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Engineering Complex Phenotypes In Industrial Strains
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Book Synopsis Engineering Complex Phenotypes in Industrial Strains by : Ranjan Patnaik
Download or read book Engineering Complex Phenotypes in Industrial Strains written by Ranjan Patnaik and published by John Wiley & Sons. This book was released on 2012-09-19 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights current trends and developments in the area of engineering strains. The book details the current and future tools used in the production of bulk chemicals and biofuels from renewable biomass using green technologies. Complex phenotypes are traits in a microbe that requires multiple genetic changes to be modulated simultaneously in the microorganism’s DNA. Knowing what those genetic changes are for a given trait and how to make those changes in the most efficient way forms the motivation behind writing this book. This book explains the newer tools to develop and enable engineered strains at time scales much faster that the natural evolution process so that we can increase a cells' production of a certain substance, increase process productivity, and extend metabolic capability. This book provides a one stop platform of reference for practicing researchers in the field of industrial biotechnology. This book also explains that the commercial success of a process that uses microbial catalysts over platforms that use chemical catalysts and fossil fuels depends on the time it takes to engineer these microbes to perform the desired reaction under harsh manufacturing conditions and at rates that meets the criteria for economic feasibility.
Book Synopsis Metabolic Engineering by : Jens Nielsen
Download or read book Metabolic Engineering written by Jens Nielsen and published by Springer. This book was released on 2003-07-03 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic engineering is a rapidly evolving field that is being applied for the optimization of many different industrial processes. In this issue of Advances in Biochemical Engineering/Biotechnology, developments in different areas of metabolic engineering are reviewed. The contributions discuss the application of metabolic engineering in the improvement of yield and productivity - illustrated by amino acid production and the production of novel compounds - in the production of polyketides and extension of the substrate range - and in the engineering of S. cerevisiae for xylose metabolism, and the improvement of a complex biotransformation process.
Book Synopsis Adaptive Evolution for the Study of Complex Phenotypes in Microbial Systems by : Luis Humberto Reyes Barrios
Download or read book Adaptive Evolution for the Study of Complex Phenotypes in Microbial Systems written by Luis Humberto Reyes Barrios and published by . This book was released on 2013 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial-based industrial production has experienced a revolutionary development in the last decades as chemical industry has shifted its focus towards more sustain- able production of fuels, building blocks for materials, polymers, chemicals, etc. The strain engineering and optimization programs for industrially relevant phenotypes tackle three challenges for increased production: optimization of titer, productivity, and yield. The yield of production is function of the robustness of the microbe, generally associated with complex phenotypes. The poor understanding of complex phenotypes associated with increased production poses a challenge for the rational design of strains of more robust microbial producers. Laboratory adaptive evolution is a strain engineering technique used to provide fundamental biological insight through observation of the evolutionary process, in order to uncover molecular determinants associated with the desired phenotype. In this dissertation, the development of different methodologies to study complex phenotypes in microbial systems using laboratory adaptive evolution is described. Several limitations imposed for the nature of the technique were discussed and tackled. Three different cases were studied. Initially, the n-butanol tolerance in Escherichia coli was studied in order to illustrate the effect of clonal interference in microbial systems propagated under selective pressure of an individual stressor. The methodology called Visualizing Evolution in Real Time (VERT) was developed, to aid in mapping out the adaptive landscape of n-butanol tolerance, allowing the uncovering of divergent mechanisms of tolerance. A second case involves the study of clonal interference of microbial systems propagated under several stressors. Using VERT, Saccharomyces cerevisiae was evolved in presence of hydrolysates of lignocellulosic biomass. Isolated mutants showed differential fitness advantage to individual inhibitors present in the hydrolysates; however, some mutants exhibited increased tolerance to hydrolysates, but not to individual stressors. Finally, dealing with the problem of using adaptive evolution to increase production of secondary metabolites, an evolutionary strategy was successfully designed and applied in S. cerevisiae, to increase the production of carotenoids in a short-term experiment. Molecular mechanisms for increased carotenoids production in isolates were identified. The electronic version of this dissertation is accessible from http://hdl.handle.net/1969.1/151207
Book Synopsis Non-conventional Yeasts: from Basic Research to Application by : Andriy Sibirny
Download or read book Non-conventional Yeasts: from Basic Research to Application written by Andriy Sibirny and published by Springer. This book was released on 2019-08-12 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume scopes several aspects of non-conventional yeast research prepared by the leading specialists in the field. An introduction on taxonomy and systematics enhances the reader’s knowledge on yeasts beyond established ones such as Saccharomyces cerevisiae. Biotechnological approaches that involve fungal utilization of unusual substrates, production of biofuels and useful chemicals as citric acid, glutathione or erythritol are discussed. Further, strategies for metabolic engineering based on knowledge on regulation of gene expression as well as sensing and signaling pathways are presented. The book targets researchers and advanced students working in Microbiology, Microbial Biotechnology and Biochemistry.
