Engineering Of Dna Mediated Assemblies For Biosensing Applications

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Engineering of DNA-mediated Assemblies for Biosensing Applications

Author : Phyllis F. Xu
Publisher :
ISBN 13 : 9781303379796
Total Pages : 97 pages
Book Rating : 4.3/5 (797 download)

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Book Synopsis Engineering of DNA-mediated Assemblies for Biosensing Applications by : Phyllis F. Xu

Download or read book Engineering of DNA-mediated Assemblies for Biosensing Applications written by Phyllis F. Xu and published by . This book was released on 2013 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditionally known as the genetic code, in recent years DNA has been engineered in new ways and applied toward novel applications in materials science and bio-nanotechnology. The nanometer features and highly specific base-pairing of DNA has enabled its use to build complex 2- and 3D nano-architectures and nano-structures. Specific DNA scaffolds include branched DNA junctions, 2D and 3D DNA "tiles" and "bricks", and DNA hydrogels that can be used for applications across various fields of materials science. Another unique feature of DNA is its ability to bind other materials through molecular recognition which has made the use of DNA aptamer or DNA-protein conjugates highly useful for applications in biosensing and identification. The main focus of this thesis is to demonstrate the use of DNA as an invaluable tool for engineering specific nanostructures for biosensing. The first chapter introduces the basics of DNA and current research in various DNA structures and assemblies and their applications. The second and third chapters describe the self-assembly of two structurally different nanomaterials using DNA, carbon nanotubes and gold nanoparticles. In the second chapter, the successful large-scale alignment of carbon nanotubes on a surface is shown. The study goes into the factors that affect the quality of alignment, including salt concentration, length of DNA, and annealing. In the third chapter, we show how DNA can be used to engineer discrete gold nanocrystal assemblies-"nanodumbbells"- that can adopt different structural conformations through DNA interactions. By incorporating DNA aptamers in the nanoparticle structure, these nanodumbbells can be used to sense particular analytes in solution. Chapter 4 continues the study of the nanodumbbell structures and their potential use as surface-enhanced Raman spectroscopy (SERS) biosensors. A large measurable difference in Raman signal was experimentally obtained from the two distinct nanodumbbell conformations. This was compared with theoretical studies of SERS enhancement to validate the signals produced. We were also able to show the successful detection of an analyte, ATP, using the DNA-mediated probe and SERS detection method.

A Study of DNA-mediated Assemblies in Cell-free Systems

Author : Aaron Bruce Rabinowitz
Publisher :
ISBN 13 :
Total Pages : 24 pages
Book Rating : 4.:/5 (244 download)

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Book Synopsis A Study of DNA-mediated Assemblies in Cell-free Systems by : Aaron Bruce Rabinowitz

Download or read book A Study of DNA-mediated Assemblies in Cell-free Systems written by Aaron Bruce Rabinowitz and published by . This book was released on 2000 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Bottom-up Surface Engineering of DNA Macro-assemblies for Nanoelectronics and Optical Biosensors

Author : Tony Jefferson Gnanaprakasa
Publisher :
ISBN 13 :
Total Pages : 123 pages
Book Rating : 4.:/5 (7 download)

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Book Synopsis Bottom-up Surface Engineering of DNA Macro-assemblies for Nanoelectronics and Optical Biosensors by : Tony Jefferson Gnanaprakasa

Download or read book Bottom-up Surface Engineering of DNA Macro-assemblies for Nanoelectronics and Optical Biosensors written by Tony Jefferson Gnanaprakasa and published by . This book was released on 2010 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of Nanoscience, Engineering, and Technology

Author : William A. Goddard III
Publisher : CRC Press
ISBN 13 : 142000784X
Total Pages : 1080 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Handbook of Nanoscience, Engineering, and Technology by : William A. Goddard III

Download or read book Handbook of Nanoscience, Engineering, and Technology written by William A. Goddard III and published by CRC Press. This book was released on 2007-05-03 with total page 1080 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability to study and manipulate matter at the nanoscale is the defining feature of 21st-century science. The first edition of the standard-setting Handbook of Nanoscience, Engineering, and Technology saw the field through its infancy. Reassembling the preeminent team of leading scientists and researchers from all areas of nanoscience and nanote

DNA-mediated Self-assembly of Nanostructures

Author : Björn Högberg
Publisher :
ISBN 13 : 9789185317394
Total Pages : 74 pages
Book Rating : 4.3/5 (173 download)

