on 2012-03-12 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.
Book Synopsis Early Environmental Origins of Neurodegenerative Disease in Later Life by : Philip J. Landrigan
Download or read book Early Environmental Origins of Neurodegenerative Disease in Later Life written by Philip J. Landrigan and published by . This book was released on 2008-10 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes: (1) Early Environmental Origins of Neurodegenerative Disease in Later Life, by Philip Landrigan; (2) The Role of Early Life Environmental Risk Factors in Parkinson Disease: What Is the Evidence?, by Giancarlo Logroscino; (3) Fetal Environment and Schizophrenia, by Mark Opler and Ezra Susser; (4) Pharmacokinetic and Pharmacodynamic Factors That Can Affect Sensitivity to Neurotoxic Sequelae in Elderly Individuals, by Gary Ginsberg; (5) Neurodegenerative Diseases: An Overview of Environmental Risk Factors, by Rebecca Brown; (6) Aging and the Environment: A Research Framework, by Andrew Geller and Harold Zenick; (7) Developmental Pesticide Models of the Parkinson Disease Phenotype, by Deborah Cory-Slechta. Illus.
Book Synopsis Handbook of Parkinson's Disease, Fifth Edition by : Rajesh Pahwa
Download or read book Handbook of Parkinson's Disease, Fifth Edition written by Rajesh Pahwa and published by CRC Press. This book was released on 2013-05-09 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highly Commended, BMA Medical Book Awards 2014 This volume has long prevailed as one of the leading resources on Parkinson's disease (PD). Fully updated with practical and engaging chapters on pathology, neurochemistry, etiology, and breakthrough research, this source spans every essential topic related to the identification, assessment, and treatment of PD. Reflecting the many advances that have taken place in the management of PD, this volume promotes a multidisciplinary approach to care and supplies new sections on the latest pharmacologic, surgical, and rehabilitative therapies, as well as essential diagnostic, imaging, and nonmotor management strategies. New to this edition: • Early identification of premotor symptoms • Potential disease modification agents • Physical and occupational therapy
Book Synopsis Neurodegenerative Diseases: Multifactorial Degenerative Processes, Biomarkers and Therapeutic Approaches (First Edition) by : Tabish Qidwai
Download or read book Neurodegenerative Diseases: Multifactorial Degenerative Processes, Biomarkers and Therapeutic Approaches (First Edition) written by Tabish Qidwai and published by Bentham Science Publishers. This book was released on 2022-08-10 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference is the definitive guide to common neurodegenerative diseases that affect humans. The book covers mechanisms of some of the most well-known neurodegenerative diseases, their biomarkers, neuropharmacology, and emerging treatment strategies. The book introduces the subject of neurodegeneration by outlining the biochemistry, pathophysiology and multifactorial neurological mechanisms (the role of genetics, environmental factors and mitochondrial damage, for example). Next, it explains some of the most studied diseases, namely, Parkinson’s Disease, Alzheimer’s Disease, Huntington’s Disease, and Multiple Sclerosis. Subsequent chapters delve into current knowledge about diagnostic and immunological biomarkers, followed by a summary of novel therapeutic strategies. Special attention has been given to the role of medicinal plants in attempting to treat neurodegenerative diseases, as well as the public health burden posed by these conditions. Key Features - give readers an overview of multifactorial disease mechanisms in neurodegeneration - covers some major neurodegenerative diseases in detail - covers diagnostic and immunological biomarkers - explores current therapeutic strategies and drug targets in common neurodegenerative diseases - offers a simple presentation with references for advanced readers The book is a suitable reference for all readers, including students, research scholars, and physicians who are interested in the mechanisms and treatment of neurodegenerative diseases.