Book Synopsis Combinatorial Search Strategies for the Metabolic Engineering of Microorganisms by : Christine Nicole San Diego Santos
Download or read book Combinatorial Search Strategies for the Metabolic Engineering of Microorganisms written by Christine Nicole San Diego Santos and published by . This book was released on 2010 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the field of microbial metabolic engineering has traditionally been dominated by rational and knowledge-driven approaches, recent advances in genetic engineering have led to the emergence of a new methodology based on phenotypic diversification and screening. Unlike "classical strain improvement," which requires the use of general mutagens to introduce nonspecific chromosomal substitutions, these novel combinatorial methods enable sampling of a wider range of phenotypic space and, additionally, offer the important feature of genetic traceability. As an example, the use of transposon mutagenesis allows for the random integration of a genetic cassette within the chromosome for the generation of gene knockout libraries. More recently, the mutagenesis of cellular transcriptional components (global transcription machinery engineering, gTME) has enabled a complete reprogramming of the transcriptome, a useful feature for eliciting a broad array of phenotypes. Despite these advances in library generation, however, the application of these combinatorial approaches has surprisingly been limited to the engineering of only a handful of cellular properties. Thus, there remains a pressing need for a full evaluation of these techniques and, more specifically, an objective comparison of their relative strengths and weaknesses when applied towards strain improvement endeavors. We decided to explore these specific issues using the metabolic engineering framework of L-tyrosine overproduction in Escherichia coli. Although this particular strain optimization problem merely represents a "model system" for these studies, such endeavors do have important industrial implications, as L-tyrosine serves both as a dietary supplement and a valuable precursor for a myriad of polymers, adhesives and coatings, pharmaceuticals, biocosmetics, and flavonoid products. To establish the early foundations for a combinatorial approach, we began with the construction of a "parental" or starting strain for the generation of these genetic libraries. This was achieved by utilizing several common rational engineering strategies to both deregulate and increase the flux through the aromatic amino acid biosynthetic pathway. The resulting strains, P1 and P2, exhibited L-tyrosine production levels of 358 mg/l and 418 mg/l, respectively, thus establishing an already high base line for this study. In a parallel investigation, we also worked on developing a simple high-throughput screen for Ltyrosine production in E. coli, another prerequisite for the use of these combinatorial approaches. This was accomplished through the heterologous expression of a bacterial tyrosinase which provided a visual link between L-tyrosine production and the synthesis of the colored pigment, melanin. When implemented on a solid agar format, this assay allowed for the identification and isolation of high L-tyrosine producers from combinatorial libraries of more than 106 mutants. Having established the basis for a combinatorial study, these strains and tools were subsequently applied for the generation and screening of three separate libraries - a random knockout library constructed through transposon integration and two plasmid-encoded gTME libraries based on the mutagenesis of the a subunit and the s70 sigma factor of RNA polymerase (rpoA and rpoD, respectively). Several strains were isolated, with some gTME mutants exhibiting impressive titers of up to ~900 mg/l L-tyrosine, a 114% increase over the parental. Upon further examination, however, we discovered that phenotypic transferability was somewhat hampered in these strains due to an unusual requirement for both the plasmidencoded rpoA/rpoD and a mutated chromosomal background to achieve the desired phenotype. Furthermore, the biochemical mechanisms triggered by these factors appeared to be nonspecific, as several plasmid-background combinations were found to lead to the same cellular behaviors. To elucidate the biochemical underpinnings for these phenomena, we decided to conduct a full characterization of three isolated gTME strains through both microarray analysis and whole genome sequencing. Interestingly, whole genome sequencing revealed the presence of a separate unique mutation within each strain in two biochemically-related loci (hisH, purF). Although microarray experiments generally yield intractable results, we were also fortunate to find patterns of expression linking this phenotype to two different cellular responses -- the acid stress resistance pathway and the stringent response. Indeed, the overexpression of two transcriptional regulators for these pathways (evgA, relA) was able to supplant the need for the mutant rpoA or rpoD plasmids, thus