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Book Synopsis DNA-mediated Self-assembly of Nanostructures by : Björn Högberg

Download or read book DNA-mediated Self-assembly of Nanostructures written by Björn Högberg and published by . This book was released on 2007 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt:

DNA Mediated Assembly of Nanostructured Materials

Author : So-Jung Park
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (517 download)

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Book Synopsis DNA Mediated Assembly of Nanostructured Materials by : So-Jung Park

Download or read book DNA Mediated Assembly of Nanostructured Materials written by So-Jung Park and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on this observation, a DNA array detection method was developed in which the binding of Au nanoparticles functionalized with oligonucleotides led to conductivity changes associated with target-probe binding events. The binding events localize gold nanoparticles in an electrode gap; silver deposition facilitated by these nanoparticles bridges the gap and leads to readily measurable conductivity changes. Using this method, we have detected target DNA at concentrations as low as 500 fM with a point mutation selectivity factor of ∼100,000:1. These unprecedented capabilities point towards a way of eliminating the need for polymerase chain reaction (PCR) in DNA detection.

Materials Science of DNA

Author : Jung-II Jin
Publisher : CRC Press
ISBN 13 : 1439827419
Total Pages : 349 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Materials Science of DNA by : Jung-II Jin

Download or read book Materials Science of DNA written by Jung-II Jin and published by CRC Press. This book was released on 2011-12-12 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of materials science and technology has undergone revolutionary advances due to the development of novel analytical tools, functional materials, and multidisciplinary approaches to engineering. Additionally, theoretical predictions combined with increasingly improved models and computational capabilities are making impressive contributions to the progress of materials science and technology. In particular, the materials science of DNA has emerged as a vital area of research and is expected to immensely broaden the horizon of material science and nanotechnology in this century. Materials Science of DNA highlights the most important subjects and perspectives in the field, with the aim of stimulating the interdisciplinary community and bringing this intensively interesting, emerging field of molecular-scale materials science to maturation. The editors have not only been involved in the research of materials science of DNA for the past decade, but also lead the series of International Biotronics Workshops supported by the US Air Force Research Laboratory. Biotechnology and DNA-based biopolymers are not only applicable for genomic sequencing and clinical diagnosis and treatment, but can also have a major impact on nonbiotech applications—such as electronics and photonics— opening up a whole new field for bioengineering. New concepts and insights gained from DNA research are expected to prove genuinely useful in a variety of devices in nano, micro, and macro dimensions in the future. Where silicon has been the building block of inorganic electronics and photonics, DNA holds promise to become the building block for organic electronics and photonics.

Nano-inspired Biosensors for Protein Assay with Clinical Applications

Author : Genxi Li
Publisher : Elsevier
ISBN 13 : 0128150548
Total Pages : 380 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Nano-inspired Biosensors for Protein Assay with Clinical Applications by : Genxi Li

Download or read book Nano-inspired Biosensors for Protein Assay with Clinical Applications written by Genxi Li and published by Elsevier. This book was released on 2018-08-29 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nano-inspired Biosensors for Protein Assay with Clinical Applications introduces the latest developments in nano-inspired biosensing, helping readers understand both the fundamentals and frontiers in this rapidly advancing field. In recent decades, there has been increased interest in nano-inspired biosensors for clinical application. Proteins, e.g. antigen-antibody, tumor markers and enzymes are the most important target in disease diagnosis, and a variety of biosensing techniques and strategies have been developed for protein assay. This book brings together all the current literature on the most recent advances of protein analysis and new methodologies in designing new kinds of biosensors for clinical diagnostic use. - Provides a single source of information on the latest developments in the field of biosensors for protein analysis and clinical diagnosis - Focuses on biosensors fabricated with nanomaterials and nanotechnology - Gives detailed methodologies for designing and fabricating nano-inspired biosensors

Engineering a Robust DNA Circuit for the Direct Detection of Biomolecular Interactions

Author : Ang Yan Shan
Publisher : Springer
ISBN 13 : 9811321884
Total Pages : 224 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Engineering a Robust DNA Circuit for the Direct Detection of Biomolecular Interactions by : Ang Yan Shan