validating the contributions of these specific mechanisms towards determining cellular phenotype. The successful identification of these critical genetic factors led us to the construction of a novel, genetically-defined strain (rpoA14R) exhibiting a titer of 902 mg/l L-tyrosine and a yield of 0.18 g L-tyrosine/g glucose in 50 ml cultures. To put these numbers into perspective, this yield on glucose is more than 150% greater than a classically-improved strain (DPD4195) currently used for the industrial production of L-tyrosine and, when excluding biomass-related glucose utilization, represents 85% of the maximum theoretical yield. As an added feature, further engineering of this strain has established its capacity to produce the flavonoid precursor naringenin at competitive levels, thus providing a route for the synthesis of other important Ltyrosine derivatives. During this study, we have successfully applied a combinatorial engineering approach for both eliciting a complex phenotype and identifying novel biochemical and genetic avenues by which to engineer future strains. As such, these combinatorial techniques have certainly proven to be valuable tools within the metabolic engineer's ever-expanding arsenal.
Book Synopsis Industrial Biotechnology by : Wim Soetaert
Download or read book Industrial Biotechnology written by Wim Soetaert and published by John Wiley & Sons. This book was released on 2010-03-30 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describing all topics of white biotechnology admitted to the 7th EU Frame Programme and new industrial production processes aiming towards the Kyoto objectives, this comprehensive overview covers the technology, applications, economic potential and implications for society. Directed at readers with a general interest in a specific technology, this is equally suitable as an introductory handbook to a wide range of industries, including chemicals, biotechnology and pharmaceuticals, food and feed, paper and pulp, personal care, energy and agriculture.
Book Synopsis Advanced Technologies for Protein Complex Production and Characterization by : M. Cristina Vega
Download or read book Advanced Technologies for Protein Complex Production and Characterization written by M. Cristina Vega and published by Springer. This book was released on 2016-05-10 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents advanced expression technologies for the production of protein complexes. Since complexes lie at the heart of modern biology, the expression, purification, and characterization of large amounts of high-quality protein complexes is crucial for the fields of biomedicine, biotechnology, and structural biology. From co-expression in E. coli, yeast, mammalian and insect cells to complex reconstitution from individual subunits, this book offers useful insights and guidance for successful protein expressionists. Across several sections readers will discover existing opportunities for the production of protein complexes in bacterial systems (including membrane proteins and cell-free co-expression), methylotrophic and non-methylotrophic yeasts, protozoa (Leishmania terantolae and Dictyostelium discoideum), baculovirus-infected insect cells, mammalian cells, plants and algae. Complex reconstitution from individually purified subunits or subcomplexes is discussed as a complementary strategy. A last section introduces briefly some of the biophysical and structural characterization techniques for macromolecular complexes using state-of-the-art solution scattering and nuclear magnetic resonance. This work is a guided tour over some of the most powerful and successful protein expression technologies, with a focus on co-expression and high-throughput applications. It is addressed to everyone interested in the production and characterization of macromolecular complexes, from university students who want an accessible description of the major co-expression systems to researchers in biomedicine and the life sciences seeking for an up-to-date survey of available technologies.
Book Synopsis Saccharomyces by : Thalita Peixoto Basso
Download or read book Saccharomyces written by Thalita Peixoto Basso and published by BoD – Books on Demand. This book was released on 2021-07-21 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the value of the Saccharomyces genus in areas of agriculture and pharmaceuticals. It includes seven chapters in two sections: “Agricultural and Biotechnological Applications” and “Medical and Pharmaceutical Applications.” The chapters cover such topics as metabolic engineering of S. cerevisiae using CRISPR-Cas9. technology to produce biopharmaceuticals, fruit juice fermentation for antioxidant activity, mode of action of indigenous S. cerevisiae, the performance of Saccharomyces as an antiviral microorganism for pandemic diseases, application of yeast to study DNA repair and damage tolerance on cell cycle division, how calorie restriction can support the anti-aging process using yeast budding cells, and secondary metabolites from S. cerevisiae with anticancer activity.
Book Synopsis Engineering Biology for Microbial Biosynthesis of Plant-Derived Bioactive Compounds by : Yongjun Wei
Download or read book Engineering Biology for Microbial Biosynthesis of Plant-Derived Bioactive Compounds written by Yongjun Wei and published by Elsevier. This book was released on 2024-03-01 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many plant-derived bioactive compounds are the foundation effective drugs to cure diseases. Usually, the bioactive compounds in plant biomass are low, and the extraction of bioactive compounds from plants is not eco-friendly, which limits their application in drugs and other industries. With the development of synthetic biology and green biomanufacturing, the biosynthesis of complex bioactive compounds is possible. However, the engineering fundamentals for microbial biosynthetic of plant-derived bioactive compounds is vast. Engineering biology for microbial biosynthesis of plant-derived bioactive compounds summarizes the engineering fundamental biotechnologies for microbial production of plant-derived bioactive compounds, allowing this content to be easily accessed. Coverage includes summaries of key achievements, identification of challenges, current approaches, tips and tricks, and helpful insights into critical bottlenecks. With a comprehensive coverage of the field, Engineering biology for microbial biosynthesis of plant-derived bioactive compounds is of great interest to undergraduate and graduate students, scientists, researchers as well as engineers who work on the microbial production of plant-derived bioactive compounds. - Provides valuable information for engineers, scientists, and industrial researchers who want to obtain microbial strains with the ability of plant-derived bioactive compound production - Guides microbial production of plant-derived bioactive compounds at the laboratory and industrial levels - Ideal resource for anyone who works on the microbial production of plant-derived bioactive compounds
Book Synopsis Fermentation and Algal Biotechnologies for the Food, Beverage and Other Bioproduct Industries by : James Chukwuma Ogbonna
Download or read book Fermentation and Algal Biotechnologies for the Food, Beverage and Other Bioproduct Industries written by James Chukwuma Ogbonna and published by CRC Press. This book was released on 2022-05-10 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers a range of important topics on dairy and fermented foods and microalgae biotechnologies for food, beverage and bioproduct industries. The topics range from traditionally fermented African foods, fermentation technologies for large-scale industrial enzyme production to microalgae cultivation and nutraceuticals in Africa, etc. The editors provide detailed information on approaches towards harnessing indigenous bioresources for food and nutrition security, climate change adaptation, industrial enzyme production, environmental remediation and healthcare delivery. The book will be useful reference material for scientists and researchers working in the field of dairy and food biotechnology, fermentation technology, enzyme biotechnology, algal biotechnology and cultivation systems, biofuels and other bioproducts from algal biomass and underutilized and novel African food sources. Emphasizes recent advances in biotechnologies that could ameliorate the high-level global food insecurity through fermentation technologies applicable to traditional African indigenous and underutilized novel foods, algal biotechnology and value-added bioproducts Provides detailed information on how to harness indigenous bioresources including microalgae for food and nutrition security, climate change adaptation, industrial enzyme production, environmental remediation and healthcare delivery Introduces new frontiers in the area of large-scale enzyme production using fermentation biotechnologies and their applications in the food and beverage industries Discusses current biotechnologies applicable in the food, beverage and bioproduct industries James Chukwuma Ogbonna, Ph.D., is a Professor of Microbiology and Biotechnology, and Director, National Biotechnology Development Agency, South East Zonal Biotechnology Centre, University of Nigeria, Nsukka, Nigeria. Sylvia Uzochukwu, Ph.D., is a Professor of Food Science and Biotechnology, and Director, Biotechnology Centre, Federal University, Oye-Ekiti, Nigeria. Emeka Godfrey Nwoba, Ph.D., is a research scholar at the Algae Research & Development Centre, Murdoch University, Western Australia. Charles Oluwaseun Adetunji, Ph.D., is an Associate Professor of Microbiology and Biotechnology, and Director of Intellectual Property and Technology Transfer, Edo State University Uzairue, Nigeria. Nwadiuto (Diuoto) Esiobu, Ph.D., is a Professor of Microbiology and Biotechnology at Florida Atlantic University, Boca Raton, FL, USA, and the President and Founder of Applied Biotech Inc. and ABINL, Abuja, Nigeria. Abdulrazak B. Ibrahim, Ph.D., is a Capacity Development Expert at the Forum for Agricultural Research in Africa (FARA), and Associate Professor of Biochemistry, Ahmadu Bello University, Zaria, Nigeria. Benjamin Ewa Ubi, Ph.D., is a Professor of Plant Breeding and Biotechnology and Director, Biotechnology Research and Development Centre, Ebonyi State University, Abakaliki, Nigeria.