Download or read book Engineering a Robust DNA Circuit for the Direct Detection of Biomolecular Interactions written by Ang Yan Shan and published by Springer. This book was released on 2018-09-21 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides essential insights into designing a localized DNA circuit to promote the rate of desired hybridization reactions over undesired leak reactions in the bulk solution. The area of dynamic DNA nanotechnology, or DNA circuits, holds great promise as a highly programmable toolbox that can be used in various applications, including molecular computing and biomolecular detection. However, a key bottleneck is the recurring issue of circuit leakage. The assembly of the localized circuit is dynamically driven by the recognition of biomolecules – a different approach from most methods, which are based on a static DNA origami assembly. The design guidelines for individual reaction modules presented here, which focus on minimizing circuit leakage, are established through NUPACK simulation and tested experimentally – which will be useful for researchers interested in adapting the concepts for other contexts. In the closing section, the design concepts are successfully applied to the biomolecular sensing of a broad range of targets including the single nucleotide mutations, proteins, and cell surface receptors.

Molecular Architectonics and Nanoarchitectonics

Author : Thimmaiah Govindaraju
Publisher :
ISBN 13 : 9789811641909
Total Pages : 0 pages
Book Rating : 4.6/5 (419 download)

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Book Synopsis Molecular Architectonics and Nanoarchitectonics by : Thimmaiah Govindaraju

Download or read book Molecular Architectonics and Nanoarchitectonics written by Thimmaiah Govindaraju and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the ultimate assembly of recent research activities on molecular architectonics and nanoarchitectonics by authors who are worldwide experts. The book proposes new ways of creating functional materials at the nano level using the concepts of molecular architectonics and nanoarchitectonics, which are expected to be the next-generation approaches beyond conventional nanotechnology. All the contents are categorized by types of materials, organic materials, biomaterials, and nanomaterials. For that reason, non-specialists including graduate and undergraduate students can start reading the book from any points they would like. Cutting-edge trends in nanotechnology and material sciences are easily visible in the contents of the book, which is highly useful for both students and experimental materials scientists. .

Handbook of Nanoscience, Engineering, and Technology, Third Edition

Author : William A. Goddard III
Publisher : CRC Press
ISBN 13 : 1439860157
Total Pages : 1097 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Handbook of Nanoscience, Engineering, and Technology, Third Edition by : William A. Goddard III

Download or read book Handbook of Nanoscience, Engineering, and Technology, Third Edition written by William A. Goddard III and published by CRC Press. This book was released on 2012-06-12 with total page 1097 pages. Available in PDF, EPUB and Kindle. Book excerpt: In his 1959 address, "There is Plenty of Room at the Bottom," Richard P. Feynman speculated about manipulating materials atom by atom and challenged the technical community "to find ways of manipulating and controlling things on a small scale." This visionary challenge has now become a reality, with recent advances enabling atomistic-level tailoring and control of materials. Exemplifying Feynman’s vision, Handbook of Nanoscience, Engineering, and Technology, Third Edition continues to explore innovative nanoscience, engineering, and technology areas. Along with updating all chapters, this third edition extends the coverage of emerging nano areas even further. Two entirely new sections on energy and biology cover nanomaterials for energy storage devices, photovoltaics, DNA devices and assembly, digital microfluidic lab-on-a-chip, and much more. This edition also includes new chapters on nanomagnet logic, quantum transport at the nanoscale, terahertz emission from Bloch oscillator systems, molecular logic, electronic optics in graphene, and electromagnetic metamaterials. With contributions from top scientists and researchers from around the globe, this color handbook presents a unified, up-to-date account of the most promising technologies and developments in the nano field. It sets the stage for the next revolution of nanoscale manufacturing—where scalable technologies are used to manufacture large numbers of devices with complex functionalities.

Nucleic Acid Amplification Strategies for Biosensing, Bioimaging and Biomedicine

Author : Shusheng Zhang
Publisher : Springer
ISBN 13 : 9811370443
Total Pages : 337 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Nucleic Acid Amplification Strategies for Biosensing, Bioimaging and Biomedicine by : Shusheng Zhang

Download or read book Nucleic Acid Amplification Strategies for Biosensing, Bioimaging and Biomedicine written by Shusheng Zhang and published by Springer. This book was released on 2019-04-25 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the rational design, development and application of nucleic acid amplification strategies for biosensing, bioimaging and biomedicine. It consists of fifteen chapters demonstrating the use of these strategies in various areas, including fluorescence techniques, Chemiluminescence biosensors, electrochemiluminescence biosensors, colorimetric assays, surface plasmon resonance technologies, electrochemical DNA sensors, photoelectrochemical biosensor, nanopore sensors, quartz crystal microbalance, fluorescence imaging, surface-enhanced Raman spectroscopy, in vitro and in vivo metal ions detection, theranostics and microdroplet chips. Offering a collection of reviews illustrating the latest advances in biochemical analysis and therapeutics, the book shares valuable insights into current challenges and future prospects, making it a valuable resource for a wide readership in the various fields of biosensing, bioimaging and biomedicine.