Book Synopsis Yeast Diversity in Human Welfare by : Tulasi Satyanarayana
Download or read book Yeast Diversity in Human Welfare written by Tulasi Satyanarayana and published by Springer. This book was released on 2017-05-13 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together and updates the latest information on the diversity of yeasts, their molecular features and their applications in the welfare of mankind. Yeasts are eukaryotic microfungi widely found in natural environments, including those with extreme conditions such as low temperatures, low oxygen levels and low water availability. To date, approximately 2,000 of the estimated 30,000 to 45,000 species of yeast on Earth, belonging to around 200 genera have been described. Although there are a few that are opportunistic human and animal pathogens, the vast majority of yeasts are beneficial, playing an important role in the food chain and in the carbon, nitrogen and sulphur cycles. In addition, yeasts such as Saccharomyces cerevisiae, Hansenula polymorpha and Pichia pastoris are used in expressing foreign genes to produce proteins of pharmaceutical interest. A landmark in biotechnology was reached in 1996 with the completion of sequencing of the entire S. cerevisiae genome, and it has now become a central player in the development of an entirely new approach to biological research and synthetic biology. The sequencing of genomes of several yeasts including Schizosaccharomyces pombe, Candida albicans and Cryptococcus neofromans has also recently been completed. candida albicans="" and="" p/pp
Download or read book Comprehensive Biotechnology written by and published by Newnes. This book was released on 2011-08-26 with total page 5304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Comprehensive Biotechnology, Six Volume Set continues the tradition of the first inclusive work on this dynamic field with up-to-date and essential entries on the principles and practice of biotechnology. The integration of the latest relevant science and industry practice with fundamental biotechnology concepts is presented with entries from internationally recognized world leaders in their given fields. With two volumes covering basic fundamentals, and four volumes of applications, from environmental biotechnology and safety to medical biotechnology and healthcare, this work serves the needs of newcomers as well as established experts combining the latest relevant science and industry practice in a manageable format. It is a multi-authored work, written by experts and vetted by a prestigious advisory board and group of volume editors who are biotechnology innovators and educators with international influence. All six volumes are published at the same time, not as a series; this is not a conventional encyclopedia but a symbiotic integration of brief articles on established topics and longer chapters on new emerging areas. Hyperlinks provide sources of extensive additional related information; material authored and edited by world-renown experts in all aspects of the broad multidisciplinary field of biotechnology Scope and nature of the work are vetted by a prestigious International Advisory Board including three Nobel laureates Each article carries a glossary and a professional summary of the authors indicating their appropriate credentials An extensive index for the entire publication gives a complete list of the many topics treated in the increasingly expanding field
Book Synopsis Microbial Sensing in Fermentation by : Satinder K. Brar
Download or read book Microbial Sensing in Fermentation written by Satinder K. Brar and published by John Wiley & Sons. This book was released on 2018-10-08 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of the fundamental molecular mechanisms in fermentation and explores the microbiology of fermentation technology and industrial applications Microbial Sensing in Fermentation presents the fundamental molecular mechanisms involved in the process of fermentation and explores the applied art of microbiology and fermentation technology. The text contains descriptions regarding the extraordinary sensing ability of microorganisms towards small physicochemical changes in their surroundings. The contributors — noted experts in the field — cover a wide range of topics such as microbial metabolism and production (fungi, bacteria, yeast etc); refined and non-refined carbon sources; bioprocessing; microbial synthesis, responses and performance; and biochemical, molecular and extra/intracellular controlling. This resource contains a compilation of literature on biochemical and cellular level mechanisms for microbial controlled production and includes the most significant recent advances in industrial fermentation. The text offers a balanced approach between theory and practical application, and helps readers gain a clear understanding of microbial physiological adaptation during fermentation and its cumulative effect on productivity. This important book: Presents the fundamental molecular mechanisms involved in microbial sensing in relation to fermentation technology Includes information on the significant recent advances in industrial fermentation Contains contributions from a panel of highly-respected experts in their respective fields Offers a resource that will be essential reading for scientists, professionals and researchers from academia and industry with an interest in the biochemistry and microbiology of fermentation technology Written for researchers, graduate and undergraduate students from diverse backgrounds, such as biochemistry and applied microbiology, Microbial Sensing in Fermentation offers a review of the fundamental molecular mechanisms involved in the process of fermentation.