Comprehensive Nanoscience and Technology

Author :
Publisher : Academic Press
ISBN 13 : 0123743966
Total Pages : 2785 pages
Book Rating : 4.1/5 (237 download)

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Book Synopsis Comprehensive Nanoscience and Technology by :

Download or read book Comprehensive Nanoscience and Technology written by and published by Academic Press. This book was released on 2010-10-29 with total page 2785 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the Introduction: Nanotechnology and its underpinning sciences are progressing with unprecedented rapidity. With technical advances in a variety of nanoscale fabrication and manipulation technologies, the whole topical area is maturing into a vibrant field that is generating new scientific research and a burgeoning range of commercial applications, with an annual market already at the trillion dollar threshold. The means of fabricating and controlling matter on the nanoscale afford striking and unprecedented opportunities to exploit a variety of exotic phenomena such as quantum, nanophotonic and nanoelectromechanical effects. Moreover, researchers are elucidating new perspectives on the electronic and optical properties of matter because of the way that nanoscale materials bridge the disparate theories describing molecules and bulk matter. Surface phenomena also gain a greatly increased significance; even the well-known link between chemical reactivity and surface-to-volume ratio becomes a major determinant of physical properties, when it operates over nanoscale dimensions. Against this background, this comprehensive work is designed to address the need for a dynamic, authoritative and readily accessible source of information, capturing the full breadth of the subject. Its six volumes, covering a broad spectrum of disciplines including material sciences, chemistry, physics and life sciences, have been written and edited by an outstanding team of international experts. Addressing an extensive, cross-disciplinary audience, each chapter aims to cover key developments in a scholarly, readable and critical style, providing an indispensible first point of entry to the literature for scientists and technologists from interdisciplinary fields. The work focuses on the major classes of nanomaterials in terms of their synthesis, structure and applications, reviewing nanomaterials and their respective technologies in well-structured and comprehensive articles with extensive cross-references. It has been a constant surprise and delight to have found, amongst the rapidly escalating number who work in nanoscience and technology, so many highly esteemed authors willing to contribute. Sharing our anticipation of a major addition to the literature, they have also captured the excitement of the field itself in each carefully crafted chapter. Along with our painstaking and meticulous volume editors, full credit for the success of this enterprise must go to these individuals, together with our thanks for (largely) adhering to the given deadlines. Lastly, we record our sincere thanks and appreciation for the skills and professionalism of the numerous Elsevier staff who have been involved in this project, notably Fiona Geraghty, Megan Palmer and Greg Harris, and especially Donna De Weerd-Wilson who has steered it through from its inception. We have greatly enjoyed working with them all, as we have with each other.

DNA Nanotechnology for Cell Research

Author : Zhou Nie
Publisher : John Wiley & Sons
ISBN 13 : 352784080X
Total Pages : 549 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis DNA Nanotechnology for Cell Research by : Zhou Nie