Book Synopsis Microbial Stress Tolerance for Biofuels by : Zonglin Lewis Liu
Download or read book Microbial Stress Tolerance for Biofuels written by Zonglin Lewis Liu and published by Springer Science & Business Media. This book was released on 2011-09-15 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of sustainable and renewable biofuels is attracting growing interest. It is vital to develop robust microbial strains for biocatalysts that are able to function under multiple stress conditions. This Microbiology Monograph provides an overview of methods for studying microbial stress tolerance for biofuels applications using a systems biology approach. Topics covered range from mechanisms to methodology for yeast and bacteria, including the genomics of yeast tolerance and detoxification; genetics and regulation of glycogen and trehalose metabolism; programmed cell death; high gravity fermentations; ethanol tolerance; improving biomass sugar utilization by engineered Saccharomyces; the genomics on tolerance of Zymomonas mobilis; microbial solvent tolerance; control of stress tolerance in bacterial host organisms; metabolomics for ethanologenic yeast; automated proteomics work cell systems for strain improvement; and unification of gene expression data for comparable analyses under stress conditions.
Download or read book Progress in Mycology written by M.K. Rai and published by Scientific Publishers. This book was released on 2017-02-01 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present book is aimed to provide the readers with current trends in the field of Mycology in general and fungal biotechnology in particular. The book would be of utmost importance to students, researchers and teachers of botany, mycology, microbiology, fungal biotechnology and nanotechnology. The readers should find the book full of information and reader-friendly.
Book Synopsis Current Developments in Biotechnology and Bioengineering by : Ashok Pandey
Download or read book Current Developments in Biotechnology and Bioengineering written by Ashok Pandey and published by Elsevier. This book was released on 2016-09-17 with total page 888 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Developments in Biotechnology and Bioengineering: Production, Isolation and Purification of Industrial Products provides extensive coverage of new developments, state-of-the-art technologies, and potential future trends, focusing on industrial biotechnology and bioengineering practices for the production of industrial products, such as enzymes, organic acids, biopolymers, and biosurfactants, and the processes for isolating and purifying them from a production medium. During the last few years, the tools of molecular biology and genetic and metabolic engineering have rendered tremendous improvements in the production of industrial products by fermentation. Structured by industrial product classifications, this book provides an overview of the current practice, status, and future potential for the production of these agents, along with reviews of the industrial scenario relating to their production. - Provides information on industrial bioprocesses for the production of microbial products by fermentation - Includes separation and purification processes of fermentation products - Presents economic and feasibility assessments of the various processes and their scaling up - Links biotechnology and bioengineering for industrial process development
Book Synopsis Metabolic Engineering for Bioprocess Commercialization by : Stephen Van Dien
Download or read book Metabolic Engineering for Bioprocess Commercialization written by Stephen Van Dien and published by Springer. This book was released on 2016-07-16 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the current metabolic engineering tools and technologies from a practical point of view, and guides researchers as they overcome challenges at various stages of organism and bioprocess development. Microbes have been engineered to produce a variety of industrial products such as fuels, basic chemicals, fine chemicals, nutritional supplements, and pharmaceutical intermediates, and new tools such as gene synthesis, advanced cloning techniques, ‘omics’ analysis, and mathematical modeling have greatly accelerated the pace of innovation in the field. Written by leading experts in the field from both academia and industry, key topics include synthetic biology, pathway engineering, metabolic flux manipulation, adaptive evolution, and fermentation process scale-up. It is suitable for non-specialists, and is a valuable resource for anyone embarking on the exciting path to harnessing the metabolic potential of microorganisms.