Download or read book DNA Nanotechnology for Cell Research written by Zhou Nie and published by John Wiley & Sons. This book was released on 2024-02-13 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Nanotechnology for Cell Research Comprehensive coverage of DNA nanotechnology with a focus on its biomedical applications in disease diagnosis, gene therapy, and drug delivery Bringing together multidisciplinary aspects of chemical, material, and biological engineering, DNA Nanotechnology for Cell Research: From Bioanalysis to Biomedicine presents an overview of DNA nanotechnology with emphasis on a variety of different applications in cell research and engineering, covering a unique collection of DNA nanotechnology for fundamental research and engineering of living cells, mostly in cellulo and in vivo, for the first time. Broad coverage of this book ranges from pioneering concepts of DNA nanotechnology to cutting-edge reports regarding the use of DNA nanotechnology for fundamental cell science and related biomedical engineering applications in sensing, bioimaging, cell manipulation, gene therapy, and drug delivery. The text is divided into four parts. Part I surveys the progress of functional DNA nanotechnology tools for cellular recognition. Part II illustrates the use of DNA-based biochemical sensors to monitor and image intracellular molecules and processes. Part III examines the use of DNA to regulate biological functions of individual cells. Part IV elucidates the use of DNA nanotechnology for cell-targeted medical applications. Sample topics covered in DNA Nanotechnology for Cell Research include: Selections and applications of functional nucleic acid toolkits, including DNA/RNA aptamers, DNAzymes, and riboswitches, for cellular recognition, metabolite detection, and liquid biopsy. Developing intelligent DNA nanodevices implemented in living cells for amplified cell imaging, smart intracellular sensing, and in cellulo programmable biocomputing. Harnessing dynamic DNA nanotechnology for non-genetic cell membrane engineering, receptor signaling reprogramming, and cellular behavior regulation. Construction of biocompatible nucleic acid nanostructures as precisely controlled vehicles for drug delivery, immunotherapy, and tissue engineering. Providing an up-to-date tutorial style overview along with a highly valuable in-depth perspective, DNA Nanotechnology for Cell Research is an essential resource for the entire DNA-based nanotechnology community, including analytical chemists, biochemists, materials scientists, and bioengineers.

Biocompatible Graphene for Bioanalytical Applications

Author : Yuwei Hu
Publisher : Springer
ISBN 13 : 3662456958
Total Pages : 122 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis Biocompatible Graphene for Bioanalytical Applications by : Yuwei Hu

Download or read book Biocompatible Graphene for Bioanalytical Applications written by Yuwei Hu and published by Springer. This book was released on 2014-12-04 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the latest advances in the use of graphene and bio-compatible-material-decorated graphene to detect various targets (e.g. DNA, RNA, amino acids, peptides, proteins, enzymes, antigens, glucose, DA, AA, UA, ATP, NADH, gas, ions, etc.). It focuses on the specific interaction of these substances with graphene (or modified graphene) and the efficient transduction of the target recognition event into detectable signals via various techniques. Particular emphasis is given to well-designed strategies for constructing graphene-based platforms and target determination. It also covers other bio-analytical applications including cellular imaging, drug delivery and bacteria inhibition, before turning to a discussion of future challenges and prospects of graphene in bio-analytical applications. This book is intended for researchers working in the fields of analytical chemistry, nanomaterials and biomedical engineering. Li Niu is a Professor at the State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences.

Advances in Bionanomaterials II

Author : Stefano Piotto
Publisher : Springer Nature
ISBN 13 : 3030477053
Total Pages : 275 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Advances in Bionanomaterials II by : Stefano Piotto

Download or read book Advances in Bionanomaterials II written by Stefano Piotto and published by Springer Nature. This book was released on 2020-05-29 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents multidisciplinary research focusing on the analysis, synthesis, and design of bio and nanomaterials. Merging biophysics, biochemistry, and bioengineering perspectives, it discusses the basic properties of materials and their interaction with biological systems; the development of new medical devices, such as implantable systems; and new algorithms and methods for modeling the mechanical, physical, and biological properties of biomaterials. The book gathers the proceedings of the 3rd International Conference on Bio and Nanomaterials, held on September 29–October 3, 2019, on an MSC cruise ship navigating the Mediterranean Sea. It particularly highlights Horizon 2020 projects, covering topics such as novel synthetic strategies for nanomaterials, the implementation of bio- and smart materials for pharmacological and medical purposes, as well as environmental applications. Intended for a broad audience of academics and professionals, it offers a comprehensive and timely snapshot of the field of biomaterials. In addition to a set of innovative theories together with the necessary practical tools for their implementation, it also addresses the current challenges in the field, fostering new discussions and possible future collaborations between diverse groups.

Biology and Engineering of Stem Cell Niches

Author : Ajaykumar Vishwakarma
Publisher : Academic Press
ISBN 13 : 0128027568
Total Pages : 644 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Biology and Engineering of Stem Cell Niches by : Ajaykumar Vishwakarma

Download or read book Biology and Engineering of Stem Cell Niches written by Ajaykumar Vishwakarma and published by Academic Press. This book was released on 2017-03-22 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions. The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro. A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type. Includes the importance of Cell-Cell and Cell Matrix Interactions in each specific tissue and system Authored and edited by authorities in this emerging and multidisciplinary field Includes valuable links to 5-10 minute YouTube© author videos that describe main points